Index of Adverse Effects and Adverse Reactions

Index of Adverse Effects and Adverse Reactions

A

abdominal bleeding octreotide, 452 abdominal cramping lithium, 201–202 misoprostol, 413 abdominal discomfort albendazole, 295 deferasirox, 199 abdominal fullness dabigatran etexilate, 363 abdominal pain agomelatine, 449 alpha 1-antitrypsin (AAT), 333 artemether–lumefantrine, 261 bevacizumab, 493 eluxadoline, 109, 381–382 enteral nutrition, 354 fenofibrate, 459 fosfomycin, 240 gadolinium-based contrast agent, 486 lanreotide, 451–452 levamisole, 400 melatonin agonists, 449 methylnaltrexone, 380 methylprednisolone, 410 naloxegol, 380–381 sofosbuvir, 273 systemic glucocorticoids, 410 teduglutide, 381 tigecycline, 225–226 valacyclovir, 272 abnormal crying CYD-TDV vaccine, 303 abnormal electrocardiogram bedaquiline, 284 abnormal feeling brivaracetam, 94 abnormal liver function fingolimod, 392 liposomal amphotericin B, 245–246 thiopurines, 399 abnormal taste sensation methimazole, 430 ache levetiracetam, 95 acid reflux acetazolamide, 191–192 acne acetazolamide, 191–192 cyclosporine, 390 acroanesthesia linezolid, 289 acute angle-closure glaucoma (AACG)

antidepressant drugs, 15 acute chest pain atomoxetine, 4 methylphenidate, 3 acute coronary syndrome haloperidol, 66 acute delirium zolpidem, 58–59 acute disseminated encephalomyelitis (ADE) human papillomavirus vaccines, 307 acute dystonia asenapine, 71 haloperidol, 74 acute hepatitis glatiramer, 393 acute kidney injury (AKI) eplerenone, 194 flecainide, 176 HMG-CoA reductase inhibitors, 461 synthetic cannabinoids, 32–33 vancomycin, 235 vitamin D, 350 acute liver failure daptomycin, 240 deferasirox, 200 acute pancreatitis atorvastatin, 459 doxycycline, 224 acute renal failure dalbavancin, 148 intravenous immunoglobulin, 335 ivaroxaban, 365–366 primaquine, 264 acute stent thrombosis eptifibatide, 367 adrenal insufficiency pembrolizumab, 475 aggression brivaracetam, 94 lacosamide, 98 levetiracetam, 95 perampanel, 101 aggressive behavior clobazam, 37 flumazenil, 60–61 agitation brexpiprazole, 71 caffeine, 505–506 donepezil, 6 flumazenil, 60–61 imipenem/cilastatin, 218 intravenous agents, 116 ketamine, 117 levetiracetam, 95 methoxyflurane, 112

525

methylphenidate, 3 synthetic cannabinoids, 31 tiagabine, 104 agranulocytosis amisulpride, 69 captopril, 183 clozapine, 73–74 methimazole, 430 thiamazole, 430–431 akathisia aripiprazole, 65 asenapine, 70 brexpiprazole, 65, 71 cariprazine, 71 clarithromycin, 237 fluphenazine, 74 haloperidol, 65 paliperidone, 77 risperidone, 80 ziprasidone, 81 akinetic mutism heroin, 39 alanine aminotransferase (ALT) agomelatine, 449 ceftaroline, 220 leflunomide, 394 liposomal amphotericin B, 245–246 tasimelteon, 449 alertness ezogabine, 104 allergic conjunctivitis sympathomimetic agents, 494 allergic rash levamisole, 400 allergic reactions alirocumab, 462 oxytocin, 450 tetrazepam, 61 allopurinol Sweet’s syndrome, 151–152 alopecia dabrafenib, 145 leflunomide, 394 lisinopril, 183 nivolumab, 474 thiopurines, 399 vemurafenib, 145 voriconazole, 253 alopecia areata monolocularis clozapine, 73 amenorrhea divalproex sodium, 92–93 analgesia methoxyflurane, 112

526 anaphylactic reaction infliximab, 147 intravenous immunoglobulin, 335 pristinamycin, 239 anaphylactoid reaction dalbavancin, 148 anaphylaxis gelatin, 335 vancomycin, 149 yellow fever vaccination, 318–319 ANCA-positive vasculitis propylthiouracil, 430–431 anemia anagrelide, 366–367 ceftaroline, 220–221 ebolavirus vaccine, 304 linezolid, 238, 288 mycophenolic acid, 395 primaquine, 264 pyrazinamide, 289 sofosbuvir, 273–274 temsirolimus, 397–398 anger levetiracetam, 95 angioedema quetiapine, 79 anorexia artemether–lumefantrine, 261 deferasirox, 199 immune checkpoint inhibitors, 473 methylphenidate, 3 anticholinergic initiation fluphenazine, 74 anticholinergic toxicity clozapine, 72 anxiety agomelatine, 449 aripiprazole, 65, 69–70 armodafinil, 5 ethosuximide, 94 flumazenil, 60–61 hopantenic acid, 348 lacosamide, 98 methoxyflurane, 112 modafinil, 5 moxifloxacin, 233 paliperidone, 77 phenobarbital, 103 risperidone, 80 aphasia nivolumab, 476 topiramate, 103 aphthous ulcers sirolimus, 396 apnea intravenous agents, 116 ketamine, 117 appetite acetazolamide, 191–192 amodiaquine–artesunate, 259–260 brexpiprazole, 71 ceftolozane/tazobactam, 223 divalproex sodium, 92–93 elvitegravir/cobicistat/ftc/tenofovir, 275

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

felbamate, 100–101 Garcinia cambogia, 507 leflunomide, 394 methylphenidate, 3 nicotine, 48–49 rufinamide, 96 systemic glucocorticoids, 409–410 yellow fever vaccines, 316–317 arrhythmia antidepressant drugs, 9–10 apomorphine, 137 bedaquiline, 284 exenatide, 439 sevoflurane, 113 voriconazole, 253 arterial and venous thrombosis bevacizumab, 465 arterial stiffness quetiapine, 66 arteriosclerosis quetiapine, 66 arthralgia brodalumab, 146 dabrafenib, 145 ebolavirus vaccine, 303 levamisole, 400 malaria vaccine, 327 methimazole, 430 MVA85A-IMX313, 321–322 prolonged-release melatonin, 449 pyrazinamide, 289 vemurafenib, 145 arthritis ebolavirus vaccine, 303 methimazole, 430 aseptic meningitis amoxicillin, 218 intravenous immunoglobulin, 335 aspartate aminotransferase (AST) agomelatine, 449 ceftaroline, 220 liposomal amphotericin B, 245–246 aspiration pneumonia clozapine, 72 asthenia amodiaquine–artesunate, 259–260 dabrafenib, 145 dihydroartemisinin–piperaquine, 259–260 EGFR-targeted monoclonal antibody, 469 immune checkpoint inhibitors, 473 mefloquine–artesunate, 259–260 nivolumab, 476 quisinostat, 145 sofosbuvir, 274 vemurafenib, 145 asthma beta blockers, 494 influenza vaccines, 308 triclosan, 212 ataxia carbamazepine, 96 lithium, 202 perampanel, 101 phenobarbital, 103 atrial fibrillation warfarin, 359

attention disturbance lacosamide, 98–99 auditory hallucinations imipenem/cilastatin, 218 moxifloxacin, 233 autism antidepressant drugs, 14 azathioprine pure red cell aplasia, 384

B

back pain agomelatine, 449 cariprazine, 71 isotretinoin, 346 prolonged-release melatonin, 449 ropinirole, 136 basal cell carcinoma vemurafenib, 145 behavioral changes aripiprazole, 69–70 systemic glucocorticoids, 409–410 behavioral effects ezogabine, 104 behavioral problems felbamate, 100–101 bilateral necrotic lesions warfarin, 360 biliary disease teduglutide, 381 bilirubin elevation liposomal amphotericin B, 245–246 octreotide, 429 posaconazole, 247 black hairy tongue olanzapine, 76 bleeding antidepressant drugs, 11 bevacizumab, 465–466 cobalamins, 346 ramucirumab, 466–467 warfarin, 222 bloating enteral nutrition, 354 fenofibrate, 459 levofloxacin, 232–233 blood creatinine increase deferasirox, 199 blood dyscrasias quetiapine, 79 blood eosinophilia pristinamycin, 239 blood glucose, low methimazole, 431 blood pressure anti-VEGF medications, 491 beta blockers, 494 bevacizumab, 492 intravenous immunoglobulin, 335 phenylephrine, 497 von Willebrand Factor, 338 blood-shot eyes steroids, 307 blurred vision isotretinoin, 345 lacosamide, 98

