- Email: [email protected]
INTERPRETATION OF FREE THYROXINE RADIOIMMUNOASSAY DATA
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1300
XBD=2528 XBD=1545 XBD=1660 XBD=1752 XBD=1785 XBD=1928 XBD=1976 XBD=2009 XBD=2121 XBD=2273 XBD=1491 XBD=1676 XBD=1769 XBD=1845 XBD=1918 XBD=2028 XBD=2218 XBD=2305 XBD=2412 XBD=2496 XBD=2535 XBD=1583 XBD=1736 XBD=1966 XBD=2060 XBD=2155 XBD=2201 XBD=2250 XBD=2306 XBD=2396 XBD=2534 XBD=1478 XBD=1545 XBD=1769 XBD=1904 XBD=1999 XBD=2183 XBD=2273 XBD=2435 XBD=2533 XBD=1589 XBD=1759 XBD=1815 XBD=2032 XBD=2137 XBD=2171 XBD=2316 XBD=2461 XBD=2534 XBD=1525 XBD=1608 XBD=1736 XBD=1828 XBD=1990 XBD=2037 XBD=2326 XBD=2423 XBD=2477 XBD=2534 XBD=1592 XBD=1824 XBD=1877 XBD=2000 XBD=2045 XBD=2116 XBD=2270 XBD=1521 XBD=1620 XBD=1804 XBD=1866 XBD=2058 XBD=2214 XBD=2297 XBD=2438 XBD=2533 XBD=1566 XBD=1634 XBD=1896 XBD=1984 XBD=2176 XBD=2472 XBD=2533 XBD=1529 XBD=1624 XBD=1667 XBD=1764 XBD=1812 XBD=1885 XBD=2035 XBD=2145 XBD=2283 XBD=2442 XBD=2533 XBD=1578 XBD=1839 XBD=1925 XBD=1978 XBD=2180 XBD=2267 XBD=2490 XBD=2538 XBD=1466 XBD=1628 XBD=1746 XBD=1853 XBD=1925 XBD=2076 XBD=2142 XBD=2347 XBD=2532
XHG=2287 XHG=1410 XHG=1560 XHG=1675 XHG=1767 XHG=1801 XHG=1943 XHG=1992 XHG=2025 XHG=2138 XHG=1416 XHG=1502 XHG=1687 XHG=1779 XHG=1856 XHG=1927 XHG=2038 XHG=2226 XHG=2313 XHG=2421 XHG=2505 XHG=1416 XHG=1600 XHG=1752 XHG=1980 XHG=2074 XHG=2169 XHG=2216 XHG=2268 XHG=2313 XHG=2410 XHG=1416 XHG=1492 XHG=1560 XHG=1784 XHG=1919 XHG=2014 XHG=2198 XHG=2287 XHG=2449 XHG=1416 XHG=1610 XHG=1780 XHG=1834 XHG=2053 XHG=2159 XHG=2192 XHG=2334 XHG=2478 XHG=1416 XHG=1538 XHG=1619 XHG=1747 XHG=1838 XHG=1998 XHG=2047 XHG=2336 XHG=2432 XHG=2486 XHG=1416 XHG=1606 XHG=1838 XHG=1883 XHG=2013 XHG=2058 XHG=2128 XHG=1451 XHG=1544 XHG=1643 XHG=1827 XHG=1883 XHG=2081 XHG=2237 XHG=2318 XHG=2459 XHG=1415 XHG=1592 XHG=1660 XHG=1923 XHG=2009 XHG=2203 XHG=2496 XHG=1415 XHG=1546 XHG=1641 XHG=1683 XHG=1782 XHG=1828 XHG=1902 XHG=2052 XHG=2161 XHG=2297 XHG=2456 XHG=1414 XHG=1594 XHG=1855 XHG=1940 XHG=1994 XHG=2198 XHG=2281 XHG=2503 XHG=1414 XHG=1502 XHG=1664 XHG=1781 XHG=1887 XHG=1961 XHG=2110 XHG=2177 XHG=2380
YBD=326 YBD=328 YBD=320 YBD=327 YBD=367 YBD=374 YBD=365 YBD=366 YBD=419 YBD=412 YBD=411 YBD=410 YBD=418 YBD=457 YBD=456 YBD=455 YBD=464 YBD=507 YBD=502 YBD=510 YBD=509 YBD=501 YBD=500 YBD=547 YBD=553 YBD=545 YBD=546 YBD=600 YBD=592 YBD=591 YBD=599 YBD=644 YBD=637 YBD=636 YBD=645 YBD=683 YBD=691 YBD=690 YBD=689 YBD=682 YBD=729 YBD=734 YBD=736 YBD=735 YBD=728 YBD=774 YBD=782 YBD=781 YBD=772 YBD=780 YBD=773 YBD=819 YBD=820 YBD=827 YBD=818 YBD=826 YBD=825
YHG=289>gonadotropins, YHG=290>patients YHG=290>(16%) YHG=290>aged YHG=291>8 YHG=291>months YHG=297>to YHG=292>6 YHG=300>years. YHG=290>Urinary YHG=336>total YHG=343>oestrogen, YHG=336>bone YHG=346>age, YHG=337>and YHG=337>pelvic YHG=346>sonograms YHG=346>were YHG=336>useful YHG=337>tools YHG=337>in YHG=381>diagnosis. YHG=381>Ovarian YHG=382>cystectomies YHG=391>were YHG=383>done YHG=382>in YHG=382>31 YHG=380>of YHG=381>these YHG=381>patients YHG=426>and YHG=426>the YHG=426>pathological YHG=434>reports YHG=436>were YHG=427>consistent YHG=427>with YHG=425>follicular YHG=433>cysts, YHG=471>unilateral, YHG=472>bilateral, YHG=482>or YHG=472>multicystic. YHG=471>Only YHG=472>1 YHG=471>ovarian YHG=470>fibroma YHG=480>was YHG=516>found. YHG=517>The YHG=516>studies YHG=517>done YHG=517>excluded YHG=526>an YHG=516>endocrinological YHG=525>cause YHG=515>for YHG=516>the YHG=570>premature YHG=562>development YHG=561>of YHG=562>breasts YHG=562>in YHG=571>our YHG=562>patients. YHG=607>The YHG=607>high YHG=607>incidence YHG=607>of YHG=614>premature YHG=607>telarche YHG=606>and YHG=606>ovarian YHG=613>cysts YHG=653>observed YHG=652>by YHG=652>paediatricians YHG=652>and YHG=652>paediatric YHG=651>endocrinologists YHG=662>on YHG=699>Puerto YHG=699>Rico YHG=698>is YHG=708>now, YHG=705>at YHG=707>our YHG=705>request, YHG=698>being YHG=698>studied YHG=696>officially YHG=698>since YHG=751>oestrogen YHG=743>contamination YHG=753>may YHG=743>be YHG=743>implicated. YHG=743>The YHG=743>development YHG=743>of YHG=790>the YHG=790>ovarian YHG=796>cysts YHG=798>may YHG=789>be YHG=788>related YHG=795>to YHG=787>prolonged YHG=794>oestrogen
" XBD=2531 XBD=1650 XHG=2444 XBD=1837 XBD=1924 XBD=1953 XBD=2086 XBD=2348 XBD=2432 XHG=1414 YBD=864 XHG=1667 XHG=1849 XHG=1937 XHG=1966 XHG=2099 XHG=2360 YBD=872 YHG=832>of YBD=863 YBD=871 YBD=862 YHG=827>consumption YHG=834>associated YHG=834>with YHG=843>a YHG=833>genetic YHG=833>predisposition; YHG=833>45% the " " " " "
XBD=2403 XBD=1497 XBD=1572 XBD=1601 XBD=1746 XBD=1867 XBD=1998 XBD=2048 XBD=2180 XBD=1485 XBD=1542 XBD=1713 XBD=1770 XBD=1957 XBD=2109 XBD=2188 XBD=2327 XBD=2422 XBD=2454 XBD=2531 XBD=1581 XBD=1760 XBD=1819 XBD=1859 XBD=2054 XBD=2203 XBD=2386 XBD=2475 XBD=2531 XBD=1608 XBD=1682 XBD=1773 XBD=1925 XBD=1975 XBD=2102 XBD=2155 XBD=2305 XBD=2360 XBD=2424 XBD=2488 XBD=2536 XBD=1553 XBD=1697 XBD=1789 XBD=1833 XBD=1926 XBD=2002 XBD=2136 XBD=2182 XBD=2274 XBD=2476
XHG=2193 XHG=1413 XHG=1510 XHG=1584 XHG=1614 XHG=1760 XHG=1879 XHG=2010 XHG=2055 XHG=1448 XHG=1503 XHG=1559 XHG=1731 XHG=1781 XHG=1974 XHG=2126 XHG=2204 XHG=2344 XHG=2438 XHG=2469 XHG=1413 XHG=1606 XHG=1784 XHG=1843 XHG=1884 XHG=2079 XHG=2228 XHG=2408 XHG=2496 XHG=1413 XHG=1625 XHG=1697 XHG=1788 XHG=1942 XHG=1991 XHG=2117 XHG=2170 XHG=2319 XHG=2373 XHG=2437 XHG=2502 XHG=1413 XHG=1566 XHG=1711 XHG=1801 XHG=1847 XHG=1940 XHG=2014 XHG=2150 XHG=2194 XHG=2287
YBD=908 YHG=878>abnormality. YBD=917 YBD=909 YHG=889>cases YHG=879>had YHG=889>a YHG=879>positive YHG=878>family YHG=879>history YHG=878>of YHG=878>ovarian YBD=963 YHG=931>true YBD=962 YBD=954 YBD=955 YHG=925>In YHG=935>an YHG=925>epidemic YHG=924>of YHG=932>premature YHG=925>telarche YHG=924>and YHG=925>ovarian YHG=931>cysts YHG=934>a YBD=1009 YHG=971>be YBD=1000 YBD=1008 YBD=1001 YHG=971>endocrine YHG=970>aetiology YHG=980>or YHG=980>a YHG=970>malignant YHG=970>ovarian YHG=970>neoplasm YHG=980>may YBD=1054 YHG=1016>of YBD=1046 YBD=1047 YHG=1016>overlooked. YHG=1017>We YHG=1025>urge YHG=1015>W.H.O. YHG=1023>to YHG=1016>review YHG=1016>its YHG=1016>position YHG=1026>on YHG=1017>the YHG=1025>use YBD=1093 YHG=1062>production. YBD=1091 YBD=1092 YBD=1100 YHG=1062>anabolic YHG=1062>steroids YHG=1062>such YHG=1071>as YHG=1061>DES YHG=1062>and YHG=1062>zeranol YHG=1062>in YHG=1069>meat Paediatric Department and Paediatric Endocrinology, De Diego Hospital, Santurce, Puerto Rico
CARMEN A. SÁENZ DE RODRÍGUEZ
Genetic Department, San Juan City and De Santurce
MARÍA A. TORO-SOLÁ
Diego Hospitals,
" XBD=1147 XBD=234 XHG=858 XBD=397 XBD=444 XBD=629 XBD=775 XBD=848 XBD=989 XHG=170 XHG=246 XHG=408 XHG=449 XHG=639 XHG=786 XHG=1002 YBD=1458 YBD=1452 YBD=1460 YBD=1453 YBD=1454 YBD=1461 YBD=1456 YHG=1427>Fig. YHG=1427>2-Cases YHG=1426>of YHG=1431>premature YHG=1427>telarche YHG=1428>and YHG=1428>puberty YHG=1430>1970-81.
