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Inflammation and oxidative stress biomarkers as predictors of diastolic dysfunction in patients with metabolic syndrome
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Abstracts / Atherosclerosis 241 (2015) e149ee229
* Corresponding author. Aim: To evaluate association between biomarkers of visceral tissue metabolism and type 2 diabetes mellitus (DM2) in patients with coronary artery disease (CAD). Methods: Total 429 consecutive patients (M/F 325/104; 61.3±9.4 yrs) who were underwent coronary angiography, were enrolled. Location and extent of coronary artery lesion were assessed using Gensini score (GS). The mean common carotid artery intima-media thickness (IMT) and carotid plaques (CP) were evaluated during ultrasound dopplerography. Results: 18% of patients had DM2; noteworthy, women suffered DM2 2.5 times more often than men: 32.7 vs 13.2%. DM2 patients had significantly higher GS (48 vs 46 points). DM2 appeared to be an independent risk factor for manifested (>45%) carotid lesions detection (OR¼2.4;95% CI¼1.0-5.6). Hypertriglyceridemia (1.7 mmol/l) was associated with higher risk of DM2 (OR¼2.1;95%CI¼1.3-3.4). Plasma leptin concentration was higher in diabetic males (median 18.8 vs 15.0 ng/ml). Adiponectin levels were lower in diabetics in both genders (males: 5.1 vs 7.1 mkg/ml; females: 8.4 vs 9.5 mkg/ml). No significant differences in insulin level between males and females with or without DM2 were detected. However, in diabetics the highest HOMA-IR was observed (males 3.6 vs 2.5; females 3.7 vs 2.5). There were no significant association between visceral tissue parameters and INT and GS in coronary patients depending on DM2 presence. Conclusion: High leptin level in males and low adiponectin level in both genders were associated with DM2 and CAD suggesting these parameters as additional markers of adipose tissue disturbances in patients with CAD aggravated by DM2.
EAS-0124. ELECTROCARDIOGRAPHIC MARKERS ASSOCIATED WITH MYOCARDIUM METABOLIC CHANGES, THEIR RELATIONSHIP WITH COMPONENTS OF METABOLIC SYNDROME IN CORONARY ATHEROSCLEROSIS Y. Ragino 1, *, N. Timoshenko 1, A. Chernjavskiy 2, O. Kamenskaja 2, M. Voevoda 3. 1 Laboratory of Biochemistry, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia; 2 Laboratory of Cardiology, 2Research State of Circulation Pathology Ministry of Public Health and Social Development, Novosibirsk, Russia; 3 Laboratory of Genetics, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia
* Corresponding author. Aim of this study was to investigate the electrocardiographic (ECG) markers associated with myocardium metabolic changes in men with coronary atherosclerosis (CA) and their associations with components of metabolic syndrome (MS). The study included 123 men aged 41-79 with CA. ECG markers associated with myocardium metabolic changes - corrected interval QT, ST segment above >0.5mm, ST segment depression >0.5mm non-ischemic type, Twave changes, syndrome TV1>TV6, signs of left ventricular hypertrophy (LVH), arrhythmias - were analyzed. All components of MS and insulin resistance associated inflammatory biomarkers - tumor necrosis factor alpha (TNF-alpha), interleukin 6 and high-sensitive C-reactive protein were estimated. In men with CA the following ECG markers of MK were registered: arrhythmias in 65% of patients, LVH e 65,9%, the syndrome TV1>TV6 e 24,4%, T-wave change e 58,5%, segment ST elevation e 48%, segment ST depression e 22%. Obesity (BMI30,0 kg/m2 was revealed in 56,9% of men. Abdominal obesity was in the majority of men (77,2%). MS in CA men was registered in 69,9%. Positive correlations between ECG signs of LVH and increased blood levels of total cholesterol, excess waist circumference above normal and the presence of the MS were founded. There was a negative correlation between elevated levels of TNF-alpha and the lengthening of interval QT. Thus, the presence of CA and MS or its components and their associations with ECG characteristics, associated with myocardium metabolic changes,
are indicated to the common metabolic disorders and pathogenesis factors of these diseases.