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

nivolumab, 477 oxybutynin, 142 body pain ivermectin, 296 body swelling mebendazole, 298 body weakness artesunate–amodiaquine, 262 bone loss levothyroxine, 428–429 bone marrow depression ganciclovir, 270 bone marrow suppression quetiapine, 79 temsirolimus, 397 bone mineral density (BMD) tenofovir, 277 bone pain sofosbuvir, 274 bradycardia amisulpride, 69 beta blockers, 491, 494 levobunolol, 494 olanzapine, 76 phenylephrine, 497 posaconazole, 252 propranolol, 185 bradycardia arrhythmia beta blockers, 494 bradykinesia nivolumab, 476 brain hypoxia synthetic cannabinoids, 33 breast cancer hormone replacement therapy, 418 risperidone, 80 bronchial obstruction tobramycin, 230 bronchitis lacosamide, 98 levetiracetam, 94 rufinamide, 96 bruising venlafaxine, 17 bullous lesions acetaminophen, 151 burning of mouth somatropin, 448

C

camptocormia olanzapine, 76 cancer HMG-CoA reductase inhibitors, 461 zolpidem, 59 Candida infection ixekizumab, 147 cardiac arrest bupivacaine, 126 clozapine, 72 levobupivacaine, 128 posaconazole, 252 risperidone, 80 yoga, 511 cardiac disorder bedaquiline, 284

cardiopulmonary arrest cyclomidril, 497 cardiovascular arrhythmia droperidol, 74 cardiovascular disease hormone replacement therapy, 418 levothyroxine, 428 low-density lipoprotein, 427 cardiovascular effects lacosamide, 97 cardiovascular endpoints niacin, 458 cartilage defects eprotirome, 427 cataracts HMG-CoA reductase inhibitors, 460 catastrophic antiphospholipid syndrome thrombopoietin and receptor, 339 catatonia aripiprazole, 70 olanzapine, 76 paliperidone, 77 catheter-related complications teduglutide, 381 cellulitis dalbavancin, 148 central nervous system toxicity carbapenems, 217 central serous chorioretinopathy dexamethosone, 498 chemical burns Ranunculus arvensis, 509 chest discomfort von Willebrand Factor, 338 chest pain caffeine, 505–506 chlorpheniramine, 157 dabigatran etexilate, 363 droxidopa, 134 glatiramer, 393 methyl salicylate, 213 chest pain, acute atomoxetine, 4 methylphenidate, 3 chest tightness ketamine, 117 chills eptifibatide, 367 quisinostat, 145 cholestasis bilirubinemia, 506–507 cholestatic hepatitis lansoprazole, 256–257 chronic bronchitis cannabis, 35 chronic kidney disease (CKD) antidepressant drugs, 9 lithium, 27 statins, 461 vitamin D, 350 chronic obstructive pulmonary disease (COPD) antidepressant drugs, 9 beta blockers, 494 Clostridium difficile infection ceftaroline, 220–221

527

cognition HMG-CoA reductase inhibitors, 459–460 cognitive and behavioral disorganization donepezil, 6 cognitive decline amisulpride, 69 cognitive disorder topiramate, 103 cognitive disturbance pregabalin, 91–92 cognitive effects ezogabine, 104 cognitive impairment antidepressant drugs, 10–11 benzodiazepines, 57 folate, 347 hopantenic acid, 348 cold contact urticaria meningococcal vaccines, 322 colitis immune checkpoint inhibitors, 473 mycophenolic acid, 395 color sensation voriconazole, 253 coma tiagabine, 104 confusion acyclovir, 271 beta blockers, 494 clindamycin, 236 Garcinia cambogia, 507 pembrolizumab, 476–477 pregabalin, 92 tiagabine, 104 zolpidem, 58–59 congenital heart disease sevoflurane, 113 congestive heart failure (CHF) antidepressant drugs, 9 bevacizumab, 492 exenatide, 439 conjunctival hyperemia sympathomimetic agents, 494 conjunctivitis nivolumab, 477 consciousness acyclovir, 272 constipation acetazolamide, 191–192 agomelatine, 449 amisulpride, 69 brivaracetam, 94 cyproheptadine, 158 dalbavancin, 148 divalproex sodium, 92–93 eluxadoline, 381–382 furosemide, 190 ginkgo biloba, 179 octreotide, 429 opioids, 107 oxybutynin, 142 paliperidone, 77 patiromer, 203 quetiapine, 78 rufinamide, 96 sofosbuvir, 273

528 contact dermatitis chlorhexidine, 211 vitamin E, 352 contractions in neck aripiprazole, 4–5 contrast-induced nephropathy (CIN) iodine-based contrast media, 484–485 convulsion aripiprazole, 69–70 brivaracetam, 94 4CMenB vaccination, 322–323 contrast media injection, 484 eslicarbazepine acetate, 97 flumazenil, 60–61 lacosamide, 97–98 levetiracetam, 94 lidocaine, 130 rufinamide, 96 corneal thickness clozapine, 72 corneal toxicity benzalkonium chloride, 212 coronary revascularization propofol, 120 Cotard’s syndrome pramipexole, 137 cough alpha 1-antitrypsin (AAT), 333 ciprofloxacin, 232 iloprost, 413 indacaterol, 135 influenza vaccines, 313 lacosamide, 99 lamotrigine, 99 levodopa, 139 methoxyflurane, 112 nicotine, 48–49 olodaterol, 164 rufinamide, 96 sofosbuvir, 273–274 tobramycin, 230–231 treprostinil, 413 crusting imiquimod, 280 cushingoid appearance: systemic glucocorticoids, 408 cushingoid habitus systemic glucocorticoids, 409–410 Cushing syndrome systemic glucocorticoids, 409–410 cutaneous leukocytoclastic vasculitis aripiprazole, 70 cutaneous malignancies voriconazole, 253 cutaneous tissue disorders subcutaneous immunoglobulin, 336 cutaneous vasculitis quetiapine, 79 cystic fibrosis tobramycin, 230–231 cytopenias temsirolimus, 398

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

D

daytime drowsiness benzodiazepines, 57 daytime somnolence lithium, 201–202 death anti-VEGF medications, 491 apixaban, 363–364 bedaquiline, 284 benzodiazepine, 37 haloperidol, 74 herpes zoster vaccines, 317–318 illicit, 40–41 inhaled corticosteroids, 161 isoflurane, 112 loperamide, 382 MDMA and ethanol, 3 olanzapine, 76 opioids, 107 propofol, 120 tapentadol, 109 decreased appetite immune checkpoint inhibitors, 473 deep vein thrombosis (DVT) bevacizumab, 492 enoxaparin, 360–361 dehydration acetazolamide, 191–192 EGFR-targeted monoclonal antibody, 469 olmesartan, 184 delayed hand-foot syndrome dabrafenib, 145 delayed QT interval prolongation vemurafenib, 145 delirium clozapine, 72 paliperidone, 77 zolpidem, 58–59 delusions donepezil, 6 dementia antidepressant drugs, 10–11 depressed mood lacosamide, 97 depression antidepressant drugs, 11 cycloserine, 285 hopantenic acid, 348 hormonal contraceptives, 422 lacosamide, 97–98 levetiracetam, 95 perampanel, 101 dermatitis daclizumab and interferon, 152 sirolimus, 396 dermatomyosite-like eruption hydroxyurea, 201 diabetes ezetimibe, 457 HMG-CoA reductase inhibitors, 460 pembrolizumab, 475 systemic glucocorticoids, 407–408 diabetic ketoacidosis (DKA) alpha 1-antitrypsin (AAT), 333 diaphoresis gadolinium-based contrast agent, 486