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INTERPRETATION OF FREE THYROXINE RADIOIMMUNOASSAY DATA
XBD=1306XHG=729 XBD=211 XBD=307 XBD=497 XBD=644 XBD=718 XBD=911 XBD=1058 XBD=1147 XBD=1211 XHG=170 XHG=225 XHG=320 XHG=508 XHG=656 XHG=923YBD=1574 XHG=1069 XHG=1158 XHG=1223 YBD=1567 YBD=1575 YBD=1566 YBD=1574 YBD=1566YHG=1536>precocious YHG=1537>2). YHG=1535>Both YHG=1543>premature YHG=1536>telarche YHG=1536>and YHG=1535>puberty YHG=1536>have YHG=1536>the YHG=1545>same XBD=382 XHG=823 XBD=624 XBD=804 XBD=969 XBD=1087 XBD=1142 XBD=1206 XBD=1306 XHG=169 XHG=400 XHG=643 XHG=987YBD=1612 XHG=1103 XHG=1152 XHG=1223 YBD=1617 YBD=1620 YBD=1621 YBD=1620 YBD=1612YHG=1581>different YBD=1611 YHG=1582>distribution, YHG=1582>representing, YHG=1581>probably, YHG=1588>stages YHG=1582>of YHG=1582>the YHG=1591>same XBD=1600 XBD=1746 XBD=1818 XBD=1873 XBD=2017 XBD=2127 XBD=2186 XBD=2227 XBD=2310 XBD=2463 XBD=2532 XHG=1450 XHG=1609 XHG=1756 XHG=1826 XHG=1883 XHG=2026 XHG=2137 XHG=2197 XHG=2239 XHG=2319 XHG=2472 YBD=1638 YBD=1644 YBD=1647 YBD=1639 YBD=1640 YHG=1609>SrR,―Dr YHG=1608>Mardell YHG=1609>and YHG=1609>Dr YHG=1607>Gamlen YHG=1608>(April YHG=1609>24, YHG=1618>p. YHG=1609>973) YHG=1609>conclude YHG=1609>that XBD=296 XHG=788 XBD=366 XBD=454 XBD=537 XBD=564 XBD=692 XBD=779 XBD=965 XBD=1076 XBD=1305 XHG=169 XHG=309 XHG=376 XHG=464 XHG=547 XHG=574 XHG=701 XHG=975YBD=1666 XHG=1087 YBD=1659 YBD=1657 YBD=1658 YBD=1657 YBD=1665 YHG=1628>disease. YHG=1628>We YHG=1628>have YHG=1637>seen YHG=1637>a YHG=1627>patient YHG=1628>with YHG=1635>premature YHG=1627>breast YHG=1628>development XBD=1477 XBD=1657 XBD=1767 XBD=1893 XBD=2053 XBD=2107 XBD=2432 XBD=2532 XHG=1414 XHG=1492 XHG=1671 XHG=1781 XHG=1907 XHG=2066 XHG=2121 XHG=2444 YBD=1685 YBD=1684 YBD=1693 YBD=1694 YHG=1654>free YHG=1655>thyroxine YHG=1654>(FT4) YHG=1655>results YHG=1654>obtained YHG=1655>by YHG=1654>radioimmunoassay YHG=1655>(RIA) XBD=232 XHG=830 XBD=395 XBD=483 XBD=573 XBD=816 XBD=924 XBD=1023 XBD=1098 XBD=1262 XBD=1305 XHG=169 XHG=244 XHG=408 XHG=496 XHG=587 XHG=938YBD=1703 XHG=1038 XHG=1112 XHG=1276 YBD=1704 YBD=1713 YBD=1711 YBD=1711 YBD=1702YHG=1673>levels YBD=1712 YBD=1704 YHG=1673>and YHG=1674>transient YHG=1683>very YHG=1674>high YHG=1673>gonadotropin YHG=1673>(over YHG=1674>200 YHG=1673>mIU/ml) YHG=1681>at XBD=1583 XBD=1696 XBD=1901 XBD=2154 XBD=2284 XBD=2337 XBD=2532 XHG=1414 XHG=1601 XHG=1715 XHG=1920 XHG=2171 XHG=2300 XHG=2355 YBD=1738 YBD=1731 YBD=1730 YBD=1739 YHG=1700>(’Amerlex YHG=1700>FT4’; YHG=1700>Amersham YHG=1701>International) YHG=1700>should YHG=1701>be YHG=1701>interpreted XBD=223 XHG=904 XBD=296 XBD=355 XBD=429 XBD=545 XBD=640 XBD=712 XBD=804 XBD=885 XBD=991 XBD=1111 XBD=1227 XBD=1305 XHG=168 XHG=241 XHG=315 XHG=367 XHG=448 XHG=566 XHG=658 XHG=731 XHG=823 XHG=1010YBD=1758 XHG=1131 XHG=1246 YBD=1751 YBD=1757 YBD=1749 YBD=1750 YBD=1749YHG=1728>years YHG=1720>the YHG=1729>age YHG=1718>of YHG=1727>two YHG=1728>years; YHG=1728>over YHG=1719>the YHG=1727>next YHG=1726>two YHG=1719>breast YHG=1720>tissue YHG=1720>disXBD=1490 XBD=1635 XBD=1747 XBD=1818 XBD=1956 XBD=2030 XBD=2066 XBD=2245 XBD=2479 XBD=2532 XHG=1414 XHG=1510 XHG=1654 XHG=1766 XHG=1838 XHG=1976 XHG=2050 XHG=2085 XHG=2264 XHG=2495 YBD=1784 YBD=1776 YBD=1777 YBD=1785 YHG=1746>with YHG=1746>caution YHG=1746>when YHG=1747>the YHG=1747>patient YHG=1746>has YHG=1756>a YHG=1746>condition YHG=1746>characterised YHG=1747>by XBD=324 XHG=795 XBD=407 XBD=657 XBD=773 XBD=960 XBD=1062 XBD=1142 XBD=1238 XBD=1306 XHG=169 XHG=345 XHG=427 XHG=678 XHG=980YBD=1795 XHG=1082 XHG=1162 XHG=1259 YBD=1803 YBD=1795 YBD=1796 YBD=1795 YHG=1766>appeared YHG=1766>and YHG=1765>gonadotropin YHG=1765>levels YHG=1765>decreased YHG=1764>from YHG=1765>less YHG=1766>than YHG=1765>six XBD=1514 XBD=1776 XBD=1882 XBD=1977 XBD=2141 XBD=2420 XBD=2531 XHG=1413 XHG=1541 XHG=1803 XHG=1909 XHG=2004 XHG=2168 XHG=2448 YBD=1821 YBD=1830 YBD=1822 YBD=1831 YHG=1791>raised YHG=1791>non-esterified YHG=1791>fatty YHG=1792>acid YHG=1792>(NEFA) YHG=1793>concentrations. YHG=1792>They XBD=296 XHG=865 XBD=387 XBD=451 XBD=630 XBD=715 XBD=853 XBD=936 XBD=1021 XBD=1071 XBD=1259 XBD=1305 XHG=169 XHG=309 XHG=398 XHG=463 XHG=645 XHG=728 XHG=947YBD=1849 XHG=1032 XHG=1084 XHG=1273 YBD=1842 YBD=1841 YBD=1840 YBD=1841 YBD=1840 YBD=1846 YBD=1841 YHG=1811>months YHG=1811>after YHG=1811>the YHG=1811>diagnosis. YHG=1810>The YHG=1820>process YHG=1820>may YHG=1811>thus YHG=1810>be YHG=1811>reversible, YHG=1811>in XBD=1537 XBD=1621 XBD=1692 XBD=1771 XBD=1857 XBD=2046 XBD=2139 XBD=2207 XBD=2355 XBD=2531 XHG=1413 XHG=1555 XHG=1639 XHG=1710 XHG=1788 XHG=1876 XHG=2063 XHG=2154 XHG=2224 XHG=2371 YBD=1875 YBD=1867 YBD=1868 YBD=1876 YHG=1844>suggest YHG=1837>that YHG=1837>the YHG=1837>low YHG=1837>FT4 YHG=1838>associated YHG=1838>with YHG=1838>the YHG=1838>amerlex YHG=1838>procedure XBD=256 XHG=409 XBD=353 XBD=395 XBD=493 XHG=169 YBD=1887 XHG=269 XHG=366 YBD=1886 YHG=1857>least. YHG=1866>some YHG=1866>cases YHG=1864>at XBD=1524 XBD=1631 XBD=1707 XBD=1900 XBD=2031 XBD=2186 XBD=2252 XBD=2423 XBD=2531 XHG=1412 XHG=1548 XHG=1654 XHG=1732 XHG=1922 XHG=2055 XHG=2210 XHG=2278 XHG=2446 YBD=1912 YBD=1913 YBD=1921 YBD=1922 YHG=1883>results YHG=1882>from YHG=1883>the YHG=1883>residually YHG=1883>bound YHG=1883>labelled YHG=1883>T4 YHG=1885>analogue YHG=1884>being XBD=381 XHG=808 XBD=558 XBD=655 XBD=793 XBD=990 XBD=1154 XBD=1198 XBD=1302 XHG=200 XHG=396 XHG=574 XHG=669 XHG=1004 XHG=1172 XHG=1214 YBD=1933 YBD=1940 YBD=1932 YBD=1941 YBD=1940 YBD=1938 YBD=1932 YHG=1902>Associated YHG=1903>diagnoses YHG=1912>were YHG=1903>various YHG=1902>syndromes YHG=1902>(Noonan YHG=1903>1, YHG=1902>LeviXBD=1570 XBD=1665 XBD=1817 XBD=1872 XBD=2007 XHG=1412 XHG=1583 XHG=1678 XHG=1830 XHG=1883 YBD=1966 YBD=1958 YBD=1967 YBD=1959 YHG=1928>displaced YHG=1928>from YHG=1929>albumin YHG=1929>by YHG=1928>NEFA. XBD=257 XHG=960 XBD=306 XBD=563 XBD=611 XBD=940 XBD=989 XBD=1302 XHG=165 XHG=281 XHG=327 XHG=583 XHG=630 XHG=1009 YBD=1978 YBD=1984 YBD=1985 YBD=1983 YBD=1986 YHG=1948>Weill YHG=1949>1, YHG=1948>Russell-Silver YHG=1949>2, YHG=1947>McCune-Albright YHG=1948>3, YHG=1948>spondylothoracic XBD=1561 XBD=1665 XBD=1831 XBD=1873 XBD=2061 XBD=2120 XBD=2341 XBD=2441 XBD=2531 XHG=1450 XHG=1570 XHG=1675 XHG=1840 XHG=1883 XHG=2070 XHG=2130 