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Immunopharmacology reviews (vol. 1)
Immunology Today, Vol. 1 I, No. 12 1990
book
53 Nara, P., Robey, W., Pyle, S. et al. (1988)J. ViroL 62,
2622-2628 54 Berman, P.W., Groopman, J.E., Gregory, T. etal. (1988) Proc. Natl Acad. Sci. USA 85, 5200-5204 55 Arthur, L.O., Bess,Jr, J.W., Waters, D.J. etal (1989) J. Virol. 63, 5046-5063 56 Berman, P.W., Gregory, T.J., Riddle, L. etal. (1990)Nature 345, 622-625 57 Esparza,J. (1990) AIDS 4, 269-275 58 Letvin, N., Daniel, M., Sehgal, P. etal. (1985)Scicnce 230, 71-73 59 Sutjipto, S., Pedersen, N.C., Gardner, M.B. etal. (1990) J. Virol. 64, 2290-2297 60 Desrosiers, R., Wyand: M., Kodama, T etal. (1989)Proc. Natl Acad. Sci. USA 86, 6353-6357 61 Murphey-Corb, M., Martin, L.N., Davidson-Fairburn, B. et a/. (1989) Science 246, 1293-1297 62 Lyerly, H., Mat:hews, T., Langlois, A. and Bolognesi, D. (1987) Proc. Natl Acad. Sci. USA 84, 4601 63 Homsy, J., Meyer, M., Tateno, M. et aL (1989) Science 244, 1357-1360 64 Robinson, W.E., Montefiori, D.C. and Mitchell, W.M. (1988) Lancet i, 790-794 6,c Takeda, A., Tuazon, C.U. and Ennis, F.A. (1988) Science
Immunopharmacology Reviews (Vol. 1} edited by J.W. Hadden and A. Szentivanyi, Plenum Press, !990. $79.50 (xiii + 418pages) ISBN0 306 43273 0
In their introductory note, the editors consider immunopharmacology to be only 30 years old, but the contents ot each chapter in the book clearly document that this science is a!most 100 years old, dating from the laboratory experiences, clinical forays and ingenious concepts of Paul Ehrlich. Cell membrane receptors, which react with an enormous number of exogenous and endogenous biologically active molecules, are the common denominator of the six chapters. These chapters cover the immunopharmacology, pharmacokinetics and toxicology of immunotherapeutic agents involved in pathophysiological processes triggered by microbes, drugs, toxic factors, environmental agents, immune dysfunctions, autoimmune disorders, malfunctions of the cell and tissue at different levels, and malignanq,. Immunotherapeutic agents were characterized with the intention of assessing their role and capacity in restoring natural and specific resistance to infections, inflammatory reactions of different origin and cancer. The coordination between classi-
u' ~ 7
I~
242, 580-583 66 Zagury, D., Bernard, J., Cheynier, R. et al. (1988)Nature 332, 728-731 67 Smith, G. and Volvovitz, F. (1990) Vl International Conterence on AIDS, San Francisco, USA Abstract S.A. 76, p. 114 68 Cooney, E.L., Corey, L., Hu, S.L et al. (i 990) VI International Conference on AIDS, San Francisco, USA
Abstra~ Th.A. 333, p. 203 69 Goldstein, A.L., Naylor, P.H., Sarin, P.S. etal. (1990) VI International Conference on AIDS, San Francisco, USA
Abstract S.A. 76, p. 114 70 Levine, A.M., Henderson, B.E., Groshen, S. etaL (1989) VI International Conference on AIDS, San Francisco, USA
Abstract Th.A., 337 p. 204 71 Dalgleish, A., Thompson, B.J., Chanh, T.C. etal. (1987) Lancet i, 1047-1050 72 Buck, D.W., Schroeder, K., Suni, Metal. (1990) VI International Conference on AIDS, San Francisco, USA
Abstract Tn.~. ~53, 208 73 Rothbard, J. (1987) Nature 330, i06-108 74 Dreesman, G. and Kennedy, R. (1985)2. Infect. Dis. 151, 761-765 75 Baltimore, D. (1988,~Mature 335, 395-396
