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Improvement of life quality in HIV(+) zoster patients by acupuncture
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Abstracts
430 Effect of 1-Year Immunotherapyon Asthma Quality of Life A. Roger, M. Baltasar, E. Martf; Allergy Unit. H.U. Germans Trias i Pujol., Badalona, SPAIN. RATIONALE: we have demonstrated that allergist treatment improves asthmatics quality of life (QL). To assess the roll of immunotherapy (IT), we decided to investigate its additional effect on asthmatics QL treated only with pharmacological agents. METHODS: 24 monosensitized (dust mites) asthmatics (age: 15-45) were visited 4 times (0, 4, 8, 12 months). At first visit 12 patients were prescribed a Dermatophagoides vaccine (IT group) and drugs. The other 12 patients remained only with pharmacological treatment (control group). At each visit, asthma QL questionnaire (AQLQ, Marks) was answered (0-10 points, being 10 the worst QL) and inhaled corticosteroids dose (IC) were adjusted according to spirometry, bronchodilator use (BD) and symptomatic days (both in percentage of total days), RESULTS: IT group mean values: FEVI 88.0 and 89.2 (p=n.s), symptoms 38.1% and 7.7% (p=0.002), BD 76.1% and 22.4% (p=0.01), AQLQ 3.1 and 2 (p=0.0 l ), IC 600 and 504 mcg (p=n.s) in initial and one year visits respectively. Control group mean values: FEV 1 90.3 and 94.8 (p=n.s), symptoms 30.0 and 8.2 (p=0.006), BD 60.0% and 12.5% (p=0.005), AQLQ 3.3 and 1.0 (p<0.001), IC 566 and 566 mcg (p=n.s) in initial and one year visits respectively. No statistically significant differences (p>0.05) were found between both groups in relation to improvements on FEVI, symptomatic days, BD use ans AQLQ. C O N C L U S I O N S : Concomitant treatment during l year with a Dermatophagoides vaccine in dust mites allergic asthmatics does not increase the QL more than patients treated with pharmacological agents alone, possibly due to a IT uncomplete effect in only one year.
Funding: Self-funded
431 AsthmaEducationand Its Elect on Quality of Life C. J. Collura-Burke j, B. Speller-Brown 2, L. J. Smith ], M. R. Nelson ], H. J. Schmidt2; IAIlergy/Immunology, Walter Reed Army Medical Center, Washington, DC, 2pediatrics, Walter Reed Army Medical Center, Washington, DC. RATIONALE: This study examined the role of education on quality of life (QOL) in a pediatric asthma center. METHODS: A retrospective chart review was conducted of an ongoing pediatric asthma education program in which validated QOL questionnaires were given at initial intake (pre) and at first lbllow-up (post) in the pediatric asthma center. QOL surveys utilized a Likert scale ranging from 1= "none of the time" to 5 = "all of the time." RESULTS: Fifty-nine charts were reviewed of children, ages 5 months to 14 years old. Patients and families received one-on-one education regarding asthma prevention at the initial visit and an individualized asthma action plan was provided. 40/59 children required no change in their asthma medication during their initial visit. We looked at these 40 to assess improvement in QOL and compared them with the mean change in QOL of the entire group. Statistically significant improvement was noted in 9/17 QOL measurements to include a decrease in nighttime and daytime coughing as well as an overall lessening of asthma interference in a patient's life. CONCLUSIONS: Asthma education programs can significantly improve QOL even when asthma medication regimens are not altered.
432 mancelmpactof Allergic Rhinitis on Simulated Real World PerforU. Satish, S. Streufert, S. Vandervort; Psychiatry, SUNY Upstate Medical University, Syracuse, NY. RATIONALE: While majority of research effort on seasonal allergic rhinitis (SAR) has focussed upon drug treatment with SAR, a few studies have shown that untreated SAR can have unfavorable effects upon human performance and quality of life. Little is known about effects of SAR upon real world effectiveness. This research explored the impact of~ SAR on
J ALLERGY CLIN IMMUNOL FEBRUARY 2003
functioning in a simulation task setting with validated real world characteristics. METHODS: Forty-eight subjects participated in the SMS simulation on two occasions: (1) outside of the allergy season and (2) during allergy season when suffering from allergies. On both occasions, participants were not taking any medications. Twenty-five measures of functioning (validated against real world) effectiveness) were calculated by the computer system. Measures vary from relatively simple responses (eg, activity) via intermediate responses (eg, initiative) through highly complex functioning (eg, strategy). RESULTS: Where task demands were simpler or where responding was cued by the environment, no differences between symptomatic and asymptomatic conditions were obtained. Where task demands were more complex, SAR decreased effectiveness on several measures (p<.001/. CONCLUSIONS: SAR can diminish human effectiveness in day-to-day functioning, especially where task demands are complex. SAR should be treated to avoid performance decrements.