EAS-0230. METABOLIC SYNDROME IN PATIENTS WITH CLINICAL PHENOTYPE OF “HYPERTRIGLYCERIDEMIC WAIST” n Nún ~ ez-Corte s 1, *, T. Mantilla 2, J.J. Millan-Perez 1, X. Pinto 3, P. J. Milla Valdivielso 4, J.M. Mostaza 5, F. Civeira 6, J. Ascaso 7. 1 Internal Medicine, ~o n, Madrid, Spain; 2 Primary Care, CS Prosperidad, HGU Gregorio Maran Madrid, Spain; 3 Internal Medicine, Hospital Bellvitge, Barcelona, Spain; 4 Internal Medicine, Hospital Clinico, Malaga, Spain; 5 Internal Medicine, Hospital Carlos III, Madrid, Spain; 6 Internal Medicine, Hospital Miguel Servet, Zaragoza, Spain; 7 Endocrinology, Hospital Clinico, Valencia, Spain
* Corresponding author. Theassociation of hypertriglyceridemia with increase in waist circumference (Knownas “hypertriglyceridemic wais”) is a common clinical phenotype in patients withmetabolic syndrome. And some previous results show that indices of abdominalobesity are better discriminators of cardiovascular risk factors than otheranthropometric parameters. So, hypertriglyceridemia and waist circumferencecould be a predictor for cardiovascular risk and used as a clinical marker. The aim ofthis study is to evaluate the potential role of hypertriglyceridemic waist asclinical predictor of metabolic syndrome in patients with hypertriglyceridemia. Patientswere included in a national register of patients with hypertriglyceridemia(Spanish Society of Atherosclerosis). Evaluable patients included were 1.369.Clinical criteria used for metabolic syndrome and the range for waistcircumference were those included in ATPIII or IDF consensus. Prevalenceof “hypertriglyceridemic waist” in patients with hypertriglyderidemia was veryhigh with almost 50 % and 80 % of the patients according with anthropometriccriteria of ATPIII and IDF, respectively. The prevalence of metabolic syndromein those patients was 97 % (ATPIII criteria) and 63 % (IDF criteria). We havefound a significantly increase of prevalence of arterial hypertension and type2 diabetes mellitus. Nevertheless, the association with cardiovascular diseaseis not founded and it was not related with waist circumference phenotype, butwas associated with the presence of metabolic syndrome. Hypertriglyceridemicwaist circumference can be used in clinical practice as a clinical marker of metabolic syndrome and cardiometabolic risk.
EAS-0280. INFLAMMATION AND OXIDATIVE STRESS BIOMARKERS AS PREDICTORS OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME M. Mocan 1, *, R. Rahaian 2, S.N. Blaga 1. 1 1st Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2 Central Laboratory, Emergency County Hospital, Cluj Napoca, Romania
* Corresponding author. Aim: New paradigm regarding heart failure with preserved ejection fraction (HF-PLEF) development has recently evolved. The authors aimed evaluate the best combination of inflammation and oxidative stress biomarkers to predict left ventricular diastolic dysfunction (LVDD) with HFPLEF in patients with MetS. Material and method: 72 patients, (59.19þ/-5.26 years, 63.89% women, 36.11% men), with MetS (AHA/NHLBI/IDF 2009 definition), without symptomatic cardiac disease were evaluated for LVDD using Dopplerechocardiography and N terminal-pro Brain Natruretic Peptide (NTproBNP) levels. Inflammation was quantified by High sensitivity C Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Fibrinogen (Fbg) levels and
Abstracts / Atherosclerosis 241 (2015) e149ee229
oxidative stress by 8 isoprostaglandina F2a, uric acid and glutathione peroxidase. Different combinations of MetS criteria and biomarkers were statistically analyzed (Statistica, www.StatSoft.com) to obtain the best prediction model for LVDD. Results: LVDD was present in 47 (65.27%) patients. In univariate analysis the number of MetS components (OR: 2.029 CI 1.001-4.115), IL-6 (OR: 2.180 CI 1.216-3.907) and hs-CRP (OR: 1.215 CI 1.004- 1.470) were strongly correlated with LVDD presence. No correlation was identified between DDVS and oxidative stress biomarkers. In multivariate analysis the best predictive model was composed of age, sex, number of MetS components, IL-6 and hs-CRP; AUC: 0.886 (0.790-0.949, p<0.0001). In all the verified models IL-6 >2.6 ng/ml remained an independent predictor for LVDD; AUC: 0.730 (0.613-0.826, p<0.0001). Conclusion: Inflammation biomarkers are predictors for LVDD in patients with MetS. IL-6 >2.6 ng/ml is the strongest independent predictor for LVDD and its predictive capacity is increased when associated to the number of MetS components and hs-CRP.