diarrhea acetazolamide, 191–192 agomelatine, 449 albendazole, 295 artemether–lumefantrine, 261 bilastine, 157 brexpiprazole, 71 brincidofovir, 270 ceftaroline, 220–221 ceftriaxone, 223 cobalamins, 346 dalbavancin, 148, 234 EGFR-targeted monoclonal antibody, 469 elvitegravir/cobicistat/ftc/tenofovir, 275 enfuvirtide, 278 enteral nutrition, 354 eplerenone, 194 ezogabine, 104 famciclovir, 271 felbamate, 100–101 fosfomycin, 240 galantamine, 6 hepatitis A vaccines, 305–306 ibrutinib, 185–186 immune checkpoint inhibitors, 472–473 influenza vaccines, 308 intravenous immunoglobulin, 335 ivermectin, 296 lanreotide, 451–452 levetiracetam, 94 levofloxacin, 232–233 lithium, 202 methylnaltrexone, 380 misoprostol, 413 moxifloxacin, 233 mycophenolic acid, 395 naloxegol, 380–381 octreotide, 452 olmesartan, 184 ornithine, 353 patiromer, 203 pristinamycin, 239 quisinostat, 145 rofumilast, 167 rotigotine, 137 rufinamide, 96 secukinumab, 147 solithromycin, 234 synthetic cannabinoids, 34 diastolic blood pressure lisdexamfetamine dimesylate, 1 diplopia lacosamide, 98 mefloquine, 265 pregabalin, 92 rufinamide, 96 discolorations chlorhexidine, 210–211 discolored feces ceftolozane/tazobactam, 223 discontinuation glatiramer, 393 disorientation ivermectin, 296 opioid, 41 distress

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

flumazenil, 60–61 dizziness acetazolamide, 191–192 agomelatine, 449 albendazole, 295 amodiaquine–artesunate, 259–260 aripiprazole, 69–70 artesunate–amodiaquine, 262 benzodiazepines, 57 bilastine, 157 brexpiprazole, 71 brivaracetam, 94 carbamazepine, 96 ceftolozane/tazobactam, 223 cycloserine, 285 eslicarbazepine acetate, 97 ethosuximide, 94 fenofibrate, 459 fosfomycin, 240 gabapentin, 91 ginkgo biloba, 179 ibrutinib, 185–186 iloperidone, 75 iloprost, 413 ivermectin, 296 ketamine, 116–117 lacosamide, 97–98 levetiracetam, 95 levodopa, 139 levofloxacin, 232–233 mefloquine, 265 oxybutynin, 142 perampanel, 101 phenobarbital, 103 pregabalin, 91–92 quetiapine, 78 ramelteon, 449 rivastigmine, 6 rufinamide, 96 sevoflurane, 114 solithromycin, 234 tiagabine, 104 von Willebrand Factor, 338 driving impairment suvorexant, 57 drowsiness carbamazepine, 96 phenobarbital, 103 pregabalin, 92 synthetic cannabinoids, 31 tiagabine, 104 drug hypersensitivity syndrome nevirapine, 149 drug induced liver injury (DILI) sertraline, 16–17 drug rash with eosinophilia and systemic symptoms (DRESS) syndrome rivaroxaban, 365–366 strontium ranelate, 153 vancomycin, 149 dry eyes isotretinoin, 345 nivolumab, 477 dry mouth acetazolamide, 191–192 amisulpride, 69

aripiprazole, 70 brexpiprazole, 71 carbamazepine, 96 ceftolozane/tazobactam, 223 iloperidone, 75 lisdexamfetamine dimesylate, 1 lithium, 26–27 oxybutynin, 142 pregabalin, 92 quetiapine, 78 suvorexant, 57 topiramate, 103 dry orgasms iloperidone, 75 dry skin dabrafenib, 145 vemurafenib, 145 Duchenne’s muscular dystrophy prednisolone, 408 prednisone, 408 dysarthria dietary and herbal supplements, 504 dysgeusia acetazolamide, 191–192 asenapine, 70 dyskinesia apomorphine, 137 aripiprazole, 70 levodopa, 137–138 dyslipidemia sirolimus, 396 systemic glucocorticoids, 407–408 dyspepsia moxifloxacin, 233 vitamin E, 352 dysphagia dabigatran etexilate, 363 dysphonia inhaled corticosteroids, 161–162 tobramycin, 230 dysphoria opioids, 107 dyspnea atomoxetine, 4 glatiramer, 392–393 rotigotine, 137 sofosbuvir, 273–274 synthetic cannabinoids, 31–32 temsirolimus, 397 dyspnoeic clindamycin, 236 dystonia paliperidone, 77 dysuria ebolavirus vaccine, 304

E

Ebstein’s anomaly lithium, 27 eczema bilastine, 157 daclizumab and interferon, 152 nivolumab, 474 eczematous reactions telaprevir, 149 edema

529

corticotrophins, 407 cycloserine, 285 dalbavancin, 148 sodium zirconium cyclosilicate, 204 temsirolimus, 397–398 edematous erythema ipilimumab, 146 electrolyte disorders bedaquiline, 284 emergence delirium katamine, 117 endophthalmitis anti-VEGF medications, 491 enuresis methylphenidate, 3 eosinophilia ceftaroline, 220–221 clozapine, 73 olanzapine, 76 teicoplanin, 234–235 eosinophilia and systemic syndrome (DRESS) moxifloxacin, 148–149 eosinophilic myocarditis olanzapine, 76 eosinophilic pneumonia ceftaroline, 221 daptomycin, 240 eosinophils increase ivaroxaban, 365–366 epigastric pain levofloxacin, 233 epilepticus synthetic cannabinoids, 34 epiphora prostaglandin analogue, 499 epistaxis bilastine, 157 erectile dysfunction apomorphine, 137 erythema carbamazepine, 96 contrast media injection, 484 dengue vaccine, 303 imiquimod, 280 isotretinoin, 345 pertussis vaccines, 324 erythema induratum of Bazin (EIB) Bacillus Calmette–Guèrin vaccine, 321 erythematic pustular lesions biguanides, 436 erythematous patch methimazole, 431 varicella zoster virus vaccine, 316–317 esophagitis dabigatran etexilate, 363 euphoria opioids, 107 excessive daytime sleepiness hydroxyurea, 201 suvorexant, 57 excoriation lacosamide, 99 extrapyramidal symptoms haloperidol, 65 eyelid oedema teicoplanin, 234–235

530 F

facial drooping dietary and herbal supplements, 504 facial edema sodium hypochlorite, 213 facial nerve paralysis vemurafenib, 145 facial swelling mebendazole, 298 faint lingering hyper-pigmentation levocetirizine, 158–159 falls antidepressant drugs, 15 droxidopa, 134 lacosamide, 97–98 Fanconi syndrome deferasirox, 200 valproate sodium, 93 fatal infections aflibercept, 150 fatigue agomelatine, 449 bevacizumab, 466 brexpiprazole, 71 brivaracetam, 94 cycloserine, 285 ebolavirus vaccine, 304 EGFR-targeted monoclonal antibody, 469 enfuvirtide, 278 eslicarbazepine acetate, 97 fingolimod, 392 Garcinia cambogia, 507 immune checkpoint inhibitors, 473 lacosamide, 97–99 lansoprazole, 256–257 leflunomide, 394 malaria vaccine, 327 mefloquine, 265 MVA85A-IMX313, 321–322 perampanel, 101 pertussis vaccines, 324 pregabalin, 91–92 quetiapine, 78 ramelteon, 449 ribavirin, 274 rufinamide, 96 simvastatin, 256–257 sofosbuvir, 273–274 suvorexant, 57 temsirolimus, 397–398 topiramate, 103 tribendimidine, 299 voriconazole, 253 feeling hot von Willebrand Factor, 338 fetal goiter nutritional iodine supplements, 429 fetal malformations antidepressant drugs, 11–12 fever azathioprine, 148 carbamazepine, 96–97 CYD-TDV vaccine, 303 diethylcarbamazine + albendazole + ivermectin, 259 diethylcarbamazine and albendazole, 259 fexofenadine, 152