XHG=2349 XHG=2450 YBD=2013 YBD=2004 YBD=2005 YHG=1975>Serum YHG=1975>levels YHG=1974>of YHG=1975>in YHG=1984>pregnancy YHG=1984>are YHG=1974>considerably YHG=1975>above YHG=1975>those NEFA XBD=319 XHG=851 XBD=378 XBD=641 XBD=835 XBD=976 XBD=1022 XBD=1188 XBD=1302 XHG=165 XHG=340 XHG=395 XHG=657 XHG=996YBD=2032 XHG=1039 XHG=1204 YBD=2031 YBD=2024 YBD=2029 YBD=2023 YBD=2031 YHG=1994>dysplasia YHG=1993>1), YHG=1994>cardiovascular YHG=1994>conditions YHG=1994>(ductus YHG=1994>1, YHG=1994>ventrical YHG=1994>septal XBD=1452 XBD=1692 XBD=1843 XBD=1922 XBD=1990 XBD=2129 XBD=2223 XBD=2263 XBD=2424 XBD=2469 XBD=2531 XHG=1413 XHG=1462 XHG=1709 XHG=1861 XHG=1937 XHG=2006 XHG=2146 XHG=2239 XHG=2279 XHG=2439 XHG=2483 YBD=2059 YBD=2056 YBD=2058 YBD=2049 YBD=2050 YHG=2020>of YHG=2027>non-pregnant YHG=2024>women, YHG=2020>and YHG=2021>highest YHG=2020>level YHG=2021>is YHG=2020>observed YHG=2020>in YHG=2021>the XBD=266 XHG=732 XBD=305 XBD=507 XBD=649 XBD=722 XBD=828 XBD=1068 XBD=1120 XBD=1302 XHG=165 XHG=282 XHG=318 XHG=517 XHG=660 XHG=840YBD=2078 XHG=1083 XHG=1133 YBD=2069 YBD=2075 YBD=2077 YBD=2070 YBD=2069 YBD=2077 YHG=2039>defect YHG=2040>1, YHG=2039>pulmonary YHG=2040>stenosis YHG=2040>and YHG=2040>cystic YHG=2040>adenomatosis YHG=2039>1), YHG=2039>iatrogenic XBD=1496 XBD=1689 XBD=1881 XBD=2055 XBD=2107 XBD=2316 XBD=2446 XBD=2530 XHG=1411 XHG=1508 XHG=1704 XHG=1893 XHG=2066 XHG=2119 XHG=2328 XHG=2457 YBD=2104 YBD=2105 YBD=2096 YHG=2067>third YHG=2059>trimester.2 YHG=2066>FT4 YHG=2067>measured YHG=2067>by YHG=2066>equilibrium YHG=2066>dialysis YHG=2076>were XBD=309 XHG=895 XBD=395 XBD=453 XBD=685 XBD=813 XBD=867 XBD=956 XBD=1037 XBD=1103 XBD=1192 XBD=1305 XHG=169 XHG=335 XHG=421 XHG=478 XHG=711 XHG=842 XHG=981YBD=2115 XHG=1067 XHG=1130 XHG=1216 YBD=2114 YBD=2123 YBD=2121 YBD=2123 YBD=2123 YBD=2115 YBD=2116 YHG=2084>illnesses YHG=2085>due YHG=2092>to YHG=2085>(oestrogenic YHG=2095>cream YHG=2085>1, YHG=2086>and YHG=2085>pill YHG=2085>1), levels YHG=2085>and YHG=2086>other XBD=1557 XBD=1600 XBD=1650 XBD=1789 XBD=1975 XHG=1411 XHG=1567 XHG=1612 XHG=1663 XHG=1800 YHG=2113>reported YHG=2119>to YHG=2112>be YHG=2112>slightly YHG=2104>increased XBD=2148 XBD=2201 XBD=2249 XBD=2455 XBD=2531 XHG=2060 XHG=2160 XHG=2212 XHG=2260 XHG=2465 YBD=2142 YBD=2150 YBD=2149 YBD=2141 YHG=2112>those YHG=2112>by YHG=2121>an YHG=2112>equilibrium YHG=2112>RIA XBD=346 XHG=782 XBD=540 XBD=582 XBD=771 XBD=910 XBD=1058 XBD=1098 XBD=1251 XBD=1302 XHG=168 XHG=358 XHG=556 XHG=595 XHG=921YBD=2161 XHG=1073 XHG=1111 XHG=1261 YBD=2160 YBD=2169 YBD=2166 YBD=2161 YBD=2166YHG=2139>tumour YBD=2170 YBD=2169 YHG=2130>conditions YHG=2130>(leukaemia YHG=2131>1, YHG=2131>interstitial YHG=2130>of YHG=2131>1,testes YHG=2131>epilepsy YHG=2132>4). XBD=1747 XBD=1877 XBD=2086 XBD=2226 XBD=2444 XBD=2529 XHG=1411 XHG=1762 XHG=1891 XHG=2102 XHG=2240 XHG=2456 YBD=2196 YBD=2195 YBD=2187 YHG=2158>microencapsulation YHG=2164>system YHG=2157>(’LiquiSol’; YHG=2157>Damon YHG=2157>Diagnostics) YHG=2166>were XBD=261 XHG=835 XBD=351 XBD=417 XBD=661 XBD=733 XBD=824 XBD=966 XBD=1009 XBD=1096 XBD=1257 XBD=1304 XHG=203 XHG=272 XHG=362 XHG=429 XHG=672 XHG=743 XHG=977YBD=2207 XHG=1021 XHG=1107 XHG=1270 YBD=2205 YBD=2215 YBD=2206 YBD=2207 YBD=2207YHG=2177>relation YHG=2176>We YHG=2175>have YHG=2183>not YHG=2176>demonstrated YHG=2186>any YHG=2177>clear YHG=2184>to YHG=2176>food YHG=2177>additives YHG=2187>or XBD=1547 XBD=1593 XBD=1792 XBD=1858 XBD=1921 XBD=2086 XBD=2231 XBD=2309 XBD=2353 XBD=2530 XHG=1411 XHG=1560 XHG=1604 XHG=1806 XHG=1868 XHG=1932 XHG=2099 XHG=2242 XHG=2322 XHG=2363 YBD=2242 YBD=2233 YBD=2240 YBD=2232 YBD=2241 YHG=2196>normal4 YHG=2204>in YHG=2212>pregnancy. YHG=2202>On YHG=2203>the YHG=2210>contrary, YHG=2204>amerlex YHG=2202>FT4 YHG=2203>in YHG=2212>pregnancy XBD=408 XHG=746 XBD=510 XBD=655 XBD=723 XBD=887 XBD=1032 XBD=1151 XBD=1306 XHG=168 XHG=433 XHG=532 XHG=677 XHG=909YBD=2260 XHG=1056 XHG=1176 YBD=2257 YBD=2259 YBD=2251 YBD=2260 YBD=2252 YBD=2260 YHG=2221>contaminants, YHG=2231>even YHG=2222>though YHG=2231>we YHG=2222>strongly YHG=2229>suspect YHG=2222>them. YHG=2222>Dietary XBD=1471 XBD=1642 XBD=1697 XBD=1759 XBD=1946 XHG=1409 XHG=1496 XHG=1665 XHG=1721 XHG=1784 YBD=2287 YHG=2258>was YHG=2249>reported YHG=2255>to YHG=2249>be YHG=2241>reduced. XBD=2225 XBD=2280 XBD=2397 XBD=2529 XHG=2052 XHG=2248 XHG=2303 XHG=2417 YBD=2279 YBD=2277 YBD=2286 YBD=2278 YHG=2248>confirmed YHG=2248>in YHG=2248>thirty YHG=2248>normal XBD=307 XHG=779 XBD=383 XBD=483 XBD=651 XBD=754 XBD=976 XBD=1033 XBD=1128 XBD=1186 XBD=1304 XHG=168 XHG=332 XHG=408 XHG=507 XHG=677 XHG=1002 XHG=1059 XHG=1154 XHG=1211 YBD=2304 YBD=2296 YBD=2305 YBD=2303 YBD=2297 YBD=2297 YBD=2298 YHG=2274>patterns YHG=2276>are YHG=2276>very YHG=2267>variable, YHG=2267>with YHG=2267>commercial YHG=2268>well YHG=2277>as YHG=2268>home XBD=1613 XBD=1693 XBD=1781 XBD=1877 XBD=2005 XBD=2108 XBD=2186 XBD=2343 XBD=2528 XHG=1410 XHG=1640 XHG=1721 XHG=1808 XHG=1905 XHG=2031 XHG=2134 XHG=2213 XHG=2369 YBD=2333 YBD=2324 YBD=2332 YHG=2294>pregnancies YHG=2294>low YHG=2293>FT4 YHG=2293>found YHG=2294>with YHG=2294>the YHG=2294>amerlex YHG=2294>procedure XBD=321 XHG=733 XBD=449 XBD=614 XBD=705 XBD=981 XBD=1124 XBD=1236 XBD=1304 XHG=168 XHG=350 XHG=480 XHG=642 XHG=1010 XHG=1153 XHG=1265 YBD=2351 YBD=2343 YBD=2344 YBD=2343 YHG=2312>prepared YHG=2312>foods. YHG=2312>Genetic YHG=2312>and YHG=2313>environmental YHG=2312>factors YHG=2320>must YHG=2314>be XBD=1733 XBD=2300 XBD=2347 XBD=2443 XBD=2528 XHG=1576 XHG=2157 XHG=2316 XHG=2364 XHG=2459 YBD=2369 YBD=2378 YBD=2370 YHG=2340>4 YHG=2339>pmol/1 YHG=2340>in YHG=2340>eight YHG=2349>nonpmol/l, (10’ 8::!:2’ XBD=338 XHG=899 XBD=381 XBD=452 XBD=706 XBD=887 XBD=956 XBD=1043 XBD=1204 XBD=1229 XBD=1304 XHG=168 XHG=348 XHG=390 XHG=461 XHG=716 XHG=965YBD=2388 XHG=1052 XHG=1212 XHG=1237 YBD=2397 YBD=2387 YBD=2396 YBD=2389 YBD=2389 YBD=2389 YBD=2397 YHG=2358>important YHG=2358>in YHG=2358>this YHG=2359>heterogeneous YHG=2358>condition. YHG=2359>We YHG=2359>have YHG=2359>observed YHG=2368>a YHG=2359>pair XBD=1563 XBD=1704 XBD=1854 XBD=2054 XBD=2223 XBD=2287 XBD=2403 XBD=2488 XBD=2535 XHG=1412 XHG=1577 XHG=1717 XHG=1867 XHG=2070 XHG=2236 XHG=2300 XHG=2416 XHG=2500 YBD=2423 YBD=2422 YBD=2414 YBD=2413 YHG=2392>pregnant YHG=2385>healthy