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Inhibitors of apoptosis
. . . ting epitopes and B-cells epitopes from the major outer membrane protein of Chlamydia trachomatis and its use as a vaccine (A Villeneuve, CA) lmmunova and the inventor N” WO 97/06263, PCT.
located on the qll-q21.3 region chromosome 17. . .. are useful in breast cancer prognosis. The invention also relates to a fifth novel human gene expressed in breast carcinoma and located on chromosome 6q22-
> Multi-subtype FIV vaccines (J Yamamoto, US) University of Florida and Regents of the University of California N” WO 97107817, PCT .. . for protecting cats from infection by a broad range of FIV strains using a multisubtype FIV vaccine... Cats vaccinated according to the methods and compositions of the subject invention exibit protective humoral and cellular immune response to FIV when challenged with homologous or heterologous strains of FIV...
> Colon cell and colon cancer cell associated nucleic acid molecules, proteins and peptides (S Welt et a/, US, AU) Ludwig Institute for Cancer Research and the inventors N” WO 97/08189, PCT. ... In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods...
> Methods for enhancing the production of viral vaccines in cell culture by interferon suppression (A Lau, US) The Regents of the University of California N” WO 97/08292, PCT
Cancer 5 Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy (G Murphy et a/, US) Pacific Northwest Cancer Foundation and the inventors N” WO 97/04802, PCT. Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed... Methods and compositions for human dendritic cells with extended life span and cryopreserved denditric cells are disclosed. > Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis (MC Rio et a/, FR, AU) Inserm, CNRS, Universite Louis-Pasteur et BristolMyers Squibb Co N” WO 97/06256, PCT. . .. four novel human genes amplified and overexpressed in breast carcinoma and 46 BIOFUTUR167 l Mai 1997
q23.w
> Telomere repeat binding factor and diagnostic and therapeutic use thereof (T de Lange, US) The Rockefeller University N”W0 97/08314, PCT. .. . Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer...
Syst~me immunitaire
> Monoclonal antibodies against soluble TNF-IX receptors p55 and p75 as well as against TNF-a and its analogues (V Curin Serbet et a/, SI, NL) Lek, Tovarna Farmacevtskih in Kemicnih Izdelkov, Zavod Republike Slovenije za Transfuzijo KRVI and the inventors N” WO 97/06251, PCT. . .. The invention also relates to a method for the quantitatives determination of human TNF-a, free or comwith soluble plexed TNF-a receptors ~5.5 and ~75, and to a kit used therefor... Another object of the invention is also the TNF-a analogue TNF-a Cys95His 107HislOKys148, which in a complex with TNF-a soluble receptors, is used as an antigen for immunization of mice. > Antigenic preparations (D Farnow et al, DE) Boehringer lngelheim Vetmedica GmbH and the inventors N” WO 97/07232, PCT. . .. comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, processes for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccrnes...
Apoptose > Recombinant 5OkDa vegetable panallergen (cofactor-independent phosphoglycerate mutase; EC 5421) (F Ferreira et al, AT) Biomay Produktions-und Handelsgesellschaft mbH and the inventors N” WO 97/05258, PCT. The description relates to a recombinant DNA molecule which codes a polypeptide antigen property of the cofactor-independant-phosphoglycerate mutase (EC 5421) of birch, mugwort or timoty grass pollen. ... The amino acid sequence and the most important B and Tcell epitopes of the molecule are derived and demonstrated. The recombinant allergen was expressed in E coli and binds the IgE serum of patients who are allergic to tree, grass and weed pollens and various foodstuffs...
> Inhibitors of apoptosis (M Rothe and D Goeddel, US) Tularik, Inc N” WO 97/06182, PCT. . .. methods and compositions relating to novel human cellular inhibitor of apoptosis proteins comprising a series of defined structural domain repeats and/or a RING finger domain... The proteins provide a CUP specific function, with preferred proteins being capable of modulating the induction of apoptosis... > Mammalian apoptosis inhibitor or protein gene family, primers, probes and detection methods (R Korneluk et a/, CA) University of Ottawa and the inventors N” WO 97/06255, PCT.