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

hepatitis A vaccines, 305 influenza vaccines, 308 intravenous immunoglobulin, 335 lamotrigine, 99 methimazole, 430 misoprostol, 413 MMR vaccine, 315 MVA85A-IMX313, 321–322 olanzapine, 77 praziquantel, 299 sofosbuvir, 273–274 teduglutide, 381 teicoplanin, 234–235 yellow fever vaccines, 316–317 flatulence naloxegol, 380–381 patiromer, 203 fluid overload teduglutide, 381 fluid retention vemurafenib, 145 flushing desmopressin, 454 iloprost, 412–413 intravenous immunoglobulin, 335 ketamine, 117 oxytocin, 450 focal motor seizures olanzapine, 76 foreign body sensation prostaglandin analogue, 499 fractures antidepressant drugs, 15 fungal superinfections fosfomycin, 240

G

gambling aripiprazole, 70 gastric discomfort felbamate, 100–101 gastric pain systemic glucocorticoids, 410 gastritis divalproex sodium, 92–93 gastroenteritis bilastine, 157 erythropoietin and derivatives, 339 gastrointestinal bleeding systemic glucocorticoids, 410 warfarin, 365 gastrointestinal complaints phenobarbital, 103 gastrointestinal discomfort inhaled corticosteroids, 162 gastrointestinal disorders bedaquiline, 284 ceftazidime/avibactam, 222–223 deferiprone and desferoxamine, 197 hepatitis A vaccines, 305 peramivir, 280 systemic glucocorticoids, 407–408 temsirolimus, 398 gastrointestinal disturbances sofosbuvir, 273–274 gastrointestinal perforation bevacizumab, 465–466

gastrointestinal side effects levofloxacin, 232 gastrointestinal symptoms flumazenil, 60–61 gastrointestinal upset deferasirox, 197 fingolimod, 392 thiopurines, 399 gestational hypertension (GH) antidepressant drugs, 12 gingival bleeding aripiprazole, 70 risperidone, 80 gingival hyperplasia cyclosporine, 390 propranolol, 185 glossitis bilastine, 157 gout flare ribavirin, 274 granulocytopenia clozapine, 74 growth suppression systemic glucocorticoids, 409–410 Guillain-Barre syndrome nivolumab, 476

H

haemoptysis tobramycin, 230–231 hair loss fingolimod, 392 hallucinations acyclovir, 271–272 aripiprazole, 69–70 imipenem/cilastatin, 218 ketamine, 116 moxifloxacin, 233 ropinirole, 136 valacyclovir, 272 hand-foot syndrome bevacizumab, 466 cabozantinib, 150 dabrafenib, 145 sorafenib, 150 vemurafenib, 145 Hashimoto’s disease pembrolizumab, 475 headache acetazolamide, 191–192 agomelatine, 449 alpha 1-antitrypsin (AAT), 333 amisulpride, 69 armodafinil, 5 azathioprine, 148 brexpiprazole, 71 brivaracetam, 94 brodalumab, 146 cariprazine, 71 ceftolozane/tazobactam, 223 cobalamins, 346 cycloserine, 285 dalbavancin, 148, 234 dengue vaccine, 302–303 divalproex sodium, 92–93 droxidopa, 134 ebolavirus vaccine, 304

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

eslicarbazepine acetate, 97 ethosuximide, 94 ezogabine, 104 famciclovir, 271 felbamate, 100–101 fosfomycin, 240 furosemide, 190 gabapentin, 91 hepatitis A vaccines, 305 herpes zoster vaccine, 272 human papillomavirus vaccines, 306 iloprost, 412–413 influenza vaccines, 313 inhaled corticosteroids, 161–162 intravenous immunoglobulin, 335 ivermectin, 296 lacosamide, 97–99 levofloxacin, 232–233 lisdexamfetamine dimesylate, 1 malaria vaccine, 327 melatonin agonists, 449 methoxyflurane, 112 modafinil, 5 MVA85A-IMX313, 321–322 naloxegol, 380–381 nicotine, 48–49 olodaterol, 164 perampanel, 101 phenobarbital, 103 phenylephrine, 134 praziquantel, 299 pregabalin, 91–92 prolonged-release melatonin, 449 rofumilast, 167 rotigotine, 137 rufinamide, 96 secukinumab, 147 sofosbuvir, 273–274 solithromycin, 234 suvorexant, 57 tasimelteon, 449 teduglutide, 381 treprostinil, 413 tribendimidine, 299 umeclidinium bromide, 166 valacyclovir, 272 yellow fever vaccines, 316–317 heartburn dabigatran etexilate, 363 heart rate beta blockers, 494 lithium, 23 heart rate variability (HRV) quetiapine, 79 heat stroke clozapine, 74 hematological toxicity ceftaroline, 221 hematoma cyclosporine, 390–391 tacrolimus, 390–391 hematuria diethylcarbamazine + albendazole + ivermectin, 259 hemolysis primaquine, 264 hemolytic anemia

apomorphine, 137 intravenous immunoglobulin, 335 hemoptysis Bacillus Calmette–Guèrin vaccine, 320 hemorrhage bevacizumab, 465 hemorrhagic shock dabigatran, 363 hemorrhagic stroke exenatide, 439 Henoch–Schonlein purpura fluoxetine, 16 hepatic effect micafungin, 248–249, 257 hepatic failure albendazole, 295–296 hepatic function, decreased ranitidine, 373 hepatitis black catechu, 507 chinese skullcap, 507 immune checkpoint inhibitors, 473 hepatobiliary disease bedaquiline, 284 ezetimibe, 457 hepatotoxicity amiodarone, 174 amphotericin, 250 antifungal agents, 245–249 dietary and herbal supplements, 506–507 ethambutol, 286 hepatotoxic product, 507 methimazole, 431 pyrazinamide, 289 temsirolimus, 399 herpes zoster varicella zoster virus vaccine, 316–317 herpetiform dermatitis ebolavirus vaccine, 304 hiccups aripiprazole, 70 high blood pressure felbamate, 100–101 hirsutism systemic glucocorticoids, 408 hives acetazolamide, 191–192 Hoigne syndrome lidocaine, 129 hot flash lacosamide, 98 hyperactivity phenobarbital, 103 hyperbilirubinemia amphotericin, 246 fluconazole, 246 simeprevir, 274 hypercalcemia vitamin D supplementation, 350 hypercalciuria deferasirox, 199 vitamin D supplementation, 350 hyperchloremia acetazolamide, 191–192 hypercoagulation levothyroxine, 429 hyperemia

531

infliximab, 147 prostaglandin analogue, 493 hyperglycemia caffeine, 505–506 corticotrophins, 407 inhaled corticosteroids, 161 lanreotide, 451–452 octreotide, 452 pasireotide, 452–453 systemic glucocorticoids, 407–408 temsirolimus, 397 hyperhidrosis agomelatine, 449 hyperkalemia quisinostat, 145 hyperkeratosis dabrafenib, 145 vemurafenib, 145 hyperlipidemia aripiprazole, 70 hypernatremia tolvaptan, 453 hyperpigmentation minocycline, 224–225 hyperpigmentation, oral cavity linezolid, 289 hyperprolactinaemia risperidone, 80 hyperreligiosity donepezil, 6 hypersalivation clozapine, 72–73 ketamine, 117 hypersensitivity bupivacaine, 125 ceftaroline, 220–221 EGFR-targeted monoclonal antibody, 470 glatiramer, 392–393 lidocaine, 125 mepivacaine, 125 proton-pump inhibitors, 377 von Willebrand Factor, 338 hypersexuality aripiprazole, 70 donepezil, 6 hypertension adrenaline, 133 beta2-adrenoceptor agonists, 163 bevacizumab, 465–467 clozapine, 72 cyclosporine, 390 dietary and herbal supplements, 508–509 fingolimod, 392 ketamine, 117 octreotide, 452 olanzapine, 65 quisinostat, 145 ramucirumab, 466–467 rotigotine, 137 systemic glucocorticoids, 407–410 temsirolimus, 397 tiagabine, 104 hyperthermia synthetic cannabinoids, 33 hyperthyroidism immune checkpoint inhibitors, 473 pembrolizumab, 475

