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Contents
T HE J OURNAL OF
Allergy Clinical Immunology AND
VOLUME 114
NUMBER 2
OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY
The editors’ choice
211
Donald Y. M. Leung, MD, PhD, Harold S. Nelson, MD, Stanley J. Szefler, MD, and William W. Busse, MD
Continued on page 7A We are excited to announce that as of June 2004, The Journal of Allergy and Clinical Immunology posts in-press articles online in advance of their appearance in the print edition of the Journal. They are available at the JACI Web site at www.mosby.com/jaci at the ‘‘Articles in Press’’ link, as well as at Elsevier’s ScienceDirect Web site, www.sciencedirect.com. Sophisticated new technology now allows us to deliver online publications to readers as soon as author corrections are received and incorporated by the publisher—potentially 6 to 9 weeks before release of the print edition of the Journal! Each print article will acknowledge the e-publication date (the date when the article first appeared online). As soon as an article is published online, it is fully citable through use of its Digital Object Identifier (DOI). This innovation significantly enhances our ability to disseminate new information in the scientific community and streamlines the launch of new thinking and ideas. Please visit the JACI Web site and view our hot-off-the-wire articles through the ‘‘Articles in Press’’ link.
Y
This month’s theme: Laboratory technology in allergy and immunology
About the cover The cover displays a photograph of David Vetter, the famous ‘‘Bubble Boy’’ who was born with SCID, in his protective plastic world built by NASA engineers. It carries a powerful message of the heroic measures needed to sustain life in the absence of that class of immune cells identified with the CD3+ T-cell marker. To the left of David is a 2004 histogram showing the total absence of CD3+ T cells in a similar child. Additional laboratory evidence of a SCIDX1 B-cell histogram and the gene sequencing of the mutant IL-2RG are depicted. Technology identifies the defect and points the way to cure the child by restoring that population of T cells so vital to human existence. Simple images reinforce the inescapable truth that technology enhances our ability to recognize human disease and will support us in moving on to its cure. For other articles in this month’s special feature on Laboratory Technology in Allergy and Immunology, look for the titles marked with the theme icon in the Table of Contents. (Artwork by JDI, LLC) Ó 2004 American Academy of Allergy, Asthma and Immunology The Journal of Allergy and Clinical Immunology (ISSN 0091-6749) is published monthly (12 issues per year) by Elsevier Inc. Corporate and editorial offices: 11830 Westline Industrial Dr, St Louis, MO 63146-3318. Accounting and circulation offices: Elsevier Inc, 6277 Sea Harbor Dr, Orlando, FL 32887-4800. Periodicals postage paid at Orlando, FL 32862 and at additional mailing offices. 2004 subscription rates: domestic, $203.00 for individuals ($101.00 for students), $441.00 for institutions. Postmaster: Send address changes to The Journal of Allergy and Clinical Immunology, Elsevier Inc, Periodicals Department, 6277 Sea Harbor Dr, Orlando, FL 32887-4800.
J ALLERGY CLIN IMMUNOL
August 2004 5A
T HE J OURNAL OF
Allergy Clinical Immunology AND
VOLUME 114
NUMBER 2
OFFICIAL JOURNAL OF THE AMERICAN ACADEMY OF ALLERGY, ASTHMA AND IMMUNOLOGY
The editors’ choice
211
Donald Y. M. Leung, MD, PhD, Harold S. Nelson, MD, Stanley J. Szefler, MD, and William W. Busse, MD
Continued on page 7A We are excited to announce that as of June 2004, The Journal of Allergy and Clinical Immunology posts in-press articles online in advance of their appearance in the print edition of the Journal. They are available at the JACI Web site at www.mosby.com/jaci at the ‘‘Articles in Press’’ link, as well as at Elsevier’s ScienceDirect Web site, www.sciencedirect.com. Sophisticated new technology now allows us to deliver online publications to readers as soon as author corrections are received and incorporated by the publisher—potentially 6 to 9 weeks before release of the print edition of the Journal! Each print article will acknowledge the e-publication date (the date when the article first appeared online). As soon as an article is published online, it is fully citable through use of its Digital Object Identifier (DOI). This innovation significantly enhances our ability to disseminate new information in the scientific community and streamlines the launch of new thinking and ideas. Please visit the JACI Web site and view our hot-off-the-wire articles through the ‘‘Articles in Press’’ link.
Y
This month’s theme: Laboratory technology in allergy and immunology
About the cover The cover displays a photograph of David Vetter, the famous ‘‘Bubble Boy’’ who was born with SCID, in his protective plastic world built by NASA engineers. It carries a powerful message of the heroic measures needed to sustain life in the absence of that class of immune cells identified with the CD3+ T-cell marker. To the left of David is a 2004 histogram showing the total absence of CD3+ T cells in a similar child. Additional laboratory evidence of a SCIDX1 B-cell histogram and the gene sequencing of the mutant IL-2RG are depicted. Technology identifies the defect and points the way to cure the child by restoring that population of T cells so vital to human existence. Simple images reinforce the inescapable truth that technology enhances our ability to recognize human disease and will support us in moving on to its cure. For other articles in this month’s special feature on Laboratory Technology in Allergy and Immunology, look for the titles marked with the theme icon in the Table of Contents. (Artwork by JDI, LLC) Ó 2004 American Academy of Allergy, Asthma and Immunology The Journal of Allergy and Clinical Immunology (ISSN 0091-6749) is published monthly (12 issues per year) by Elsevier Inc. Corporate and editorial offices: 11830 Westline Industrial Dr, St Louis, MO 63146-3318. Accounting and circulation offices: Elsevier Inc, 6277 Sea Harbor Dr, Orlando, FL 32887-4800. Periodicals postage paid at Orlando, FL 32862 and at additional mailing offices. 2004 subscription rates: domestic, $203.00 for individuals ($101.00 for students), $441.00 for institutions. Postmaster: Send address changes to The Journal of Allergy and Clinical Immunology, Elsevier Inc, Periodicals Department, 6277 Sea Harbor Dr, Orlando, FL 32887-4800.
J ALLERGY CLIN IMMUNOL
August 2004 5A