EAS-0352. RELATIONSHIP BETWEEN METABOLIC SYNDROME AND RADIOGRAPHIC KNEE OSTEOARTHRITIS AMONG KOREAN ADULTS AGED MORE THAN 50YEARS OLD E. Choi*. Family Medicine, Dankook University College of Medicine, Cheonan, South Korea
* Corresponding author. Backgrouds: This study was to investigate the relationship of radiographic knee osteoarthritis (rKOA) with metabolic syndrome (MetS) among Korean subjects aged more than 50years old. Methods: Total 8895 Korean adults aged more than 50 years were analyzed from Korean National Nutrition and Health Examination Survey (KNHANES) conducted in 2010-12. rKOA was defined as Kellgren-Lawrence grade2. Multiple logistic regression models examined the association of rKOA with MetS and MetS components adjusting for age, smoking, alcohol drinking, exercise and BMI. Results: MetS was associated with the increased risk of rKOA in Both male (OR 1.2, 95% CI 1.0-1.4) and female (OR 2.1, 95% CI 1.9-2.4) subjects in unadjusted analysis, but this significance disappeared after adjusting for confounding variables including BMI. Among the components of MetS, high blood pressure was significantly associated with rKOA in both male (OR 1.2, 95% CI 1.0-1.4) and female (OR 1.2, 95% CI: 1.0-1.4) subjects and high TG was significantly associated with rKOA in male subjects (OR 0.8, 95% CI: 0.7-1.0) after adjusting for confounding variables. Conclusions: There was no association of rKOA with MetS after adjusting for confounding variables including BMI in both male and female. The association between MetS and kROA can be explained by BMI.
EAS-0378. ELASTIC PROPERTIES OF THE VESSEL WALL IN MENOPAUSAL WOMEN WITH METABOLIC DISORDERS T. Petelina 1, N. Musikhina 2, L. Gapon 1, K. Avdeeva 1, V. Kuznetsov 3, *, I. Osipova 2, O. Belosludseva 2. 1 Arterial Hypertension Department, Tyumen Cardiology Center, Tyumen, Russia; 2 Urgent Cardiology Department, Tyumen Cardiology Center, Tyumen, Russia; 3 Instrumental Diagnostics Department, Tyumen Cardiology Center, Tyumen, Russia
* Corresponding author. Aim: To study structural parameters of elastic properties of the vessel wall, 24-hour blood pressure monitoring, biochemical lipid profile, inflammatory response and lipid peroxidation products in menopausal women with metabolic disorders (MD): arterial hypertension (AH) and abdominal obesity (AO). Methods: 80 patients were divided into 3 groups: I - included 35 postmenopausal women with MD, AH and AO, II e 30 men with AH and AO,
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and III (control) e 15 women with AH, without AO. Parameters of sphygmography, 24-hour blood pressure monitoring, anklebrachial index (R,LABI); lipid profile, peroxidation products, inflammatory and endothelial dysfunction markers were estimated. Results: In all groups there were detected increased levels of cholesterol, peroxidation products and inflammatory markers. Significantly lower values of R,L-ABI were found in the group of menopausal women with MD compared to group II. There was detected a tendency for higher levels of homocysteine, endotelina-1 and lower level of nitritis. In group I compared to group III there were found significantly higher values of hs-CRP, mean daytime, nighttime systolic and diastolic blood pressure (SBP, DBP), time index and square index of SBP and DBP, variability of SBP and DBP (p< 0.05). Significant association of L-ABI with nighttime DBP, BMI, and hs-CRP was detected in group I, while in group II L-ABI was directly associated with the level of malonic dialdehyde. Conclusion: In menopausal women with MD compared to men significant decrease of elastic properties of the vessel wall was found and it was associated with the most evident inflammatory response and endothelial dysfunction markers.