532 hypertransaminasemia levamisole, 400 hypertricosis cyclosporine, 390 hypertriglyceridemia clozapine, 73 olanzapine, 76 sirolimus, 396 temsirolimus, 397 hypertriglyceridemia-induced pancreatitis quetiapine, 79 hyperuricemia pyrazinamide, 289 hypofibrinolytic effect levothyroxine, 429 hypoglycemia beta blockers, 494 doxycyline, 224 propranolol, 185 risperidone, 80 hypokalemia acetazolamide, 191–192 amphotericin, 249 caffeine, 505–506 ceftaroline, 221 dietary and herbal supplements, 508–509 sodium zirconium cyclosilicate, 204 temsirolimus, 397 hypomagnesemia EGFR-targeted monoclonal antibody, 469 patiromer, 203 hyponatremia aripiprazole, 70 felbamate, 100–101 oxytocin, 451 SGAs, 66 hypophysitis pembrolizumab, 475 hypotension alpha 1-antitrypsin (AAT), 333 amisulpride, 69 clindamycin, 236 droperidol, 74 flumazenil, 60–61 intravenous agents, 116 methimazole, 431 methoxyflurane, 112 opioid, 41 oxytocin, 450 propranolol, 185 hypotensive shock contrast media injection, 484 hypothermia risperidone, 80 hypothyroidism digoxin, 175 immune checkpoint inhibitors, 473 iodine, 430 lithium, 201–202 pembrolizumab, 475 hypotonia lithium, 27 hypotony bevacizumab, 492

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

hypoxemia eptifibatide, 367 hypoxia intravenous agents, 116

I

ileus paliperidone, 78 immediate QT interval prolongation vemurafenib, 145 impaired balance ezogabine, 104 impaired cognition oxybutynin, 142 impaired speech ezogabine, 104 impulse control disorder apomorphine, 137 levodopa, 139 incontinence katamine, 117 increased intraocular pressure anti-VEGF medications, 491 increased transaminase levels leflunomide, 393 infection cyclosporine, 390 teduglutide, 381 temsirolimus, 397 infectious complications temsirolimus, 398 inflammatory bowel disease ixekizumab, 147 influenza lacosamide, 98 levetiracetam, 95 infusion site reactions fosfomycin, 240 inhaled corticosteroids fluticasone, 162 pneumonia, 162 injection site pain paliperidone, 77 risperidone, 80 injection site reaction CYD-TDV, 302–303 enfuvirtide, 278 Herpes zoster vaccine, 272 influenza vaccines, 308 ixekizumab, 147 levofloxacin, 232 insomnia agomelatine, 449 amisulpride, 69 aripiprazole, 65 armodafinil, 5 brexpiprazole, 71 cariprazine, 71 corticotrophins, 407 dalbavancin, 148 divalproex sodium, 92–93 donepezil, 6 droxidopa, 134 felbamate, 100–101 ginkgo biloba, 179 linezolid, 289

lisdexamfetamine dimesylate, 1 lithium, 201–202 melatonin agonists, 449 methylphenidate, 3 modafinil, 5 moxifloxacin, 233 paliperidone, 77 ramelteon, 449 systemic glucocorticoids, 408 voriconazole, 253 intense facial pain sodium hypochlorite, 213 interstitial granulomatous cutaneous reaction quetiapine, 79 interstitial pneumonia influenza vaccines, 308 intestinal obstruction teduglutide, 381 intracerebral hemorrhage (ICH) HMG-CoA reductase inhibitors, 460–461 intraocular inflammation anti-VEGF medications, 491 intraocular pressure corticosteroids, 497 iodide mumps iodine-based contrast media, 484 iodine deficiency dietary iodine, 429–430 iris pigmentation prostaglandin analogue, 493 iritis nivolumab, 477 irregular menstruation leflunomide, 394 irritability nicotine, 48–49 irritable bowel disease with diarrhea eluxadoline, 109 irritation CYD-TDV vaccine, 303 hepatitis A vaccines, 305–306 imiquimod, 280 lacosamide, 98 perampanel, 101 sympathomimetic agents, 494 valacyclovir, 272 vitamin E, 352 ischemic colitis phentermine, 6 itchiness prostaglandin analogue, 499 itching contrast media injection, 484 hepatitis A vaccines, 304–305 ivermectin, 296 vitamin E, 352

J

jaundice lansoprazole, 256–257 methylprednisolone, 410 rivaroxaban, 365 jaundice with icteric sclera levocetirizine, 159 jaw pain iloprost, 413

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

joint pain sofosbuvir, 274

K

keratoderma hydroxyurea, 201 keratotic papules hydroxyurea, 201 leflunomide, 395 kidney stones vitamin D supplementation, 350 Kounis syndrome (type 1) ziprasidone, 81

L

lactic acidosis caffeine, 505–506 laryngospasm katamine, 117 sirolimus, 396 lash growth, increased prostaglandin analogue, 493 lesions methylprednisolone, 410–411 pirfenidone, 153 warfarin, 360 lethargy hepatitis A vaccines, 305 lithium, 27 quisinostat, 145 synthetic cannabinoids, 31 tiagabine, 104 leukopenia ceftaroline, 221 dalbavancin, 148 leflunomide, 394 levamisole, 400 linezolid, 288 mycophenolic acid, 395 paliperidone, 78 thiopurines, 399 lightheadedness gabapentin, 91 methyl salicylate, 213 pregabalin, 92 linear IgA bullous dermatosis vancomycin, 149 lingual dystonia olanzapine, 76 lipodystrophy leuprolide, 448 lipohypertrophy leuprolide, 448 livedo reticularis amantadine, 140 liver damage atomoxetine, 4 liver enzymes elevation felbamate, 100–101 liver failure G. cambogia, 507 liver injury lacosamide, 97 liver toxicity ayurvedic herbal tea, 506 itraconazole, 246–247

loose stools brincidofovir, 270 lupus erythematosus ziprasidone, 81 lupus-like syndrome clozapine, 73–74 infliximab, 147 lymphocytopenia ebolavirus vaccine, 304 lymphopenia fingolimod, 392 temsirolimus, 398

M

macular edema fingolimod, 392 macular hole formation anti-VEGF medications, 491 maculopapular rash contrast media injection, 484 deferasirox, 200 methylphenidate, 3 pristinamycin, 239 malaise dengue vaccine, 302–303 ebolavirus vaccine, 304 hepatitis A vaccines, 305 ibrutinib, 185–186 influenza vaccines, 313 mefloquine, 265 methyl salicylate, 213 MVA85A-IMX313, 321–322 praziquantel, 299 melena dabigatran etexilate, 363 memory impairment lacosamide, 99 topiramate, 103 mental slowness lacosamide, 98 metabolic acidosis acetazolamide, 191–192 metallic taste lithium, 25 methemoglobinemia benzocaine, 126 microalbuminuria losartan, 184 migraine agomelatine, 449 mild cholestasis ivaroxaban, 365–366 mild diarrhea octreotide, 429 mild redness vitamin E, 352 mining-radiculitis nivolumab, 476 miotic pupils opioid, 41 mirtazapine edema, 18 mitochondrial dysfunction tolcapone, 141 mood effects ezogabine, 104

533

felbamate, 100–101 mood swings corticotrophins, 407 mortality rate paliperidone, 78 mouth burning somatropin, 448 mouth muscles contraction aripiprazole, 5 mucositis EGFR-targeted monoclonal antibody, 469 temsirolimus, 398 mucous membrane pemphigoid (MMP) intravenous immunoglobulin, 335 muffled speech lithium, 23 multiorgan failure quetiapine, 79 multiple eruptive milia imiquimod, 280 multiple erythematous nonfollicular pustules fexofenadine, 152 multiple skin afflictions digoxin, 173 multiple subungual pyogenic granulomas levothyroxine, 428 multiple ventricular beats flumazenil, 60–61 muscle symptoms evolocumab, 462 ezetimibe, 462 muscle tone lithium, 23 muscle toxicity daptomycin, 240 musculo-articular pain ebolavirus vaccine, 304 musculoskeletal pain isotretinoin, 346 myalgia dengue vaccine, 302–303 diethylcarbamazine + albendazole + ivermectin, 259 hepatitis A vaccines, 305 HMG-CoA reductase inhibitors, 461 malaria vaccine, 327 MVA85A-IMX313, 321–322 olodaterol, 164 sofosbuvir, 274 yellow fever vaccines, 316–317 mydriasis tiagabine, 104 myelosuppression linezolid, 288–289 myocardial infarction (MI) adrenaline, 133 antidepressant drugs, 9 anti-VEGF medications, 491 bevacizumab, 492 propofol, 120 myocardial ischemia beta2-adrenoceptor agonists, 163 myocarditis clozapine, 72–74 myopathy HMG-CoA reductase inhibitors, 461

