DIABETES RESEARCH AND CLINICAL PRACTICE 120S1 (2016) S40–S64
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Diabetes Research and Clinical Practice journal hom epage: ww w.e lsevier.com/lo cat e/dia bres
Oral Presentations Epidemiology and Prevention of Diabetes OL01-2 Characteristics of abnormal oral glucose tolerance test in GDM diagnosis Dittakarn BORIBOONHIRUNSARN1 *. 1Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand Objectives: To describe characteristics of abnormal OGTT values in GDM diagnosis and their clinical correlation. In addition, the effects of omitting any OGTT value on GDM diagnosis were evaluated. Methods: A total of 415 women diagnosed with GDM were included. GDM screening and diagnosis results were extracted from medical records. Detailed analysis of OGTT values at the time of GDM diagnosis was performed, including prevalence of abnormalities of each value, number of abnormal values. In addition, relationship between abnormal OGTT values and maternal characteristics and clinical characteristics were also evaluated. Results: Mean age was 32.9 years, 46% were nulliparous, and 39% were overweight. Mean gestational age at diagnosis was 19.2 weeks and 42.4% were diagnosed during 24–28 weeks. Insulin therapy was indicated in 12% of cases. Most common abnormalities were found in the 2nd and 3rd values (85.3% and 96.6% respectively). In terms of number of abnormal OGTT values, abnormal 2 values was found in 42.9% while abnormal 3 or 4 values were found in 34.2% and 22.9%, respectively. Detailed analysis revealed that 16.7% of GDM would be missed if the 4th OGTT was omitted, including 2 cases who required insulin therapy. Number of abnormal OGTT values were significantly higher among overweight women ( p = 0.02) and those who required insulin therapy ( p < 0.001), but not related to timing of diagnosis. Mean birth weight and rate of macrosomia were also comparable between different numbers of abnormal OGTT values. Conclusion: Among GDM women, 57.1% had abnormal 3 or 4 OGTT values. Number of abnormal OGTT values were positively related to overweight and insulin requirement. Omitting the 4th OGTT value would result in unacceptable 16.7% undiagnosed GDM. OL01-3 Increased risk for diabetes development in subjects with large variation in total cholesterol levels in Koreans Eun-Jung RHEE1*, Kyungdo HAN2, Seung-Hyun KO3, Kyung Soo KO4, Ki-Up LEE5, Won-Young LEE1. 1Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 2Department of Medical Statistics, College of Medicine, The Catholic University of Korea, 3Divisin of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent’s Hospital, College of Medicine, The Catholic University of Korea, 4Department of Internal Medicine, Cardiovascular and Metabolic Disease Center, Inje University 0168-8227© 2016 Elsevier Ireland Ltd. All rights reserved.
Sanggye Paik Hospital, Inje University College of Medicine, 5 Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Korea Background: Recent studies suggest the role of hyperlipidemia on development of diabetes. However, statins are reported to increase the risk for diabetes development. We analyzed the relationship between the variations of total cholesterol (TC) levels and the risk of type 2 diabetes in data from a Korean nationwide population-based study. Methods: In 2,827,950 Korea examinees in general health check-up database (DB) as a sub-dataset of Korean National Health Insurance Service (NHIS), in whom at least two health check-up data were available between 2002 and 2006, and did not have diabetes at baseline, the variations of TC between the examinations were calculated. The examinees were divided into 10 groups according to deciles of TC variation and the hazard ratio for diabetes development from 2007 to 2013 were analyzed. Results: During the follow-up period, 3.4% of the examinees developed diabetes. The subjects with the highest decile of TC variation (32.5%) showed the highest incidence rate for diabetes among the decile groups of TC variation (5.24%), and the incidence rate for diabetes showed J-shaped curve with fourth decile group showed the lowest incidence rate for diabetes. The highest decile group of TC variation showed increased hazard ratio for diabetes development after adjustment for confounding variables (1.16; 95% CI 1.14–1.18). These results were similarly observed in either group with or without hyperlipidemic medication. Conclusions: The subjects with large variation of TC showed increased risk for diabetes development, independent to the medication of hyperlipidemic agents. These results suggest the possibility of contribution of variation in TC level, not the medication itself that affects the risk for diabetes development. OL01-4 Central blood pressure and insulin sensitivity after an oral glucose loading Ang-Tse LEE1, Chia-Lin LEE1,2,4, I-Te LEE1,7, Jun-Sing WANG1,8, Chen-Chi WANG3, Shih-An LIU3, Wen-Jane LEE4, Shih-Yi LIN1,5,7, Chen-Huan CHEN6,7,9, Wayne H-H SHEU1,7,10 *. 1 Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, 2Department of Public Health, College of Public Health, China Medical University, 3 Department of Otolaryngology, Taichung Veterans General Hospital, 4 Department of Medical Research, Taichung Veterans General Hospital, 5Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, 6Department of Medicine, Taipei Veterans General Hospital, 7School of Medicine, National Yang-Ming University, 8Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, 9Institute of Public Health, National Yang-Ming University, 10College of Medicine, National Defense Medical Center, Taipei, Taiwan Background: Although peripheral blood pressure (BP) is generally used to guide therapeutic decisions, recent