Funding: Integrated Therapeutics
433 Acupuncture Improvement of Life Quality in HIV(+) Zoster Patients by K. Cui; Department of Traditional Chinese Medicine, I st People Hospital of Zhengzhou, Zhengzhou, CHINA. RATIONALE: Bad life quality of HIV(+) Zoster patients results from severe pain and refractory herpes. New strategy is still needed to treat Zoster in this particular population. Acupuncture has been shown effective in pain control and helps to improve body immune function. During 19972001 the author worked as guest physician in AIDS Clinic at Kabwe General Hospital, Zambia, where the Zoster patients were treated. We report here the treatment by using acupuncture in compare with Zovirax, a well accepted anti-virus agent in that local area. METHODS: 90 adult Zoster patients, all HIV(+), were randomized into two treatment groups: 60 with acupuncture and 30 with Zovirax. Both groups had similar herpes size and pain level prior to treatment. The duration of treatment is four weeks for both groups. Patients in acupuncture group received 30 mins acupuncture, twice a day. While patients in Zovirax group received Zovirax topically and 200mg orally, three times a day. Effectiveness was assessed by checking size of herpes and level of pain. RESULTS: The assessment was done at the end of treatment. 95% patients in acupuncture group showed significant reduction of herpes size, while the reduction rate in Zovirax group was 70%. Mean pain score was 0-1 out of 6 at end of treatment for acupuncture group and I-3 out of 6 for Zovirax group. CONCLUSIONS: By removing herpes and decreasing pain, acupuncture helps to improve life quality of HIV(+) Zoster patients.
Funding: Self-funded
434 tomsPersisUItentofcerativeEOSinophiliacolitisandSkin Lesionsas PresentingSympH. J. Moday ], D. Berkowitz 2, D. L. RosenstreichJ; IDivision of Allergy and Immunology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 2Dept of Gastroenterology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY. The differential diagnosis of persistent eosinophilia is long, but does not usually include ulcerative colitis. We report here on a 28 year old, previously healthy female who presented with four months of eosinophilia and intermittent rash. The rash consisted of recurrent, erythematous, painful lesions on the thighs and ankles. Skin biopsy reported subcutaneous, deep dermal, and perivascular inflammation with eosinophils. The skin lesions did not respond to topical steroids or antibiotics but resolved after 2-3 weeks, leaving a hyperpigmented area. She worked as a secretary and had no history of atopic disease, drug use, unusual environmental exposures or travel. Skin testing with a battery of aeroallergens was negative. The ESR was elevated at 55 mm/hr, but ANA and Lyme disease titers were negative. The total leukocyte count was 10,100/p.I with 22% eosinophils. Stool studies were negative lbr parasites. Four months after the onset of the rash
Abstracts
430 Effect of 1-Year Immunotherapyon Asthma Quality of Life A. Roger, M. Baltasar, E. Martf; Allergy Unit. H.U. Germans Trias i Pujol., Badalona, SPAIN. RATIONALE: we have demonstrated that allergist treatment improves asthmatics quality of life (QL). To assess the roll of immunotherapy (IT), we decided to investigate its additional effect on asthmatics QL treated only with pharmacological agents. METHODS: 24 monosensitized (dust mites) asthmatics (age: 15-45) were visited 4 times (0, 4, 8, 12 months). At first visit 12 patients were prescribed a Dermatophagoides vaccine (IT group) and drugs. The other 12 patients remained only with pharmacological treatment (control group). At each visit, asthma QL questionnaire (AQLQ, Marks) was answered (0-10 points, being 10 the worst QL) and inhaled corticosteroids dose (IC) were adjusted according to spirometry, bronchodilator use (BD) and symptomatic days (both in percentage of total days), RESULTS: IT group mean values: FEVI 88.0 and 89.2 (p=n.s), symptoms 38.1% and 7.7% (p=0.002), BD 76.1% and 22.4% (p=0.01), AQLQ 3.1 and 2 (p=0.0 l ), IC 600 and 504 mcg (p=n.s) in initial and one year visits respectively. Control group mean values: FEV 1 90.3 and 94.8 (p=n.s), symptoms 30.0 and 8.2 (p=0.006), BD 60.0% and 12.5% (p=0.005), AQLQ 3.3 and 1.0 (p<0.001), IC 566 and 566 mcg (p=n.s) in initial and one year visits respectively. No statistically significant differences (p>0.05) were found between both groups in relation to improvements on FEVI, symptomatic days, BD use ans AQLQ. C O N C L U S I O N S : Concomitant treatment during l year with a Dermatophagoides vaccine in dust mites allergic asthmatics does not increase the QL more than patients treated with pharmacological agents alone, possibly due to a IT uncomplete effect in only one year.
