III. Carcinoma of the cervix uteri

CERVIX III.

27

cARc~oFTElE-urm?I

ANA'IXIMY(ICD-0 180) Primary Site. The cervix is the lower third of the uterus. It is roughly cylindrical in shape, projects through the upper, anterior vaginal wall, and communicates with the vagina through an orifice called the external OS. Cancer of the cervix may originate on the vaginal surface or in the canal. Nodal Stations. The cervix is drained by preureteral, postureteral and uterosacral routes first station nodes: Parametrial, into the following hypogastic (obturator), external iliac, presacral and common iliac. Paraaortic nodes are second station and are considered metastases. Metastatic Sites. The most common sites of distant and mediastinal nodes, the lungs and skeleton.

spread include

the aortic

RULES FORCLINICALSTAGING The staging should be based on careful clinical examination and should be the performed before any definitive therapy. It is desirable that examination be performed by an experienced examiner and under anaesthesia. The clinical stage must under no circumstances subsequent findings. When it is doubtful to which stage a particular the case must be referred to the earlier stage.

be changed on the basis case should

of

be allotted,

For staging purpose the following examination methods are permitted: Palpation, inspection, colposcopy, endocervical curettage, hysteroscopy, cystoscopy, proctoscopy, intravenous urography, and X-ray examination of the lungs and skeleton. Suspected bladder or rectal involvement should be confirmed by biopsy and histologic evidence. Findings by examinations such as lymphangiography, arteriography, venography, laparoscopy, etc. are of value for the planning of therapy, but because these are not yet generally available and also because the interpretation of results is variable, the findings of such studies should not be the basis for changing the clinical staging. Infrequently, it happens that hysterectomy of unsuspected extensive invasive cervical clinically staged or included in therapeutic that they be reported separately. Only if possible

the rules for clinical staging to compare results among clinics

is carried out in the presence carcinoma. Such cases cannot be statistics, but it is desirable

are strictly observed will it be and by differing modes of therapy.

CERVIX

28 DElXNITIONSOFTHECLINICAL STAGES IN cARcINot4AoFTBEcEKvlxuTKRI (Correlation

Stage 0

between the FIGO, UICC and AJCC nomenclatures) Carcinoma in situ, Cases of therapeutic

Stage1 Stage Ia Stage Ial Stage Ia

Stage Ib

Stage II

intra-epithelial

Stage 0 statistics

carcinoma.

should not for invasive

be included carcinoma.

the The carcinoma is strictly confined to (extension to the corpus should be disregarded).

any

cervix

Preclinical carcinomas of the cervix, that is diagnosed only by microscopy. Minimal microscopically evident stromal invasion.

those

Lesions detected microscopically that can be measured. The upper limit of the measurement should not show a depth of invasion of more than 5 mm taken from the base of the epithelium, either surface or glandular, from which it originates. A second dimension, the horizontal spread, must not exceed 7 mm. Larger lesions should be staged as Ib. Lesions of greater dimensions than Stage Ia whether seen clinically or not. Preformed space involvement should not alter the staging but should be specifically recorded so as to determine whether it should affect treatment decisions in the future.

Stage IIa

The carcinoma extends beyond the cervix, but extended on to the pelvic wall. The carcinoma the vagina, but not as far as the lower third. No obvious parametrial involvement.

Stage IIb

Obvious parametrial

Stage III

in

has not involves

involvement.

The carcinoma has extended on to the pelvic wall. On rectal examination there is no cancer-free space between the tumour and the pelvic wall. The tumour involves the lower third of the vagina. All or non-functioning kidney cases with a hydronephrosis should be included, unless they are known to be due to other cause.

Stage IIIa

No extension on to the pelvic the lower third of the vagina.

Stage IIIb

Extension on to the pelvic non-functioning kidney.

wall, wall

or

but involvement

of

hydronephrosis

or

Stage

The carcinoma has clinically rectum.

IV

Stage IVa

Spread of the growth to adjacent Spread to distant organs.

Stage IVb Notes

to

the

has extended beyond the involved the mucosa of

t.XRVIX

29

true *pelvis the bladder

or or

organs.

staging

thickness involvement Stage 0 comprises those cases with full epithelium with atypical cells, but with no signs of invasion stroma.

of into

the the

Over the last several decades there has been continued confusion about the stages of preclinical invasive carcinoma of the cervix. Several classification systems have been developed which have not been generally satisfactory. The addition of colposcopy in many countries has caused further confusion as to what is a clinical lesion for obvious reasons. There has also been an increased pressure to put measurements into the definition. As a result of the above a new definition was proposed in volume 20 which is as follows: Stage Ia Carcinoma should include minimal microscopically evident stromal invasion as well as small cancerous tumours of measurable size. Stage Ia should be divided into those lesions with minute foci of invasion visible only microscopically as Stage Ial, and the macroscopically measurable micro-carcinomas as Stage Ia in order to gain furhter knowledge of the clinical behaviour of these lesions. The term Ib Occult should be omitted. The diagnosis of both of Stage Ial and Ia should be based on microscopic examination of removed tissue, preferably a cone, which must include the entire lesion. As noted above, the lower limit of Stage Ia should be that it can be measured macroscopically (even if dots need to be placed on the slide prior to measurement) and the upper limit of Ia is given by measurement of the two largest dimensions in any given section. The depth of invasion should not be more than 5 mm taken from the base of the epithelium, either surface or glandular, from which it originates. The second dimention, the horizontal spread, must not exceed 7 mm. Vascular space involvement, either venous or lymphatic, should not alter the staging, but should be specifically recorded as it may affect treatment decisions in the future. The remaining Stage I cases should be allotted to Stage Ib. cases can be diagnosed by routine clinical examination.

As a rule

these

As a rule, it is impossible to estimate clinically whether a cancer of the cervix has extended to the corpus or not. Extension to the corpus should therefore be disregarded.

30 CERVM A patient with a growth fixed to the pelvic wall by a short and indurated but not nodular parametrium should be allotted to Stage IIb. It is impossible, at clinical examination, to decide whether a smoth and indurated parametrium is truly cancerous or only inflammatory. Therefore the case should be placed in Stage III only if the parametrium is nodular out on the pelvic wall or if the growth itself extends out on the pelvic wall. The presence of hydronephrosis of the ureter by cancer permits according to the other findings, Stage II.

or non-functioning kidney due to stenosis a case to be allotted to Stage III even if, the case should be allotted to Stage I or

The presence of bullous oedema, as such, should not permit a case to be allotted to Stage IV. Ridges and furrows into the bladder wall should be interpreted as signs of submucous involvement of the bladder if they remain fixed to the growth at palposcopy (i.e. examination from the vagina or the rectum during cystoscopy). A finding of malignant cells in cytologic washings from the urinary bladder requires further examination and biopsy from the wall of the bladder.

Cases should be classified as carcinoma of the cervix if the primary growth is in the cervix. All histologic types must be included. Grading by any of several methods is encouraged but is not a basis for modifying the stage groupings. It is desirable that all tumours be microscopically verified, but cases that clinically are likely to be cancer without such confirmation should be included with special attention to descriptive detail. The number should be kept to a minimum. RUMS

REATING

TO STATIMNTS

1.

A statement should preferably comprise at least year, but reports of fewer cases will be accepted.

2.

Statements should include all cases of primary invasive carcinoma of of the the cervix including carcinoma of the stump, irrespective histological type of the carcinoma or its stage of development. Cases should be clinically staged according to the staging system adopted by FIG0 (see above). All patients examined at the institution with a view to treatment, should be included in the statement, whether or private or non-private, not treatment is given, whether treatment is complete, incomplete or and whether submitted to radiotherapy, surgery or any only palliative, other therapeutic procedure.

3. 4.

20 treated

cases per

CKRVIX

31

The increasing complexity of treatment regimens has resulted in many Hospitals care at more than one institution. patients receiving contributing data to the Annual Report should include all cases seen whether or not all therapy was rendered at with a view to treatment, the reporting hospital. For example: Patients referred for treatment outside the reporting institution (i) should be included in the statement provided that treatment was originally planned at the reporting institution, and that the patients have been referred back for follow-up or did not survive the treatment. (ii)

Patients examined and/or primarily treated at another institution may be included in the statement on condition that both examination and treatment have been carried out according to an agreed protocol, and that all patients examined and treated according to this protocol are included in the statement.

When treatment is shared by another institution which also in the Annual Report, special care should be taken to individual cases are reported from only one source. 5.

collaborates ensure that

The following categories of cases should not be included: a) Patients originally examined and primarily treated elsewhere (exception, see above). b) Patients

referred

for diagnosis

only.

c) When the diagnosis is based on smears only. d) Pre-invasive carcinoma of the cervix (Stage 0). Such cases should be reported in a special form, which can be obtained from the Editorial Office of the Annual Report. e) Recurrent carcinoma of the cervix. f) Patients with a secondary cervical extra-genital site. g) Chorio-epithelioma,

sarcoma.

carcinoma

from a genital

or an

Altogether 515 125 cases of carcinoma of the uterine cervix treated in the years 1913 to 1986 incl. have been reported to the Editorial Office of the Annual Report. Fig. A.l, which is based on data from 44 clinics reporting treatment results from 1950 to 1986, incl., reviews the stage changes in stage distribution. The proportion taken by Stage I continously increases from 23.0% in the period 1950-1954 to 38.8% among cases treated in 1982-1986. During the same period the Stage II cases decrease from 38.0% to 29.8% and Stage III cases from 32.7% to 26.0%. The proportion taken by Stage IV cases is more or less unchanged.

Pig.

A.1

Carcinoma ofthe uterine cervix. Distribution by stage percentages of total number treated. Forty-four institutions collaborating in volumes 12 through 21 ofthe Annual Report. -StageI . .._..- St&.@

---

11

Stagelll

- - Stage IV

12 1950 -54

13 1953 -57

14 1958 -60

15 1959 -63

16 1954 -68

17 1959 -72

18 1873 -75

18 1979 -78

20 1979 -81

1982 -86

Rdmts treated

in

CERvlx Fig. A.2 gives the five-year survival by stage for the carcinoma of the uterine cervix reported contributing to volumes 12 to 21. The results for from 74.9% to 78.89; five-year survival rate, and for 58.2%. For Stage III the change was from 26.0X to from 6.0X to 10.2%.

Fig.

the from Stage Stage 32.6%

33

total material of the 44 clinics I cases improved II from 52.7X to and for Stage IV

Carcinoma ofthe uterine cervix. Five year eurvival ratea Forty-four

A.2

institutionscollaborating in volumes 12 through 21 of the Annual Rsport. -StegeI ------stege

II

- - - stege Ill - - StageIV

40-

m_*_._.-----

-

_c-----___L---

12 1950 -54

I 13 1953 -57

.__-.-.-.-.-.-.---.-.-.-.-

zo-

0

Carcinoma

of

the

_---I 14 1955 -60

I 15 1959 -63

uterine

I 16 1984 -68

I 17

1969 -72

I 18 1973 -75

I

I

19 1976 -78

20 1979 -81

I+ 21 1982 -88

wulm IWents

treatedin

cervix

Altogether 38 378 cases of carcinoma of the uterine cervix were reported to volume 21. Individualized reports on patients with data on age, histology, stage of disease, mode of treatment, involvement of lymph nodes and results of follow-up were given from 125 collaborators comprising 32 052 cases,and summarized data were submitted by 12 collaborators on 6 326 patients.

34

CERVIX

Distribution

by age and mean age. The histogram

distribution profile. cervix were 40 years older.

Fig.

in Fig. A.3 gives the age 42.2% of the women with carcinoma of the uterine of age or younger and 35.7% were 60 years of age or

Carcinoma of the uterine cervix, 1962-1966. Age distribution.

A.3

o-29

30-

40-

5&

60-

70+ Age

Table A.1 gives the mean age by stage and histological type. The mean age increases with stage for both epidermoid and adenocarcinoma cases. Table A.1

Histological

Carcinoma of the uterine cervix. Mean age by stage and histological type. Patients treated in 1982-1986.

type

Epidermoid ca Adenocarcinoma Other

Stage I 47.8 47.1 47.7

Stage II 55.1 54.6 53.7

Stage III

Stage IV

No Stage

57.5 58.6 58.8

59.4 62.2 61.4

54.0 63.8 54.6

CERVIX

35

Stage distribution and actuarial survival by stage. Table A.IIa gives the stage distribution and survival for the 32 052 individually reported cases. 60.0% of the cases were in Stage I or Stage II. The total three-year actuarial survival rate was 68.4% and the five-year actuarial survival rate 59.8%. Table A.IIb gives distribution by stage and the five-year crude survival for cases reported as summarized statistics. The five-year direct crude survival rate for the 6 326 reported cases was 53.7% (please, observe that this figure is not corrected for intercurrent deaths or cases lost to follow-up in contrast to the actuarial survival rate for the individually reported cases). Table

A.IIa

Stage

Carcinoma of the uterine cervix. survival rate by stage. Patients Patients

Three and five-year actuarial treated in 1982-1986.

treated

Survival

No.

%

3-year No.