Maladies infectieuses > Mycobacterium vaccae for treatment of long term autoimmune conditions (JL Stanford and GA Rook, UK) University College London N” 763361, EP. Antigenic and/or immunoregulatory material derived from Mycobacterium vacuze is useful in the treatment of the auto immunologically mediated consequences of Chaga’s disease or the prophylaxis or treatment of vascular diseases or complications which may be immunologically mediated such as those associated with tuberculosis or diabetes.
Maladies cardio-vascuiaires > t-PA polymorphism and use thereof in diagnosis of risk of thrombus associated disease (C Kluft and D Grobbee, NL) Akzo Nobel NV and the inventors N” WO 97/07240, PCT. > Remedy for heart diseases (A Matsumori, JP) Toray Industries, Inc N” WO 97/07820, PCT. A remedy for heart diseases wherein the cardiac muscular tissue is infected with human hepatitis C virus which comprises as the active ingredient an antiviral agent. The remedy is useful in treating viral myocarditis and heart diseases in association therewith.
Maladies neurodCg6nSratives z Enhanced artificial viral envelopes for cellular delivery of therapeutic substances (J Conary and H Schreier, US) Advanced Therapies Inc and the inventors N” WO 97/04748, PCT. .. . artificial viral envelopes and other lipid vesicles that encapsulate therapeutic substances, such as expression vectors, targeted to mammalian cells.... The vesicles may also be provided with a fusogenic component that facilitates delivery of the therapeutic substance into the cell. The materials and rea-
located on the qll-q21.3 region chromosome 17. . .. are useful in breast cancer prognosis. The invention also relates to a fifth novel human gene expressed in breast carcinoma and located on chromosome 6q22-
> Multi-subtype FIV vaccines (J Yamamoto, US) University of Florida and Regents of the University of California N” WO 97107817, PCT .. . for protecting cats from infection by a broad range of FIV strains using a multisubtype FIV vaccine... Cats vaccinated according to the methods and compositions of the subject invention exibit protective humoral and cellular immune response to FIV when challenged with homologous or heterologous strains of FIV...
> Colon cell and colon cancer cell associated nucleic acid molecules, proteins and peptides (S Welt et a/, US, AU) Ludwig Institute for Cancer Research and the inventors N” WO 97/08189, PCT. ... In addition, this invention relates to the use of said nucleic acid molecules, protein, in monomeric or multimeric form, and to antibodies to said peptides in diagnostic, screening and therapeutic methods...
> Methods for enhancing the production of viral vaccines in cell culture by interferon suppression (A Lau, US) The Regents of the University of California N” WO 97/08292, PCT
Cancer 5 Isolation and/or preservation of dendritic cells for prostate cancer immunotherapy (G Murphy et a/, US) Pacific Northwest Cancer Foundation and the inventors N” WO 97/04802, PCT. Methods and compositions for use of human dendritic cells to activate T cells for immunotherapeutic responses against primary and metastatic prostate cancer are disclosed... Methods and compositions for human dendritic cells with extended life span and cryopreserved denditric cells are disclosed. > Isolated nucleic acid molecules useful as leukemia markers and in breast cancer prognosis (MC Rio et a/, FR, AU) Inserm, CNRS, Universite Louis-Pasteur et BristolMyers Squibb Co N” WO 97/06256, PCT. . .. four novel human genes amplified and overexpressed in breast carcinoma and 46 BIOFUTUR167 l Mai 1997
q23.w
> Telomere repeat binding factor and diagnostic and therapeutic use thereof (T de Lange, US) The Rockefeller University N”W0 97/08314, PCT. .. . Methods of identifying antagonists of the telomeric protein, diagnostic methods of identifying the telomeric protein in a sample, and therapeutic uses of the telomeric protein, particularly in the treatment of aging and cancer...
