Journal of the American Society of Cytopathology (2016) 5, S84eS89
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ANNUAL SCIENTIFIC MEETING 2016 November 5, 2016 11:00 am e 12:00 pm
diagnostically challenging on FNA cytology. Immediate adequacy assessment at the time of FNA is critical for identifying cases requiring additional material for FISH.
MORNING PLATFORM PRESENTATIONS PL01
PL02
Molecular Testing on Fine Needle Aspiration Specimens by Fluorescence in Situ Hybridization: Diagnostic and Management Implications
Impact of a Community Education Program to Promote Pap Test Screening Among Asian-American Women: An ASC Advocacy Award Program
Adam Gomez, MD, Soo-Ryum Yang, MD, Christina Kong, MD, Steven Long, MD. Stanford Hospital and Clinics, Stanford, CA
Kristine Miller, BS, Diana Ha, BS, Stina Andersen, MSc, PhD, Roshelle Chan, BS, Lydia Pleotis Howell, MD. University of California Davis Health System, Sacramento, CA
Introduction: Fluorescence in situ hybridization (FISH) is a highly specific diagnostic modality that can be performed on the minimal tissue obtained by fine needle aspiration (FNA). We evaluated the impact of FISH on cytologic diagnosis and patient management. Materials and Methods: We queried our pathology database for FNAs with FISH performed on formalin-fixed paraffin-embedded cell block material for MDM2 amplification or rearrangement of MYB, SYT, EWSR, FOXO1, or MAML2. We assessed the FISH success rate, impact on final diagnosis and patient management, # FNAs performed by pathologists, and # FNAs with immediate adequacy assessment. Results: FISH was successfully performed in 33/38 FNAs (87%) (Table 1); FISH was not performed or unsuccessful in 5 cases. Immediate adequacy assessment was performed in 37/38 (97%) of cases; 50% of FNAs were performed by pathologists. The single case without immediate adequacy had cell block material collected and was positive for EWSR1. FISH results significantly impacted management with regards to extent of surgical resection and chemotherapy regimen. Conclusions: FISH can be successfully performed on FNA specimens for a variety of cytogenetic abnormalities that have significant management implications for the patient and offers a specific advantage in cases that are
Introduction: Cancer is the leading cause of death among Asian-American women. Amongst ethnic groups, they have the highest incidence of cervical cancer as well as low screening rates, according to the CDC, and are more likely to state “never thought about” and “don’t need” testing as reasons for not receiving screening. A 2014 Advocacy Award from the American Society of Cytopathology allowed us to develop a culturally sensitive educational outreach program to enhance Pap screening in the AsianAmerican community in Sacramento. Materials and Methods: We developed educational presentations and brochures, which were additionally translated into Chinese and Vietnamese, and shared at nine community educational events by undergraduate and medical student volunteers. Pre- and post-education surveys on awareness and attitudes towards screening as well as a pre- and posteducation knowledge test to assess educational impact were administered. Results: 328 surveys were completed within the age group 21-64 with 84% Asian responders. Within our sample, 20% were not up to date (NUTD) in screening. Knowledge of Pap tests reported as “excellent”/“good” rose from 46% before to 85% after education. Those who reported they were “very likely”/”likely” to schedule a Pap test increased from 73% to 92% in the NUTD group and from 85% to 97% in the 21-29 age group. Those reporting they were “very likely”/”likely” to recommend a Pap test to others also increased from 68% to 98% in the NUTD group and from 77% to 97% in those aged 21-29. Conclusions: A student-led community-based culturally sensitive outreach approach can improve Pap test knowledge and awareness among AsianAmerican women. The largest increase in likelihood to screen and recommend the test to others were in the NUTD group and the 21-29 age group, suggesting influence on those especially in need - those behind in screening practices and those establishing lifelong health practices. PL03 The Morphologic Analysis of Non-invasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features(NIFTP) on FNAC: Our Institutional Experience Esther Rossi, MD, PhD, Tommaso Bizzarro, BD, Maurizio Martini, MD, PhD, Celestino Lombardi, MD,
2213-2945/$36 Ó 2016 Published by Elsevier Inc. on behalf of the American Society of Cytopathology. http://dx.doi.org/10.1016/j.jasc.2016.07.192