Interaction with others and the social self

S244

Abstracts

P3-l03 Peer-social response in 4 juvenile marmosets represented the emotional development traits depending on family structure Koki Shimizu 1 , Koki Mimura 1 , Yuka Shirakawa 1 , Hidetoshi Ishibashi 2 , Ikuko Tanaka 3 , Yoshiko Honda 3 , Setuo Usui 3 , Tohru Tokuno 3 , Shun Nakamura 1,2 , Mamiko Kodama 3 , Hironobu Koshiba 1,2 1

Tokyo Univ. of A&T, Japan;

2

NCNP, Japan;

3

TMIN, Japan

Family structure around a child is one of the strongest environmental factors for his/her social and mental development. To investigate how the behavioral traits of juvenile primate represent human development, we prepared three groups of subjects different in their family structure, that is, bred without other siblings, either by human (H1) or by its own parents (P1), and with another sibling by its own parents (P2). We evaluated their behavioral development in our original meeting test between two or four peers. The multivariate analysis of the test result expressed the different behavioral patterns more distinctly at the contexts in 4 peers than 2. Interestingly, P1’s pattern showed the least change from 2- to 4-peer-context, comparing to H1’s or P2’s. These results suggest that social brain function was sculpted through social interaction between parent–child and peers during development.

(Ainsworth and Bowlby, 1991). Loneliness is caused by a lack of social adjustment, and could result in extreme states of mind (Skodlar et al., 2008). Eye gaze activates the striatum associated with reward prediction (Knut et al., 2001), whereas social rewards activate the striatum in a manner similar to the monetary reward (Izuma et al., 2008). Here we examine the significance of attention and involvement of others as rewards in a social game, where the subjects interact with others and exchange attention and other personal resources. The results illuminate a process of induced-isolation in the presence of others. We discuss the importance of interaction with others in the construction and maintenance of the social self, in the context of the neural basis of attachment in adulthood. doi:10.1016/j.neures.2009.09.1382

P3-l07 Social interaction and concern for others in episodic memory: an fMRI study Yoko Mano 1 , Motoaki Sugiura 1 , Takashi Tsukiura 1 , Yukihito Jeong 1 , Atsushi Sekiguchi 1 , Yuko Yomogida 1,2 , Hyeonjeong Akitsuki 1 , Ryuta Kawashima 1,3 1

Tohoku Univ., IDAC, Sendai, Japan; Tokyo, Japan

doi:10.1016/j.neures.2009.09.1379

P3-l04 Neural development in amygdala region modulated by Peer–Social Environment Koki Mimura, Yuka Shirakawa, Shun Nakamura, Mamiko Koshiba Tokyo Univ. A&T, Japan The increase of developmental disorders gains much attention. We focus on the effect of decrease of Peer–Social interaction in growth environment, like fewer children, on neural development. The effect of social developmental environment on chicks, which lacks parent–child relationship, can be controlled by being bred in isolated or grouped condition. We analyzed chick’s social response behavior in auditory and visual communication scene quantitatively using principal component analysis. As the result, the behavior is separated into two distinct emotional action types. To find out the neural function which affects on the action type difference, we focus on the amygdala complex, one of the emotional center. 7T-MRI analysis revealed the significant difference on the size of male ventral limbic system including amygdala. By multi-staining with Nissl, Myelin, and Hoechst, we found the significant difference of the number of neurons and the axon development in this area. We’ll show the results of the in vivo tracer experiments to analyze neuronal network development. doi:10.1016/j.neures.2009.09.1380

2

JSPS, Tokyo, Japan;

3

JST/RISTEX,

Social interaction (SI) may be embedded in episodic memory (EM) partially dependent on the degree of concern for others. We examined the neural correlates of SI in EM and their association with the degree of concern for others. During an encoding session, using specified words, a pair of subjects alternately generated/read a sequence of sentences together (SI condition) or did individually (non-SI condition). During an fMRI retrieval session, the subjects performed a word recognition test. After the fMRI session, each subject rated the personality traits of the partner, and an average of all the ratings was used as an index of the degree of concern for others. Activation in SI was identified in the medial prefrontal cortex (MPFC), and their positive correlation with the degree of concern for others was in the precuneus. The results suggested that EM of SI involves the MPFC, and also the precuneus when the degree of concern for others is high. doi:10.1016/j.neures.2009.09.1383