I II

12 143 10 285

37.9

9 429

III IV

8 206

32.1 25.6

6 182 2 915

1 378 40 32 052

4.3 0.1 100.0

177 19 18 722

No stage TOTAL

Table

A.IIb

%

5-year No.

%

86.9 69.5

4 441 2 752

81.6 61.3

44.6 16.6 59.2

1 267 70

36.7 12.1

8 8 538

52.3 59.8

68.4

Carcinoma of the uterine cervix. Five-year crude survival rate by stage. Patients treated in 1982-1984. These results refer to institutions, which have contributed summarized data.

Stage

Patients No.

I II

1 834

III IV

2 272 1 922 253

No stage TOTAL

45 6 326

treated %

5-year survival No. %

29.0 35.9 30.4

1 446 1 277 639

4.0 0.7

12 22

100.0

3 396

78.8 56.2 33.2 4.7 48.9 53.7

36

CERVIX

Stage

distribution

and

actuarial

survival

by

stage.

Table A.IIa gives the stage distribution and survival for the 32 052 individually reported cases. 60.0% of the cases were in Stage I or Stage II. The total three-year actuarial survival rate was 68.4% and the five-year actuarial survival rate 59.8%. Table A.IIb gives distribution by stage and the five-year crude survival for cases reported as summarized statistics. The five-year direct crude survival rate for the 6 326 reported cases was 53.7% (please, observe that this figure is not corrected for intercurrent deaths or cases lost to follow-up in contrast to the actuarial survival rate for the individually reported cases>. Table

A.IIa

Stage

Carcinoma of the uterine cervix. survival rate by stage. Patients Patients

Three and five-year actuarial treated in 1982-1986.

treated

Survival 3-year

No. I II

12 143

III

8 206 1 378 40

25.6

32 052

100.0

10 285

IV No

stage

TOTAL

Table

A.IIb

Stage

%

No.

%

37.9 32.1

9 429

86.9

6 182 2 915

69.5

4.3 0.1

Patients

treated %

I

1 834

29.0

II III

2 272 1 922 253

35.9 30.4

No stage

TOTAL

68.4

4 441 2 752

% 81.6

1 267

61.3 36.7

70 8 8 538

12.1 52.3 59.8

Carcinoma of the uterine cervix. Five-year .crude survival rate by stage. Patients treated in 1982-1984. These results refer to institutions, which have contributed summarized data.

No.

IV

177 19 18 722

44.6 16.6 59.2

5-year No.

45 6 326

5-year survival No. % 1 446 1 277

4.0 0.7

639 12 22

100.0

3 396

78.8 56.2 33.2 4.7 48.9 53.7

CERVIX Table A.IIIa gives the three-year result for on individually records. Within the three-year of and 2.0% died from intercurrent disease. Table A.IIIa

the 31 950 patients reported period 6.8% were lost sight

Carcinoma of the uterine cervix. Patients treated in 1982-1986 and reported with individual data. Three-year result.

Alive Died of carcinoma of the cervix Lost sight of Died from intercurrent

disease

TOTAL

Table A.IIIb tables. Table A.IIIb

37

gives the five-year

result

No.

%

20 096 9 029

62.9 28.3

2 161 664

6.8 2.0

31 950

100.0

for 6 326 cases reported

in summarized

Carcinoma of the uterine cervix. Patients treated and reported as summarized data. Five-year result.

Alive Died of carcinoma of the cervix Died from intercurrent disease Lost sight of TOTAL

)

in 1982-1984

No.

%

3 396

53.7

2 714 216

42.9 3.4

6 326

100.0

38

CERVIX

Table A.IVa gives the three and five-year actuarial survival rate by stage, histopathology and mode of treatment as reported on individual records for 30 322 patients. In all comparisons the outcome for adenocarcinomas seems to be worse than that for the epidermoid carcinomas. Table

Stage

A.IVa

30 322 cases of carcinoma of the uterine cervix treated in 1982-1986 at 125 institutions. Three and five-year actuarial survival rate by histological type and mode of treatment.

Histology

Radiotherapy

alone

Surgery alone

No. treated

Survival 3-year S-year No. % No. %

No. treated

Survival 3-year S-year No. % No. % 3279 95.4 1454 92.2 434 94.3 196 90.9

I

Epidermoid ca Adenocarcinoma

2382 195

1646 77.5 116 68.1

788 69.4 55 61.8

3909 524

II

Epidermoid ca Adenocarcinoma

6459 364

3843 68.3 1711 59.5 154 48.7 63 39.8

430 46

282 81.4 23 66.8

III

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

7143 374 1058 82

2613 90 136 8

39 5 9 10

15 52.3 2l3 34.7

IV

I II III IV

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

45.9 1146 38.2 30.2 35 21.5 16.7 56 12.5 15.0 0 4.2

129 75.2 7 58.1 0 0 o 2

34.7

Surgery and radiotherapy

Radiotherapy

No. treated

Survival 3-year S-year No. % No. %

No. treated

Survival 3-year S-year No. % No. %

2202 310 1046 101 117 14 46 6

1693 231 703 53 58 5 11 l-

1648 290 1240 137 113 7 16 0

1306 87.8 237 86.9 797 76.1 92 81.6 45 50.0 37 53.8 0

84.3 80.5 75.2 61.0 54.2 50.3 26.8

822 113 308 29 20 2 2 l-

78.8 72.2 67.1 57.3 41.2 40.2 15.3

and surgery

698 110 365 40 19 l3 0

82.9 81.8 69.6 72.9 39.8 53.8

From Table A.IVb can be seen that the adenocarcinoma cases on average are older than the epidermoid cancer cases in each group of comparison. Table A.lVb

Stage

30 322 cases of carcinoma of the uterine cervix treated in 1982-1986 at 125 institutions. Mean age by histological type and mode of treatment. Histology

Radiotherapy

alone

Surgery alone

Age

Age

I

Epidermoid ca Adenocarcinoma

58.8 59.4

42.8 42.3

II

Epidermoid ca Adenocarcinoma

57.6 60.1

49.6 52.2

III

Epidermoid ca Adenocarcinoma

57.7 59.7

54.0 60.6

IV

Epidermoid ca Adenocarcinoma

60.1 64.5

51.3 67.9

Surgery and radiotherapy

Radiotherapy and surgery

Age

Age

I

Epidermoid ca Adenocarcinoma

46.5 48.6

45.1 47.4

II

Epidermoid ca Adenocarcinoma

49.9 51.0

48.0 49.6

III

Epidermoid ca Adenocarcinoma

52.6 48.1

49.8 50.9

IV

Epidermoid ca Adenocarcinoma

50.9 53.8

53.1 61.0

39

40

cERvlx

Table A.Vb gives the mean age of the patients groups in early stages. Table A.Vb

Mean age by mode of treatment of the uterine cervix.

Stage

Histology

Ia Ib IIa IIb

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

Radiotherapy

alone

Surgery alone

60.0 53.3 42.1 42.2 48.8 54.9 44.3 55.4

59.0 60.1 43.3 42.0 46.3 47.1 45.1 46.5 Radiotherapy and surgery

Age

Age 56.9 57.6 48.1 50.0 50.1 51.4 46.8 48.3

Epidermoid ca Adenocarcinoma

61.4 62.5

Ib

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

50.7 49.2 49.0 48.3 49.8 48.7

sub-

stages of carcinoma

Age

Ia

IIb

in early

treatment

Age

Surgery and radiotherapy

IIa

in different

cm

Table A.Va reviews the three and five-year actuarial survival of treatment in the early stages of carcinoma of the uterine Table

A.Va

Radiotherapy No. treated

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

IIa

Epidermoid ca Adenocarcinoma

IIb

Epidermoid ca Adenocarcinoma

No.

No. treated %

42 74.6 1 644 60 375 22 1189 46

68.0 58.6 60.9 48.3 59.9 37.9

Survival 3-year 5-year No.

Ib

Epidermoid ca Adenocarcinoma Epidermoid ca Adenocarcinoma

1940 398 381 45 637 87

168 97.3 13 1481 298 270 25 415 40

82.8 79.4 78.3 63.4 73.4 54.4

%

657 28

99.2 97.7

2301 573 243 32

1868 473 166 19 144 21

783 207

98.1 89.0

183 37

No. treated

197 15

No.

1380 99.6 78 97.7

No. treated

Survival 3-year 5-year No. % No. %

%

1567 99

Radiotherapy

Epidermoid ca Adenocarcinoma

Epidermoid ca Adenocarcinoma

Surgery alone

Surgery and radiotherapy

Ia

IIb

%

109 85 86.6 6 5 2031 1375 76.3 226 128 64.6 1306 831 71.0 105 50 54.0 4398 2642 67.8 315 132 47.7

-

IIa

alone

Survival 3-year 5-year No.

Ib

rate by mode cervix.

Three and five-year actuarial survival rate by mode of treatment in the early stages of carcinoma of the uterine cervix.

Stage Histology

Ia

41

93.0 93.6 87.4 81.1 74.0 68.3

81 81.3 11 75.5 48 67.6 4 64.4

and surgery

Survival 3-year 5-year No. % No. %

90 6

95.2

95 6

78 93.2 5

707 143

76.9 69.8

1398 346

1131 87.5 278 84.9

132 14

70.6 61.0

504 87

367 79.1 62 75.6

166 66.2 20 49.5

625 96

369 72.5 61 77.8

39 2 600 125 173 24 170 29

90.1 82.5 79.9 72.1 60.8 66.6 69.9

42

CERVIX

Graphical presentation of the five-year survival rate by histological type and stage. Fig. A.4 - A.7 indicate that the prognosis in terms of five-year actuarial survival rate for the cases reported is better for the epidermoid cancer cases than for the adenocarcinoma cases of the uterine cervix in most comparisons irrespective of mode of treatment. ig.

Carcinoma ofthe uterine cervix, 1982-1986. Fig. &year survival by histological type and stage for patients treated with radiation alone.

A.4

100

5-yews

survivd

(%I

t

80

A. 5

Carcinoma ofthe uterine cervix, 1982-1986. &year survival by histological type and stage for patients treated with surgery alone.

lo() -+ 5-ye&we

q Epidermoid ca. q N enocarcinoma

suIvival

(%I Adenocarcinoma

80

3 60

60

Ii

40 20 0 3 IV

rig.

A.6

100 80

Stage

Carcinoma of the uterine cervix, 1982- 1986. S-year survival by histological type and stage for patients treated with surgery followed by radiation. B-years

auwival

IV

Fig.

A. 7

Carcinoma of the uterine cervix, 1982-1986. B-year survival by histological type and stage for patients treated with radiation followed by Surgery

I()() -$ 5-years

(%I

-I

Epidermoid 0

SurviveI 4%) Epidermoid

ca.

Adenocarcinoma

Stage

80

0

ca.

Adenocarcinoma

60

60

IV

Stage

I

II

Ill

IV

Stage

CERVM Life

table

Fig.

The actuarial survival by year after treatment and by for epidermoid carcinoma of the uterine cervix respectively of the uterine cervix in Fig. A.8 and A.9.

analysis.

stage is given adenocarcinoma

Epidermoid carcinoma of the cervix uteri, 1982- 1986. Life table presentation by stage.

A.8

Cumulative proportion surviving %

.-. \-. \---_ ---

‘~~~

Fz$ij

40

‘.

.-..

20

‘.. \

--.-_ .-., -.-..

0

1

2

--.--.-

3

A.9

5

4 Survival

Fig.

._.._..__,__

Adenocarcinoma of the cervix uteri. Life table presentation by stage.

time (years)

1982-1986.

Cumulative proportion survhting %

. . --. \

\

\

\ \\

\ -.\

-.

.

.

- -. . . - - - . ._ - --.. . --. ---------. ---. .

---

-. ‘\. ‘\-

--..__,

- - . . .. . ---.---..-.‘-’

---

-..-..

--

--

-.. ----.--.--.--

0 i

I

0

1

I 2

I 4

3 Survival

time (years)

t 5

Stage la Stage lb Stage Ila Stagellb Stage Ill StagelV

43

Fig.

A.10

Switzerland

Spain Sweden

Fed. Rep

lbtal

no. treated s-1

of the uterine cervix, 35 countries representing

Un.ofSwthAfrica United Kii United States USSR Yugoelavia

German

Carcinoma stage in StaQeII

1982-1986. Percentage 137 institutions.

distribution

Stage

IV

of

cases

bv"

Fig.

A.11

Chile Czechoelovakie Finland Fmnce German Fed. Rep GretXX Hong Kong Hungary India W Japan Korea Netherlands New Zealand NV F? Ft. of china &land RXtUgal Roumenia Saudi Arabia Spain Sweden swit7merland Un. of South Africa United Kiidom United States USSR Yugoeliwie

Btasil Eulgafia canada

Argentine Austtalim Austria Belgium

Ibtel

na treated

Carcinoma of the uterine 35 countries representing Stage

I

cervix, 1982-1986. 137 institutions.

Five-year

survival

rate

by stage

Stage

in

I-IV

46

CERVIX

Fig. A.12

Carcinoma of the uterine cervix, 1982-1986. Twenty-nine I and II, ranked according to rate of major surgery performed

fw3@!I 70.

Firenze

78.

Seoul

35.