YHG=2384>controls YHG=2384>(p<0-001). YHG=2384>However YHG=2384>the YHG=2384>lowest YHG=2384>level YHG=2383>of XBD=207 XHG=931 XBD=325 XBD=433 XBD=518 XBD=593 XBD=640 XBD=707 XBD=805 XBD=917 XBD=993 XBD=1077 XBD=1139 XBD=1206 XBD=1304 XHG=167 XHG=215 XHG=340 XHG=447 XHG=533 XHG=608 XHG=653 XHG=721 XHG=818 XHG=1006 XHG=1092 XHG=1153 XHG=1220 YBD=2434 YBD=2433 YBD=2435 YBD=2434 YHG=2402>of YHG=2404>female YHG=2403>twins YHG=2404>who YHG=2404>live YHG=2404>in YHG=2404>the YHG=2413>same YHG=2404>house YHG=2404>and YHG=2405>who YHG=2412>eat YHG=2405>the YHG=2414>same XBD=1482 XBD=1554 XBD=1715 XBD=1757 XBD=1873 XBD=1984 XBD=2220 XBD=2284 XBD=2346 XBD=2386 XBD=2445 XBD=2530 XHG=1412 XHG=1493 XHG=1564 XHG=1724 XHG=1767 XHG=1883 XHG=1992 XHG=2229 XHG=2294 XHG=2356 XHG=2394 XHG=2452 YBD=2468 YBD=2459 YBD=2458 YHG=2430>FT4 YHG=2440>was YHG=2430>observed YHG=2430>20-25 YHG=2430>weeks YHG=2429>of YHG=2430>but YHG=2436>not YHG=2430>in YHG=2430>the YHG=2429>third XBD=252 XHG=700 XBD=283 XBD=356 XBD=497 XBD=686 XBD=801 XBD=1046 XBD=1113 XBD=1216 XBD=1304 XHG=167 XHG=272 XHG=300 XHG=370 XHG=510 XHG=817YBD=2479 XHG=1061 XHG=1126 XHG=1229 YBD=2477 YBD=2486 YBD=2487 YBD=2480 YHG=2448>food: YHG=2449>1 YHG=2449>has YHG=2449>marked YHG=2456>premature YHG=2450>breast YHG=2449>development, YHG=2450>thepregnancy, YHG=2450>other YHG=2450>does
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XBD=2534 XBD=1591 XBD=1671 XBD=1777 XBD=1867 XBD=2047 XBD=2131 XBD=2244 XBD=2491 XHG=1445 XHG=1600 XHG=1683 XHG=1786 XHG=1877 XHG=2055 XHG=2141 XHG=2252 XHG=2499 YBD=2557 YBD=2550 YBD=2549 YHG=2520>Amerlex YHG=2520>FT4 YHG=2520>levels YHG=2529>were YHG=2520>correlated YHG=2520>with YHG=2529>serum YHG=2520>concentrations YHG=2518>of XBD=290 XHG=739 XBD=535 XBD=615 XBD=721 XBD=986 XBD=1117 XBD=1248 XBD=1303 XHG=202 XHG=306 XHG=553 XHG=631 XHG=1004 XHG=1135 XHG=1264 YBD=2570 YBD=2569 YBD=2570 YBD=2569 YHG=2539>Food YHG=2539>contaminants YHG=2539>and YHG=2540>other YHG=2540>environmental YHG=2539>factors YHG=2540>should YHG=2540>be XBD=2001 XBD=2073 XBD=2166 XBD=2269 XBD=2323 XBD=2526 XHG=1945 XHG=2019 XHG=2090 XHG=2181 XHG=2285 XHG=2333 YBD=2594 YBD=2595 YBD=2602 YHG=2565>but YHG=2571>not YHG=2565>with YHG=2565>those YHG=2564>of YHG=2564>prealbumin. XBD=1550 XBD=1744 XBD=1848 XHG=1410 XHG=1567 XHG=1762 YBD=2603 YHG=2565>albumin YHG=2565>(r=0’609, YHG=2566>p<0 XBD=279 XHG=896 XBD=317 XBD=414 XBD=477 XBD=659 XBD=704 XBD=845 XBD=886 XBD=973 XBD=1092 XBD=1212 XBD=1303 XHG=167 XHG=289 XHG=329 XHG=424 XHG=488 XHG=672 XHG=714 XHG=854 XHG=982YBD=2615 XHG=1104 XHG=1222 YBD=2616 YBD=2620 YBD=2614 YBD=2620 YBD=2614 YHG=2585>looked YHG=2592>at YHG=2585>since YHG=2585>the YHG=2584>incidence, YHG=2585>in YHG=2585>relation YHG=2592>to YHG=2585>total YHG=2585>births, YHG=2584>differs YHG=2584>from XBD=1514 XBD=1665 XBD=1801 XBD=1879 XBD=2024 XBD=2106 XBD=2222 XBD=2303 XBD=2349 XBD=2528 XHG=1410 XHG=1526 XHG=1677 XHG=1813 XHG=1891 XHG=2035 XHG=2118 XHG=2234 XHG=2312 XHG=2361 YBD=2647 YBD=2639 YBD=2648 YBD=2640 YHG=2611>These YHG=2610>findings YHG=2617>suggest YHG=2611>that YHG=2610>amerlex YHG=2610>FT4 YHG=2611>values YHG=2619>may YHG=2611>be YHG=2609>influenced XBD=252 XHG=518 XBD=296 XBD=395 XBD=440 XBD=506 XBD=636 XHG=166 YBD=2667 XHG=264 XHG=309 XHG=407 XHG=452 YBD=2661 YHG=2631>region. YBD=2660 YHG=2638>to YHG=2638>town YHG=2631>in YHG=2631>the XBD=1450 XHG=2425 XBD=1567 XBD=1830 XBD=1882 XBD=2027 XBD=2071 XBD=2153 XBD=2197 XBD=2330 XBD=2412 XBD=2527 XHG=1409 YBD=2685 XHG=1463 XHG=1580 XHG=1843 XHG=1888 XHG=2040 XHG=2084 XHG=2166 XHG=2209 XHG=2344 YBD=2693 YHG=2655>results YBD=2684 YBD=2692 YHG=2656>by YHG=2664>serum YHG=2655>concentrations YHG=2655>of YHG=2655>albumin YHG=2655>well YHG=2665>as YHG=2655>NEFA. YHG=2655>FT4 of Paediatrics,YBD=2729 Department XBD=1556 XBD=1606 XBD=1750 XBD=1831 XBD=1916 XBD=2039 XBD=2085 XBD=2243 XBD=2435 XBD=2526 XHG=1409 XHG=1565 XHG=1616 XHG=1760 XHG=1843 XHG=1925 XHG=2047 XHG=2095 XHG=2251 XHG=2443 YBD=2737 YBD=2730 YBD=2738 YHG=2700>obtained YHG=2700>by YHG=2700>amerlex YHG=2700>FT4 YHG=2700>RIA YHG=2700>should YHG=2700>be YHG=2700>carefully YHG=2700>interpreted YHG=2701>when Ponce School of Medicine, XBD=1461 XBD=1590 XBD=1655 XBD=1682 XBD=1827 XBD=1930 XBD=1979 XBD=2087 XBD=2245 XBD=2287 XBD=2329 XBD=2528 XHG=1408 XHG=1471 XHG=1600 XHG=1666 XHG=1692 XHG=1837 XHG=1940 XHG=1983 XHG=2096 XHG=2256 XHG=2297 XHG=2338 YBD=2781 YBD=2775 YBD=2774 YBD=2783 YHG=2746>the YHG=2745>patient YHG=2745>has YHG=2755>a YHG=2745>reduced YHG=2745>levels YHG=2745>of YHG=2754>serum YHG=2745>albumin, YHG=2755>as YHG=2746>in YHG=2744>non-thyroid ADOLFO PÉREZ COMAS Puerto Rico 00709 Mayaguez,
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Laboratory for Clinical Investigation and Departments of Laboratory Medicine and Obstetrics and Gynaecology, Osaka University Medical School, Osaka 553, Japan Central
XBD=1304XHG=904 XBD=219 XBD=310 XBD=509 XBD=581 XBD=629 XBD=716 XBD=853 XBD=895 XBD=951 XBD=1019 XBD=1079 XBD=1163 XHG=166 XHG=229 XHG=320 XHG=518 XHG=591 XHG=632 XHG=727 XHG=863 XHG=963YBD=3106 XHG=1029 XHG=1089 XHG=1171 YBD=3114 YBD=3107 YBD=3106 YBD=3115 YBD=3107 YHG=3079>the YHG=3084>meat YHG=3078>production YHG=3087>was YHG=3076>of YHG=3084>great YHG=3078>interest YHG=3084>to YHG=3087>us. YHG=3076>We YHG=3087>are YHG=3087>very YHG=3078>worried XBD=261 XHG=917 XBD=346 XBD=512 XBD=560 XBD=638 XBD=741 XBD=894 XBD=958 XBD=1032 XBD=1164 XBD=1303 XHG=165 XHG=283 XHG=368 XHG=537 XHG=584 XHG=661 XHG=763 XHG=980YBD=3159 XHG=1055 XHG=1186 YBD=3153 YBD=3160 YBD=3151 YBD=3152 YBD=3151 YBD=3152 YHG=3123>about YHG=3122>this YHG=3122>practice: YHG=3123>it YHG=3123>has YHG=3122>been YHG=3122>allowed YHG=3122>by YHG=3122>the YHG=3122>World YHG=3122>Health XBD=387 XHG=915 XBD=451 XBD=515 XBD=687 XBD=833 XBD=905 XBD=970 XBD=1017 XBD=1146 XBD=1303 XHG=166 XHG=396 XHG=462 XHG=525 XHG=696 XHG=842 XHG=979YBD=3197 XHG=1027 XHG=1156 YBD=3205 YBD=3196 YBD=3197 YBD=3204 YBD=3197 YHG=3167>Organisation YHG=3168>but YHG=3167>the YHG=3176>necessary YHG=3167>controls YHG=3167>will YHG=3174>not YHG=3167>be YHG=3167>strictly YHG=3166>enforced XBD=198 XHG=832 XBD=337 XBD=545 XBD=629 XBD=788 XBD=910 XBD=1103 XBD=1226 XBD=1301 XHG=165 XHG=243 XHG=379 XHG=593 XHG=673 XHG=955YBD=3242 XHG=1148 XHG=1269 YBD=3251 