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Inorganic Nitrate as a Regulator of Vascular Function
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A. Newman / Free Radical Biology and Medicine 128 (2018) S1–S20
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Inorganic Nitrate as a Regulator of Vascular Function Amrita Ahluwalia, PhD, William Harvey Research Institute, UK The sequential chemical reduction of inorganic nitrate to nitrite and then to nitric oxide (NO) provides a source of NO that exerts important effects upon the cardiovascular system. In particular, this pathway has been demonstrated to provide clinically relevant blood pressure lowering in the setting of hypertension, antiinflammatory activity in the setting of atherosclerosis and cardioprotective actions in the setting of myocardial infarction. The first step in this pathway i.e. the reduction of nitrate to nitrite is critically dependent upon the activity of commensal bacteria, particularly residing within the oral cavity, whilst the second step of this process is due to the activity of mammalian nitrite reductases expressed within the cardiovascular system. Recent research suggests that this process of chemical reduction not only operates in the disease setting offering opportunities for therapeutics, but also plays a critical role in maintaining cardiovascular health. https://doi.org/10.1016/j.freeradbiomed.2018.10.376
A. Newman / Free Radical Biology and Medicine 128 (2018) S1–S20
P2
Inorganic Nitrate as a Regulator of Vascular Function Amrita Ahluwalia, PhD, William Harvey Research Institute, UK The sequential chemical reduction of inorganic nitrate to nitrite and then to nitric oxide (NO) provides a source of NO that exerts important effects upon the cardiovascular system. In particular, this pathway has been demonstrated to provide clinically relevant blood pressure lowering in the setting of hypertension, antiinflammatory activity in the setting of atherosclerosis and cardioprotective actions in the setting of myocardial infarction. The first step in this pathway i.e. the reduction of nitrate to nitrite is critically dependent upon the activity of commensal bacteria, particularly residing within the oral cavity, whilst the second step of this process is due to the activity of mammalian nitrite reductases expressed within the cardiovascular system. Recent research suggests that this process of chemical reduction not only operates in the disease setting offering opportunities for therapeutics, but also plays a critical role in maintaining cardiovascular health. https://doi.org/10.1016/j.freeradbiomed.2018.10.376