Caen

75.

Okayama

42. 7.

Villejuif Graz

6.

Camperdown

57.

Leipzig

145.

Kladovo

107.

Gothenburg

30.

Praha

2.

Brisbane

146. 28.

Ljubljana Brno (VUKEO)

96.

Wroclaw *

58.

Munich I

147.

Zagreb*

108.

Stockholm

43.

Berlin

94.

Warsaw

85.

Oslo

13.

Sao Paul0

27.

Bratislava

64.

Budapest *

97.

Lisboa

66.

Calcutta*

23.

Toronto*

121.

Manchester*

12.

Belo Horisonte

80

60 m m

* Crude survival

rate.

All

the other actuarial

survival

100%

Survival rate Rate of Surgery

rates.

CERVIX

institutions reporting as part of the primary

a minimum of 100 treated cases in each of the Stages treatment. 5-year survival rates are also given.

Stage II 35. 78.

Caen

75.

Okayama

7. 70.

Seoul Graz Firenze

43. 42.

Villejuif

57. 2.

Leipzig Brisbane

Berlin

107.

Gothenburg

145.

Kladovo

6. 66.

Camperdown Calcutta*

108.

Stockholm

147. 146. 73.

Zagreb Ljubljana Sao Paul0

58.

Munich I

97.

Lisboa

30.

Praha

27.

Bratislava

95.

Wroclaw *

85. 28.

Oslo 8rno (VUKEO)

23.

Toronto*

94.

Warsaw

64.

Budapest *

121.

Manchester*

12.

8elo Horisonte 0

20

40

I

60

I

I

80

I

b

100%

Survival rate EBI Rate of Surgery

47

48cERvIx Three and cervix in surgery.

five-year early

actuarial by

stages

survival condition

rate of carcinoma of regional lymph

of the uterine nodes found at

From Table A.VI can be seen that the five-year actuarial survival rate for Stage Ib cases without regional lymph node involvement was 89.59,, but for cases with histologically proven involvement of lymph nodes the rate dropped to 59.0%. The corresponding figures for Stage IIa was 84.6% for cases lymph node metastases, without regional but only 48.9% for cases with histologically proven lymph node involvement. Carcinoma of the uterine cervix, 1982-1986. Stage Ib and Stage IIa patients submitted to surgery. 3 and 5-year survival by condition of regional lymph nodes.

Table A-VI

Involvement of regional lymph nodes

Not involved Clin. suspicious Histol.

proven

Result of techniques

Stage Ib

Stage IIa

No. treated

Survival 3-year 5-year % %

No. treated

Survival 3-year 5-year % %

4 489 157

93.1

89.5

683

88.8

84.6

82.5 69.0

74.0 59.0

66 269

81.4 62.3

73.7 48.9

after

different

949

treatment after for intracavitary

conventional radiotherapy.

and

Table A.VII gives the three and five-year actuarial by mode of intracavitary radiotherapy technique.

survival

afterloading

rate

by stage

Table A-VII

Stage

Conventional Total no. treated

I II III IV TOTAL

Carcinoma of the uterine cervix: Patients treated in 19821986. 17 606 patients with epidermoid cancer not submitted to surgery, who have received intracavitary radiotherapy. Three and five-year actuarial survival rate by mode of radiotherapy.

1 063 2 878 2 942 203 7 086

intracav.

rad.

Survival 3-year %

S-year %

79.2 68.4 53.4 20.6 62,6

70.5 59.7 44.9 17.8 54.2

Afterloading intracav. low dose rate Total no. treated

rad.

Survival 3-year %

S-year %

Afterloading Total no. treated 98 373 278 20 769

intracav.

rad. NOS

Survival 3-year %

S-year %

87.3 78.4 57.7 25.0 70.7

74.9 68.7 49.5 10.0 61.0

Afterloading intracav. high dose rate Total no. treated

rad.

Survival 3-year %

S-year %

I II III IV

671 1 695 1 346 128

77.2 70.2 48.3 24.8

69.4 60.8 39.0 19.2

288 655 755 64

77.8 74.6 50.9 26.9

71.0 65.9 43.4 21.2

TOTAL

3 840

62.6

53.7

1 772

63.4

55.7

Comb. of conv. intracav. rad and afterloading Comb. of conv. intracav. rad. and afterloading Comb. of afterloading low dose and high dose Total no. treated I 330 II 907 III 1 997 IV 905 TOTAL 4 139

Survival 3-year %

S-year %

66.9 49.3 23.8 9.5 30.1

57.9 40.6 18.6 6.0 24.2

low dose, or high dose, or

CERVIX 51 COt4BINEDTABLBsFORTEEIND~

mTITurIoNs

The tabular forms to be used when reporting on carcinoma of the uterine cervix are available on application to the Editorial Office of the Annual Report, Radiumhemmet, S-104 01 Stockholm, Sweden. For the definitions of the classification and staging of carcinoma of the cervix and the rules to statements to be furnished by collaborators the reader is referred to pp. 27-31. Notes

on the

presentation

of

the

material.

Information concerning cases of carcinoma of the uterine cervix examined with a view to treatment in the years 1982-1986 has been furnished by 137 institutions. 125 collaborators have reported on individual cases and 12 have submitted reports in the form of summarized data. The total material is presented in Tables A.VIIIa, A.VIIIb and A.IX. Table A.VIIIa reviews the series reported by the different contributors. The three and five-year actuarial survival is given for institutions with individual reports, whereas the five-year crude survival is given for institutions reporting summarized statistics. The institutions, which have submitted summarized data are marked with an asterisk. Table A.VIIIb gives an account of the number of cases treated and surviving three and five years by stage for the different contributors. Table A.IX reviews the number of cases reported by the different institutions and the 3 and S-year actuarial survival by mode of treatment. Survival rate; (per cent) are not calculated on samples containing ten cases. Figures given may include non-staged patients.

less

than

Patients for whom the cause of dead of carcinoma of the cervix.

death was unknown have been registered

as

Information concerning cases of is given in Chapter IV.

carcinoma

0)

in situ

of the

cervix

(Stage

T A B L E A.VIIIa

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and 5-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

Stages No. treated

I

-

IV

Survivors 3-year No.

5-year No.

297

173

146

468 257 186 113 405

297 151 126 62 261

275 139 117 59 233

359 338 65 450 242

237 54 210 127

220 211 54 180 123

1984-86

132

75

68

Brasil 12. Belo Horisonte 13. Sao Paul0

1984-86 1982-86

1213 1213

591 605

525 587

Bulgaria 14. Sofia

1984-86

247

122

102

15. 16. 17. 18. 19. 20.

1984-86 1984-86 1982-86 1982-86 1982-86 1984-86

211 191 91 181 109 29

137 103 66 152 76 17

128 97 64 144 68 15

Argentine 1. Buenos Aires

1982-86

Australia 2. Brisbane 1982-86 3. Melbourne,P MacCallum 1984-86 4. Carlton, R Women's Hosp 1984-86 5. Paddington,R H for Women 1982-86 6. Camperdown, R P A 1982-86 Austria 7. Graz 1982-86 8. Innsbruck* 1982-85 9a. Vienna,I.Frauenklinik 1984-86 9b. Vienna,Gyn Strahlen 1982-86 10. Vienna,II. Frauenklinik 1982-86 Belgim 11.

Louvain

Halifax Montreal,Centre d'Onco1 Montreal, H8tel Dieu Montreal,Royal Victoria Ont Ca Found, Kingston Ont Ca Found, Windsor

CmMx

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

106

129

132 91 39 14 93

87

sight 5 -year

of

Actuarial 3-year

survival S-year

Total no. not treated

%

%

%

14

4.7

62.3

49.8

0

148 102 47 17 112

21 3 17 37 32

4.5 1.2 9.1 32.7 7.9

65.3 57.4 74.5 81.3 69.5

59.2 49.8 65.7 75.6 60.9

19 2 3 a 8

29 4 4 1 25

8.1 0.5 6.2 0.2 10.3

70.3

4 213 87

99 119 4 237 91

88.1 47.6 59.0

65.0 62.4 88.1 39.0 56.3

18 10 0 5 1

51

58

4

3.0

58.5

47.4

0

394 291

459 309

211 310

17.4 25.6

59.4 66.4

50.0 62.6

23 72

50

69

71

28.7

70.8

57.6

56 28 17 28 29 10

63 33 19 33 34 12

11 54 6 0 0 0

5.2 28.3 6.6

67.1 75.6 76.2 81.9 69.4 58.6

56.5 68.6 72.4 76.4 60.4 48.9

53

54

CERVIX

T A B L E

A.VIIIa

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and 5-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

21. 22. 23. 24.

Saint John Regina Toronto* Vancouver

Years reported

Stages No . treated

I

-

IV

Survivors 3-year No.

77 74

5-year No.

1984-86 1984-86 1982-84 1984-86

107 114 540 267

183

77 72 279 173

1984-86 1982-86

237 245

155 148

149 136

Bratislava Brno, VUKEO Brno, UJEP Praha

1982-85 1982-86 1982-86 1984-86

415 464 96 302

266 339 63 179

250 328 60 165

Helsinki* Turku

1982-84 1984-86

244 44

32

131 31

Angers Bordeaux Caen Dijon Grenoble Lille Lyon Nice Villejuif

1982,83,86 1982-86 1982-86 1984-86 1982-86 1982-86 1984-86 1984 1982-86

131 332 382 98 19 524 120 44 847

86 238 249 64 13 290 69 29 420

77 223 227 61 13 263 66 26 399

1982-86 1982-84 1982-86

610 288 79

369

334 199 42

Chile

25. 26.

Santiago, Santiago,

P.Jaraquemada San Juan

Czechoslovakia

27. 28. 29. 30. Finland

31. 32. France

33. 34. 35. 36. 37. 38. 39. 40. 42.

German

43. 44. 45.

Federal

Berlin Chemnitz* Essen

Republic

47

CEKVIX

Stages

I-IV deaths ca.

Lost

5-yr

No.

%

%

%

3 4 21 3

2.8 3.5 3.9 3.1

68.6 63.7

74

30 33 2402 83

68.5

53.6 58.4 51.7 61.5

21 6 14 3

69 96

73 105

13 1

15.5 0.4

67.9 53.1

65.1 47.6

8 43

118 119 31 96

131 128 34 110

14 0 1 22

3.4 1.0 7.3

66.6 73.0 65.2 65.6

61.9 70.4 61.2 58.2

4

91 5

0 6

13.6

76.8

53.7 73.8

6 5

39 86 115 11 4 197 23 15 223

46 98 135 12 4 217 26 18 244

1 1 6 9 1 25 28 0 199

0.8 0.3 1.6 9.2 5.3 4.8 23.3 23.5

64.0 71.9 66.1 71.0 66.5 56.6 77.3 66.8 67.3

56.8 66.4 59.4 62.7 66.5 49.5 72.6 58.9 61.8

7 0 4 0 0 20 0 0 16

228

4 0 9

0.7

59.2

22

258 83 27

11.4

66.8

51.4 69.1 58.3

0 0 5

* Incl.

deaths

No. of cervix 3-yr 26 33

of

cervix

sight 5-year

of

ca as well

Actuarial 3-year

as from

intercurrent

survival 5-year

disease

Total no. not treated

55

56

CKRVTX

T A B L E

A.VIIIa

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and 5-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

46. 47. 48. 49. 50. 51. 52. 54. 55. 56. 57. 58. 59. 60. 61.

Years reported

Stages No . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

Freiburg Fulda Giessen Greifswald Gijttingen Hamburg Hannover Jena Kiel KBln Leipzig Munich, I. Frauenklinik Munich, Grosshadern Restock Wiirzburg

1984-86 1982-86 1982-86 1984-86 1982-86 1984-86 1985-86 1984-86 1982-86 1984-86 1982-86 1982-86 1984-86 1983-86 1982-86

217 53 204 221 309 123 133 201 263 78 672 408 182 263 219

144 35 114 122 192 43 84 153 160 38 459 246 117 175 124

140 30 101 115 174 39 76 145 144 31 421 211 109 165 104

Athens

1982-84

312

186

148

1984-86

60

38

37

1982-86

638 346

253

Calcutta*

1984-86

909

Brescia Florence Padova Rome

1984-86 1982-86 1984-86 1984-86

174 307 117 72

Greece

62.

Hong Kong

63.

Shatin

Hungary 64. Budapest* 65. Debrecen

1982-84

349

252

India

66.

433

Italy 69.

70. 71. 72.

