Increased fearfulness in Fyn-deficient mice

s99

821

INCREASED FEARFULNESS IN FYN-DEFICIENT MICE. TSUYOSHI MIYAKAWAl,TAKESHI YAGl2 AND HIROAKI

NIKll,tDeot.

aTokvo.113.e Myodaiii.

2,

Okazaki.

poster

elevated

radial

deficient

mice

avoidance The

reported we

in the

tests.

than

fynzlfyw

822

In

light

light-dark

Seizures

associated

mutation

in

audiogenic

fyn seizures.

Sci..

novelty

it was

with

myelin

of we

produced

mice.

the

limbic

plus-maze

(+lfynz)

more

mice.

fearful

The

were

Homozygously

that

defects

mutant

for

gene locus. four

indicate

that

MICE.

YAGIP 1-f Behav.

Genet.,

444. Japan.

Fyn-deficient

were

examined

passive

in these

results

n, 2Deot. of Neurobiol.

found

an Fyn-

stimuli.

AND TAKESHI

Okazaki.

in of

and

lac Z into the fyn

were

In a

mice

emotionality

OF AUDIOGENIC SEIZURES IN FYN-DEFICIENT MlYAKAWAl

system.

Fyn-deficient

elevated

mice

to fear-inducing

in the

examined

by inserting

found

mice

exhibited

in several

impaired

mouse

myelination.

mutants.

their

susceptibility

to

(fywlfym)

mice were

significantly

have seizures and showed stronger seizure syndromes. susceptibility of acoustically-primed audiogenic seizures deficient

strong

preference,

(fymlfynz)

Myodaiii.

study genes

findings

Fyn-kinase-deficient

are hyperresponsive

Inst. of Phvsiol.

was

fear-response these

mice were

heterozygously

In our previous

of

Fyn-kinase-deficient

HIROAKI NIKIl,TSUYOSHI niv. f T k o H

National

expression

choice,

INCREASED SUSCEPTlBlLlTY

L tt. e.U

fyn

the

increased

the

Fyn-deficient

the mice

that

described

maze.

homozygously

tests

Fat. of Lett.. Univ. of Tokyo. Hoage

444. Japan.

We previously separate

of Psvchol..

.

Mice

with

acoustically-primed more

likely

to

These results indicate that the is enhanced in the Fyn-kinase-