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Inflammatory markers and progression of end-stage renal and cardiovascular disease in patients with diabetic nephropathy
S42 POSTER PRESENTATIONS
Heart, Lung and Circulation 2008;17S:S4–S53
Poster Presentations
Statistical analysis was performed with Student’s t-test, χ2 test. Results: Group B, had lower haemoglobin level (12.6 g/dl vs. 13.6 g/dl, p = 0.006), lower creatinine clearance (50 ml/min vs. 80 ml/min, p = 0.0001) and elderly patients (60.5 years vs. 49.7 years, p = 0.006). There was also the incidence of CVD (p = 0.001) and CV (p = 0.002) was significantly higher. Conclusion: In our study the stage IV of diabetic nephropathy were greater the high rates of cardiovascular and cerebrovascular disease. doi:10.1016/j.hlc.2007.11.106 Inflammatory markers and progression of end-stage renal and cardiovascular disease in patients with diabetic nephropathy ˜ Neves Ana Paula Silva ∗ , Alexandre Baptista, Pedro Leao Hospital Distrital de Faro Introduction and aims: Chronic inflammation is increasingly recognized as an important issue due to its role in various pathological states. Diabetes is a risk factor for atherosclerosis and low-degree inflammation may play a central role in both diseases. Various reports have indicated a significant association between increase serum of inflammatory biomarkers, such as interleukin-6 (IL-6) and high sensitivity C reactive protein (hs CRP) and cardiovascular disease (CVD), mortality, morbidity and progression of end-stage renal disease (ESRD) in diabetic patients group. The aim of the present study was to assess the association between inflammatory biomarkers and fast progression of ESRD and cardiovascular disease in patients with diabetic nephropathy stage IV. Methods: We included 30 patients, type 2, and stage IV DN, mean age 68.2 years, followed in outpatient clinic for more than 24 months. The presence of inflammation parameters obtained from blood sample collected monthly since the first day of consultation. The CVD is manifested by myocardial infarction, angina pectoris, heart failure. The patients were divided in two groups: group A = 12 patients develop ESRD and beginning dialysis and group B = 18 patients not develop ESRD. The two groups were compared relation of IL-6, hs CPR and fast progression of ESRD and the cardiovascular disease. Results: The patients group A showed elevated IL-6 and hs CRP levels (6.7 vs. 4.0, p = 0.08) and (1.3 vs. 0.46, p = 0.015) and develop ESRD 20 months later and increase the cardiovascular disease. Conclusions: The present study elevated levels of IL-6 and hs CPR contribute to the development and the fast progression of ESRD and cardiovascular disease in patients with DN stage IV. doi:10.1016/j.hlc.2007.11.107
Interleukin-6 (IL-6): Is a marker for cardiovascular disease in patients with diabetic nephropathy Ana Paula Silva ∗ , Alexandre Baptista, Ana Cabrita, Pedro ˜ Neves Leao Hospital Distrital de Faro Interleukin-6 (IL-6) is synthesized in response to diverse inflammatory stimuli and causes cellular damage and promotes atherosclerotic process. Elevated concentrations of IL-6 are associated with the development and severity of coronary heart and renal disease. The aim of the present study was to assess the relationship between increased plasma IL-6 levels and outcome in patients with diabetic nephropathy (DN). We included 30 patients, mean age 80 years, followed in on low clearance outpatient clinic for more than 12 months. The presence of inflammation parameters obtained from blood samples collected monthly since the first day of consultation and the criterion of hospitalization (cardiovascular disease) is defined by medical history and clinical symptoms. The patients were divided in two groups: Group A = 12 patients beginning dialysis and Group B = 18 patients that not evolution of ESRF. The two groups were compared in relation of IL-6 and outcome (number and day of hospitalization from cardiovascular disease) in patients with DN. The IL-6 is measured by means IMMULITE 2000 analyser. The presence of clinical cardiovascular disease (CVD) was defined by medical history and clinical symptoms. For comparisons between groups, Student’s t-test and the χ2 test were used. The patients in the A group showed elevated IL-6 levels (6.7 vs. 4.0, p = 0.08) and the number and the duration of hospitalization in this group is significantly higher (1.42 vs. 0.1, p = 0.002 and 12 vs. 0.6 day, p = 0.004. The present study the elevated IL-6 plasma level has a major effect on cardiovascular disease in patients with diabetic nephropathy doi:10.1016/j.hlc.2007.11.108 Donor heart procurement experience in Singapore David Kheng Leng Sim ∗ , R.N. Ka Lee Kerk, R.N. Chia Lee Neo, Chong-Hee Lim, C. Sivathasan, Teing Ee Tan, Bernard Wing Kuin Kwok National Heart Centre, Singapore Background: Heart transplantation began in Singapore at our centre in 1990. Although the incidence of heart failure is increasing, the number of heart transplant being done remains low, mainly due to low organ donation rate and limited population. To alleviate the demand for more organ donors, Human Organ Transplant Act (HOTA) was amended in 2004 to allow removal of organ upon death unless the individual registered an objection. We review our organ procurement experience before after HOTA amendment.