YBD=3243 YBD=3250 YBD=3242 YHG=3213>in YHG=3222>many YHG=3213>countries. YHG=3213>In YHG=3212>Puerto YHG=3212>Rico YHG=3213>products YHG=3212>such YHG=3222>as XBD=473 XHG=917 XBD=600 XBD=681 XBD=825 XBD=895 XBD=985 XBD=1078 XBD=1151 XBD=1302 XHG=164 XHG=494 XHG=620 XHG=701 XHG=845 XHG=1005 XHG=1098 XHG=1172 YBD=3296 YBD=3288 YBD=3287 YBD=3288 YBD=3287 YHG=3257>diethylstilboestrol YHG=3257>(DES) YHG=3258>and YHG=3259>zeranol YHG=3267>are YHG=3258>sold YHG=3267>over YHG=3258>the YHG=3264>counter XBD=297 XHG=916 XBD=327 XBD=513 XBD=742 XBD=813 XBD=903 XBD=995 XBD=1227 XBD=1301 XHG=164 XHG=310 XHG=339 XHG=525 XHG=757 XHG=826 XHG=1008 XHG=1238 YBD=3333 YBD=3340 YBD=3332 YBD=3339 YBD=3332 YHG=3303>without YHG=3312>a YHG=3303>veterinary YHG=3303>prescription. YHG=3303>We YHG=3303>have YHG=3303>been YHG=3302>investigating YHG=3303>this XBD=275 XHG=880 XBD=421 XBD=475 XBD=523 XBD=689 XBD=865 XBD=919 XBD=1104 XBD=1253 XBD=1301 XHG=164 XHG=290 XHG=436 XHG=484 XHG=538 XHG=704 XHG=928YBD=3377 XHG=1118 XHG=1268 YBD=3384 YBD=3385 YBD=3376 YBD=3377 YHG=3355>matter YHG=3348>because YHG=3357>an YHG=3348>alarming YHG=3348>incidence YHG=3347>of YHG=3355>premature YHG=3347>telarche YHG=3348>in
" XBD=380 XBD=278 XHG=292 XHG=164 YBD=3421 YBD=3422 YHG=3392>Rico. YHG=3392>Puerto
" XBD=1153 XBD=1300XHG=886 XBD=323 XBD=389 XBD=471 XBD=537 XBD=648 XBD=724 XBD=872 XBD=963 XHG=198 XHG=336 XHG=403 XHG=485 XHG=550 XHG=664 XHG=738 XHG=976YBD=3467 XHG=1165 YBD=3473 YBD=3466 YBD=3474 YBD=3474 YBD=3467 YHG=3436>During YHG=3437>the YHG=3444>past YHG=3443>ten YHG=3446>years, YHG=3438>375 YHG=3437>patients YHG=3437>with YHG=3444>premature YHG=3437>telarche " XBD=1300 XBD=241 XHG=867 XBD=331 XBD=496 XBD=539 XBD=610 XBD=766 XBD=855 XBD=906 XBD=997 XBD=1090 XBD=1174 XHG=911 XHG=163 XHG=254 XHG=345 XHG=508 XHG=552 XHG=622 XHG=780 XHG=1009 XHG=1102 XHG=1187 YBD=3510 YBD=3519 YBD=3511 YBD=3511 YBD=3520 YHG=3481>have YHG=3482>been YHG=3481>observed YHG=3481>in YHG=3491>our YHG=3481>practice: YHG=3482>85% YHG=3481>of YHG=3482>these YHG=3491>were YHG=3491>seen YHG=3482>during " XBD=1294 XBD=215 XHG=783 XBD=310 XBD=488 XBD=555 XBD=666 XBD=689 XBD=776 XBD=945 XBD=1119 XBD=1210 XBD=1250 XHG=162 XHG=224 XHG=323 XHG=500 XHG=565 XHG=674 XHG=699 XHG=953YBD=3563 XHG=1128 XHG=1218 XHG=1259 YBD=3556 YBD=3562 YBD=3554 YBD=3555 YBD=3556 YBD=3564 YBD=3556 YHG=3526>the YHG=3535>years YHG=3526>1979 YHG=3525>We YHG=3525>found YHG=3536>a YHG=3526>high YHG=3527>incidence YHG=3526>of YHG=3534>cysts YHG=3527>in YHG=3528>61 ovarian - 81.
NOBUYUKI AMINO KEIKO NISHI KIYOSHI MIYAI OSAMU TANIZAWA
1. Block E. Quantitative morphological investigation of follicular system in woman: Variations in different phases of sexual cycle. Acta Endocrinol 1951; 8: 33. 2. Burt RL. Plasma nonesterified fatty acids in normal pregnancy and the puerperium. Obstet Gynecol 1960; 15: 460-64. 3. Yamamoto T, Amino N, Tanizawa O, Doi K, Ichihara K, Azukizawa M, Miyai K. Longitudinal study of serum thyroid hormones, chorionic gonadotrophin and thyrotrophin during and after normal pregnancy. Clin Endocrinol 1979; 10: 459-68 4. Ammo N, Yamada T, Mitsuma T, Nogimori T, Tanizawa O, Kawashima M, Kurachi K, Miyai K Increase in plasma thyrotropin-releasing hormone in normal human pregnancy. J Clin Endocrinol Metab 1981; 53: 1288-90. 5. Midgley JEM, Wilkins TA The direct estimation of free hormones by a simple equilibrium radioimmunoassay. Amersham, Bucks: Amersham International Ltd, 1981
1300
XBD=2528 XBD=1545 XBD=1660 XBD=1752 XBD=1785 XBD=1928 XBD=1976 XBD=2009 XBD=2121 XBD=2273 XBD=1491 XBD=1676 XBD=1769 XBD=1845 XBD=1918 XBD=2028 XBD=2218 XBD=2305 XBD=2412 XBD=2496 XBD=2535 XBD=1583 XBD=1736 XBD=1966 XBD=2060 XBD=2155 XBD=2201 XBD=2250 XBD=2306 XBD=2396 XBD=2534 XBD=1478 XBD=1545 XBD=1769 XBD=1904 XBD=1999 XBD=2183 XBD=2273 XBD=2435 XBD=2533 XBD=1589 XBD=1759 XBD=1815 XBD=2032 XBD=2137 XBD=2171 XBD=2316 XBD=2461 XBD=2534 XBD=1525 XBD=1608 XBD=1736 XBD=1828 XBD=1990 XBD=2037 XBD=2326 XBD=2423 XBD=2477 XBD=2534 XBD=1592 XBD=1824 XBD=1877 XBD=2000 XBD=2045 XBD=2116 XBD=2270 XBD=1521 XBD=1620 XBD=1804 XBD=1866 XBD=2058 XBD=2214 XBD=2297 XBD=2438 XBD=2533 XBD=1566 XBD=1634 XBD=1896 XBD=1984 XBD=2176 XBD=2472 XBD=2533 XBD=1529 XBD=1624 XBD=1667 XBD=1764 XBD=1812 XBD=1885 XBD=2035 XBD=2145 XBD=2283 XBD=2442 XBD=2533 XBD=1578 XBD=1839 XBD=1925 XBD=1978 XBD=2180 XBD=2267 XBD=2490 XBD=2538 XBD=1466 XBD=1628 XBD=1746 XBD=1853 XBD=1925 XBD=2076 XBD=2142 XBD=2347 XBD=2532
XHG=2287 XHG=1410 XHG=1560 XHG=1675 XHG=1767 XHG=1801 XHG=1943 XHG=1992 XHG=2025 XHG=2138 XHG=1416 XHG=1502 XHG=1687 XHG=1779 XHG=1856 XHG=1927 XHG=2038 XHG=2226 XHG=2313 XHG=2421 XHG=2505 XHG=1416 XHG=1600 XHG=1752 XHG=1980 XHG=2074 XHG=2169 XHG=2216 XHG=2268 XHG=2313 XHG=2410 XHG=1416 XHG=1492 XHG=1560 XHG=1784 XHG=1919 XHG=2014 XHG=2198 XHG=2287 XHG=2449 XHG=1416 XHG=1610 XHG=1780 XHG=1834 XHG=2053 XHG=2159 XHG=2192 XHG=2334 XHG=2478 XHG=1416 XHG=1538 XHG=1619 XHG=1747 XHG=1838 XHG=1998 XHG=2047 XHG=2336 XHG=2432 XHG=2486 XHG=1416 XHG=1606 XHG=1838 XHG=1883 XHG=2013 XHG=2058 XHG=2128 XHG=1451 XHG=1544 XHG=1643 XHG=1827 XHG=1883 XHG=2081 XHG=2237 XHG=2318 XHG=2459 XHG=1415 XHG=1592 XHG=1660 XHG=1923 XHG=2009 XHG=2203 XHG=2496 XHG=1415 XHG=1546 XHG=1641 XHG=1683 XHG=1782 XHG=1828 XHG=1902 XHG=2052 XHG=2161 XHG=2297 XHG=2456 XHG=1414 XHG=1594 XHG=1855 XHG=1940 XHG=1994 XHG=2198 XHG=2281 XHG=2503 XHG=1414 XHG=1502 XHG=1664 XHG=1781 XHG=1887 XHG=1961 XHG=2110 XHG=2177 XHG=2380
YBD=326 YBD=328 YBD=320 YBD=327 YBD=367 YBD=374 YBD=365 YBD=366 YBD=419 YBD=412 YBD=411 YBD=410 YBD=418 YBD=457 YBD=456 YBD=455 YBD=464 YBD=507 YBD=502 YBD=510 YBD=509 YBD=501 YBD=500 YBD=547 YBD=553 YBD=545 YBD=546 YBD=600 YBD=592 YBD=591 YBD=599 YBD=644 YBD=637 YBD=636 YBD=645 YBD=683 YBD=691 YBD=690 YBD=689 YBD=682 YBD=729 YBD=734 YBD=736 YBD=735 YBD=728 YBD=774 YBD=782 YBD=781 YBD=772 YBD=780 YBD=773 YBD=819 YBD=820 YBD=827 YBD=818 YBD=826 YBD=825