127 193 78 47

121 178 75 46

CERVM

Stages I-IV No. of deaths cervix ca. 3-yr

5-yr

Lost sight of 5-year No. %

59 16 82 69 99 42 48 41 89 39 193 124 51 75 86

63 19 95 74 112 46 54 47 105 46 228 157 59 84 100

2 0 2 9 1 38 0 2 5 1 8 34 13 8 1

78

111

40

12.8

71.0

56.1

1

12

13

9

15.0

77.0

74.8

0

21

233 22

24 72

398 20.8

89.3

54.7 88.1

0 21

242

112

12.3

47.6

26

39 103 26 25

10 20 15 1

5.7 6.5 12.8 1.4

71.9 59.0 68.8 65.4

0 21 3 1

34 92 23 24

Actuarial 3-year %

%

1.0 1.9 1.3 1.2 8.3 7.1 3.0 0.5

67.3 63.7 55.1 57.4 61.4 47.5 61.8 76.3 60.1 48.2 67.5 67.5 70.1 68.4 55.6

61.3 51.7 47.5 48.2 54.8 39.1 54.7 71.6 53.7 35.7 60.7 57.3 63.1 63.2 46.0

0 2 3 4 6 3 3 2 8 0 18 4 1 4 7

9.9 1.0 4.1 0.3 30.9

77.8 65.5 74.9 66.8

survival S-year

Total no. not treated

57

58

CERVIX

T A B L E

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and 5-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

A.VIJXa

Institution

Years reported

Full name of institution is given in List of Collaborators

73. 74. 75. 76. 77.

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

Kumamoto Nagasaki Okayama Osaka Tokyo

1982-86 1984-86 1984-86 1984-86 1984-86

205 98 322 312 274

132 79 268 254 233

122 76 267 244 224

Seoul

1982-85

230

86

79

1984-86 1982-86 1982-86 1984-86 1984-86

190 219 274 191 70

134 129 205 100 36

125 117 199 89 33

Auckland

1984-86

210

111

98

Oslo

1984-86

765

493

460

Beijing, Ca Inst (Hasp) Beijing, G H of PLA Chong-Qing Shanghai, Mat Peace Wuhan, Tongji Hosp

1984-86 1982-86 1984-86 1984-86 1982-86

463 106 53 146 286

349

105 47 127 207

332 105 41 122 192

Krakow* Lodz" Warsaw

1982-84 1982-84 1982-86

521 463 1446

904

261 269 863

Korea

78.

The Netherlands 79.

80. 81. 82. 83.

Amsterdam, Acad Med Cen Amsterdam, Neth Ca Inst Groningen Rotterdam Tilburg

NewZealand

84. Norway

85.

Peoples

86. 87. 89. 90. 91b.

Republic

of

china

Poland 92.

93. 94.

Stages I-IV No. of deaths cervix ca.

Lost sight 5-year

3-yr

5-yr

No.

%

%

%

41 16 34 48 41

51 19 35 56 48

13 2 17 6 0

15.6 2.0 5.3 1.9

78.5 82.7 86.7 83.1 84.8

71.8 78.7 86.2 78.6 80.2

0 1 0 0 0

9

16

135

58.7

93.7

83.8

1

45 74 53 74 30

52 86 58 79 33

8 14 6 1 3

4.2 6.4 2.2 0.5 4.7

73.1 63.3 74.8 52.8 53.6

66.1 56.1 71.6 45.3 46.6

2 1 5 3 0

76

88

16

7.6

57.3

48.2

9

230

252

11

1.4

62.9

56.5

15

89 1 3 11 36

105 1 9 13 48

21 0 2 7 40

4.5 3.8 4.8 14.0

78.5 99.1 92.3 91.6 85.5

72.3 99.1 77.5 87.7 77.3

0 0 0 1 0

498

244 176 522

15 9 10

2.9 2.9 0.7

62.7

50.1 58.1 59.3

61 71 11

of

Actuarial 3-year

survival 5-year

Total no. not treated

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and S-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

T A B L E "A.VIIIa

Institution Full name of institution is given in List of Collaborators 95.

Wroclaw*

Years reported

Stages No. treated

I

-

IV

Survivors 3-year No.

5-year No.

1982-84

503

Coimbra Lisboa

1983-86 1982-86

167 1096

122 670

120 597

Bucharest

1984-85

409

297

294

Riyadh

1984-86

100

59

49

Barcelona, H Clin y Prov Barcelona, San Juan Barcelona, Inst Dexeus Granada Madrid, "12 de Octubre" Madrid, Univ Autonoma

1984-86 1984 1982-86 1982-86 1982-86 1982-86

80 4 53 105 75 210

53 2 37 72 52 109

52 2 35 61 50 102

1982-86 1982-86 1984-86 1984-86

393 535 120 115

253 364 78 65

234 313 71 58

1982-86 1984-86 1982-86

84 76 185

52 34 136

52 27 125

1984-86

362

167

133

281

Portugal 96.

97. R-la 98. Saudi 99.

Arabia

Spain

101. 102. 103. 104. 105. 106.

Sweden 107. Gothenburg 108a.Stockholm,Radiumhemmet 109. Umei 110. ijrebro Switzerland

111. Base1 113. Lausanne 114. Zurich Republic

of

South

115. Observatory

Africa

CERVIX

Stages No. of cervix

I-IV deaths ca.

Lost

5-yr

No.

218

0

33 382

35 453

12 41

7.2 3.7

103

106

5

38

48

17 1 14 27 20 54

3-yr

sight 5-year

of %

Actuarial 3-year %

survival 5-year %

Total no. not treated

55.9

3

74.2 61.6

72.4 52.4

13 77

1.2

70.4

68.3

3

3

3.0

60.1

47.0

3

18 1 15 38 22 61

9 0 2 6 2 44

11.3

70.4

68.5

3:‘8 5.7 2.7 21.0

72.5 67.6 68.0 69.7

68.0 55.0 64.2 65.4

5 0 0 10 4

122 146 39 41

139 183 45 44

0 7 0 2

1.7

64.5 68.7 65.0 57.0

58.8 58.7 58.0 49.6

5 0 1

31 29 40

31 34 46

0 12 1

15.8 0.5

60.5 53.6 73.3

60.5 41.5 65.6

2 2 1

125

154

63

17.4

56.6

40.9

28

1.3

61

62

CRKVIX

T A B L E

A.VIIIa

Carcinoma of the uterine cervix. Patients treated in 1982-1986. Stage I-IV by 3 and 5-year actuarial survival Information is also given about number of survivors and deaths of carcinoma of the uterine cervix, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

Stages No . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

UnitedKingdom

116. 117. 118. 120. 121. 122. 123. 124. 125.

Bristol* Cambridge Edinburgh London, Royal Marsden Manchester* Northwood Oxford Southampton Tyne & Wear

UnitedStates

126. 128. 129. 131. 132. 133. 134. 135. 137. 138. 139. 140. 141. 142. 143.

1982-84 1982-86 1984-86 1984-86 1982-84 1982-86 1984-86 1984-86 1984-86

174 360 266 100 921 234 194 233 233

1984-86 1984-86 1984-86 1984-86 1984-86 1984-86 1984-86 1984-86 1984-86 1984-86 1982-86 1982-86 1984-86 1984-86 1984-86

233 164 67

69 209

148 141 170 185

145 66 428 140 132 159 175

170 111 72 84 53 102 174 56 210 162 258 115 36 87 182

121 72 43 47 34 82 112 32 151 98 168 66 20 57 129

117 68 40 44 30 72 106 31 142 87 151 61 17 48 123

1984-86

194

160

153

1982-86 1982-86 1984-86

660 704 787

409

383 368 486

of America

Atlanta Boston, Mass Gen Hosp Charleston Chicago, Rush Med Co11 Danville Evanston & Maywood Galveston Lost Angeles,South Calif Minneapolis New Haven NY Brooklyn,State Univ NY Stony Brook Philadelphia, Hahnemann Philadelphia, Univ Penn Winston-Salem

U.S.S.R.

144. Leningrad Yugoslavia

145. Kladovo 146. Ljubljana 147. Zagreb*

406

CEKVIX

Stages

I-IV

No. of deaths cervix ca.

Lost sight of 5-year No. %

3-yr

5-yr

119 92 16 83 44 50 31

136 106 17 415 91 52 58 40

2 3 3 17 12 1 2 3 12

1.1 0.8 1.1 17.0 1.3 0.4 1.0 1.3 5.2

33 34 25 32 17 14 53 18 54 51 77 43 14 25 42

35 38 28 35 20 23 59 18 62 61 89 47 16 31 48

15 4 2 4 0 1 7 6 0 13 1 4 1 5 8

8.8 3.6 2.8 4.8

33

40

0

227 284

251 322 242

16 2 17

90

1.0 4.0 10.7 8.0 0.4 3.5 2.8 5.7 4.4

2.4 0.3 2.2

Actuarial 3-year %

survival S-year %

Total no. not treated

63.0 72.3 74.0 80.7

55:o 52.3 79.4 46.5 58.6 65.6 68.0 74.0

2 11 6 0 100 0 5 0 11

78.5 68.2 58.1 58.2 58.3 80.9 65.9 62.7 71.2 65.2 62.1 57.6 57.6 70.6 68.0

75.0 63.4 50.1 50.0 44.1 66.4 60.0 59.3 66.5 54.6 53.5 49.5 41.9 58.1 59.7

1 1 8 1 5 2 2 3 2 0 15 2 1 0 6

82.5

78.5

0

64.3 57.3

59.6 51.2 61.8

1 12 12

39.7

63.6 61.2 80.9

63

T A B L E

A.VIIIb

Carcinoma of the uterine cervix. Patients treated in 1982-1986, incl., by stage and number of 3 and 5-year survivors.

Institution Full name of institution in List of Collaborators

Stage I is

given

No. treated

No. alive 3-yr

at 5-yr

Argentine 1.

91

75

66

Brisbane Melbourne,P MacCallum Carlton, R Women's Hosp Paddington, Royal Hosp for Women Camperdown, Royal Prince Alfred

252 118 119 80 241

201 91 93 48 187

188 85 90 47 175

Graz Innsbruck* Vienna, I. Frauenklinik Vienna, Ordinariat Strahlentherapie Vienna, II. Frauenklinik

169 154 61 63

147

67

52 43 47

139 135 52 40 46

57

42

40

173 183

142 122

138 120

Buenos Aires

Australia

2. 3. 4. 5. 6. Austria

7. 8. 9a. 9b. 10.

BdgiUm

11.

Louvain

Brasil

12. 13.

Belo Horisonte Sao Paul0

Bulgaria

14.

Sofia

131

76

65

15. 16. 17. 18. 19. 20. 21. 22.

Halifax Montreal, Centre d'Onco1 Montreal, H&e1 Dieu Montreal, Royal Victoria Ont Ca Found, Kingston Ont Ca Found, Windsor Saint John Regina

102 87 46 62 58 12 56 74

85 55 45 56 50 11 48 60

82 52 45 54 47 11 46 58

CEKVTX

Stage II No. treated

Stage III

No. alive at 3-yr 5-yr

No. treated

Stage IV

No. alive at 3-yr 5-yr

No. treated

No. alive at 3-yr 5-yr

118

73

59

82

24

20

6

1

1

114 87 44 23 109

73 43 25 11 62

66 39 22 10 49

83 43 17 9 46

20 14 5 3 12

18 13 2 2 9

19 8 6 1 9

3 2 3 0 0

3 2 3 0 0

105 57 4 136 86

63

74 111 0 212 70

24

18 42

3 2

79 24

64 22

11 16 0 39 15

3

2 79 51

60 32 2 69 50

9 3

7 3

49

28

24

20

4

3

5

0

0

560 260

297 156

254 154

456 684

147 305

128 292

24 86

5 22

5 21

63

30

28

52

16

9

1

0

0

54 62 31 86 32 8 31 22

33 39 17 76 24 6 24 12

29 38 17 72 20 4 20 12

45 24 12 30 16 7 16 14

13 9 3 19 1 0 5 2

13 7 2 17 1 0 5 2

6 18 2 3 3 2 4 4

2 0 1 1 1 0 0 0

2 0 0 1 0 0 0 0

65

66

CERVIX

T A B L E

A.VIIIb

Carcinoma of the uterine cervix. Patients treated by stage and number of 3 and in 1982-1986, incl., 5-year survivors. Stage I

Institution Full name of institution in List of Collaborators

23. 24.

is

given

No. treated

No. alive 3-yr

181 156

136

131 131

133 101

101 85

98 79

Bratislava Brno, VUKEO Brno, UJEP Praha

206 134 51 111

166 126 47 87

162 126 45 83

Helsinki* Turku

112 20

19

82 18

Angers Bordeaux Caen Dijon Grenoble Lille Lyon Nice Villejuif

44 138 162 41 13 83 69 22 250

37 125 139 36 12 71 44 22 178

33 122 134 35 12 71 42 20 170

200 154 31 73 30 95 82 122 21

160

154 136 25 64 23 60 67 95 11

Toronto* Vancouver

at 5-yr

Chile

25. 26.

Santiago, Santiago,

P Jaraquemada San Juan de Dios

Czechoslovakia

27. 28. 29. 30. Finland

31. 32. France

33. 34. 35. 36. 37. 38. 39. 40. 42.

German

43. 44. 45. 46. 47. 48. 49. 50. 51.

