IMP spect cerebral perfusion studies in drug-naive schizophrenics

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JJ Pahl, M.D.*, K F&zai, M.D., m Cc&m, M.D., FU Alliger, Ph.D., VW Swayze, II, M.D., ND Ambxmzn, M.D., F&D.

Universityof IowaPsychiatricHospital, 5OONewtonF&xd, IcwaCity, Iowa 52242

measwkiwithaGanunaSPEC!Fcameraand ionalcerebralperfusion(rB)was "sz inll neumleptic-naive Em-111 diagnosea II 3l 1-(IMP) s&izophreni= (age = 33.6kll.l;disease duration = 8.45Ll.2.0,[mean f SD]) and 14 nomal contmls (age = 31.9k6.1)during a restirq baseline state (eyes andears opm state). Regions of intemst (FUX)wemdefined for12 corticalardsubcorticalareas: left and right superior,middle and inferior frontal corticies,teqero-parietal cortex, basalgangliaard cerebella. C.em&alperfusionvaluesarereportedhereasFUX/cezbellum ratios. Rredatawemanalyzed forsignificancewiththeMann+hitneytwotailed t-test. Significantlydecreased restingcerebralperfusionvalueswemdetectedin bothfmntalldzes inthedmg-naiveschiz~cs. Theothercortical regionsandthebasalganglia demnstmtednomalblcodflowpatterns. OurfindingsareaansistentwithprwiausXenorr-133corticdLpmbeCBFdata showing ~thypofmntality.~~Thedata are, howeve.r, stillconsidemdquite IUXswere preliminary foramnkerofmethodological rfxmms. First, definedonthefunctiondlS~studyratherthanon~plresolutionMRI images. TranscriptionofMFUdefinedROIstocorrespcndingSPECTscans wouldresultin impravedaMtanicdllocalizationofbrainregicns. Second, the relative (IEDI/reference skmkure)cerebralperfusionratiosreported !J?Euse of such a ratio wmld hereusetbe cex&ellumasdenminator. clearly be inaca.lra te if the cerebellmwereaffected functionallyin schiixphmnia. Iastly, the small nu&er of drug-naive subjects (n=ll) and flcwp&terns. pmcludetheevaluationofcorrelations~syr@ms