534 N

Nager syndrome propranolol, 185 nail effect voriconazole, 253 nasal bleeding aripiprazole, 70 nasal congestion influenza vaccines, 313 nasal irritation furosemide, 190 nasopharyngitis brivaracetam, 94 brodalumab, 146 ciprofloxacin, 232 fingolimod, 392 ixekizumab, 147 lacosamide, 97–99 levetiracetam, 95 nicotine, 48–49 paliperidone, 77 prolonged-release melatonin, 449 rofumilast, 167 secukinumab, 147 tobramycin, 230–231 umeclidinium bromide, 166 nausea acetazolamide, 191–192 agomelatine, 449 amisulpride, 69 amodiaquine–artesunate, 259–260 apomorphine, 137 aripiprazole, 70 armodafinil, 5 artemether–lumefantrine, 261 artesunate–mefloquine and lopinavir, 266 beta blockers, 494 brexpiprazole, 71 brincidofovir, 270 carbamazepine, 96 ceftaroline, 221 contrast media injection, 484 cycloserine, 285 dabigatran etexilate, 363 dalbavancin, 148, 234 deferasirox, 199 dietary and herbal supplements, 507 divalproex sodium, 92–93 droxidopa, 134 eluxadoline, 381–382 enfuvirtide, 278 etomidate, 116 famciclovir, 271 felbamate, 100–101 fenofibrate, 459 flumazenil, 60–61 fosfomycin, 240 gadolinium-based contrast agent, 486 hepatitis A vaccines, 305 ibrutinib, 185–186 iloprost, 412–413 immune checkpoint inhibitors, 473 influenza vaccines, 308 intravenous immunoglobulin, 335 ivermectin, 296

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

ketamine, 116–117 lacosamide, 97–99 levodopa, 139 levofloxacin, 232–233 linezolid, 289 melatonin agonists, 449 methimazole, 430 methoxyflurane, 112 methylnaltrexone, 380 modafinil, 5 moxifloxacin, 233 MVA85A-IMX313, 321–322 naloxegol, 380–381 octreotide, 429 ornithine, 353 patiromer, 203 perampanel, 101 praziquantel, 299 pregabalin, 91–92 pristinamycin, 239 pyrazinamide, 289 quisinostat, 145 ramelteon, 449 rivastigmine, 7 rofumilast, 167 rotigotine, 137 rufinamide, 96 sevoflurane, 114 sofosbuvir, 273 solithromycin, 234 synthetic cannabinoids, 31–32 teduglutide, 381 tribendimidine, 299 valacyclovir, 272 vitamin E, 352 necrotizing pancreatitis olanzapine, 76 necrotizing pneumonia clozapine, 72 nephrogenic diabetes lithium, 201–202 nephrogenic systemic fibrosis (NSF) gadolinium-based contrast agent, 486 nephrotoxicity aminoglycosides, 283 dietary and herbal supplements, 506 nervousness armodafinil, 5 ethosuximide, 94 levetiracetam, 95 methylphenidate, 3 nervous system disorders FGAs, 65 phenylephrine, 134 subcutaneous immunoglobulin, 336 neurodevelopmental disorders antidepressant drugs, 14–15 neurodevelopmental issues thyroid therapy, 428 neuroleptic malignant syndrome (NMS) aripiprazole, 69–70 lithium, 25 neurological side effects mefloquine, 265 neurological symptoms

artemether–lumefantrine, 261 neurologic disease yellow fever vaccination, 318–319 neurologic effects voriconazole, 253 neuromuscular blockade aminoglycosides, 283 neuropathy linezolid, 288–289 neuropsychiatric events apomorphine, 137 neurotoxicity acyclovir, 271 dietary and herbal supplements, 504 linezolid, 288 penicillin, 219 neutropenia ammonium tetrathiomolybdate, 198 bevacizumab, 466 ceftaroline, 221 clozapine, 72–74 daptomycin, 240 ebolavirus vaccine, 304 EGFR-targeted monoclonal antibody, 469 ganciclovir, 270 ixekizumab, 147 levamisole, 401 paliperidone, 78 quetiapine, 79 nightmares ketamine, 116 tasimelteon, 449 nocturnal enuresis risperidone, 80 non-anaphylaxis allergic reaction influenza vaccines, 308 non-painful rash digoxin, 173 nonpruritic maculopapular skin rash methylphenidate, 3 numbness cycloserine, 285 nutrition disorders bedaquiline, 284 nystagmus ketamine, 117

O

ocular pain prostaglandin analogue, 499 odynophagia dabigatran etexilate, 363 oral candidiasis inhaled corticosteroids, 161 systemic glucocorticoids, 409–410 oral cavity, hyperpigmentation linezolid, 289 oral hypoesthesia asenapine, 70 oral irritation inhaled corticosteroids, 162 oral lesions somatropin, 448 oral/oropharyngeal candidiasis inhaled corticosteroids, 161

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

oropharyngeal pain tobramycin, 230 orthostatic hypotension apomorphine, 137 osteitis Bacillus Calmette–Guèrin vaccine, 321 osteomyelitis exenatide, 439 osteoporosis systemic glucocorticoids, 408 ototoxicity aminoglycosides, 283 deferoxamine, 197 over-sedation methoxyflurane, 112 oxygen desaturation methoxyflurane, 112

P

pain ciprofloxacin, 232 dengue vaccine, 302–303 ebolavirus vaccine, 304 ezogabine, 104 hepatitis A vaccines, 305 influenza vaccines, 308 ketamine, 116 MMR vaccine, 315 pregabalin, 91–92 propofol, 119 voriconazole, 254 painful vesicular skin rash azathioprine, 148 palpitation caffeine, 505–506 chlorpheniramine, 157 droxidopa, 134 linezolid, 289 melatonin agonists, 449 pancreatic disease teduglutide, 381 pancreatitis atorvastatin, 459 dalbavancin, 148 doxycycline, 224 eluxadoline, 381–382 HMG-CoA reductase inhibitors, 460 methimazole, 431 tigecycline, 225–226 pancytopenia dalbavancin, 148 teicoplanin, 235 trientine, 204 panniculitis hydroxyurea, 201 papular rash infliximab, 147 papular skin rash cotrimoxazole, 298 papulopustular eruption afatinib, 149–150 paradoxical agitation ketamine, 117 parasomnia eszopiclone, 58

parenchymal lung disease clozapine, 72 paresis nivolumab, 476 paresthesia acetazolamide, 191–192 lacosamide, 98 nivolumab, 476 topiramate, 102 parkinsonian syndrome nivolumab, 476 parkinsonism aripiprazole, 69–70 levosulpiride, 75 partial seizures efavirenz, 277–278 lacosamide, 98 pedal edema quetiapine, 79 pericarditis clozapine, 72 periocular skin pigmentation prostaglandin analogue, 493 periorbital cellulitis sodium hypochlorite, 213 peri-orbital oedema cotrimoxazole, 298 periostitis voriconazole, 253 peripheral edema divalproex sodium, 92–93 ropinirole, 136 peripheral neuropathy anti-TB therapy, 291 peritonitis erythropoietin and derivatives, 339 persistent pulmonary hypertension of the newborn (PPHN) antidepressant drugs, 13 pharyngitis levetiracetam, 95 phobia methylphenidate, 3 photophobia steroids, 307 voriconazole, 253 photosensitivity dabrafenib, 145 simeprevir, 274 vemurafenib, 145 phototoxicity tetracyclines, 224 pigastric pain dabigatran etexilate, 363 piloerection milnacipran, 18 pisa syndrome paliperidone, 77 pityriasis rosea atenolol, 184–185 plaques enzalutamide, 150 pneumonia daptomycin, 240 fingolimod, 392