EAS-0427. RELATIONSHIP BETWEEN METABOLIC SYNDROME AND PHYSICAL ACTIVITY AND ARTERIAL STIFFNESS IN OBESE POPULATION H. Joo, J. Cho, J. Park, C. Yu, S. Hong, D. Lim*. Department of Cardiology Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea
* Corresponding author. Background: Although the relationship of physical activity on arterial stiffness has been known in healthy individuals, it has been still controversial in obese populations. Moreover, no clinical data on metabolic abnormality and its relationship on physical activity and arterial stiffness have been reported. Methods: From January to September 2014, we included 795 obese subjects from 24 public health centers in Seoul. Among them, 336 subjects met the IDA criteria for metabolic syndrome (MetS). We investigated their physical activities with the international physical activity questionnaire and measured brachial-ankle pulse wave velocity (baPWV) for arterial stiffness. We compared physical activity and baPWV between obese subjects with MetS (Metabolically obese group, MO) and obese subjects without Mets (Non-metabolically obeses group, NMO). Results: MO group had more men, higher BMI, higher fasting glucose level, lower HDL-cholesterol level, and higher triglyceride level. Mean physical activities were similar between both groups. Mean baPWV was slightly higher in MO group compared to NMO group. Multivariate regression analysis demonstrated that baPWV was significantly associated with age, BMI, blood pressure and glucose level. Interestingly, baPWV response to physical activity was impaired in MO group. Apolipoprotein A1 and B levels showed the similar impaired response to physical activity in MO group compared to NMO group. Conclusion: physical activity was different effect on arterial stiffness dependent to metabolic status in obese population. Lipid metabolism might be associated with their different relationships and vascular function.
EAS-0515. PARAOXONASE 1 (PON1) GENE POLYMORPHISMS AND METABOLIC SYNDROME IN THAI WITH CIGARETTE SMOKING N. Decharatchakul 1, *, C. Settasatian 2, N. Settasatian 3, P. Yongsakulchai 1, I. R. Rattanatham 1, S. Khaichaiyaphum 3, P. Sarutipaiboon 1, Boonsiri 4. 1 Postgraduate Program in Biomedical Sciences and Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand; 2 Department of Pathology Faculty of Medicine and Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand; 3 Department of Clinical Chemistry Faculty of Associated Medical Sciences and Cardiovascular Research Group, Khon Kaen University, Khon
Abstracts / Atherosclerosis 241 (2015) e149ee229
* Corresponding author. Aim: To evaluate association between biomarkers of visceral tissue metabolism and type 2 diabetes mellitus (DM2) in patients with coronary artery disease (CAD). Methods: Total 429 consecutive patients (M/F 325/104; 61.3±9.4 yrs) who were underwent coronary angiography, were enrolled. Location and extent of coronary artery lesion were assessed using Gensini score (GS). The mean common carotid artery intima-media thickness (IMT) and carotid plaques (CP) were evaluated during ultrasound dopplerography. Results: 18% of patients had DM2; noteworthy, women suffered DM2 2.5 times more often than men: 32.7 vs 13.2%. DM2 patients had significantly higher GS (48 vs 46 points). DM2 appeared to be an independent risk factor for manifested (>45%) carotid lesions detection (OR¼2.4;95% CI¼1.0-5.6). Hypertriglyceridemia (1.7 mmol/l) was associated with higher risk of DM2 (OR¼2.1;95%CI¼1.3-3.4). Plasma leptin concentration was higher in diabetic males (median 18.8 vs 15.0 ng/ml). Adiponectin levels were lower in diabetics in both genders (males: 5.1 vs 7.1 mkg/ml; females: 8.4 vs 9.5 mkg/ml). No significant differences in insulin level between males and females with or without DM2 were detected. However, in diabetics the highest HOMA-IR was observed (males 3.6 vs 2.5; females 3.7 vs 2.5). There were no significant association between visceral tissue parameters and INT and GS in coronary patients depending on DM2 presence. Conclusion: High leptin level in males and low adiponectin level in both genders were associated with DM2 and CAD suggesting these parameters as additional markers of adipose tissue disturbances in patients with CAD aggravated by DM2.