Federal

Berlin Chemnitz* Essen Freiburg Fulda Giessen Greifswald Gijttingen Hamburg

Republic

26 65 27 63 69 104 11

CERVM

Stage II No. treated 140 45

Stage IV

Stage III

No. alive at 3-yr 5-yr

No. treated

28

74 26

149 53

56 56

42 38

40 36

140 129 23 127

84 105 12 79

63 12

67

No. alive at 3-yr 5-yr

No. treated

No. alive at 5-yr 3-yr

la

51 15

25 12

1

1 1

40 80

12 25

11 21

8 8

0 0

0 0

74 100 12 71

60 187 20 57

15 106 4 12

13 100 3 11

9 14 2 7

1 2 0 1

1 2 0 0

9

37 9

60 8

4

12 4

9 4

0

0 0

62 76 103 29 5 171 41 12 221

42 56 66 14 1 120 19 7 129

37 52 60 12 1 109 18 6 122

21 102 89 16 0 197 8 8 318

7 53 37 8

7 46 28 8

84 6 0 105

68 6 0 100

4 16 26 5 1 73 2 2 58

0 4 5 2 0 15 0 0 8

0 3 3 2 0 15 0 0 7

271 74 21 69 13 60 45 96 16

171

148 46 12 49 6 26 30 54 9

100 54 22 61 9 37 83 79 78

26

22 17 4 25 1 12 18 25 18

39 6 5 14 1 12 11 12 7

12

10 0 1 2 0 3 0 0 1

14 52 6 30 31 60 9

6 25 2 18 22 28 22

1 2 0 3 0 0 1

68

CERVM

T A B L E A.VIIIb

Carcinoma of the uterine cervix. Patients treated in 1982-1986, incl., by stage and number of 3 and 5-year survivors. Stage I

Institution Full name of institution in List of Collaborators

is given

No. treated

No. alive 3-yr

71 131 81 13 384 140 86 145 88

62 116 70 10 338 101 72 124 70

58 115 63 10 320 93 67 120 65

Athens

76

64

58

Hong gone 63. Shatin

26

21

20

207 79

75

176 75

52. 54. 55. 56. 57. 58. 59. 60. 61.

Hannover Jena Kiel Kijln Leipzig Munich, I. Frauenblinik Munich, Grosshadern Restock Wiirzburg

at 5-yr

Greece 62.

Hungary 64. Budapest* 65. Debrecen

India 66.

Calcutta*

Italy 69. Brescia 70. 71. 72.

Florence Padova Rome

128

152 114 149 68 39

126 55 31

85 120 54 31

88 60 112 146 134

74 57 102 143 129

72 56 101 142 128

104

50

49

90

Japan 73. 74. 75. 76. 77.

Kumamoto Nagasaki Okayama Osaka Tokyo

Korea 78.

Seoul

Stage II No. treated

Stage III

No. alive at 3-yr 5-yr

Stage IV

No. treated

No. alive at 3-yr 5-yr

No. treated

a

3 3 14 6 15 23 11 3 7

44 41 111 19 160 139 56 54 71

20 28 73 9 92 87 35 34 42

17 23 68 6 82 77 32 33 31

15 26 56 40 113 101 29 61 53

2 8 14 19 28 49 a 16 12

86

58

46

129

63

43

21

1

1

25

15

15

8

2

2

1

0

0

310 118

95

159 94

107 145

82

14 82

14 4

1

0 1

128

519

177

0

1 1

1 0

1

1

238

1 7 10 15

No. alive at 3-yr 5-yr

18

35

a

12

56 101 43 29

37 53 22 16

36 47 21 15

4 48 5 4

0 13 0 0

0 10 0 0

68 30 142 82 78

43 19 126 70 67

40 17 126 68 62

36 7 43 .68 54

13 3 35 39 35

9 3 35 32 32

13 1 25 16 a

103

31

27

18

4

2

5

70

CERVIX

T A B L E

Carcinoma of the uterine cervix. Patients treated in 1982-1986, incl., by stage and number of 3 and 5-year survivors.

A.VIIIb

Institution

Stage I

Full name of institution in List of Collaborators

is

given

No.

treated

No. alive 3-yr

at 5-yr

TheNetherlands 79.

80. 81. 82. 83.

Amsterdam, Acad Med Centrum Amsterdam, Netherland Ca Inst Groningen Rotterdam Tilburg

70 151 80 29

84 56 135 51 23

78 52 132 47 23

78

59

56

340

319

1 9 6 34 9

1 9 6 32 9

97

New Zealand

84.

Auckland

Norway

85.

Oslo

Peoples

86. 87. 89. 90. 91b.

Republic

394 of

China

Beijing, China Ca Inst (Hasp) Beijing, Gen Hosp of PLA Chong-Qing Shanghai, Mat Peace Wuhan, Tongji Hosp

1 9 6 35 11

Krakow* Lodz" Warsaw Wroclaw"

89

Poland 92.

93. 94. 95.

66 49 270 114

56 331 142

281

71 226

62 190

60 185

66

60

59

17

16

14

Portugal 96.

97.

Coimbra Lisboa

Roumania 98. Saudi 99.

Bucharest Arabia

Riyadh

CRKVIX

Stage II No. treated

Stage III

No. alive at 3-yr 5-yr

52 65 97 63 19

40 42 64 33 8

94

No. treated

Stage IV

No. alive at 3-yr 5-yr

No. treated

No. alive at 3.-yr 5-yr

61 29 7

33 70 21 41 16

8 29 5 16 4

6 25 5 13 3

8 13 4 7 6

2 1 1 0 1

2 0 1 0 0

46

38

36

6

4

2

0

0

188

110

103

128

36

32

54

6

5

240 45 47 83 30

204 45 41 72 25

194 45 35 70 24

215 52 0 17 243

143 51

136 51

1

1

13 172

13 158

7 0 0 11 2

8 1

7 1

165 181 434 136

113 122 433 117

167

30 39 158 30

9 22 27 6

310 263 655 238

455

39 39

30 564

24 381

24 335

60 259

33 90

33 71

5 47

229

178

178

106

56

54

8

39

27

24

27

14

10

17

2 6

71

72

CXRVIX

T A B L E

Carcinoma of the uterine cervix. Patients treated in 1982-1986, incl., by stage and number of 3 and 5-year survivors.

A.VIIIb

Institution

Stage I

Full name of institution in List of Collaborators

is

given

No. treated

No. alive 3-yr

at 5-yr

Spain

101. 102. 103. 104. 105. 106.

Barcelona, Hosp Clin y Prov Barcelona, San Juan de Dios Barcelona, Inst Dexeus Granada Madrid, "12 de Octubre" Madrid, Univ Autonoma

107. Gothenburg lOSa.Stockholm, Radiumhemmet 109. Umei 110. ijrebro

33 1 21 31 24 78

30 0 18 27 20 54

18 26 19 51

178 240 58 43

155 212 54 35

148 197 50 34

45 14 109

39

39

8 91

7 85

85

54

48

67 179 113 74 96 111 103 171

154 95 56 76 94 95 144

143 86 55 74 90 89 137

109 62 31 54

84 52 25 34

83 51 24 32

29 0

Switzerland

111. Base1 113. Lausanne 114. Zurich Republic

of

South

Africa

115. Observatory UnitedKingdom

116. 117. 118. 120. 122. 123. 124. 125.

Bristol* Cambridge Edinburgh London, Royal Marsden Northwood Oxford Southampton Tyne & Wear

UnitedStates

126. 128. 129. 131.

39

of America

Atlanta Boston, Mass Gen Hosp Charleston Chicago, Rush Medical College

CERVIX

Stage II No. treated

Stage IV

Stage III

No. alive at 3-yr 5-yr

No. treated

No. alive at 3-yr 5-yr

No. treated

No. alive at 3-yr 5-yr

16 2 23 41 24 73

10 2 19 31 21 45

10 2 17 23 20 42

27 1 7 31 22 49

13 0 0 14 8 9

13 0 0 12 8 8

4 0 2 2 5 10

0

0

0 0

0 0

3 1

3 1

110 183 34 32

67 117 17 18

61 93 16 17

80 88 19 28

29 33 5 11

25 21 3 7

25 23 8 12

2 2 2 1

0 2 2 0

?3

21 40

10 10 31

10 10 28

15 31 29

2 13 14

2 8 12

6 10 7

1 3 0

1 2 0

74

44

34

193

68

50

10

1

45 97 81 14 74 52 90 40

60 56 7 55 32 63 29

19 50 47 7 50 28 61 27

45 65 48 8 47 27 28 20

18 12 3 15 14 11 11

10 15 11 3 15 13 8 11

17 19 24 4 17 2 11 2

1 1 1 2 0 0 1

1 1 1 1 1 0 0 0

49 26 24 25

34 16 12 13

31 15 10 12

9 16 13 2

3 4 6 0

3 2 6 0

3 7 3 3

0 0 0 0

0 0 0 0

73

74 CERVM T A B L E A.VIIIb

Carcinoma of the uterine cervix. Patients treated by stage and number of 3 and in 1982-1986, incl., 5-year survivors. Stage I

Institution Full name of institution in List of Collaborators

is

given

132. Danville 133. Evanston & Maywood 134. Galveston 135. Los Angeles, Southern Calif 137. Minneapolis 138. New Haven 139. N Y Brooklyn, State University 140. N Y Stony Brook 141. Philadelphia, Hahnemann Univ of Penn 142. Philadelphia, 143. Winston-Salem U.S.S.R. 144. Leningrad

No. treated

No. alive 3-yr

at

24 68 120 26 126 93 141 75 21 49 127

17 59 93 19 106 72 114 55 15 40 100

16 59 88 19 103 67 103 51 13 36 96

78

73

71

119 285 252

94 234

93 218 216

5-yr

Yugoslavia 145. Kladovo 146. Ljubljana 147. Zagreb*

CERVIX

Stage II No. treated

Stage III

No. alive at 3-yr 5-yr

No. treated

Stage IV

No. alive at 3-yr 5-yr

No. treated

No. alive at 3-yr 5-yr

20 20 22 18 53 39 51 22 8 21 34

16 18 13 10 36 16 32 8 3 14 18

13 10 13 10 33 12 29 7 2 10 18

6 7 16 12 17 14 53 15 5 11 15

1 4 3 3 8 3 20 3 1 3 10

1 3 2 2 6 3 19 3 1 2 8

3 7 16 0 14 15 11 3 2 6 6

0 1 3

0 0 3

84

67

65

31

20

17

1

0

0

220 188 171

160 101

147 92 117

315 193 289

153 68

141 55 149

6 38 75

2 3

2 3 4

75

76 CERVIX TABLE A.M.

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Argentine 1. Buenos Aires Surgery alone Surgery foll by rad Radiation alone Chemotherapy

Years reported

Stages No . treated

I

-

IV

Survivors 3-year No.

5-year No.

1982-86 34 95 166 2

31 72 70 0

31 62 53 0

158 61 51 197 1

134 43 34 86 0

130 40 27 78 0

7 64 22 8 155 1

7 44 18 2 80 0

7 41 16 1 74 0

71 12 25 8 69 1

61 8 21 3 33 0

60 8 19 3 27 0

70 16 3 24

41 6 3 12

40 5 3 11

Australia 2.

3.

4.

5.

Brisbane 1982-86 Surgery alone Surgery foll by rad ,Rad foll by surgery Radiation alone Chemotherapy Melbourne, P MacCallum 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Carlton, R Women's H 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Paddington, R H Women 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

CERVM

Stages

I-IV

No. of deaths cervix ca.

Lost

3-yr

5-yr

No.

%

14

4.7

0 15 89 2

0 24 103 2

10 15 15 91 1

13 18 21 95 1

0 17 3 6 64 1

0 20 5 7 69 1

1 2 2 5 28 1

2 2 4 5 33 1

2 5 0 7

3 6 0 8

21

3

17

37

sight S-year

of

Actuarial 3-year

survival S-year

%

%

100.0 83.4 45.6

100.0 70.0 34.7

93.3 84.4 72.1 51.5

90.5 67.9 57.6 48.9

Total no. not treated

0

4.5

19

1.2

2 72.3 85.3

64.9 69.1

54.7

48.2

98.5 81.7 91.3

96.4 81.7 72.1

56.9

44.7

96.5 56.4

93.6 42.3

73.9

100.0

9.1

32.7

77

78

CERVM

TABLE

A.M.

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

6.

Years reported

Stages R. . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

Camperdown, R P A 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

200 63 2 2 132 6

166 38 1 2 53 1

156 34 0 2 40 1

Graz Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

1982-86

187 33 2 129 8

160 24 2 51 0

153 23 2 42 0

Innsbruck* Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Vienna, I.Frauenklinik Surgery alone Vienna, Ord Strahlen Radiation alone

1982-85

Austria

7.

8.

9a. 9b. 10.

92 48 1 197

87 37 0 87

1984-86

65

54

54

450

210

180

39 60 3 3 137

27 37 1 0 62

27 36 1 0 59

1982-86

1982-86 Vienna, II.Frauenklinik Surgery alone Surgery foll by rad Rad foll by surg Rad foll by surg by rad Radiation alone

CERVM

Stages

I-IV

No. of deaths cervix ca. 3-yr

5-yr

19 15 1 0 57 1

26 la 2 0 65 1

13 a 0 58 a

19 a 0 64 a

Lost sight of S-year No. % 32

29

4

3 15 2 2 65

3 16 2 2 68

1.2

4

6.2

25

%

%

90.0 72.9

85.‘6 66.1

51.0

41.6

93.0 75.8

89.3 75.8

53.7

46.4

Total no. not treated a

a.1

4

1 237

survival 5-vear

7.9

4

213

Actuarial 3-year

la

62.4

93.1

93.1

51.3

43.9

90.5 72.5

90.5 67.0

48.8

44.3

0.2 10.3

10

79

TABLE

A.M.