535

lacosamide, 97 piperacillin and tazobactam, 149 synthetic cannabinoids, 34 systemic glucocorticoids, 410 triazolam, 61 pneumonitis immune checkpoint inhibitors, 472–473 polyneuropathy nivolumab, 476 postinjection delirium syndrome (PDSS) olanzapine, 76 postoperative nausea and vomiting (PONV) pregabalin, 92 postpartum hemorrhage (PPH) antidepressant drugs, 13–14 preeclampsia (PE) antidepressant drugs, 12 pressure ulcer triazolam, 61 preterm birth (PTB) antidepressant drugs, 12 priapism risperidone, 80 progressive dyspnea beta blockers, 494 prolactin-related symptoms aripiprazole, 70 risperidone, 65, 80–81 prophylaxis clindamycin, 236 proteinuria bevacizumab, 465–466 diethylcarbamazine + albendazole + ivermectin, 259 temsirolimus, 397 proximal muscular atrophy deferasirox, 199 prurisit fingolimod, 392 pruritic maculopapular rash deferasirox, 200 pruritis acetazolamide, 191–192 ceftaroline, 220–221 ketamine, 116–117 pruritus anthrax vaccines, 320 contrast media injection, 484 dalbavancin, 148, 234 diethylcarbamazine + albendazole + ivermectin, 259 immune checkpoint inhibitors, 473 methimazole, 430 nivolumab, 474 pregabalin, 92 quisinostat, 145 simeprevir, 274 pseudopheochromocytoma clozapine, 73 psoriasiform plaques hydroxyurea, 201 psoriasis infliximab, 147 psychatric side effects mefloquine, 265

536 psychiatric disorders systemic glucocorticoids, 407–408 psychiatric disturbance inhaled corticosteroids, 162 psychiatric effects lacosamide, 97 psychiatric symptoms methamphetamine, 2 psychological distress opioid, 42–43 psychotic symptoms cannabis, 35 pulmonary edema adrenaline, 133 beta blockers, 494 pulmonary embolism clozapine, 72 EGFR-targeted monoclonal antibody, 469 pulmonary hypertension leflunomide, 394 pulmonary tuberculosis systemic glucocorticoids, 411 pulse rate lisdexamfetamine dimesylate, 1 methylphenidate, 3 pulse wave velocity (PWV) quetiapine, 66 pupil dilation sympathomimetic agents, 494 pupillary dilation cycloplegics, 496 mydriatics, 496 purpuric lesions eptifibatide, 367 levofloxacin, 148 pustules enzalutamide, 150 pyrexia ciprofloxacin, 232 divalproex sodium, 92–93 hepatitis A vaccines, 305–306 levetiracetam, 94 quisinostat, 145

Q

QT prolongation amisulpride, 69 atomoxetine, 4 ketoconazole, 252 lithium, 201–202 memantine, 7 posaconazole, 252

R

rash acetazolamide, 191–192 anthrax vaccines, 320 ceftaroline, 220–221 daclizumab, 152 daclizumab and interferon, 152 dalbavancin, 148 erlotinib, 150 hepatitis A vaccines, 304–305 immune checkpoint inhibitors, 473 lacosamide, 98 lamotrigine, 99 levofloxacin, 232

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

methimazole, 430 MMR vaccine, 315 nivolumab, 474 octreotide, 452 rufinamide, 96 simeprevir, 274 temsirolimus, 398 varicella zoster virus vaccine, 316–317 vitamin E, 352 Raynaud’s phenomenon aripiprazole, 70 rebound insomnia melatonin agonists, 449 redness hepatitis A vaccines, 305 influenza vaccines, 308 red scaly papular skin lesions interferon-alpha and ribavirin, 149 reduced bone density systemic glucocorticoids, 407–408 REM sleep behavior disorder quetiapine, 79 renal dysfunction cadmium, 198 ganciclovir, 270 renal effect micafungin, 257 renal failure ceftaroline, 221 intravenous immunoglobulin, 336 olmesartan, 184 primaquine, 264 propofol, 120 renal function ranitidine, 373 renal toxicity daptomycin, 240 respiration beta blockers, 494 respiratory depression katamine, 117 opioids, 107 respiratory distress lithium, 27 primaquine, 264 risperidone, 80 respiratory failure MDMA and ethanol, 3 sofosbuvir, 273–274 respiratory hypoxia droperidol, 74 respiratory infections enteral nutrition, 354 mycophenolic acid, 395 respiratory tract paralysis aminoglycosides, 283 restless legs syndrome (RLS) clozapine, 72 restlessness cariprazine, 71 zolpidem, 58–59 retinal detachment anti-VEGF medications, 491 retinal detachment, exudative bevacizumab, 492 retinal hemorrhage fingolimod, 392

retinal tear anti-VEGF medications, 491 retinal vascular occlusions anti-VEGF medications, 491 retinal vein occlusion fingolimod, 392 retrograde ejaculation paliperidone, 78 rhabdomyolysis fluconazole, 256 mefloquine, 265 paliperidone, 77 simvastatin, 231–232 rheumatoid arthritis (RA) levothyroxine, 428 rhinitis divalproex sodium, 92–93 rhythm changes lithium, 23 rigors eptifibatide, 367 runny nose influenza vaccines, 313

S

sacroiliitis isotretinoin, 346 salivation clozapine, 65 scaly papules on palms/soles somatropin, 448 schizoaffective disorder synthetic cannabinoids, 32 schizophrenia brexpiprazole, 71 scleroderma capecitabine, 150 sedation apomorphine, 137 aripiprazole, 65 brexpiprazole, 71 clozapine, 72 cycloserine, 285 methylphenidate, 3 olanzapine, 65 opioids, 107 paliperidone, 77 pregabalin, 92 quetiapine, 78 risperidone, 80 seizure acyclovir, 271 antidepressant drugs, 10 brivaracetam, 94 bupivacaine, 128 calcitonin, 447 ertapenem, 217 nivolumab, 476 paliperidone, 77 quetiapine, 79 selective immunoglobulin M immunodeficiency (SIgMD) clozapine, 73 sepsis systemic glucocorticoids, 411 serotonin syndrome paliperidone, 77

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

serum creatinine deferasirox, 199 itraconazole, 246–247 sexual desire donepezil, 6 shock beta blockers, 494 shortness of breath caffeine, 505–506 methyl salicylate, 213 ribavirin, 274 shuffling gait lithium, 23 sialorrhoea clozapine, 72 sinusitis sirolimus, 396 sinus tachycardia ceftazidime/avibactam, 222–223 skin biopsy lamotrigine, 151 skin cancer methotrexate, 152–153 skin eruptions methylphenidate, 3 skin infection fusidic acid, 241 skin lesions azathioprine, 148 fluconazole, 250–251 skin patch etoricoxib, 152 skin rash deferasirox, 197 digoxin, 173 nivolumab, 146 phenobarbital, 103 systemic glucocorticoids, 410 teicoplanin, 234–235 skin reaction ceftolozane/tazobactam, 223 oxcarbazepine, 151 skin toxicity EGFR-targeted monoclonal antibody, 469 sleep disorder benzodiazepines, 59–60 systemic glucocorticoids, 407–408 sleep disturbance aripiprazole, 69–70 levetiracetam, 95 sleep eating ziprasidone, 81 sleepiness cyproheptadine, 158 dimenhydrinate, 158 influenza vaccines, 308 sleep paralysis suvorexant, 57 sleep-related eating disorder risperidone, 80 sleep walking ziprasidone, 81 slurred speech opioid, 41 small intestinal obstruction teduglutide, 381 somnolence

agomelatine, 449 brexpiprazole, 71 brivaracetam, 94 divalproex sodium, 92–93 gabapentin, 91 iloperidone, 75 lacosamide, 97–99 levetiracetam, 95 melatonin agonists, 449 paliperidone, 77 perampanel, 101 pregabalin, 91–92 quetiapine, 78 ramelteon, 449 risperidone, 80 ropinirole, 136 rufinamide, 96 suvorexant, 57 soreness hepatitis A vaccines, 305 sore throat nicotine, 48–49 spastic quadriplegia heroin, 39 speech difficulties katamine, 117 spongiotic dermatitis telaprevir, 149 squamous cell carcinoma hydroxyurea, 201 vemurafenib, 146 status epilepticus acyclovir, 272 Stevens-Johnson syndrome ibuprofen, 152 nevirapine, 149 regorafenib, 150 vemurafenib, 146 stomach upset levetiracetam, 95 stomatitis bilastine, 157 EGFR-targeted monoclonal antibody, 469 stroke antidepressant drugs, 9–10 anti-VEGF medications, 491 propofol, 120 stuttering olanzapine, 76 suicide eszopiclone, 58 lacosamide, 97 supraventricular arrhythmia flumazenil, 60–61 swallowing difficulty aripiprazole, 5 katamine, 117 sweating clozapine, 65 eplerenone, 194 swelling glatiramer, 392–393 hepatitis A vaccines, 305 influenza vaccines, 308 pertussis vaccines, 324 syncope