EAS-0124. ELECTROCARDIOGRAPHIC MARKERS ASSOCIATED WITH MYOCARDIUM METABOLIC CHANGES, THEIR RELATIONSHIP WITH COMPONENTS OF METABOLIC SYNDROME IN CORONARY ATHEROSCLEROSIS Y. Ragino 1, *, N. Timoshenko 1, A. Chernjavskiy 2, O. Kamenskaja 2, M. Voevoda 3. 1 Laboratory of Biochemistry, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia; 2 Laboratory of Cardiology, 2Research State of Circulation Pathology Ministry of Public Health and Social Development, Novosibirsk, Russia; 3 Laboratory of Genetics, Federal State Budgetary Institution of Internal and Preventive Medicine Siberian, Novosibirsk, Russia
* Corresponding author. Aim of this study was to investigate the electrocardiographic (ECG) markers associated with myocardium metabolic changes in men with coronary atherosclerosis (CA) and their associations with components of metabolic syndrome (MS). The study included 123 men aged 41-79 with CA. ECG markers associated with myocardium metabolic changes - corrected interval QT, ST segment above >0.5mm, ST segment depression >0.5mm non-ischemic type, Twave changes, syndrome TV1>TV6, signs of left ventricular hypertrophy (LVH), arrhythmias - were analyzed. All components of MS and insulin resistance associated inflammatory biomarkers - tumor necrosis factor alpha (TNF-alpha), interleukin 6 and high-sensitive C-reactive protein were estimated. In men with CA the following ECG markers of MK were registered: arrhythmias in 65% of patients, LVH e 65,9%, the syndrome TV1>TV6 e 24,4%, T-wave change e 58,5%, segment ST elevation e 48%, segment ST depression e 22%. Obesity (BMI30,0 kg/m2 was revealed in 56,9% of men. Abdominal obesity was in the majority of men (77,2%). MS in CA men was registered in 69,9%. Positive correlations between ECG signs of LVH and increased blood levels of total cholesterol, excess waist circumference above normal and the presence of the MS were founded. There was a negative correlation between elevated levels of TNF-alpha and the lengthening of interval QT. Thus, the presence of CA and MS or its components and their associations with ECG characteristics, associated with myocardium metabolic changes,
are indicated to the common metabolic disorders and pathogenesis factors of these diseases.
EAS-0230. METABOLIC SYNDROME IN PATIENTS WITH CLINICAL PHENOTYPE OF “HYPERTRIGLYCERIDEMIC WAIST” n Nún ~ ez-Corte s 1, *, T. Mantilla 2, J.J. Millan-Perez 1, X. Pinto 3, P. J. Milla Valdivielso 4, J.M. Mostaza 5, F. Civeira 6, J. Ascaso 7. 1 Internal Medicine, ~o n, Madrid, Spain; 2 Primary Care, CS Prosperidad, HGU Gregorio Maran Madrid, Spain; 3 Internal Medicine, Hospital Bellvitge, Barcelona, Spain; 4 Internal Medicine, Hospital Clinico, Malaga, Spain; 5 Internal Medicine, Hospital Carlos III, Madrid, Spain; 6 Internal Medicine, Hospital Miguel Servet, Zaragoza, Spain; 7 Endocrinology, Hospital Clinico, Valencia, Spain
* Corresponding author. Theassociation of hypertriglyceridemia with increase in waist circumference (Knownas “hypertriglyceridemic wais”) is a common clinical phenotype in patients withmetabolic syndrome. And some previous results show that indices of abdominalobesity are better discriminators of cardiovascular risk factors than otheranthropometric parameters. So, hypertriglyceridemia and waist circumferencecould be a predictor for cardiovascular risk and used as a clinical marker. The aim ofthis study is to evaluate the potential role of hypertriglyceridemic waist asclinical predictor of metabolic syndrome in patients with hypertriglyceridemia. Patientswere included in a national register of patients with hypertriglyceridemia(Spanish Society of Atherosclerosis). Evaluable patients included were 1.369.Clinical criteria used for metabolic syndrome and the range for waistcircumference were those included in ATPIII or IDF consensus. Prevalenceof “hypertriglyceridemic waist” in patients with hypertriglyderidemia was veryhigh with almost 50 % and 80 % of the patients according with anthropometriccriteria of ATPIII and IDF, respectively. The prevalence of metabolic syndromein those patients was 97 % (ATPIII criteria) and 63 % (IDF criteria). We havefound a significantly increase of prevalence of arterial hypertension and type2 diabetes mellitus. Nevertheless, the association with cardiovascular diseaseis not founded and it was not related with waist circumference phenotype, butwas associated with the presence of metabolic syndrome. Hypertriglyceridemicwaist circumference can be used in clinical practice as a clinical marker of metabolic syndrome and cardiometabolic risk.