YHG=289>gonadotropins, YHG=290>patients YHG=290>(16%) YHG=290>aged YHG=291>8 YHG=291>months YHG=297>to YHG=292>6 YHG=300>years. YHG=290>Urinary YHG=336>total YHG=343>oestrogen, YHG=336>bone YHG=346>age, YHG=337>and YHG=337>pelvic YHG=346>sonograms YHG=346>were YHG=336>useful YHG=337>tools YHG=337>in YHG=381>diagnosis. YHG=381>Ovarian YHG=382>cystectomies YHG=391>were YHG=383>done YHG=382>in YHG=382>31 YHG=380>of YHG=381>these YHG=381>patients YHG=426>and YHG=426>the YHG=426>pathological YHG=434>reports YHG=436>were YHG=427>consistent YHG=427>with YHG=425>follicular YHG=433>cysts, YHG=471>unilateral, YHG=472>bilateral, YHG=482>or YHG=472>multicystic. YHG=471>Only YHG=472>1 YHG=471>ovarian YHG=470>fibroma YHG=480>was YHG=516>found. YHG=517>The YHG=516>studies YHG=517>done YHG=517>excluded YHG=526>an YHG=516>endocrinological YHG=525>cause YHG=515>for YHG=516>the YHG=570>premature YHG=562>development YHG=561>of YHG=562>breasts YHG=562>in YHG=571>our YHG=562>patients. YHG=607>The YHG=607>high YHG=607>incidence YHG=607>of YHG=614>premature YHG=607>telarche YHG=606>and YHG=606>ovarian YHG=613>cysts YHG=653>observed YHG=652>by YHG=652>paediatricians YHG=652>and YHG=652>paediatric YHG=651>endocrinologists YHG=662>on YHG=699>Puerto YHG=699>Rico YHG=698>is YHG=708>now, YHG=705>at YHG=707>our YHG=705>request, YHG=698>being YHG=698>studied YHG=696>officially YHG=698>since YHG=751>oestrogen YHG=743>contamination YHG=753>may YHG=743>be YHG=743>implicated. YHG=743>The YHG=743>development YHG=743>of YHG=790>the YHG=790>ovarian YHG=796>cysts YHG=798>may YHG=789>be YHG=788>related YHG=795>to YHG=787>prolonged YHG=794>oestrogen
" XBD=2531 XBD=1650 XHG=2444 XBD=1837 XBD=1924 XBD=1953 XBD=2086 XBD=2348 XBD=2432 XHG=1414 YBD=864 XHG=1667 XHG=1849 XHG=1937 XHG=1966 XHG=2099 XHG=2360 YBD=872 YHG=832>of YBD=863 YBD=871 YBD=862 YHG=827>consumption YHG=834>associated YHG=834>with YHG=843>a YHG=833>genetic YHG=833>predisposition; YHG=833>45% the " " " " "
XBD=2403 XBD=1497 XBD=1572 XBD=1601 XBD=1746 XBD=1867 XBD=1998 XBD=2048 XBD=2180 XBD=1485 XBD=1542 XBD=1713 XBD=1770 XBD=1957 XBD=2109 XBD=2188 XBD=2327 XBD=2422 XBD=2454 XBD=2531 XBD=1581 XBD=1760 XBD=1819 XBD=1859 XBD=2054 XBD=2203 XBD=2386 XBD=2475 XBD=2531 XBD=1608 XBD=1682 XBD=1773 XBD=1925 XBD=1975 XBD=2102 XBD=2155 XBD=2305 XBD=2360 XBD=2424 XBD=2488 XBD=2536 XBD=1553 XBD=1697 XBD=1789 XBD=1833 XBD=1926 XBD=2002 XBD=2136 XBD=2182 XBD=2274 XBD=2476
XHG=2193 XHG=1413 XHG=1510 XHG=1584 XHG=1614 XHG=1760 XHG=1879 XHG=2010 XHG=2055 XHG=1448 XHG=1503 XHG=1559 XHG=1731 XHG=1781 XHG=1974 XHG=2126 XHG=2204 XHG=2344 XHG=2438 XHG=2469 XHG=1413 XHG=1606 XHG=1784 XHG=1843 XHG=1884 XHG=2079 XHG=2228 XHG=2408 XHG=2496 XHG=1413 XHG=1625 XHG=1697 XHG=1788 XHG=1942 XHG=1991 XHG=2117 XHG=2170 XHG=2319 XHG=2373 XHG=2437 XHG=2502 XHG=1413 XHG=1566 XHG=1711 XHG=1801 XHG=1847 XHG=1940 XHG=2014 XHG=2150 XHG=2194 XHG=2287
YBD=908 YHG=878>abnormality. YBD=917 YBD=909 YHG=889>cases YHG=879>had YHG=889>a YHG=879>positive YHG=878>family YHG=879>history YHG=878>of YHG=878>ovarian YBD=963 YHG=931>true YBD=962 YBD=954 YBD=955 YHG=925>In YHG=935>an YHG=925>epidemic YHG=924>of YHG=932>premature YHG=925>telarche YHG=924>and YHG=925>ovarian YHG=931>cysts YHG=934>a YBD=1009 YHG=971>be YBD=1000 YBD=1008 YBD=1001 YHG=971>endocrine YHG=970>aetiology YHG=980>or YHG=980>a YHG=970>malignant YHG=970>ovarian YHG=970>neoplasm YHG=980>may YBD=1054 YHG=1016>of YBD=1046 YBD=1047 YHG=1016>overlooked. YHG=1017>We YHG=1025>urge YHG=1015>W.H.O. YHG=1023>to YHG=1016>review YHG=1016>its YHG=1016>position YHG=1026>on YHG=1017>the YHG=1025>use YBD=1093 YHG=1062>production. YBD=1091 YBD=1092 YBD=1100 YHG=1062>anabolic YHG=1062>steroids YHG=1062>such YHG=1071>as YHG=1061>DES YHG=1062>and YHG=1062>zeranol YHG=1062>in YHG=1069>meat Paediatric Department and Paediatric Endocrinology, De Diego Hospital, Santurce, Puerto Rico
CARMEN A. SÁENZ DE RODRÍGUEZ
Genetic Department, San Juan City and De Santurce
MARÍA A. TORO-SOLÁ
Diego Hospitals,
" XBD=1147 XBD=234 XHG=858 XBD=397 XBD=444 XBD=629 XBD=775 XBD=848 XBD=989 XHG=170 XHG=246 XHG=408 XHG=449 XHG=639 XHG=786 XHG=1002 YBD=1458 YBD=1452 YBD=1460 YBD=1453 YBD=1454 YBD=1461 YBD=1456 YHG=1427>Fig. YHG=1427>2-Cases YHG=1426>of YHG=1431>premature YHG=1427>telarche YHG=1428>and YHG=1428>puberty YHG=1430>1970-81.
" " "" "" " " " " "" " " "" " " " " " " "" "" " " "" "" "" "" "" " "
INTERPRETATION OF FREE THYROXINE RADIOIMMUNOASSAY DATA
XBD=1306XHG=729 XBD=211 XBD=307 XBD=497 XBD=644 XBD=718 XBD=911 XBD=1058 XBD=1147 XBD=1211 XHG=170 XHG=225 XHG=320 XHG=508 XHG=656 XHG=923YBD=1574 XHG=1069 XHG=1158 XHG=1223 YBD=1567 YBD=1575 YBD=1566 YBD=1574 YBD=1566YHG=1536>precocious YHG=1537>2). YHG=1535>Both YHG=1543>premature YHG=1536>telarche YHG=1536>and YHG=1535>puberty YHG=1536>have YHG=1536>the YHG=1545>same XBD=382 XHG=823 XBD=624 XBD=804 XBD=969 XBD=1087 XBD=1142 XBD=1206 XBD=1306 XHG=169 XHG=400 XHG=643 XHG=987YBD=1612 XHG=1103 XHG=1152 XHG=1223 YBD=1617 YBD=1620 YBD=1621 YBD=1620 YBD=1612YHG=1581>different YBD=1611 YHG=1582>distribution, YHG=1582>representing, YHG=1581>probably, YHG=1588>stages YHG=1582>of YHG=1582>the YHG=1591>same XBD=1600 XBD=1746 XBD=1818 XBD=1873 XBD=2017 XBD=2127 XBD=2186 XBD=2227 XBD=2310 XBD=2463 XBD=2532 XHG=1450 XHG=1609 XHG=1756 XHG=1826 XHG=1883 XHG=2026 XHG=2137 XHG=2197 XHG=2239 XHG=2319 XHG=2472 YBD=1638 YBD=1644 YBD=1647 YBD=1639 YBD=1640 YHG=1609>SrR,―Dr YHG=1608>Mardell YHG=1609>and YHG=1609>Dr YHG=1607>Gamlen YHG=1608>(April YHG=1609>24, YHG=1618>p. YHG=1609>973) YHG=1609>conclude YHG=1609>that XBD=296 XHG=788 XBD=366 XBD=454 XBD=537 XBD=564 XBD=692 XBD=779 XBD=965 XBD=1076 XBD=1305 XHG=169 XHG=309 XHG=376 XHG=464 XHG=547 XHG=574 XHG=701 XHG=975YBD=1666 XHG=1087 YBD=1659 YBD=1657 YBD=1658 YBD=1657 YBD=1665 YHG=1628>disease. YHG=1628>We YHG=1628>have YHG=1637>seen YHG=1637>a YHG=1627>patient YHG=1628>with YHG=1635>premature YHG=1627>breast YHG=1628>development XBD=1477 XBD=1657 XBD=1767 XBD=1893 XBD=2053 XBD=2107 XBD=2432 XBD=2532 XHG=1414 XHG=1492 XHG=1671 XHG=1781 XHG=1907 XHG=2066 XHG=2121 XHG=2444 YBD=1685 YBD=1684 YBD=1693 YBD=1694 YHG=1654>free YHG=1655>thyroxine YHG=1654>(FT4) YHG=1655>results YHG=1654>obtained YHG=1655>by YHG=1654>radioimmunoassay YHG=1655>(RIA) XBD=232 XHG=830 XBD=395 XBD=483 XBD=573 XBD=816 XBD=924 XBD=1023 XBD=1098 XBD=1262 XBD=1305 XHG=169 XHG=244 XHG=408 XHG=496 XHG=587 XHG=938YBD=1703 XHG=1038 XHG=1112 XHG=1276 YBD=1704 YBD=1713 YBD=1711 YBD=1711 YBD=1702YHG=1673>levels YBD=1712 YBD=1704 YHG=1673>and YHG=1674>transient YHG=1683>very YHG=1674>high YHG=1673>gonadotropin YHG=1673>(over YHG=1674>200 YHG=1673>mIU/ml) YHG=1681>at XBD=1583 