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

5 10 55 8 54

4 3 43 7 68

4 3 42 6 13

1213

591

525

101 22 53 8 1021 7

73 12 39 4 476 1

73 12 38 4 459 1

36 57 29 45 78 1

26 26 13 26 31 0

24 23 10 23 22 0

64 20 4 123

55 12 4 66

55 12 4 57

Belgium

11.

1984-86 Louvain Surgery alone Surgery foil by rad Rad foll by surgery Rad foll by surg by rad Radiation alone

Brasil

12. 13.

Belo Horisonte Radiation alone

1984-86

Sao Paul0 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

Bulgaria

14.

15.

Sofia 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Halifax Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

%

4

3.0

1 5 10 1 34

1 5 11 2 39

211 394

459

3 3 11 2 269 2

3 3 12 2 286 2

1 6 5 7 30 1

‘2 9 8 10 39 1

4 6 0 46

4 6 0 53

310

70

11

sight 5 -year

of

Actuarial 3-year %

survival 5-year %

Total no. not treated

0 42.2 80.1

42.2 77.5

36.2

16.4

61.3

51.3

96.7 82.0 77.2

96.7 82.0 74.9

63.7

58.8

96.8 82.0 73.2 82.2 53.5

91.1 70.9 56.3 69.8 37.4

92.5 67.3

92.5 67.3

58.9

47.1

17.4

23

25.6

72

28.7

5.2

82 CERVIX TABLE A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

16.

17.

18.

19.

20.

21.

Montreal, Surgery Surgery Rad foll Radiation

Years reported

Centre d'Onco1 1984-86 alone foll by rad by surgery alone

Montreal, H6tel Dieu Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemoterhapy

I

-

IV

Survivors 3-year

S-year

No.

No.

33 26 16 116

24 18 13 48

22 18 12 45

40 9 5 36 1

39

39

7 1 18 1

7 1 17 0

34 13 6 1 127

33 12 3 1 103

33 11 2 1 97

33 16 60

31 14 31

31 13 24

1982-86

Montreal, Royal Victoria 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Ont Ca Found, Kingston Surgery alone Surgery foll by rad Radiation alone Ont Ca Found, Windsor Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Saint John Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

Stages No . treated

1982-86

1984-86 1 7 1 20 1984-86 26 10 1 70

(XRV3.X

Stages

I-IV

No. of deaths cervix ca. 5-yr 3-yr

Lost sight of 5-year No. % 54

0 3 3 22

1 3 4 25

1 1 3 12 0

1 1 3 13 1

6

Actuarial 3-year %

survival 5-year %

100.0 86.3 80.8 72.4

88.9 86.3 73.1 65.3

97.5

97.5

66.7

58.1

4

28.3

6.6

4

0 1 1 3 0 23

1 1 4 0 27

1 2 26

1 3 30

97.0 91.7

97.0 91.7

81.7

77.7

97.0 86.7 55.4

97.0 79.7 46.9

0

3

0

0

0 2 0 10

50.5

41.3

90.5 100.0

82.6 100.0

66.0

51.0

2.8 2 0 0 24

3 0 0 27

Total no. not treated

21

83

84 cERM[ TABLE A.M

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full

name of institution in List of Collaborators

Years reported

is given

22.

23.

24.

Regina Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Toronto* Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

Stages R. . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

48 17 5 41

45 9 3 15

45 8 3 14

66 44 6 420 4

-

51 27 3 198 0

60 39 10 1 157

58 30 7 0 88

57 29 6 0 81

61 3 40 3 130

51 1 27 2 74

48 1 27 2 71

51 11 1 182

49 11 1 87

46 10 1 79

1984-86

1982-84

Vancouver 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone

Chile 25.

26.

1984-86 Santiago,P Jaraquemada Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 1982-86 Santiago, San Juan Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

CERVIX

Stages No. of cervix 3-yr

0 7 3 0 23

I-IV deaths ca.

Lost

sight S-year

of

5-yr

No.

%

4

3.5

0 7 3 0 23 240

0 8 3 1 62

1 9 4 1 68

5 2 9 1 52

7 2 9 1 54

2 0 0 94

3 1 0 101

21

3.9

3

1.1

13

1

Actuarial 3-year

survival S-year

%

%

100.0 56.5

100.0 56.5

40.7

40.7’

Total no. not treated 6

14

3 100.0 78.8 69.3

94.9 75.3 52.0

59.1

53.0

91.7

87.7

76.0

76.0

59.3

57.5

96.0 100.0

93.5 90.0

47.9

43.4

8

5.5

0.4

43

85

86

c3xRvIx

TABLE

A.IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

29 98 17 4 267

27 86 10 2 141

27 84 10 2 127

33 77 8 345 1

32 68 7 232 0

32 68 6 222 0

28 19 1 48

26 17 1 19

26 16 1 17

2 105 195

2 86 91

2 82 81

Czechoslovakia 27.

Bratislava Surgery Surgery Rad foil Rad foil Radiation

1982-85 alone foll by rad by surgery by surg by rad alone-

Brno, VUKEO Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

1982-86

Brno, UJEP Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone 30. Praha Surgery alone Surgery foll by rad Radiation alone Finland

1982-86

28.

29.

31.

1984-86

Helsinki* 1982-84 Surgery alone Surgery foll by rad Rad foll by surgery Rad foil by surg by rad Radiation alone Chemotherapy

14 5 24 82 117 2

13 4 22 55 37 0

CKKVIX

Stages I-IV No. of deaths cervix ca. 3-yr 5-yr

Lost sight of S-year No. %

14 1 8 5 2 102

1 10 5 2 113

1 9 1 107 1

1 9 2 115 1

2 2 0 27

2 3 0 29

0 16 80

0 20 90

%

%

96.2 91.7 68.1

96.2 89.4 68.1

59.4

53.8

97.0 88.2

97.0 88.2

68.7

66.0

92.7 89.5

92.7 82.9

42.5

36.8

Total no. not treated

1

1.3

1

1.0

22

2

7.3

0 84.5 56.7

0

survival S-year

3.4

6

91

Actuarial 3-year

*

79.2 47.4 6

87

88 TABLE

CKKVIX A.lX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators 32.

Years reported

Turku 1984-86 Rad foll by surgery Rad foll by surg by rad Radiation alone

Stages R. . treated

I

-

IV

Survivors 3-year No.

5-year No.

9

9

9

7 28

4 19

3 19

8 43 19 2 59

7 29 16 2 32

7 25 15 1 29

19 10 86 18 195 4

19 6 81 10 122 0

18 6 81 8 110 0

9 13 168 64 128

7 9 142 40 51

7 8 137 36 39

8 12 11 67

7 7 9 41

7 7 9 38

France

33.

34.

35.

36.

Angers Surgery Surgery Rad foll Rad foil Radiation

1982,83,86 alone foll by rad by surgery by surg by rad alone

Bordeaux 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Caen 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 1984-86 Dijon Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

f.XRWX

Stages

I-IV

No. of deaths cervix ca. 3-yr 5-yr

Lost sight of 5-year No. % 6

0 2 2

0 3 2

0 11 1 0 27

0 14 1 1 30

0 3 4 a 69 2

0 3 4 10 79 2

1 2 21 24 67

1 3 25 28 78

1

1

6

9 1 0 0 11

Actuarial 3-year %

survival 5-year - %

13.6

Total no. not treated 5

91.2

91.2

73.4 94.1

65.7 94.1

54.2

49.1

100.0 68.8 95.4 55.3 64.1

100.0 68.8 95.4 42.1 57.6

82.5 87.8 62.2 44.9

71.5 84.2 55.2 34.5

0.8

0.3

1.6

9.2

0 100.0 100.0 82.6

100.0 100.0 76.0

89

90

CERVM

TABLE

A-IX

Institution Full name of institution is given in List of Collaborators

37.

38.

39.

40.

42.

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number 'of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated. Years reported

Grenoble 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 1982-86 Lille Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 1984-86 Lyon Surgery alone Surgery foll by rad Rad foll by surg by rad 1984 Nice Surgery alone Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 1982-86 Villejuif Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone

Stages No . treated

I

-

IV

Survivors 3-year

S-year

No.

No.

21 24 102 39 334 3

20 17 86 23 144 0

20 17 82 21 123 0

100 18 1

58 9 1

55 9 1

3 21 6 12 2

3 19 4 3 0

3 19 2 2 0

6 63 233 68 470

3 43 164 33 176

3 41 157 31 167

Stages

I-IV

No. of deaths cervix 3-yr

ca. 5-yr

1 6 11 14 161 3

1 6 14 16 176 3

17 6 0

20 6 0

Lost sight of S-year No. % 1

5.3

25

4.8

Actuarial 3-year %

%

Total no. not treated

0

20 73.2 88.5 63.0 47.5

95.2 73.2 84.2 54.3 40.8

80.7 52.5

75.3 52.5

95.2

28

survival S-year

0

23.3

0

0

0 2 4 10 2 199 1 10 20 21 167 4

1 12 27 23 176 5

90.0

90.0

27.3

16.4

23.5

16 81.7 90.3 63.0 55.2

74.8 84.6 58.2 50.2

92 CERVIX TABLE A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

German Federal 43.

44.

45.

46.

47.

48.

Years reported

Stages No. treated

I

-

IV

3-year No.

No.

10 288 12 15 284 1

6 217 7 9 130 0

5 202 7 9 111 0

Survivors 5-year

Republic

Berlin 1982-86 Surgery alone Surgery foil by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Chemnitz* 1982-84 Surgery alone Surgery foll by rad Radiation alone 1982-86 Essen Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy Freiburg Surgery alone Surgery foll by rad Radiation alone

1984-86

Fulda Surgery alone Surgery foll by rad Radiation alone

1982-66

Giessen 1982-86 Surgery alone Surgery foll by rad Rad foli by surgery Rad foil by surg by rad Radiation alone

100 58 130

94 42 63

32 12 1 33 1

28 7 1 11 0

26 6 1 9 0

61 38 118

55 30 59

55 28 57

3 28

21

2 25 8

2 21 7

15 36 3 4 146

12 22 3 3 74

12 21 3 3 62

Stages

I-IV deaths ca.

Lost

3-yr

5-yr

No.

%

4

0.7

4 68 4 6 .45 1

5 82 4 6 160 1

No. of cervix

83

2 4 0 21 0

4 8 47

4 10 49

0 3 13

0 5 14

2 13 0 1 66

2 14 0 1 78

of

Actuarial

survival

%

%

53.7 75.6 61.4 57.5 44.7

38.4 69.3 61.4 57.5 37.1

2

2

2

Total treated

0

0

9 0 3 0 19 0

sight 5-year

0

11.4

5 100.0 70.8

92.3 60.7

39.8

32.9

93.1 84.1 57.0

93.1 67.5 52.5

0.9

0

3.8

2 88.4 38.1

78.9 33.3

85.4 62.8

85.4 59.4

52.7

42.9

1.0

no.

94

CERVM

TABLE

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stag,es I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

A-IX

Institution Full name of institution is given in List of Collaborators 49.

50.

51.

52.

54.

55.

Years reported

Greifswald 1984-86 Surgery alone Surgery foll by rad Radiation alone Giittingen 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Hamburg Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

Hannover Surgery Surgery Rad foll Rad foll Radiation

1985-86 alone foll by rad by surgery by surg by rad alone

Jena Surgery alone Surgery foll by rad Radiation alone

1984-86

Kiel Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

1982-86

Stages R. . treated

I

- IV Survivors

3-year

5-year

No.

No.

51 32 138

47 26 49

47 26 42

46 76 2 1 184

41 55 0 0 96

47 0 0 88

24 1 98

13 1 29

13 1 25

36 45 2 4 46

35 34 1 1 13

35 30 0 1 10

66 85 50

62 68 23

61 66 18

20 23 1 218 1

19

17 18 0 109 0

18 0 123 0

39

cEKvlx

Stages

I-IV

No. of deaths cervix ea. 3-yr 5-yr

Lost sight of 5-year No. % 9

0 5 64

0 5 69

3 16 1 1 78

4 21 1 1 85

1 0 41

1 0 45

1 10 1 3 33

1 13 1 3 36

2 15 24

2 16 29

0 5 1 82 1

2 5 1 96 1

1

38

1

2

5

Actuarial 3-year %

survival 5-year %

4.1

Total no. not treated 4

100.0 83.8 47.2

100.0 83.8 36.0

93.3 78.3

90.8 69.7

56.4

51.8

91.3

91.3

37.9

28.4

97.2 77.3

97.2 69.7

28.3

20.7

96.9 82.0 50.7

96.9 80.7 37.0

100.0 78.3

87.0 78.3

60.8

53.4

0.3

30.9

0.8

1.0

1.9

95

96

CERVM

TABLE

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, numbers of patients lost sight of and cases not treated.

A-IX

Institution Full name of institution is given in List of Collaborators

56.

57.

58.

59.

60.

61.