EAS-0280. INFLAMMATION AND OXIDATIVE STRESS BIOMARKERS AS PREDICTORS OF DIASTOLIC DYSFUNCTION IN PATIENTS WITH METABOLIC SYNDROME M. Mocan 1, *, R. Rahaian 2, S.N. Blaga 1. 1 1st Department of Internal Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania; 2 Central Laboratory, Emergency County Hospital, Cluj Napoca, Romania
* Corresponding author. Aim: New paradigm regarding heart failure with preserved ejection fraction (HF-PLEF) development has recently evolved. The authors aimed evaluate the best combination of inflammation and oxidative stress biomarkers to predict left ventricular diastolic dysfunction (LVDD) with HFPLEF in patients with MetS. Material and method: 72 patients, (59.19þ/-5.26 years, 63.89% women, 36.11% men), with MetS (AHA/NHLBI/IDF 2009 definition), without symptomatic cardiac disease were evaluated for LVDD using Dopplerechocardiography and N terminal-pro Brain Natruretic Peptide (NTproBNP) levels. Inflammation was quantified by High sensitivity C Reactive Protein (hs-CRP), Interleukin 6 (IL-6) and Fibrinogen (Fbg) levels and
Abstracts / Atherosclerosis 241 (2015) e149ee229
oxidative stress by 8 isoprostaglandina F2a, uric acid and glutathione peroxidase. Different combinations of MetS criteria and biomarkers were statistically analyzed (Statistica, www.StatSoft.com) to obtain the best prediction model for LVDD. Results: LVDD was present in 47 (65.27%) patients. In univariate analysis the number of MetS components (OR: 2.029 CI 1.001-4.115), IL-6 (OR: 2.180 CI 1.216-3.907) and hs-CRP (OR: 1.215 CI 1.004- 1.470) were strongly correlated with LVDD presence. No correlation was identified between DDVS and oxidative stress biomarkers. In multivariate analysis the best predictive model was composed of age, sex, number of MetS components, IL-6 and hs-CRP; AUC: 0.886 (0.790-0.949, p<0.0001). In all the verified models IL-6 >2.6 ng/ml remained an independent predictor for LVDD; AUC: 0.730 (0.613-0.826, p<0.0001). Conclusion: Inflammation biomarkers are predictors for LVDD in patients with MetS. IL-6 >2.6 ng/ml is the strongest independent predictor for LVDD and its predictive capacity is increased when associated to the number of MetS components and hs-CRP.
EAS-0352. RELATIONSHIP BETWEEN METABOLIC SYNDROME AND RADIOGRAPHIC KNEE OSTEOARTHRITIS AMONG KOREAN ADULTS AGED MORE THAN 50YEARS OLD E. Choi*. Family Medicine, Dankook University College of Medicine, Cheonan, South Korea
* Corresponding author. Backgrouds: This study was to investigate the relationship of radiographic knee osteoarthritis (rKOA) with metabolic syndrome (MetS) among Korean subjects aged more than 50years old. Methods: Total 8895 Korean adults aged more than 50 years were analyzed from Korean National Nutrition and Health Examination Survey (KNHANES) conducted in 2010-12. rKOA was defined as Kellgren-Lawrence grade2. Multiple logistic regression models examined the association of rKOA with MetS and MetS components adjusting for age, smoking, alcohol drinking, exercise and BMI. Results: MetS was associated with the increased risk of rKOA in Both male (OR 1.2, 95% CI 1.0-1.4) and female (OR 2.1, 95% CI 1.9-2.4) subjects in unadjusted analysis, but this significance disappeared after adjusting for confounding variables including BMI. Among the components of MetS, high blood pressure was significantly associated with rKOA in both male (OR 1.2, 95% CI 1.0-1.4) and female (OR 1.2, 95% CI: 1.0-1.4) subjects and high TG was significantly associated with rKOA in male subjects (OR 0.8, 95% CI: 0.7-1.0) after adjusting for confounding variables. Conclusions: There was no association of rKOA with MetS after adjusting for confounding variables including BMI in both male and female. The association between MetS and kROA can be explained by BMI.