XBD=1696 XBD=1901 XBD=2154 XBD=2284 XBD=2337 XBD=2532 XHG=1414 XHG=1601 XHG=1715 XHG=1920 XHG=2171 XHG=2300 XHG=2355 YBD=1738 YBD=1731 YBD=1730 YBD=1739 YHG=1700>(’Amerlex YHG=1700>FT4’; YHG=1700>Amersham YHG=1701>International) YHG=1700>should YHG=1701>be YHG=1701>interpreted XBD=223 XHG=904 XBD=296 XBD=355 XBD=429 XBD=545 XBD=640 XBD=712 XBD=804 XBD=885 XBD=991 XBD=1111 XBD=1227 XBD=1305 XHG=168 XHG=241 XHG=315 XHG=367 XHG=448 XHG=566 XHG=658 XHG=731 XHG=823 XHG=1010YBD=1758 XHG=1131 XHG=1246 YBD=1751 YBD=1757 YBD=1749 YBD=1750 YBD=1749YHG=1728>years YHG=1720>the YHG=1729>age YHG=1718>of YHG=1727>two YHG=1728>years; YHG=1728>over YHG=1719>the YHG=1727>next YHG=1726>two YHG=1719>breast YHG=1720>tissue YHG=1720>disXBD=1490 XBD=1635 XBD=1747 XBD=1818 XBD=1956 XBD=2030 XBD=2066 XBD=2245 XBD=2479 XBD=2532 XHG=1414 XHG=1510 XHG=1654 XHG=1766 XHG=1838 XHG=1976 XHG=2050 XHG=2085 XHG=2264 XHG=2495 YBD=1784 YBD=1776 YBD=1777 YBD=1785 YHG=1746>with YHG=1746>caution YHG=1746>when YHG=1747>the YHG=1747>patient YHG=1746>has YHG=1756>a YHG=1746>condition YHG=1746>characterised YHG=1747>by XBD=324 XHG=795 XBD=407 XBD=657 XBD=773 XBD=960 XBD=1062 XBD=1142 XBD=1238 XBD=1306 XHG=169 XHG=345 XHG=427 XHG=678 XHG=980YBD=1795 XHG=1082 XHG=1162 XHG=1259 YBD=1803 YBD=1795 YBD=1796 YBD=1795 YHG=1766>appeared YHG=1766>and YHG=1765>gonadotropin YHG=1765>levels YHG=1765>decreased YHG=1764>from YHG=1765>less YHG=1766>than YHG=1765>six XBD=1514 XBD=1776 XBD=1882 XBD=1977 XBD=2141 XBD=2420 XBD=2531 XHG=1413 XHG=1541 XHG=1803 XHG=1909 XHG=2004 XHG=2168 XHG=2448 YBD=1821 YBD=1830 YBD=1822 YBD=1831 YHG=1791>raised YHG=1791>non-esterified YHG=1791>fatty YHG=1792>acid YHG=1792>(NEFA) YHG=1793>concentrations. YHG=1792>They XBD=296 XHG=865 XBD=387 XBD=451 XBD=630 XBD=715 XBD=853 XBD=936 XBD=1021 XBD=1071 XBD=1259 XBD=1305 XHG=169 XHG=309 XHG=398 XHG=463 XHG=645 XHG=728 XHG=947YBD=1849 XHG=1032 XHG=1084 XHG=1273 YBD=1842 YBD=1841 YBD=1840 YBD=1841 YBD=1840 YBD=1846 YBD=1841 YHG=1811>months YHG=1811>after YHG=1811>the YHG=1811>diagnosis. YHG=1810>The YHG=1820>process YHG=1820>may YHG=1811>thus YHG=1810>be YHG=1811>reversible, YHG=1811>in XBD=1537 XBD=1621 XBD=1692 XBD=1771 XBD=1857 XBD=2046 XBD=2139 XBD=2207 XBD=2355 XBD=2531 XHG=1413 XHG=1555 XHG=1639 XHG=1710 XHG=1788 XHG=1876 XHG=2063 XHG=2154 XHG=2224 XHG=2371 YBD=1875 YBD=1867 YBD=1868 YBD=1876 YHG=1844>suggest YHG=1837>that YHG=1837>the YHG=1837>low YHG=1837>FT4 YHG=1838>associated YHG=1838>with YHG=1838>the YHG=1838>amerlex YHG=1838>procedure XBD=256 XHG=409 XBD=353 XBD=395 XBD=493 XHG=169 YBD=1887 XHG=269 XHG=366 YBD=1886 YHG=1857>least. YHG=1866>some YHG=1866>cases YHG=1864>at XBD=1524 XBD=1631 XBD=1707 XBD=1900 XBD=2031 XBD=2186 XBD=2252 XBD=2423 XBD=2531 XHG=1412 XHG=1548 XHG=1654 XHG=1732 XHG=1922 XHG=2055 XHG=2210 XHG=2278 XHG=2446 YBD=1912 YBD=1913 YBD=1921 YBD=1922 YHG=1883>results YHG=1882>from YHG=1883>the YHG=1883>residually YHG=1883>bound YHG=1883>labelled YHG=1883>T4 YHG=1885>analogue YHG=1884>being XBD=381 XHG=808 XBD=558 XBD=655 XBD=793 XBD=990 XBD=1154 XBD=1198 XBD=1302 XHG=200 XHG=396 XHG=574 XHG=669 XHG=1004 XHG=1172 XHG=1214 YBD=1933 YBD=1940 YBD=1932 YBD=1941 YBD=1940 YBD=1938 YBD=1932 YHG=1902>Associated YHG=1903>diagnoses YHG=1912>were YHG=1903>various YHG=1902>syndromes YHG=1902>(Noonan YHG=1903>1, YHG=1902>LeviXBD=1570 XBD=1665 XBD=1817 XBD=1872 XBD=2007 XHG=1412 XHG=1583 XHG=1678 XHG=1830 XHG=1883 YBD=1966 YBD=1958 YBD=1967 YBD=1959 YHG=1928>displaced YHG=1928>from YHG=1929>albumin YHG=1929>by YHG=1928>NEFA. XBD=257 XHG=960 XBD=306 XBD=563 XBD=611 XBD=940 XBD=989 XBD=1302 XHG=165 XHG=281 XHG=327 XHG=583 XHG=630 XHG=1009 YBD=1978 YBD=1984 YBD=1985 YBD=1983 YBD=1986 YHG=1948>Weill YHG=1949>1, YHG=1948>Russell-Silver YHG=1949>2, YHG=1947>McCune-Albright YHG=1948>3, YHG=1948>spondylothoracic XBD=1561 XBD=1665 XBD=1831 XBD=1873 XBD=2061 XBD=2120 XBD=2341 XBD=2441 XBD=2531 XHG=1450 XHG=1570 XHG=1675 XHG=1840 XHG=1883 XHG=2070 XHG=2130 XHG=2349 XHG=2450 YBD=2013 YBD=2004 YBD=2005 YHG=1975>Serum YHG=1975>levels YHG=1974>of YHG=1975>in YHG=1984>pregnancy YHG=1984>are YHG=1974>considerably YHG=1975>above YHG=1975>those NEFA XBD=319 XHG=851 XBD=378 XBD=641 XBD=835 XBD=976 XBD=1022 XBD=1188 XBD=1302 XHG=165 XHG=340 XHG=395 XHG=657 XHG=996YBD=2032 XHG=1039 XHG=1204 YBD=2031 YBD=2024 YBD=2029 YBD=2023 YBD=2031 YHG=1994>dysplasia YHG=1993>1), YHG=1994>cardiovascular YHG=1994>conditions YHG=1994>(ductus YHG=1994>1, YHG=1994>ventrical YHG=1994>septal XBD=1452 XBD=1692 XBD=1843 XBD=1922 XBD=1990 XBD=2129 XBD=2223 XBD=2263 XBD=2424 XBD=2469 XBD=2531 XHG=1413 XHG=1462 XHG=1709 XHG=1861 XHG=1937 XHG=2006 XHG=2146 XHG=2239 XHG=2279 XHG=2439 XHG=2483 YBD=2059 YBD=2056 YBD=2058 YBD=2049 YBD=2050 YHG=2020>of YHG=2027>non-pregnant YHG=2024>women, YHG=2020>and YHG=2021>highest YHG=2020>level YHG=2021>is YHG=2020>observed YHG=2020>in YHG=2021>the XBD=266 XHG=732 XBD=305 XBD=507 XBD=649 XBD=722 XBD=828 XBD=1068 XBD=1120 XBD=1302 XHG=165 XHG=282 XHG=318 XHG=517 XHG=660 XHG=840YBD=2078 XHG=1083 XHG=1133 YBD=2069 YBD=2075 YBD=2077 YBD=2070 YBD=2069 YBD=2077 YHG=2039>defect YHG=2040>1, YHG=2039>pulmonary YHG=2040>stenosis YHG=2040>and YHG=2040>cystic YHG=2040>adenomatosis YHG=2039>1), YHG=2039>iatrogenic XBD=1496 XBD=1689 XBD=1881 XBD=2055 XBD=2107 XBD=2316 XBD=2446 XBD=2530 XHG=1411 XHG=1508 XHG=1704 XHG=1893 XHG=2066 XHG=2119 XHG=2328 XHG=2457 YBD=2104 YBD=2105 YBD=2096 YHG=2067>third YHG=2059>trimester.2 YHG=2066>FT4 YHG=2067>measured YHG=2067>by YHG=2066>equilibrium YHG=2066>dialysis YHG=2076>were XBD=309 XHG=895 XBD=395 XBD=453 XBD=685 XBD=813 XBD=867 XBD=956 XBD=1037 XBD=1103 XBD=1192 XBD=1305 XHG=169 XHG=335 XHG=421 XHG=478 XHG=711 XHG=842 XHG=981YBD=2115 XHG=1067 XHG=1130 XHG=1216 YBD=2114 YBD=2123 YBD=2121 YBD=2123 YBD=2123 YBD=2115 YBD=2116 YHG=2084>illnesses YHG=2085>due YHG=2092>to YHG=2085>(oestrogenic YHG=2095>cream YHG=2085>1, YHG=2086>and YHG=2085>pill YHG=2085>1), levels YHG=2085>and YHG=2086>other XBD=1557 XBD=1600 XBD=1650 XBD=1789 XBD=1975 XHG=1411 XHG=1567 XHG=1612 XHG=1663 XHG=1800 YHG=2113>reported YHG=2119>to YHG=2112>be YHG=2112>slightly YHG=2104>increased XBD=2148 XBD=2201 XBD=2249 XBD=2455 XBD=2531 XHG=2060 XHG=2160 XHG=2212 XHG=2260 XHG=2465 YBD=2142 YBD=2150 YBD=2149 YBD=2141 YHG=2112>those