cal cytotoxic chemotherapy, radiotherapy and surgery on the one hand, and the use of immunopotentiating and immunosuppressing substances on the other, is taken as a sine qua non in further prospects for the immunotherapy of solid tumors. In considering the pharmacologically active effector factors associated with immunity, immunopathological phenomena, hypersensitivity, inflammation and the expression of various immune and para-immune reactions, a large number of mediators/ regulators/modulators with irnmunopharmacological properties have been listed. These include lymphokines, monokines, interleukins and effector molecules acting on cell types other than lymphocytes and their associates but more or less related to the immune machinery. For example, the immunopharmacological activities of amines such as histamine ahd serotonin and peptide mediators (from immunopeptides released in the thymus to neuroactive immunoregulatory peptides) have been outlined. The fascinating issue of the immunoregulatory function of neuropeptides encompasses neurmensin and vasoactive intestinal peptide but in considering the immur, omodulatory actions of opioid peptides the emphasis is primarily placed on endorphins and on in vitro models. Only a few lines are devoted to enkephalins, and very iitde to their
outstanding capacity to modulate immune phenomena in vivo. The always provocative, but still unsolved, problem of the early b~ochemical events of T-cell activation provides the bulk of the evidence for structural and humoral components that constitute a complex network of T-cell responsiveness. Dysfunction of the irr,mune system due to foreign substances that are toxic for the system is related, in this volume, mainly to environmental pollutants. Nevertheless, this chapter represents a useful introduction for the exploration of more specific phenomena, such as the effects of therapeutic drugs on immune responsiveness. The latter is still a most important problem and should be studied more systematically and on a large scale, both in experimental and clinical medicine. In conclusion, the first volume of Immunopharmacology Reviews offers useful information to both the newcomer and the experienced research worker and will be of value in experimental design, clinical work and aiding general understanding of the subject. Branislav D. Jankovi~
hnmuno!ogy Researc,5Center, Vojvode Ste~ 458, 11221 Belgrade, Yugoslavia_ 471
7
!
book
53 Nara, P., Robey, W., Pyle, S. et al. (1988)J. ViroL 62,
2622-2628 54 Berman, P.W., Groopman, J.E., Gregory, T. etal. (1988) Proc. Natl Acad. Sci. USA 85, 5200-5204 55 Arthur, L.O., Bess,Jr, J.W., Waters, D.J. etal (1989) J. Virol. 63, 5046-5063 56 Berman, P.W., Gregory, T.J., Riddle, L. etal. (1990)Nature 345, 622-625 57 Esparza,J. (1990) AIDS 4, 269-275 58 Letvin, N., Daniel, M., Sehgal, P. etal. (1985)Scicnce 230, 71-73 59 Sutjipto, S., Pedersen, N.C., Gardner, M.B. etal. (1990) J. Virol. 64, 2290-2297 60 Desrosiers, R., Wyand: M., Kodama, T etal. (1989)Proc. Natl Acad. Sci. USA 86, 6353-6357 61 Murphey-Corb, M., Martin, L.N., Davidson-Fairburn, B. et a/. (1989) Science 246, 1293-1297 62 Lyerly, H., Mat:hews, T., Langlois, A. and Bolognesi, D. (1987) Proc. Natl Acad. Sci. USA 84, 4601 63 Homsy, J., Meyer, M., Tateno, M. et aL (1989) Science 244, 1357-1360 64 Robinson, W.E., Montefiori, D.C. and Mitchell, W.M. (1988) Lancet i, 790-794 6,c Takeda, A., Tuazon, C.U. and Ennis, F.A. (1988) Science
Immunopharmacology Reviews (Vol. 1} edited by J.W. Hadden and A. Szentivanyi, Plenum Press, !990. $79.50 (xiii + 418pages) ISBN0 306 43273 0
In their introductory note, the editors consider immunopharmacology to be only 30 years old, but the contents ot each chapter in the book clearly document that this science is a!most 100 years old, dating from the laboratory experiences, clinical forays and ingenious concepts of Paul Ehrlich. Cell membrane receptors, which react with an enormous number of exogenous and endogenous biologically active molecules, are the common denominator of the six chapters. These chapters cover the immunopharmacology, pharmacokinetics and toxicology of immunotherapeutic agents involved in pathophysiological processes triggered by microbes, drugs, toxic factors, environmental agents, immune dysfunctions, autoimmune disorders, malfunctions of the cell and tissue at different levels, and malignanq,. Immunotherapeutic agents were characterized with the intention of assessing their role and capacity in restoring natural and specific resistance to infections, inflammatory reactions of different origin and cancer. The coordination between classi-