537

anti-TB therapy, 291 influenza vaccines, 308 lacosamide, 97–98 systemic erythrodermic eruptions carbamazepine, 96–97 systemic inflammatory response syndrome clozapine, 73–74 systemic vasodilatation iloprost, 413 systolic blood pressure lisdexamfetamine dimesylate, 1

T

tachycardia beta2-adrenoceptor agonists, 163 caffeine, 505–506 clindamycin, 236 clozapine, 65, 72 flumazenil, 60–61 intravenous immunoglobulin, 335 oxytocin, 450 synthetic cannabinoids, 31 tiagabine, 104 takotsubo cardiomyopathy atomoxetine, 4 tardive dyskinesia iloperidone, 75 paliperidone, 77 tardive dystonia paliperidone, 77 targetoid erythematous acetaminophen, 151 taste distortion levofloxacin, 232–233 taste disturbances chlorhexidine, 210–211 tear production clozapine, 72 telangiectasia escitalopram, 15–16 venlafaxine, 15–16 throat irritation treprostinil, 413 thrombocytopenia ceftaroline, 221 dalbavancin, 148 daptomycin, 240 leflunomide, 394 levamisole, 400 linezolid, 238, 288 olanzapine, 76 quetiapine, 79 quisinostat, 145 temsirolimus, 397 thromboembolic events bevacizumab, 465–466 thrombophlebitis conivaptan, 453 thrombosis hydroxyurea, 200–201 thrombopoietin and receptor, 339 thrombotic complications intravenous immunoglobulin, 335 thromboticmicroangiopathy clopidogrel, 368 thrombotic thrombocytopenic purpura quetiapine, 79

538 thyroid dysfunction amiodarone, 174 iodine-based contrast media, 484 thyrotoxicosis iodine-based contrast media, 484 tingling cycloserine, 285 tiredness hepatitis A vaccines, 305 lacosamide, 98 perampanel, 101 tonic-clonic seizure synthetic cannabinoids, 32 torsades de pointes (TdP) antidepressant drugs, 9–10 toxic epidermal necrolysis ibuprofen, 152 levofloxacin, 233 nevirapine, 149 paliperidone, 78 regorafenib, 150 toxicity paclitaxel, 368 transfusion-associated circulatory overload (TACO) cryoprecipitate, 334 transfusion-related acute lung injury (TRALI) cryoprecipitate, 334 transient ischemic attack antidepressant drugs, 9 bevacizumab, 492 transient morning pseudoneutropenia aripiprazole, 70 transient visual impairment linezolid, 289 trauma triazolam, 61 tremor aripiprazole, 65 cariprazine, 71 divalproex sodium, 92–93 lacosamide, 98 lithium, 201–202 methylphenidate, 3 risperidone, 81 triglycerides asenapine, 71 tuberculosis Bacillus Calmette–Guèrin vaccine, 321 Turner syndrome somatropin, 448 T-wave changes lithium, 201–202

U

ulcerations hydroxyurea, 201 unconsciousness heroin, 39 unsteadiness lacosamide, 98 opioid, 41 upper abdominal complaints leflunomide, 393

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

upper abdominal pain naloxegol, 380–381 upper gastrointestinal bleed lacosamide, 97 upper respiratory tract infection brodalumab, 146 ciprofloxacin, 232 divalproex sodium, 92–93 fingolimod, 392 lacosamide, 97–99 perampanel, 101 rufinamide, 96 secukinumab, 147 tasimelteon, 449 topiramate, 103 upregulation low-density lipoprotein, 427 urinary incontinence clozapine, 73 urinary symptoms droxidopa, 134 urinary tract infection dalbavancin, 148 droxidopa, 134 fingolimod, 392 nitrofurantoin, 149 tasimelteon, 449 urticaria ceftriaxone, 223 intravenous immunoglobulin, 335 methimazole, 430 pertussis vaccine, 323–324 urticarial rash etanercept, 147 uveitis nivolumab, 477

V

vaginal bleeding misoprostol, 413 valvular heart disease (VHD) antidepressant drugs, 9 vanishing bile duct syndrome (VBDS) sertraline, 16–17 vaso-occlusive pain hydroxyurea, 200–201 venous thromboembolism testosterone, 423–424 ventricular arrhythmia adrenaline, 133 tolvaptan, 453 ventricular tachycardia clozapine, 72 oxytocin and methylergometrine, 451 vertigo artesunate–mefloquine and lopinavir, 266 gabapentin, 91 ivermectin, 296 praziquantel, 299 pregabalin, 91 tribendimidine, 299 vesicular eruption varicella zoster virus vaccine, 316–317 violent behaviors donepezil, 6

viral infections fingolimod, 392 viscerotropic disease yellow fever vaccination, 318–319 vision loss isotretinoin, 345 visual disturbances voriconazole, 247 visual field defects vigabatrin, 104 visual hallucinations imipenem/cilastatin, 218 moxifloxacin, 233 voriconazole, 247, 253 zolpidem, 58–59 visual impairment ezogabine, 104 visual loss risperidone, 80 vitamin B12+B6 deficiency levodopa, 139 vitamin D deficiency levothyroxine, 428 vitiligo dabrafenib, 145 nivolumab, 474 vemurafenib, 145 vitreous hemorrhage anti-VEGF medications, 491 vocal fold lesions alirocumab, 462 voiding dysfunction pseudoephedrine, 133 vomiting acetazolamide, 191–192 agomelatine, 449 amodiaquine–artesunate, 259–260 amphotericin, 249 apomorphine, 137 aripiprazole, 70 artemether–lumefantrine, 261 artesunate–mefloquine and lopinavir, 266 brincidofovir, 270 ceftaroline, 220–221 cycloserine, 285 dalbavancin, 148, 234 dihydroartemisinin–piperaquine, 263 divalproex sodium, 92–93 droxidopa, 134 EGFR-targeted monoclonal antibody, 469 enteral nutrition, 354 etomidate, 116 felbamate, 100–101 fenofibrate, 459 flumazenil, 60–61 gadolinium-based contrast agent, 486 immune checkpoint inhibitors, 473 influenza vaccines, 308 intravenous agents, 116 ketamine, 116 levofloxacin, 232–233 linezolid, 289 lithium, 202 methimazole, 430 methoxyflurane, 112

INDEX OF ADVERSE EFFECTS AND ADVERSE REACTIONS

methyl salicylate, 213 ornithine, 353 patiromer, 203 perampanel, 101 pregabalin, 91–92 pristinamycin, 239 pyrazinamide, 289 quisinostat, 145 rivastigmine, 7 rotigotine, 137 rufinamide, 96 sevoflurane, 114 sofosbuvir, 273 solithromycin, 234 synthetic cannabinoids, 31–32 systemic glucocorticoids, 410 teduglutide, 381 tiagabine, 104

W

walking, difficulty pregabalin, 92 weakness deferasirox, 199 pembrolizumab, 476–477 weight gain amisulpride, 69 aripiprazole, 69–70 asenapine, 70–71 brexpiprazole, 71 cariprazine, 71 divalproex sodium, 92–93 droxidopa, 134 elvitegravir/cobicistat/ftc/tenofovir, 275 ezogabine, 104 lithium, 26, 201–202

olanzapine, 65, 75–77 paliperidone, 77 quetiapine, 65 risperidone, 80 SGAs, 65 systemic glucocorticoids, 407–410 weight loss ezogabine, 104 felbamate, 100–101 methylphenidate, 3 rufinamide, 96 synthetic cannabinoids, 34 worsening of anemia folate, 347

X

xerostomia methylphenidate, 3

539