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Inhalation of chemotherapeutic substances
Asthma
and
19
Hay Feuer
the use of oxygen and helium-oxygen mixtures, by inhalation sprays of bronchodilator, vasoconstrictor, aminophyllin, and sulfonamide soTwenty-one patients in the lutions, and by positive pressure therapy. series were suffering from bronchial asthma. The majority of the asthma patients were said to be adrenalin-fast and had not responded to intravenous aminophyllin, oxygen, or sedation with morphine and paraldehyde. Positive pressure therapy with either oxygen or heliumoxygen mixtures was administered through the B.E.M. mask, which is metered for positire pressure up to 4 cm. of water in the expiratory phase. Where bronchospasm was severe, positive-pressure helium and oxygen mixtures were elnployetl in both phases of respiration with the hood apparatus. Rectal aminophyllin, dilaudid, iodides, nebnlization with neosynephrin and aaponefrin, and proper humidification were also employed to obtain continued bronchial relaxation. Neosynephrin in ZL1 per cent solution was found to be very effective as a vasoconstrictor of the tracheobronchial tree and to eont,rol exressire secretions. Frequently refractoriness to adrenalin was abolished after nrosynephrin inhalation. Refractoriness to neosynephrin was never observed. Vaponcfrin al;pcarcd t,o be an effective hronchodilator, especially when caombinrd jvith neosynephrin. Aminophyllin, when nebulizrtl. \vas also efYt>ctire in the I-reatment of bronchial asthma in doses of 0.5 to 0.7 am. In patients with chronic hronchicctasis and pulmonary fibrosis, raponefrin sprays followed by continuous vaporization sprays of a microcrystalline suspension of sulfat,hiazole, together wit,h the oral administration of iodides, appeared to be the most effective form of t,reatment. Inhalation therapy is regarded as an important adjunct in the treatment of cardiorespiratory disease. A.
Inhalation
of Chemotherapeutic
Substances.
Mutch.
S. : Lancct
2:
775, 1944. Quantitative studies are reported in connection with the inhalation of sulfonamide mists, produced by a Collison inhalation apparatus which was modified by the writer. ‘\l’hrn a 50 per cent aqueous solution of sulfonamide E,.O.S., nebulized by 6 to 8 L. of oxygen per minute, was inhaled through a &mall rubber nose mask, it was est,imated that, the subject absorbed approximately 1 cc. of solution per hour. Bronchiectntic patients absorbed more than normals. The amounts absorbed by dyspneic patients increased as the ventilation rate rose. Only 7 to 14 per cent of the nebulized drug reached the blood stream. The feasibility of penicillin inhalation therapy is discussed. H.
and
19
Hay Feuer
the use of oxygen and helium-oxygen mixtures, by inhalation sprays of bronchodilator, vasoconstrictor, aminophyllin, and sulfonamide soTwenty-one patients in the lutions, and by positive pressure therapy. series were suffering from bronchial asthma. The majority of the asthma patients were said to be adrenalin-fast and had not responded to intravenous aminophyllin, oxygen, or sedation with morphine and paraldehyde. Positive pressure therapy with either oxygen or heliumoxygen mixtures was administered through the B.E.M. mask, which is metered for positire pressure up to 4 cm. of water in the expiratory phase. Where bronchospasm was severe, positive-pressure helium and oxygen mixtures were elnployetl in both phases of respiration with the hood apparatus. Rectal aminophyllin, dilaudid, iodides, nebnlization with neosynephrin and aaponefrin, and proper humidification were also employed to obtain continued bronchial relaxation. Neosynephrin in ZL1 per cent solution was found to be very effective as a vasoconstrictor of the tracheobronchial tree and to eont,rol exressire secretions. Frequently refractoriness to adrenalin was abolished after nrosynephrin inhalation. Refractoriness to neosynephrin was never observed. Vaponcfrin al;pcarcd t,o be an effective hronchodilator, especially when caombinrd jvith neosynephrin. Aminophyllin, when nebulizrtl. \vas also efYt>ctire in the I-reatment of bronchial asthma in doses of 0.5 to 0.7 am. In patients with chronic hronchicctasis and pulmonary fibrosis, raponefrin sprays followed by continuous vaporization sprays of a microcrystalline suspension of sulfat,hiazole, together wit,h the oral administration of iodides, appeared to be the most effective form of t,reatment. Inhalation therapy is regarded as an important adjunct in the treatment of cardiorespiratory disease. A.
Inhalation
of Chemotherapeutic
Substances.
Mutch.
S. : Lancct
2:
775, 1944. Quantitative studies are reported in connection with the inhalation of sulfonamide mists, produced by a Collison inhalation apparatus which was modified by the writer. ‘\l’hrn a 50 per cent aqueous solution of sulfonamide E,.O.S., nebulized by 6 to 8 L. of oxygen per minute, was inhaled through a &mall rubber nose mask, it was est,imated that, the subject absorbed approximately 1 cc. of solution per hour. Bronchiectntic patients absorbed more than normals. The amounts absorbed by dyspneic patients increased as the ventilation rate rose. Only 7 to 14 per cent of the nebulized drug reached the blood stream. The feasibility of penicillin inhalation therapy is discussed. H.