Immunobiology of proteins and peptides—I

Immunobiology of proteins and peptides—I

199 glucosyltransferase antibddies interacting with the S. m u t a n s cells (pp. 731-733). Each section of the proceedings contains minutes of discus...

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199 glucosyltransferase antibddies interacting with the S. m u t a n s cells (pp. 731-733). Each section of the proceedings contains minutes of discussions among symposium participants. The b o o k closes with the R e p o r t of the Summation Committee and a subject index. The concept of secretory immunity has gained in importance since the appearance of Besredka's 'Local Immunization' half a century ago. Publications on this subject should, therefore, receive considerable attention from medical specialists. This book, in particular, offers information of potential interest to bacteriologists, stomatologists, internists, and gynaecologists. F. Borek

Immunobiology of Proteins and Peptides -- I, edited by M.Z. Atassi and A.B. Stavitsky. Plenum Press, New York, 1978 (513 pp., illus.)

This b o o k is based on the First International Symposium on the above topic, held in Minneapolis, U.S.A., in September 1977. Its contents are divided into five parts: (1) Antigenic Structure of Proteins, (2) Immunobiology of Proteins and Peptides, (3) Immunobiology of Protein Conjugates, (4) Immune Responses to Synthetic Polymers and to Proteins, and (5) L y m p h o c y t e Membrane Structure. Both original research reports and reviews are included. The papers in Part 1 describe experiments aiming at the characterization of antigenic determinants in biologically significant proteins such as lysozyme and c y t o c h r o m e c. Part 2 contains presentations on various subjects ranging from the relationship between antigen structure and lymphocyte activation to the use of derived and synthetic peptides in studying the pathogenesis of EAE and multiple sclerosis. Most of the remaining papers deal with the application of hapten-protein conjugates and synthetic polypeptides to the investigation of genetically restricted immune responses. The last contribution (Part 5) reviews experiments on the expression of surface c o m p o n e n t s of cultured murine B-lymphoma and plasmacytoma cells. Some of the sections of the proceedings are provided with authoritative introductions. Part 2 comprises two discussions which serve to elucidate and integrate the complex subject matter. A comprehensive subject index is appended to the text. The b o o k offers a good deal of valuable information to interested readers. F. Borek