Years reported

Kiiln Surgery alone Surgery foll by rad Radiation alone

1984-86

Leipzig Surgery Surgery Rad foll Rad foil Radiation

1982-86 alone foll by rad by surgery by surg by rad alone

Munich,I.Prauenklinik Surgery alone Surgery foll by rad Radiation alone Munich, Grosshadern Surgery alone Surgery foll by rad Radiation alone Restock Surgery alone Surgery foll by rad Radiation alone Wiirzburg Surgery alone Surgery foll by rad Radiation alone Chemotherapy

Stages R. . treated

I

-

IV

Survivors 3-year No.

S-year No.

6 10 62

6 6 26

6 5 20

221 207 3 2 239

202 157 1 2 97

197 148 1 2 73

70 66 272

56 37 153

53 34 124

81 40 61

69 27 21

66 24 19

122 41 99

109 27 39

108 24 33

50 24 143 1

46 16 61 0

44 14 45 0

1982-86

1984-86

1983-86

1982-86

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

0 4 35

0 5 41

12 47 1 0 133

15 55 1 0 157

1

8

34 2 22 100

5 24 128

5 10 36

8 13 38

7 14 53

8 17 58

3 8 74 1

3 10 86 1

13

8

1

sight 5-year

of %

Actuarial 3-year %

survival 5-year %

Total not treated 0

1.3 57.4 42.1

44.6 28.6

94.4 77.0

92.8 72.4

43.4

30.4

18

1.2

4

8.3 97.1 66.3 61.9

92.3 62.4 49.1

93.4 73.3 38.6

87.8 63.8 33.8

94.2 65.9 44.4

93.2 56.9 37.4

93.9 66.7 46.2

93.9 57.3 36.3

7.1

3.0

4

0.5

no.

98 CE8VIX TABLE A.IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

Stages No. treated

I

-

IV

Survivors 3-year No.

5-year No.

Greece 62.

Athens Surgery Surgery Rad foll Rad foll Radiation

1982-84 alone foll by rad by surgery by surg by rad alone

Hong gong 63. Shatin Surgery alone Surgery foll by rad Radiation alone 64.

65.

24 52 9 24 202

21 43 6 20 96

20 40 5 18 65

20 4 36

15 3 20

14 3 20

8 25 83 31 488 3

-

7 20 73 25 224 0

7 14 14 83 227 1

7 13 13 74 146 0

7 13 13 74 145 0

34 156 719

-

24 100 309

1984-86

Budapest* 1982-84 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy Debrecen 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

India 66.

Calcutta* Surgery alone Surgery foll by rad Radiation alone

1984-86

cKR.vIx

Stages

I-IV

No. of deaths cervix ca.

Lost sight S-year

3-yr

5-yr

No.

%

40

12.8

1 6 0 1 70

1 9 1 2 98 9

1 0 11

Actuarial 3-year

survival 5-year

%

%

95.8 88.3

95.8 81.9

95.6 62.6

90.8 43.5

Total no. not treated

1

0

15.0

2 0 11 233

9 0 1 5 15 0

of

93.6

86.4

67.7

67.7

24

3.8

26

72

20.8

21

0 0 1 5 16 0

100.0 92.6 92.6 86.9

112

12.3

100.0 92.6 92.6 84.3

606

99

loo

CERVM

TABLE

A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Italy 69. Brescia

Years reported

71.

72.

Florence Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

I

- IV Survivors

3-year

5-year

No.

No.

27 66 1 80

24 54 1 48

23 50 1 47

138 53 28 85 2

115 39 17 22 0

111 36 15 16 0

37 38 23 5 13 1

27 26 14 3 8 0

27 25 14 3 6 0

48 17 5 2

40 4 3 0

40 3 3 0

41 61 101 3

37 44 51 0

36 41 45 0

1984-86

Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone 70.

Stages No. treated

1982-86

1984-86 Padova Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 1984-86 Rome Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

Japan 73.

Kumamoto Surgery alone Surgery foll by rad Radiation alone Chemotherapy

1982-86

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

%

10

5.7

2 10 0 22

3 14 0 22

16 13 11 50 1

18 16 13 54 1

20

15

1 8 12 2 2

8 13 2 2

1 13 26 1

2 16 32 1

32

sight 5-year

of

Actuarial 3-year

survival 5-year

%

%

92.4 84.6

87.2 76.9

69.8

69.8

87.9 74.8 60.7 30.8

85.8 67.8 53.4 23.9

77.4 80.9 65.3

77.4 74.9 65.3

90.5

50.3

83.3 26.0

83.3 19.5

97.6 .78.4 70.6

94.7 72.8 60.7

Total no. not treated

0

6.5

21

12.8

1.4

15.6

102

CKRVlX

TABLE

A.lX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

74.

75.

76.

77.

Years reported

Nagasaki Surgery alone Surgery foll by rad Radiation alone

1984-86

Okayama Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy Osaka Surgery alone Surgery foll by rad Radiation alone Chemotherapy Tokyo Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

Seoul Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1982-85

Stages No . treated

I

- IV Survivors

3-year

5-year

No.

No.

50 28 20

48 22 9

48 20 8

10 195 2 114 1

7 180 1 80 0

7 179 1 80 0

153 68 90 1

147 60 47 0

145 58 41 0

133 27 4 110

125 22 4 82

125 18 4 77

146 29 7 48

64 10 3 9

58 9 3 9

77 41 1 71

73 34 0 27

71 30 0 24

1984-86

1984-86

Korea

78.

The Netherlands 79.

Amsterdam, Surgical Surgical Rad foll Radiation

Acad Med C alone foll by rad by surgery alone

1984-86

Stages

I-IV

No. of deaths cervix ca. 3-yr

5-yr

2 6 8

2 8 9

0 8 1 24 1

0 9 1 24 1

3 7 37 1

4 9 42 1

8 5 0 28

8 8 0 32

4 2 0 3

10 3 0 3

1 5 1 38

2 8 1 41

Lost sight of 5-year No. % 2

17

6

Actuarial 3-year

survival 5-year

%

%

96.0

78.6 56.4

96.0 70.2 49.4

100.0 95.6

100.0 94.9

71.6

71.6

98.0 89.6 56.6

97.2

Total no. not treated 1

2.0

0

5.3

1.9 86.2 48.6

0

135

8

94.0

94.0

81.2

63.4

73.6

68.4

96.1 90.5

84.3 78.4

84.3

84.3

98.7

87.4

97.0 77.0

43.3

37.1

58.7

4.2

2

104

CERVM

TABLE

A.M

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

81.

81.

82.

83.

Amsterdam, Neth Ca Inst Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

Years reported

I

-

IV

Survivors 3-year No.

5-year No.

1982-86

1982-86 Groningen Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 1984-86 Rotterdam Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Tilburg Surgery alone Surgery foll by rad Rad foil by surgery Radiation alone

Stages No . treated

40 17 2 157 3

33 13 2 81 0

30 13 2 72 0

52 19 110 34 58 1

49 11 97 25 23 0

48 11 95 24 21 0

11 47 5 1 127

8 30 3 0 59

7 27 3 0 52

4 19 4 43

4 13 1 18

4 13 1 15

14 3 70 2 121

9

9

2 55 1 44

2 51 0 36

1984-86

New Zealand 84.

Auckland 1984-86 Surgery alone Surgery foll by rad Rad foll by surg Rad foll by surg by rad Radiation alone

Stages

I-IV

No. of deaths cervix ca. 3-yr 5-yr 3 4 0 64 3

6 4 0 73 3

1 4 11 8 28 1

1 4 13 9 30 1

3 14 1 1 55

4 15 1 1 58

0 5 3 22

0

5, 3 25

0

0

1 9 1 65

1 13 2 72

Lost sight 5-year

of

No.

%

14

6.4

6

1

3

16

Actuarial 3-year

survival 5-year

%

%

91.6 76.5

79.7 76.5

56.1

48.7

98.0 78.3 89.7 75.8 44.5

98.0 78.3 86.6 72.2 38.7

72.7 68.5

60.6 65.9

55.6

51.6

Total no. not treated 1

2.2

5

0.5

3

4.3

0

72.3

72.3

46.0

32.0

100.0

100.0

87.1

77.0

41.2

32.0

7.6

106

CERVIX

TABLE

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

A.IX

Institution

Years reported

Full name of institution is given in List of Collaborators

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

Norway

85.

Oslo Surgery Surgery Rad foll Rad foll Radiation

Peoples

86. 87.

89.

Republic

1984-86 alone foll by rad by surgery by surg by rad alone of

101 42 112 29 480

37 107 14 242

91 35 103 10 221

463

349

332

92

China

Beijing. China Ca Inst Radiation alone

1984-86

Beijing. G H of PLA Surgery alone Surgery foll by rad Radiation alone

1982-86

Chong-Qing Surgery alone Rad foll by surgery Radiation alone

1984-86

1984-86 Shanghai Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 91b. Wuhan 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

6 4 96

6 4 95

6 4 95

5 29 19

5 25 17

4 23 14

9 10 40 19 65 3

9 9 39

a 9 39

19 51 0

19 47 0

2 1 3 280

2 1 3 201

2 1 2 187

90.

Stages

I-IV

of deaths cervix ca.

No.

3-yr

5-yr

5 3 3 15 204

6 5 6 19 215

89

105

0 0 1

0 0 1

0 2 1

1 4 4

Lost sight of S-year No. %

11

21

Actuarial 3-year

survival S-year

%

%

94.6 92.6 97.2 48.3 53.9

93.2 85.9 93.6 30.6 49.9

75.3

71.8

99.0

99.0

92.8 94.4

84.2 76.7

15

1.4

4.5

0

2

7

3.8

4.8

0 0 0 0 10 3 0 0 1 47

100.0 100.0 87.1

100.0 100.0 100.0 83.3

86.2

80.1

100.0

40 0 0 0 36

Total no. not treated

14.0

108 CERVIX TABLE A.M

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Poland 92. Krakow* Surgery alone Rad foll by surgery Radiation alone 93.

94.

Lodz* Surgical alone Surgery foll by rad Radiation alone Chemotherapy

Years reported

Stages No. treated

-

IV

Survivors 3-year

5-year

No.

No.

1982-84 5 71 445

5 48 208

2 27 428 6

1 22 246 0

1982-84

Warsaw 1982-86 Surgery alone Surgery foll by rad Rad foil by surgery Rad foll by surg by rad Radiation alone

5 72 142 42 1184

Wroclaw* 1982-84 Surgery alone Surgery foll by rad Rad foil by surgery Rad foll by surg by rad Radiation alone Chemotherapy

58 57 6 1 377 4

Portugal 1983-86 96. Coimbra Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone

7 6 25 22 107

95.

I

5 55 135 32 676

5 53 129 32 643 51 39 5 0 186 0

7 6 24 20 65

7 5 24 19 65

CKRVIX

Stages

I-IV

of deaths cervix ca. 3-yr 5-yr

No.

176

0

16 7 9 466

Lost sight 5-year No.

Actuarial 3-year %

survival 5-year %

61

9

1.9

71

10

0:7

11 77.5 95.1 78.1 60.0

12 9 483

74.4 91.4 78.1 58.0 3

0

7.2

13

0

1 1 1 32

Total no. not treated

2.9

12 1 0 32

%

0 18

218

0 0

of

96.0

96.0

100.0 64.1

94.4 64.1

109

110

CERVM

TABLE

A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

97.

Lisbon Surgery alone Surgery foil by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

Years reported

Stages No . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

4 23 147 28 891 3

2 20 135 19 494 0

2 20 130 16 429 0

2 1 239 35 131 1

2 1 200 22 72 0

2 1 199 22 70 0

9 6 4 80 1

9 3 2 45 0

9 2 2 36 0

19 20 1 39 1

16 18 1 18 0

16 17 1 18 0

1982-86

Romania 98.

Saudi 99.

Bucharest Surgery alone Surgery foll by rad Rad foil by surgery Rad foil by surg by rad Radiation alone Chemotherapy

1984-85

Arabia Riyadh Surgery alone Surgery foll by rad Rad foil by surgery Radiation alone Chemotherapy

1984-86

Barcelona,H Clin y Prov Surgery alone Surgery foll by rad Rad foil by surgery Radiation alone Chemotherapy

1984-86

Spain 101.

CERM(

Stages I-IV No. of deaths cervix ca.

Lost sight 5-year

3-yr

5-yr

No.

%

41

3.7

1 3 10 9 356 3

1 3 15 11 420 3

0 0

0 0 39 13 53 1

0

0

3 2 32 1

4 2 41 1

0

0

2 0 14 1

3 0 14 1

Actuarial 3-year %

9

Total no. not treated

86.9 88.3 60.0 48.4

1.2

3 82.8 56.0 53.9

3

survival 5-year %

77 86.9 93.1 70.4 58.1

5 38 13 51 1

of

81.2 56.0 48.6

3.0

3

58.0

43.9

100.0 89.7

100.0 83.7

50.4

50.4

11.2

5

111

112

CERVIX

TABLE

A-IX

Institution Full name of institution is given in List of Collaborators

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated. Years reported

102. Barcelona, San Juan 1984 Surgery alone Surgery foll by rad Radiation alone 103. Barcelona, Inst Dexeus 1982-86 Surgery alone Surgery foil by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 104. Granada 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy 105. Madrid, "12 de Octubre" 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 1982-86 106. Madrid, Univ Autonoma Surgery alone Surgery foll by rad Radiation alone Sweden 107. Gothenburg 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

Stages No . treated

I

-

IV

Survivors 3-year

5-year

No.