Funding: Self-funded
431 AsthmaEducationand Its Elect on Quality of Life C. J. Collura-Burke j, B. Speller-Brown 2, L. J. Smith ], M. R. Nelson ], H. J. Schmidt2; IAIlergy/Immunology, Walter Reed Army Medical Center, Washington, DC, 2pediatrics, Walter Reed Army Medical Center, Washington, DC. RATIONALE: This study examined the role of education on quality of life (QOL) in a pediatric asthma center. METHODS: A retrospective chart review was conducted of an ongoing pediatric asthma education program in which validated QOL questionnaires were given at initial intake (pre) and at first lbllow-up (post) in the pediatric asthma center. QOL surveys utilized a Likert scale ranging from 1= "none of the time" to 5 = "all of the time." RESULTS: Fifty-nine charts were reviewed of children, ages 5 months to 14 years old. Patients and families received one-on-one education regarding asthma prevention at the initial visit and an individualized asthma action plan was provided. 40/59 children required no change in their asthma medication during their initial visit. We looked at these 40 to assess improvement in QOL and compared them with the mean change in QOL of the entire group. Statistically significant improvement was noted in 9/17 QOL measurements to include a decrease in nighttime and daytime coughing as well as an overall lessening of asthma interference in a patient's life. CONCLUSIONS: Asthma education programs can significantly improve QOL even when asthma medication regimens are not altered.
432 mancelmpactof Allergic Rhinitis on Simulated Real World PerforU. Satish, S. Streufert, S. Vandervort; Psychiatry, SUNY Upstate Medical University, Syracuse, NY. RATIONALE: While majority of research effort on seasonal allergic rhinitis (SAR) has focussed upon drug treatment with SAR, a few studies have shown that untreated SAR can have unfavorable effects upon human performance and quality of life. Little is known about effects of SAR upon real world effectiveness. This research explored the impact of~ SAR on
J ALLERGY CLIN IMMUNOL FEBRUARY 2003
functioning in a simulation task setting with validated real world characteristics. METHODS: Forty-eight subjects participated in the SMS simulation on two occasions: (1) outside of the allergy season and (2) during allergy season when suffering from allergies. On both occasions, participants were not taking any medications. Twenty-five measures of functioning (validated against real world) effectiveness) were calculated by the computer system. Measures vary from relatively simple responses (eg, activity) via intermediate responses (eg, initiative) through highly complex functioning (eg, strategy). RESULTS: Where task demands were simpler or where responding was cued by the environment, no differences between symptomatic and asymptomatic conditions were obtained. Where task demands were more complex, SAR decreased effectiveness on several measures (p<.001/. CONCLUSIONS: SAR can diminish human effectiveness in day-to-day functioning, especially where task demands are complex. SAR should be treated to avoid performance decrements.
Funding: Integrated Therapeutics
433 Acupuncture Improvement of Life Quality in HIV(+) Zoster Patients by K. Cui; Department of Traditional Chinese Medicine, I st People Hospital of Zhengzhou, Zhengzhou, CHINA. RATIONALE: Bad life quality of HIV(+) Zoster patients results from severe pain and refractory herpes. New strategy is still needed to treat Zoster in this particular population. Acupuncture has been shown effective in pain control and helps to improve body immune function. During 19972001 the author worked as guest physician in AIDS Clinic at Kabwe General Hospital, Zambia, where the Zoster patients were treated. We report here the treatment by using acupuncture in compare with Zovirax, a well accepted anti-virus agent in that local area. METHODS: 90 adult Zoster patients, all HIV(+), were randomized into two treatment groups: 60 with acupuncture and 30 with Zovirax. Both groups had similar herpes size and pain level prior to treatment. The duration of treatment is four weeks for both groups. Patients in acupuncture group received 30 mins acupuncture, twice a day. While patients in Zovirax group received Zovirax topically and 200mg orally, three times a day. Effectiveness was assessed by checking size of herpes and level of pain. RESULTS: The assessment was done at the end of treatment. 95% patients in acupuncture group showed significant reduction of herpes size, while the reduction rate in Zovirax group was 70%. Mean pain score was 0-1 out of 6 at end of treatment for acupuncture group and I-3 out of 6 for Zovirax group. CONCLUSIONS: By removing herpes and decreasing pain, acupuncture helps to improve life quality of HIV(+) Zoster patients.
Funding: Self-funded
434 tomsPersisUItentofcerativeEOSinophiliacolitisandSkin Lesionsas PresentingSympH. J. Moday ], D. Berkowitz 2, D. L. RosenstreichJ; IDivision of Allergy and Immunology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, 2Dept of Gastroenterology, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY. The differential diagnosis of persistent eosinophilia is long, but does not usually include ulcerative colitis. We report here on a 28 year old, previously healthy female who presented with four months of eosinophilia and intermittent rash. The rash consisted of recurrent, erythematous, painful lesions on the thighs and ankles. Skin biopsy reported subcutaneous, deep dermal, and perivascular inflammation with eosinophils. The skin lesions did not respond to topical steroids or antibiotics but resolved after 2-3 weeks, leaving a hyperpigmented area. She worked as a secretary and had no history of atopic disease, drug use, unusual environmental exposures or travel. Skin testing with a battery of aeroallergens was negative. The ESR was elevated at 55 mm/hr, but ANA and Lyme disease titers were negative. The total leukocyte count was 10,100/p.I with 22% eosinophils. Stool studies were negative lbr parasites. Four months after the onset of the rash