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Information Services
RMAIION SERYICE Members of the American Pharmaceutical Association are invited to submit their professional problems to the Journal, 2215 Constitution Ave., N. W., Washington 7, D. C., giving all pertinent details. Advisory service is provided by the A. Ph. A. library and technical staff and the Journal panel of technical consultants.
AMEBACIDE I am enclosing a newspaper .clipping submilled by a physician concerning chloro-iodohydroxyquinoline used in the treatment of skin disorders. Where can this product be obtained?-B. E. Arkansas This product is listed in the National Formulary VIII as Iodochlorohydroxyquinoline and may be purchased in powder form from several sources including Chemo Puro Mfg. Corp., 26-32 Skillman Ave., Long Island City 1, N. Y.; Darsyn Laboratories, Inc., 200 Wagaraw Road, Hawthorne, N. J.; and McKesson & Robbins, Inc., Chemical Div., 155 East 44th St., New York 17, N.Y. Under the trade name Vioform, the Ciba Pharmaceutical Products, Inc., Lafayette Park, Summit, N. J., markets the product in a variety of forms. The product is discussed further under its National Formulary name in the U. S. Dispensatory.
FUNGICIDAL PREPARATION We have a problem relative to a prescription and we request your aid. T/tis prescription recently appeared in a medical journal but the physician does not remember in which journal he has seen this particular formula: Salicylanilide (Shirlan Extra). . . 5% Trimethyl ocladecyl ammonium pentachloro phenate (Hyamine
3258).. . . . . .. .. . . .. .. .. . .. ..
1%
Isopropylalcohol ............... 94% ~E. B., West Virginia This preparation has recently been placed on the market under the trade name FungiPage 750
Treat by Dome Chemicals, Inc., W. 64th St., New York 17, N. Y. It is used for the treatment of athlete's foot through the combination of the fungicide (salicylanilide) and a penetrant (Hyamine 3258). It is available in I-ounce, pint, quart and gallon bottles.
NITROGEN MUSTARD A physician in our vicinity is anxious to procure 200 mg. of a nitrogen mustard being used in the treatment of cancer.-C. D., Texas
The nitrogen mustard which is under clinical investigation is methyl-bis (betachloroethyl) amine hydrochloride. This product is being produced by Merck and Co., Rahway, N. J., for clinic'al investigational use only. The margin of safety in the use of nitrogen mustards is narrow, necessitating the exercise of considerable caution. We suggest that the physician write or wire Dr. David Karnofsky, Memorial Hospital, New York City. It is our understanding that Dr. Karnofsky is conducting clinical investigations. The physician may be interested in the article titled "Experiences with Nitrogen Mustard," J. Am. Med. Assoc., March 19 (1949).
SOURCE OF BENZODIOXANE Will you kindly advise as to a source of benzodioxane?-W. B., Michigan
Benzodioxane is available for experimental use from Merck and Co., Rahway, N. J. (Continued on Page 757)
PRACTICAL PHARMACY EDITION
What do your doctors demand in a toxoid, Mr. Pharmacist? ,-
small dosage volume? purity? concentrated potency? high antigenicity? Of course your doctors want the best possible combination of these advantages. Rese.a rch and manufacturing know-how of CUTTER, first producer of combined toxoids, have developed in their new purified toxoids, products which meet all of these demands.
As an example, consider the superiority of the new, purified DIP-PERT-TET*-for simultaneous immunization against diphtheria, pertussis, and tetanus: 1. Immunization routine is simplified with three injections of O.Scc each at monthly intervals. 2. Purified toxoids assure virtual freedom from reactions due to bacterial protein components. 3. Alhydrox**-CUTTER'S exclusive adsorbing agentresults in a more solid immunity, f ewer post-injection reactions, and less pain on injection.
When single immunizations are indicated or booster shots are required, there is a PURIFIED TOXOIDCUTTER-available in both single and multiple dose packages. You can meet your doctors' requirements by stocking PURIFIED TOXOIDS-CUTTER.
*DIP.PERT.TET-Trade name for combined immunization against diphtheria, pertussis, and tetanus-originally introduced by CUTTER. ** Alhydrox- Trade name for aluminum alhydrox adsorption, exclusive with CUTTER.