u' ~ 7
I~
242, 580-583 66 Zagury, D., Bernard, J., Cheynier, R. et al. (1988)Nature 332, 728-731 67 Smith, G. and Volvovitz, F. (1990) Vl International Conterence on AIDS, San Francisco, USA Abstract S.A. 76, p. 114 68 Cooney, E.L., Corey, L., Hu, S.L et al. (i 990) VI International Conference on AIDS, San Francisco, USA
Abstra~ Th.A. 333, p. 203 69 Goldstein, A.L., Naylor, P.H., Sarin, P.S. etal. (1990) VI International Conference on AIDS, San Francisco, USA
Abstract S.A. 76, p. 114 70 Levine, A.M., Henderson, B.E., Groshen, S. etaL (1989) VI International Conference on AIDS, San Francisco, USA
Abstract Th.A., 337 p. 204 71 Dalgleish, A., Thompson, B.J., Chanh, T.C. etal. (1987) Lancet i, 1047-1050 72 Buck, D.W., Schroeder, K., Suni, Metal. (1990) VI International Conference on AIDS, San Francisco, USA
Abstract Tn.~. ~53, 208 73 Rothbard, J. (1987) Nature 330, i06-108 74 Dreesman, G. and Kennedy, R. (1985)2. Infect. Dis. 151, 761-765 75 Baltimore, D. (1988,~Mature 335, 395-396
cal cytotoxic chemotherapy, radiotherapy and surgery on the one hand, and the use of immunopotentiating and immunosuppressing substances on the other, is taken as a sine qua non in further prospects for the immunotherapy of solid tumors. In considering the pharmacologically active effector factors associated with immunity, immunopathological phenomena, hypersensitivity, inflammation and the expression of various immune and para-immune reactions, a large number of mediators/ regulators/modulators with irnmunopharmacological properties have been listed. These include lymphokines, monokines, interleukins and effector molecules acting on cell types other than lymphocytes and their associates but more or less related to the immune machinery. For example, the immunopharmacological activities of amines such as histamine ahd serotonin and peptide mediators (from immunopeptides released in the thymus to neuroactive immunoregulatory peptides) have been outlined. The fascinating issue of the immunoregulatory function of neuropeptides encompasses neurmensin and vasoactive intestinal peptide but in considering the immur, omodulatory actions of opioid peptides the emphasis is primarily placed on endorphins and on in vitro models. Only a few lines are devoted to enkephalins, and very iitde to their
outstanding capacity to modulate immune phenomena in vivo. The always provocative, but still unsolved, problem of the early b~ochemical events of T-cell activation provides the bulk of the evidence for structural and humoral components that constitute a complex network of T-cell responsiveness. Dysfunction of the irr,mune system due to foreign substances that are toxic for the system is related, in this volume, mainly to environmental pollutants. Nevertheless, this chapter represents a useful introduction for the exploration of more specific phenomena, such as the effects of therapeutic drugs on immune responsiveness. The latter is still a most important problem and should be studied more systematically and on a large scale, both in experimental and clinical medicine. In conclusion, the first volume of Immunopharmacology Reviews offers useful information to both the newcomer and the experienced research worker and will be of value in experimental design, clinical work and aiding general understanding of the subject. Branislav D. Jankovi~
hnmuno!ogy Researc,5Center, Vojvode Ste~ 458, 11221 Belgrade, Yugoslavia_ 471
7
!