Syst~me immunitaire
> Monoclonal antibodies against soluble TNF-IX receptors p55 and p75 as well as against TNF-a and its analogues (V Curin Serbet et a/, SI, NL) Lek, Tovarna Farmacevtskih in Kemicnih Izdelkov, Zavod Republike Slovenije za Transfuzijo KRVI and the inventors N” WO 97/06251, PCT. . .. The invention also relates to a method for the quantitatives determination of human TNF-a, free or comwith soluble plexed TNF-a receptors ~5.5 and ~75, and to a kit used therefor... Another object of the invention is also the TNF-a analogue TNF-a Cys95His 107HislOKys148, which in a complex with TNF-a soluble receptors, is used as an antigen for immunization of mice. > Antigenic preparations (D Farnow et al, DE) Boehringer lngelheim Vetmedica GmbH and the inventors N” WO 97/07232, PCT. . .. comprising polysaccharides and/or glycopeptides preparable from keratinophilic fungi as well as yeasts, processes for the preparation of these antigenic preparations, their use as pharmaceutical substances as well as their use as vaccrnes...
Apoptose > Recombinant 5OkDa vegetable panallergen (cofactor-independent phosphoglycerate mutase; EC 5421) (F Ferreira et al, AT) Biomay Produktions-und Handelsgesellschaft mbH and the inventors N” WO 97/05258, PCT. The description relates to a recombinant DNA molecule which codes a polypeptide antigen property of the cofactor-independant-phosphoglycerate mutase (EC 5421) of birch, mugwort or timoty grass pollen. ... The amino acid sequence and the most important B and Tcell epitopes of the molecule are derived and demonstrated. The recombinant allergen was expressed in E coli and binds the IgE serum of patients who are allergic to tree, grass and weed pollens and various foodstuffs...
> Inhibitors of apoptosis (M Rothe and D Goeddel, US) Tularik, Inc N” WO 97/06182, PCT. . .. methods and compositions relating to novel human cellular inhibitor of apoptosis proteins comprising a series of defined structural domain repeats and/or a RING finger domain... The proteins provide a CUP specific function, with preferred proteins being capable of modulating the induction of apoptosis... > Mammalian apoptosis inhibitor or protein gene family, primers, probes and detection methods (R Korneluk et a/, CA) University of Ottawa and the inventors N” WO 97/06255, PCT.
Maladies infectieuses > Mycobacterium vaccae for treatment of long term autoimmune conditions (JL Stanford and GA Rook, UK) University College London N” 763361, EP. Antigenic and/or immunoregulatory material derived from Mycobacterium vacuze is useful in the treatment of the auto immunologically mediated consequences of Chaga’s disease or the prophylaxis or treatment of vascular diseases or complications which may be immunologically mediated such as those associated with tuberculosis or diabetes.
Maladies cardio-vascuiaires > t-PA polymorphism and use thereof in diagnosis of risk of thrombus associated disease (C Kluft and D Grobbee, NL) Akzo Nobel NV and the inventors N” WO 97/07240, PCT. > Remedy for heart diseases (A Matsumori, JP) Toray Industries, Inc N” WO 97/07820, PCT. A remedy for heart diseases wherein the cardiac muscular tissue is infected with human hepatitis C virus which comprises as the active ingredient an antiviral agent. The remedy is useful in treating viral myocarditis and heart diseases in association therewith.
Maladies neurodCg6nSratives z Enhanced artificial viral envelopes for cellular delivery of therapeutic substances (J Conary and H Schreier, US) Advanced Therapies Inc and the inventors N” WO 97/04748, PCT. .. . artificial viral envelopes and other lipid vesicles that encapsulate therapeutic substances, such as expression vectors, targeted to mammalian cells.... The vesicles may also be provided with a fusogenic component that facilitates delivery of the therapeutic substance into the cell. The materials and rea-