EAS-0378. ELASTIC PROPERTIES OF THE VESSEL WALL IN MENOPAUSAL WOMEN WITH METABOLIC DISORDERS T. Petelina 1, N. Musikhina 2, L. Gapon 1, K. Avdeeva 1, V. Kuznetsov 3, *, I. Osipova 2, O. Belosludseva 2. 1 Arterial Hypertension Department, Tyumen Cardiology Center, Tyumen, Russia; 2 Urgent Cardiology Department, Tyumen Cardiology Center, Tyumen, Russia; 3 Instrumental Diagnostics Department, Tyumen Cardiology Center, Tyumen, Russia
* Corresponding author. Aim: To study structural parameters of elastic properties of the vessel wall, 24-hour blood pressure monitoring, biochemical lipid profile, inflammatory response and lipid peroxidation products in menopausal women with metabolic disorders (MD): arterial hypertension (AH) and abdominal obesity (AO). Methods: 80 patients were divided into 3 groups: I - included 35 postmenopausal women with MD, AH and AO, II e 30 men with AH and AO,
e173
and III (control) e 15 women with AH, without AO. Parameters of sphygmography, 24-hour blood pressure monitoring, anklebrachial index (R,LABI); lipid profile, peroxidation products, inflammatory and endothelial dysfunction markers were estimated. Results: In all groups there were detected increased levels of cholesterol, peroxidation products and inflammatory markers. Significantly lower values of R,L-ABI were found in the group of menopausal women with MD compared to group II. There was detected a tendency for higher levels of homocysteine, endotelina-1 and lower level of nitritis. In group I compared to group III there were found significantly higher values of hs-CRP, mean daytime, nighttime systolic and diastolic blood pressure (SBP, DBP), time index and square index of SBP and DBP, variability of SBP and DBP (p< 0.05). Significant association of L-ABI with nighttime DBP, BMI, and hs-CRP was detected in group I, while in group II L-ABI was directly associated with the level of malonic dialdehyde. Conclusion: In menopausal women with MD compared to men significant decrease of elastic properties of the vessel wall was found and it was associated with the most evident inflammatory response and endothelial dysfunction markers.
EAS-0427. RELATIONSHIP BETWEEN METABOLIC SYNDROME AND PHYSICAL ACTIVITY AND ARTERIAL STIFFNESS IN OBESE POPULATION H. Joo, J. Cho, J. Park, C. Yu, S. Hong, D. Lim*. Department of Cardiology Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea
* Corresponding author. Background: Although the relationship of physical activity on arterial stiffness has been known in healthy individuals, it has been still controversial in obese populations. Moreover, no clinical data on metabolic abnormality and its relationship on physical activity and arterial stiffness have been reported. Methods: From January to September 2014, we included 795 obese subjects from 24 public health centers in Seoul. Among them, 336 subjects met the IDA criteria for metabolic syndrome (MetS). We investigated their physical activities with the international physical activity questionnaire and measured brachial-ankle pulse wave velocity (baPWV) for arterial stiffness. We compared physical activity and baPWV between obese subjects with MetS (Metabolically obese group, MO) and obese subjects without Mets (Non-metabolically obeses group, NMO). Results: MO group had more men, higher BMI, higher fasting glucose level, lower HDL-cholesterol level, and higher triglyceride level. Mean physical activities were similar between both groups. Mean baPWV was slightly higher in MO group compared to NMO group. Multivariate regression analysis demonstrated that baPWV was significantly associated with age, BMI, blood pressure and glucose level. Interestingly, baPWV response to physical activity was impaired in MO group. Apolipoprotein A1 and B levels showed the similar impaired response to physical activity in MO group compared to NMO group. Conclusion: physical activity was different effect on arterial stiffness dependent to metabolic status in obese population. Lipid metabolism might be associated with their different relationships and vascular function.
EAS-0515. PARAOXONASE 1 (PON1) GENE POLYMORPHISMS AND METABOLIC SYNDROME IN THAI WITH CIGARETTE SMOKING N. Decharatchakul 1, *, C. Settasatian 2, N. Settasatian 3, P. Yongsakulchai 1, I. R. Rattanatham 1, S. Khaichaiyaphum 3, P. Sarutipaiboon 1, Boonsiri 4. 1 Postgraduate Program in Biomedical Sciences and Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand; 2 Department of Pathology Faculty of Medicine and Cardiovascular Research Group, Khon Kaen University, Khon Kaen, Thailand; 3 Department of Clinical Chemistry Faculty of Associated Medical Sciences and Cardiovascular Research Group, Khon Kaen University, Khon