Heart, Lung and Circulation 2008;17S:S4–S53
Poster Presentations
Statistical analysis was performed with Student’s t-test, χ2 test. Results: Group B, had lower haemoglobin level (12.6 g/dl vs. 13.6 g/dl, p = 0.006), lower creatinine clearance (50 ml/min vs. 80 ml/min, p = 0.0001) and elderly patients (60.5 years vs. 49.7 years, p = 0.006). There was also the incidence of CVD (p = 0.001) and CV (p = 0.002) was significantly higher. Conclusion: In our study the stage IV of diabetic nephropathy were greater the high rates of cardiovascular and cerebrovascular disease. doi:10.1016/j.hlc.2007.11.106 Inflammatory markers and progression of end-stage renal and cardiovascular disease in patients with diabetic nephropathy ˜ Neves Ana Paula Silva ∗ , Alexandre Baptista, Pedro Leao Hospital Distrital de Faro Introduction and aims: Chronic inflammation is increasingly recognized as an important issue due to its role in various pathological states. Diabetes is a risk factor for atherosclerosis and low-degree inflammation may play a central role in both diseases. Various reports have indicated a significant association between increase serum of inflammatory biomarkers, such as interleukin-6 (IL-6) and high sensitivity C reactive protein (hs CRP) and cardiovascular disease (CVD), mortality, morbidity and progression of end-stage renal disease (ESRD) in diabetic patients group. The aim of the present study was to assess the association between inflammatory biomarkers and fast progression of ESRD and cardiovascular disease in patients with diabetic nephropathy stage IV. Methods: We included 30 patients, type 2, and stage IV DN, mean age 68.2 years, followed in outpatient clinic for more than 24 months. The presence of inflammation parameters obtained from blood sample collected monthly since the first day of consultation. The CVD is manifested by myocardial infarction, angina pectoris, heart failure. The patients were divided in two groups: group A = 12 patients develop ESRD and beginning dialysis and group B = 18 patients not develop ESRD. The two groups were compared relation of IL-6, hs CPR and fast progression of ESRD and the cardiovascular disease. Results: The patients group A showed elevated IL-6 and hs CRP levels (6.7 vs. 4.0, p = 0.08) and (1.3 vs. 0.46, p = 0.015) and develop ESRD 20 months later and increase the cardiovascular disease. Conclusions: The present study elevated levels of IL-6 and hs CPR contribute to the development and the fast progression of ESRD and cardiovascular disease in patients with DN stage IV. doi:10.1016/j.hlc.2007.11.107
Interleukin-6 (IL-6): Is a marker for cardiovascular disease in patients with diabetic nephropathy Ana Paula Silva ∗ , Alexandre Baptista, Ana Cabrita, Pedro ˜ Neves Leao Hospital Distrital de Faro Interleukin-6 (IL-6) is synthesized in response to diverse inflammatory stimuli and causes cellular damage and promotes atherosclerotic process. Elevated concentrations of IL-6 are associated with the development and severity of coronary heart and renal disease. The aim of the present study was to assess the relationship between increased plasma IL-6 levels and outcome in patients with diabetic nephropathy (DN). We included 30 patients, mean age 80 years, followed in on low clearance outpatient clinic for more than 12 months. The presence of inflammation parameters obtained from blood samples collected monthly since the first day of consultation and the criterion of hospitalization (cardiovascular disease) is defined by medical history and clinical symptoms. The patients were divided in two groups: Group A = 12 patients beginning dialysis and Group B = 18 patients that not evolution of ESRF. The two groups were compared in relation of IL-6 and outcome (number and day of hospitalization from cardiovascular disease) in patients with DN. The IL-6 is measured by means IMMULITE 2000 analyser. The presence of clinical cardiovascular disease (CVD) was defined by medical history and clinical symptoms. For comparisons between groups, Student’s t-test and the χ2 test were used. The patients in the A group showed elevated IL-6 levels (6.7 vs. 4.0, p = 0.08) and the number and the duration of hospitalization in this group is significantly higher (1.42 vs. 0.1, p = 0.002 and 12 vs. 0.6 day, p = 0.004. The present study the elevated IL-6 plasma level has a major effect on cardiovascular disease in patients with diabetic nephropathy doi:10.1016/j.hlc.2007.11.108 Donor heart procurement experience in Singapore David Kheng Leng Sim ∗ , R.N. Ka Lee Kerk, R.N. Chia Lee Neo, Chong-Hee Lim, C. Sivathasan, Teing Ee Tan, Bernard Wing Kuin Kwok National Heart Centre, Singapore Background: Heart transplantation began in Singapore at our centre in 1990. Although the incidence of heart failure is increasing, the number of heart transplant being done remains low, mainly due to low organ donation rate and limited population. To alleviate the demand for more organ donors, Human Organ Transplant Act (HOTA) was amended in 2004 to allow removal of organ upon death unless the individual registered an objection. We review our organ procurement experience before after HOTA amendment.