CUT ,- ER
CUTTER LABORATORIES· BERKELEY, CALIFORNIA Page 751 .
AMEBACIDE I am enclosing a newspaper .clipping submilled by a physician concerning chloro-iodohydroxyquinoline used in the treatment of skin disorders. Where can this product be obtained?-B. E. Arkansas This product is listed in the National Formulary VIII as Iodochlorohydroxyquinoline and may be purchased in powder form from several sources including Chemo Puro Mfg. Corp., 26-32 Skillman Ave., Long Island City 1, N. Y.; Darsyn Laboratories, Inc., 200 Wagaraw Road, Hawthorne, N. J.; and McKesson & Robbins, Inc., Chemical Div., 155 East 44th St., New York 17, N.Y. Under the trade name Vioform, the Ciba Pharmaceutical Products, Inc., Lafayette Park, Summit, N. J., markets the product in a variety of forms. The product is discussed further under its National Formulary name in the U. S. Dispensatory.
FUNGICIDAL PREPARATION We have a problem relative to a prescription and we request your aid. T/tis prescription recently appeared in a medical journal but the physician does not remember in which journal he has seen this particular formula: Salicylanilide (Shirlan Extra). . . 5% Trimethyl ocladecyl ammonium pentachloro phenate (Hyamine
3258).. . . . . .. .. . . .. .. .. . .. ..
1%
Isopropylalcohol ............... 94% ~E. B., West Virginia This preparation has recently been placed on the market under the trade name FungiPage 750
Treat by Dome Chemicals, Inc., W. 64th St., New York 17, N. Y. It is used for the treatment of athlete's foot through the combination of the fungicide (salicylanilide) and a penetrant (Hyamine 3258). It is available in I-ounce, pint, quart and gallon bottles.
NITROGEN MUSTARD A physician in our vicinity is anxious to procure 200 mg. of a nitrogen mustard being used in the treatment of cancer.-C. D., Texas
The nitrogen mustard which is under clinical investigation is methyl-bis (betachloroethyl) amine hydrochloride. This product is being produced by Merck and Co., Rahway, N. J., for clinic'al investigational use only. The margin of safety in the use of nitrogen mustards is narrow, necessitating the exercise of considerable caution. We suggest that the physician write or wire Dr. David Karnofsky, Memorial Hospital, New York City. It is our understanding that Dr. Karnofsky is conducting clinical investigations. The physician may be interested in the article titled "Experiences with Nitrogen Mustard," J. Am. Med. Assoc., March 19 (1949).
SOURCE OF BENZODIOXANE Will you kindly advise as to a source of benzodioxane?-W. B., Michigan
Benzodioxane is available for experimental use from Merck and Co., Rahway, N. J. (Continued on Page 757)
PRACTICAL PHARMACY EDITION
What do your doctors demand in a toxoid, Mr. Pharmacist? ,-
small dosage volume? purity? concentrated potency? high antigenicity? Of course your doctors want the best possible combination of these advantages. Rese.a rch and manufacturing know-how of CUTTER, first producer of combined toxoids, have developed in their new purified toxoids, products which meet all of these demands.
As an example, consider the superiority of the new, purified DIP-PERT-TET*-for simultaneous immunization against diphtheria, pertussis, and tetanus: 1. Immunization routine is simplified with three injections of O.Scc each at monthly intervals. 2. Purified toxoids assure virtual freedom from reactions due to bacterial protein components. 3. Alhydrox**-CUTTER'S exclusive adsorbing agentresults in a more solid immunity, f ewer post-injection reactions, and less pain on injection.
When single immunizations are indicated or booster shots are required, there is a PURIFIED TOXOIDCUTTER-available in both single and multiple dose packages. You can meet your doctors' requirements by stocking PURIFIED TOXOIDS-CUTTER.
*DIP.PERT.TET-Trade name for combined immunization against diphtheria, pertussis, and tetanus-originally introduced by CUTTER. ** Alhydrox- Trade name for aluminum alhydrox adsorption, exclusive with CUTTER.
CUT ,- ER
CUTTER LABORATORIES· BERKELEY, CALIFORNIA Page 751 .