P3-l08 Electroconvulsive stimulation blocks intracellular amyloid␤-mediated suppression of BK channels in a homer 1a/vesl-1Sdependent mechanism Kenji Yamamoto 1,2 , Yoshifumi Ueta 2 , Ryo Yamamoto 2 , Naoko Inoue 3 , Kaoru Inokuchi 3 , Nobuo Kato 2 1

P3-l05 Tapping touch improves negative mood via serotonergic system Yasushi Nakatani, Ichiro Nakagawa, Tamami Sekiyama, Yoshinari Seki, Hiromi Kikuchi, Xinjun Yu, Iikuko Sato-Suzuki, Hideho Arita Dept. Physiol., Toho Univ. Sch. Med., Tokyo, Japan Tapping Touch (TT) is a healing technique, characterized as follows. A practitioner stands behind the receiver; he/she begins tapping rhythmically, alternating left and right hands, in the area of receiver’s shoulder, neck, head and the back for 15 min. Then, the role of a practitioner and receiver is replaced. The purpose of this study is to evaluate the effects of TT on negative mood states as well as blood/urine serotonin (5-HT) levels. Whole blood (WB)/urine 5-HT and negative mood states were assessed before and immediately after TT. Negative mood states including anxiety, pain, guilt feeling, stress and tension were evaluated, using Visual Analog Scale and Profile of Mood States. As a result, we found significant increases in WB/urine 5-HT levels, and decreases in all negative mood scores after TT. There was a significant negative correlation between WB 5-HT level and the negative moods of anxiety, stress and tension. Since 5-HT system is involved in regulation of mood states, we hypothesized that Tapping Touch may affect 5-HT system. doi:10.1016/j.neures.2009.09.1381

P3-l06 Interaction with others and the social self Tsugumi Takano 1 , Kenichiro Mogi 2 1

Tokyo Institute of Technology, Kanagawa, Japan; Laboratories, Tokyo, Japan

2

Sony Computer Science

Interactions between the parent and child at the early-stage of life have an influence on the subsequent social adjustment abilities. Attachment is the affective bond of parent–child relation and supports the cognitive development of a child, with the attachment figure in adulthood generalizing to persons other than the parents

Dept. Neurol., Utano Natl. Hospital, Japan; 2 Dept. Physiol., Kanazawa Med. Univ., Japan; 3 Mitsubishi Kagaku Inst. Life Sci., Japan

Recent studies have indicated that intracellular amyloid-␤(A␤) can induce cognitive defect in the early stage of Alzheimer disease(AD). Here we report the pathophysiological significance of intracellular A␤ by applying A␤ protein into rat and mouse neocortical pyramidal neurons through whole-cell patch pipettes. Intracellular A␤1–42 , but not A␤1–40 , broadened spike width and augmented Ca2+ influx. Charybdotoxin, a blocker of large-conductance Ca2+ - activated K+ (BK) channel, mimicked and occluded these effects of A␤1–42 . Electroconvulsive stimulation (ECS), which we previously showed to facilitate BK channel opening via homer 1a expression, blocked the BK channel suppression by A␤1–42 in rats and wild-type mice, but not in homer 1a knockout mice. These findings suggest that the suppression of BK channel mediated by intracellular A␤1–42 may represent an early dysfunction in the AD brain, which is counteracted by activity-dependent expression of Homer 1a during ECS. doi:10.1016/j.neures.2009.09.1384

P3-l09 Resveratrol improves age-related changes in SAMP10 CNS Takeuchi 1 , Naoya Hayakawa 1 , Motoko Shiozaki 1 , Shoichi Masahiro Shibata 2 , Masato Koike 3 , Yasuo Uchiyama 3 , Takahiro Gotow 1 1

Lab. Cell Biol., Koshien Univ., Takarazuka, Japan; 2 Div. Gross Anat. Morphogen, Niigata Univ. Grad. Med. Dent., Niigata, Japan; 3 Dept. Cell Biol. Neurosci., Juntendo Univ., Sch. Med., Tokyo, Japan Resveratrol, a polyphenol present at high level in red wine, is reported to have protective effects on the nervous system and extend the lifespan. We examined brainspecific senescence-accelerated mice (SAMP10), which were treated with 0.04% resveratrol included in the diet for 20 weeks from the age of 35 weeks, by immunohistochemistry, electron microscopy and immunoblotting to know how they were