No.

2 1 1

2 0 0

2 0 0

13 8 10 17 5

12 4 9 11 1

12 3 8 11 1

18 23 3 57 2

11 23 2 36 0

10 20 2 29 0

3 21 4 8 39

3 16 4 8 21

3 15 4 8 20

15 46 149

13 32 64

13 29 60

18 17 129 44 184 1

18 16 113 25 81 0

17 15 111 18 73 0

Stages

I-IV

of deaths cervix ca. 3-yr 5-yr

No.

0 0 1

Lost sight 5-year No.

of %

Actuarial 3-year

survival 5-year

%

%

92.3

92.3

100.0 64.2

100.0 64.2

87.1 100.0

75.5 84.4

64.2

49.2

Total no. not treated

0 0

1 2

6 2 0 1 20 2

3 3 1 27 2

0 3 0 0 17

0

4 0 0 18

1 7 46

1 10 50

0 1 11 17 92 1

0

2

44

18 2 13 23 100 1

3.8

0

5.7

10

2.7

4 85.2

79.1

55.1

50.7

93.1 83.9 64.6

93.1 76.3 60.8

100.0 94.1 91.3 59.9 48.2

100.0 88.2 89.7 73.0 42.8

21.0

4.6

1

114

CERVM

TABLE

A.M

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

108a.Stockhol.m, Radiumhemmet 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 109. Umei 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone 1984-86 110. ijrebro Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

Stages I - IV No . 9 Survivors treat3-year ed No.

5-year No.

29 8 151 53 293

28 8 137 35 156

28 6 132 25 122

1 2 15 21 81

1 2 14 19 42

0 2 13 17 39

8 17 1 1 86 1

8 12 1 1 43 0

8 11 1 0 38 0

33 9 12 28 2

33 6 8 5 0

33 6 8 5 0

5 4 1 66

1 4 0 29

1 4 0 22

Switzerland 111. Base1 Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy 113. Lausanne Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1982-86

1984-86

Stages I-IV No. of deaths cervix ca. 3-yr 5-yr

Lost sight of 5-year No. % 7

0 0

1.3

0

12 18 116

2 16 26 139

0 0 1 2 36

1 0 2 4 38

0 5 0 0 35 1

0

6 0 1 36 1

0

0

3 4 22 2

3 4 22 2

0 0 0 29

0 0 0

3

Actuarial 3-year %

survival S-year %

5 100.0

100.0

92.0 67.3 58.9

89.1 51.3 49.3

2.5

0

93.3 90.5

54.8

85.2 77.7 52.0 1

0.9

1

34

70.6

64.5

56.9

55.3

100.0

100.0

2

1.2 66.7 18.7

12

Total no. not treated

66.7 18.7

15.8

2

52.1

42.3

116

CERVIX

TABLE

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

A-IX

Institution Full name of institution is given in List of Collaborators

114. Zurich Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Republic

of

South

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

1982-86 88 28 2 67

79

18 2 37

76 16 2 31

41 26 7 285 2

28 17 5 116 0

26 14 2 90 0

Africa

115. Observatory Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy United

Years reported

1984-86

Kingdom

116. Bristol* 1982-84 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 117. Cambridge 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone 118. Edinburgh Surgery Surgery Rad foll Rad foll Radiation

7 8 10 1 146 2

6 2 5 1 55 0

119 16 14 209

100 11 9 113

95

37 10 14 1 204

36 8 13 1 106

34 6 13 1 91

10 7 97

1984-86 alone foll by rad by surgery by surg by rad alone

117

Stages

I-IV

No. of deaths cervix ca.

Lost sight 5-year

3-yr

5-yr

No.

%

1

0.5

5 10 0 25

7 11 0 28

0

2 9 5 137 1

63 6 2 116 1

16 5 4 92

18 6 5 105

1 1 1 0 89

2 2 1 0 101

of

survival 5-ye&

%

%

94.0 64.3

90.3 59.3

61.2

55.4

100.0 75.8

92.0 61.1

54.8

41.3

1.1

3

0.8

Total no. not treated 1

17.4

2

3

Actuarial 3-year

28

2

11 86.1 67.8 71.4 56.1

83.7 56.5 63.0 48.0

97.2 89.5 92.9

94.1 73.2 92.9

55.5

47.5

1.1

118

CERVIX

TABLE

A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution

Years reported

Full name of institution is given in List of Collaborators

120. London, Royal Marsden 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 121. Manchester* Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by Radiation alone Chemotherapy 122. Northwood Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by Radiation alone Chemotherapy 123. Oxford Surgery alone Surgery foll by rad Rad foil by surgery Rad foll by surg by Radiation alone Chemotherapy 124. Southampton Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by Radiation alone Chemotherapy

Stages No . treated

54 9 16 2 17 1

I

-

IV

Survivors 3-year

5-year

No.

No.

50 4 9 0 4 0

50 3 9 0 4 0

1982-84

0 0

2 3 10 1 900 5

rad

7 0 421 0

1982-86

rad

8 12 4 1 207 2

8 9 3 0 128 0

8 8 3 0 121 0

19 22 96 18 37 1

17 19 83 9 13 0

17 17 80 7 11 0

3 8 109 6 104 1

3 8 91 6 60 0

2 8 88 5 54 0

1984-86

rad

1984-86

rad

CERVIX 119

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

%

17

17.0

2 4 4 0 5 0

2 5 4 0 5 0

0

0

3 1 1 76 2

4 1 1 83 2

0

0

3 11 7 21 1

5 13 9 23 1

0 0

1 0 15 1 40 1

13 0 36 1

sight 5-year

of

Actuarial 3-year

survival 5-year

%

%

96.2

96.2

70.5

70.5

44.4

44.4

Total no. not treated 0

12

1.3

100

1

0.4

0

2

3

75.0

56.3

62.3

58.1

100.0 86.3 88.1 58.9 39.1

100.0 71.9 85.5 45.0 22.6

1.0

0

1.3

87.7

85.4

64.1

59.1

120

CERVIX

TABLE

A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

125. Tyne & Wear Surgery alone Surgery foll by rad Radiation alone United

States

Years reported

Stages No. treated

I

-

IV

Survivors 3-year

5-year

No.

No.

165 13 55

142 10 33

139 8 28

77 18 39 36

67 13 24 17

67 12 21 17

36 20 9 2 43 1

34 12 6 2 18 0

34 11 6 2 15 0

16 3 2 51

14 2 0 27

13 2 0 25

22 14 9 1 37 1

19 6 5 0 17 0

18 6 5 0 15 0

1984-86

of America

126. Atlanta Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

128. Boston, Mass Gen Hosp 1984-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy 1984-86 129. Charleston Surgery alone Surgery foil by rad Rad foil by surgery Radiation alone 131. Chicago, Rush Med Co11 1984-86 Surgery alone Surgery foll by rad Rad foil by surgery Rad foil by surg by rad Radiation alone Chemotherapy

CERVIX

Stages No. of cervix

I-IV deaths ca.

Lost

3-yr

5-yr

No.

%

12

5.2

11 3 17

13 5 22

2 4 11 16

2 5 12 16

0 6 2 0 25 1

0 7 2 0 28 1

1 1 2 21

2 1 2 23

1 8 2 1 19 1

2 8 2 1 21 1

15

4

2

4

sight 5-year

of

Actuarial 3-year

survival 5-year

%

%

92.4 76.9 63.1

90.1 57.0 44.8

97.1 77.4 69.9 53.6

97.1 71.0 66.9 53.6

100.0 68.3

100.0 61.5

41.6

32.9

93.6

76.5

56.4

49.1

94.3 42.3

87.3 42.3

46.6

38.5

Total no. not treated 11

1

8.8

3.6

1

2.8

8

4.8

1

121

TABLE

A.IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

132. Danville Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

133. Evanston Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

134. Galveston Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

135. Los Angeles, South Calif Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1984-86

137. Minneapolis Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone 138. New Haven Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone Chemotherapy

1984-86

Stages No. treated

I

- IV Survivors

3-year No.

5-year No.

7 4 4 38

7 2 3 22

7 2 2 19

54 13 2 33

46 13 2 21

46 10 2 14

64 16 10 84

60 9 4 39

59

6 12 2 36

5 9 2 16

5 9 2 15

71 30 1 108

67 21 1 62

65 18 1 58

47 15 4 95 1

40 13 3 42 0

36 13 2 36 0

7 4 36

1984-86

123

Stages I-IV No. of deaths cervix ca. 3-yr 5-yr

Lost sight of 5 year No. %

Actuarial 3-year %

survival 5-year %

5

0 0

0

2 1 14

2 2 16 1

7 2 8 4 45

0 2 0 16

0

2 0 16

2 9 0 42

5 12 0 45

0 2 1 47 1

3 2 2 53 1

6

5

13

61.1

46.2

86.4 100.0

86.4 75.0

79.1

45.7

98.3 59.5 47.4 47.6

96.2 39.7 47.4 40.2

1.0

7 3 0 13 1 6 4 42

Total no. not treated

2

4.0

2

10.7

3 78.4

78.4

49.9

49.9

95.8

70.0

91.9 59.5

60.1

57.0

100.0 86.7

88.7 86.7

46.6

36.9

2.4

8.0

124

CERVIX

T A B LYE A.M

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution Full name of institution is given in List of Collaborators

Years reported

139. N Y Brooklyn,State Univ Surgery alone Surgery foll by rad Rad foll by surgery Radiation alone

1982-86

140. N Y Stony Surgery Surgery Rad foll Radiation

1982-86

Brook alone foll by rad by surgery alone

141. Philadelphia, Hahnemann 1984-86 Surgery alone Surgery foil by rad Rad foll by surg by rad Radiation alone 142. Philadelphia, Univ Penn Surgery alone Surgery foil by rad Rad foll by surgery Radiation alone Chemotherapy 143. Winston-Salem Surgery alone Surgery foll by rad Radiation alone Chemotherapy

Stages No. treated

I

-

IV

Survivors 3-year No.

5-year

54 65 2 137

46 52 1 69

44 48 0 59

68 4 1 42

55 1 0 10

53 0 0 8

5 7 1 23

4 4 0 12

3 4 0 10

32 6 3 45 1

30 4 0 23 0

30 2 0 16 0

80 21 78 2

66 16 46 0

64 14 44 0

46 51 4 13 79 1

45 41 3 11 60 0

45 39 3 11 55 0

1984-86

No.

1984-86

U.S.S.R. 1984-86 144. Leningrad Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone Chemotherapy

125

Stages I-IV No. of deaths cervix ca.

Lost sight S-year

3-yr

5-yr

No.

5 13 1 58

6 17 2 64

9 3 1 30

10 4 1 32

1

4

1

of %

5 1 4 2 23 1

11 3 26 2

13 5 28 2

1 10 1 2 19 0

1 12 1 2 24 0

a

1

survival S-year

%

%

90.3 79.2

87.3 70.9

54.3

47.5

85.8

83.4

24.2

17.3

57.3

42.0

96.9

96.9

56.7

45.5

82.2 al.2 59.3

75.0 62.1 53.5

97.8 80.4

97.8 75.3

84.6 69.3

84.6 69.3

Total no. not treated 15

0.4

3.5

2

2.8

1 3 1 11 1 2 2 19 1

Actuarial 3-year

5.7

0

4.4

6

0.5

126 CERVIX TABLE A-IX

Carcinoma of the uterine cervix. Patients treated in 1982-1986 incl. Stages I-IV. Three and five-year actuarial survival by mode of treatment. Information is also given about number of survivors, number of deaths of carcinoma of the cervix uteri, number of patients lost sight of and cases not treated.

Institution

Stages No. treated

3-year No.

5-year

Yugoslavia 145. Kladovo 1982-86 Surgery alone Surgery foll by rad Rad foll by surgery Rad foll by surg by rad Radiation alone

5 194 2 7 452

5 156 2 4 242

5 149 2 4 223

146. Ljubljana Surgery Surgery Rad foll Rad foll Radiation

96 98 67 24 419

93 77 49 10 177

93 69 45 8 153

89 16 40 178 464

-

89 14 29 82 272

Full

name of institution in List of Collaborators

Years reported

is given

I

-

IV

Survivors No.

1982-86 alone foll by rad by surgery by surg by rad alone

147. Zagreb* 1984-86 Surgery alone Surgery foll by rad Rad foil by surgery Rad foll by surg by rad Radiation alone

127

Stages I-IV No. of deaths cervix ca. 3-yr 5-yr

Lost sight of S-year No. %

16 0 35 0 3 189

0 40 0 3 208

1 16 18 14 235

1 24 22 16 259 242

2

17

Actuarial 3-year %

survival S-year %

2.4

1 82.2

79.0

57.4

52.2

98.9 83.2 73.1 41.7 43.6

98.9 73.5 66.1 32.1 36.7

0.3

2.2

Total no. not treated

12

12