YHG=2112>by YHG=2121>an YHG=2112>equilibrium YHG=2112>RIA XBD=346 XHG=782 XBD=540 XBD=582 XBD=771 XBD=910 XBD=1058 XBD=1098 XBD=1251 XBD=1302 XHG=168 XHG=358 XHG=556 XHG=595 XHG=921YBD=2161 XHG=1073 XHG=1111 XHG=1261 YBD=2160 YBD=2169 YBD=2166 YBD=2161 YBD=2166YHG=2139>tumour YBD=2170 YBD=2169 YHG=2130>conditions YHG=2130>(leukaemia YHG=2131>1, YHG=2131>interstitial YHG=2130>of YHG=2131>1,testes YHG=2131>epilepsy YHG=2132>4). XBD=1747 XBD=1877 XBD=2086 XBD=2226 XBD=2444 XBD=2529 XHG=1411 XHG=1762 XHG=1891 XHG=2102 XHG=2240 XHG=2456 YBD=2196 YBD=2195 YBD=2187 YHG=2158>microencapsulation YHG=2164>system YHG=2157>(’LiquiSol’; YHG=2157>Damon YHG=2157>Diagnostics) YHG=2166>were XBD=261 XHG=835 XBD=351 XBD=417 XBD=661 XBD=733 XBD=824 XBD=966 XBD=1009 XBD=1096 XBD=1257 XBD=1304 XHG=203 XHG=272 XHG=362 XHG=429 XHG=672 XHG=743 XHG=977YBD=2207 XHG=1021 XHG=1107 XHG=1270 YBD=2205 YBD=2215 YBD=2206 YBD=2207 YBD=2207YHG=2177>relation YHG=2176>We YHG=2175>have YHG=2183>not YHG=2176>demonstrated YHG=2186>any YHG=2177>clear YHG=2184>to YHG=2176>food YHG=2177>additives YHG=2187>or XBD=1547 XBD=1593 XBD=1792 XBD=1858 XBD=1921 XBD=2086 XBD=2231 XBD=2309 XBD=2353 XBD=2530 XHG=1411 XHG=1560 XHG=1604 XHG=1806 XHG=1868 XHG=1932 XHG=2099 XHG=2242 XHG=2322 XHG=2363 YBD=2242 YBD=2233 YBD=2240 YBD=2232 YBD=2241 YHG=2196>normal4 YHG=2204>in YHG=2212>pregnancy. YHG=2202>On YHG=2203>the YHG=2210>contrary, YHG=2204>amerlex YHG=2202>FT4 YHG=2203>in YHG=2212>pregnancy XBD=408 XHG=746 XBD=510 XBD=655 XBD=723 XBD=887 XBD=1032 XBD=1151 XBD=1306 XHG=168 XHG=433 XHG=532 XHG=677 XHG=909YBD=2260 XHG=1056 XHG=1176 YBD=2257 YBD=2259 YBD=2251 YBD=2260 YBD=2252 YBD=2260 YHG=2221>contaminants, YHG=2231>even YHG=2222>though YHG=2231>we YHG=2222>strongly YHG=2229>suspect YHG=2222>them. YHG=2222>Dietary XBD=1471 XBD=1642 XBD=1697 XBD=1759 XBD=1946 XHG=1409 XHG=1496 XHG=1665 XHG=1721 XHG=1784 YBD=2287 YHG=2258>was YHG=2249>reported YHG=2255>to YHG=2249>be YHG=2241>reduced. XBD=2225 XBD=2280 XBD=2397 XBD=2529 XHG=2052 XHG=2248 XHG=2303 XHG=2417 YBD=2279 YBD=2277 YBD=2286 YBD=2278 YHG=2248>confirmed YHG=2248>in YHG=2248>thirty YHG=2248>normal XBD=307 XHG=779 XBD=383 XBD=483 XBD=651 XBD=754 XBD=976 XBD=1033 XBD=1128 XBD=1186 XBD=1304 XHG=168 XHG=332 XHG=408 XHG=507 XHG=677 XHG=1002 XHG=1059 XHG=1154 XHG=1211 YBD=2304 YBD=2296 YBD=2305 YBD=2303 YBD=2297 YBD=2297 YBD=2298 YHG=2274>patterns YHG=2276>are YHG=2276>very YHG=2267>variable, YHG=2267>with YHG=2267>commercial YHG=2268>well YHG=2277>as YHG=2268>home XBD=1613 XBD=1693 XBD=1781 XBD=1877 XBD=2005 XBD=2108 XBD=2186 XBD=2343 XBD=2528 XHG=1410 XHG=1640 XHG=1721 XHG=1808 XHG=1905 XHG=2031 XHG=2134 XHG=2213 XHG=2369 YBD=2333 YBD=2324 YBD=2332 YHG=2294>pregnancies YHG=2294>low YHG=2293>FT4 YHG=2293>found YHG=2294>with YHG=2294>the YHG=2294>amerlex YHG=2294>procedure XBD=321 XHG=733 XBD=449 XBD=614 XBD=705 XBD=981 XBD=1124 XBD=1236 XBD=1304 XHG=168 XHG=350 XHG=480 XHG=642 XHG=1010 XHG=1153 XHG=1265 YBD=2351 YBD=2343 YBD=2344 YBD=2343 YHG=2312>prepared YHG=2312>foods. YHG=2312>Genetic YHG=2312>and YHG=2313>environmental YHG=2312>factors YHG=2320>must YHG=2314>be XBD=1733 XBD=2300 XBD=2347 XBD=2443 XBD=2528 XHG=1576 XHG=2157 XHG=2316 XHG=2364 XHG=2459 YBD=2369 YBD=2378 YBD=2370 YHG=2340>4 YHG=2339>pmol/1 YHG=2340>in YHG=2340>eight YHG=2349>nonpmol/l, (10’ 8::!:2’ XBD=338 XHG=899 XBD=381 XBD=452 XBD=706 XBD=887 XBD=956 XBD=1043 XBD=1204 XBD=1229 XBD=1304 XHG=168 XHG=348 XHG=390 XHG=461 XHG=716 XHG=965YBD=2388 XHG=1052 XHG=1212 XHG=1237 YBD=2397 YBD=2387 YBD=2396 YBD=2389 YBD=2389 YBD=2389 YBD=2397 YHG=2358>important YHG=2358>in YHG=2358>this YHG=2359>heterogeneous YHG=2358>condition. YHG=2359>We YHG=2359>have YHG=2359>observed YHG=2368>a YHG=2359>pair XBD=1563 XBD=1704 XBD=1854 XBD=2054 XBD=2223 XBD=2287 XBD=2403 XBD=2488 XBD=2535 XHG=1412 XHG=1577 XHG=1717 XHG=1867 XHG=2070 XHG=2236 XHG=2300 XHG=2416 XHG=2500 YBD=2423 YBD=2422 YBD=2414 YBD=2413 YHG=2392>pregnant YHG=2385>healthy YHG=2384>controls YHG=2384>(p<0-001). YHG=2384>However YHG=2384>the YHG=2384>lowest YHG=2384>level YHG=2383>of XBD=207 XHG=931 XBD=325 XBD=433 XBD=518 XBD=593 XBD=640 XBD=707 XBD=805 XBD=917 XBD=993 XBD=1077 XBD=1139 XBD=1206 XBD=1304 XHG=167 XHG=215 XHG=340 XHG=447 XHG=533 XHG=608 XHG=653 XHG=721 XHG=818 XHG=1006 XHG=1092 XHG=1153 XHG=1220 YBD=2434 YBD=2433 YBD=2435 YBD=2434 YHG=2402>of YHG=2404>female YHG=2403>twins YHG=2404>who YHG=2404>live YHG=2404>in YHG=2404>the YHG=2413>same YHG=2404>house YHG=2404>and YHG=2405>who YHG=2412>eat YHG=2405>the YHG=2414>same XBD=1482 XBD=1554 XBD=1715 XBD=1757 XBD=1873 XBD=1984 XBD=2220 XBD=2284 XBD=2346 XBD=2386 XBD=2445 XBD=2530 XHG=1412 XHG=1493 XHG=1564 XHG=1724 XHG=1767 XHG=1883 XHG=1992 XHG=2229 XHG=2294 XHG=2356 XHG=2394 XHG=2452 YBD=2468 YBD=2459 YBD=2458 YHG=2430>FT4 YHG=2440>was YHG=2430>observed YHG=2430>20-25 YHG=2430>weeks YHG=2429>of YHG=2430>but YHG=2436>not YHG=2430>in YHG=2430>the YHG=2429>third XBD=252 XHG=700 XBD=283 XBD=356 XBD=497 XBD=686 XBD=801 XBD=1046 XBD=1113 XBD=1216 XBD=1304 XHG=167 XHG=272 XHG=300 XHG=370 XHG=510 XHG=817YBD=2479 XHG=1061 XHG=1126 XHG=1229 YBD=2477 YBD=2486 YBD=2487 YBD=2480 YHG=2448>food: YHG=2449>1 YHG=2449>has YHG=2449>marked YHG=2456>premature YHG=2450>breast YHG=2449>development, YHG=2450>thepregnancy, YHG=2450>other YHG=2450>does
and We
mean±SD)
17. 3::!:2.
" XBD=1574 XHG=1411 YBD=2505 YHG=2476>trimester. " XBD=232 XHG=166 YBD=2525 YHG=2502>not.
" " " " " " " " "
XBD=2534 XBD=1591 XBD=1671 XBD=1777 XBD=1867 XBD=2047 XBD=2131 XBD=2244 XBD=2491 XHG=1445 XHG=1600 XHG=1683 XHG=1786 XHG=1877 XHG=2055 XHG=2141 XHG=2252 XHG=2499 YBD=2557 YBD=2550 YBD=2549 YHG=2520>Amerlex YHG=2520>FT4 YHG=2520>levels YHG=2529>were YHG=2520>correlated YHG=2520>with YHG=2529>serum YHG=2520>concentrations YHG=2518>of XBD=290 XHG=739 XBD=535 XBD=615 XBD=721 XBD=986 XBD=1117 XBD=1248 XBD=1303 XHG=202 XHG=306 XHG=553 XHG=631 XHG=1004 XHG=1135 XHG=1264 YBD=2570 YBD=2569 YBD=2570 YBD=2569 YHG=2539>Food YHG=2539>contaminants YHG=2539>and YHG=2540>other YHG=2540>environmental YHG=2539>factors YHG=2540>should YHG=2540>be XBD=2001 XBD=2073 XBD=2166 XBD=2269 XBD=2323 XBD=2526 XHG=1945 XHG=2019 XHG=2090 XHG=2181 XHG=2285 XHG=2333 YBD=2594 YBD=2595 YBD=2602 YHG=2565>but YHG=2571>not YHG=2565>with YHG=2565>those YHG=2564>of YHG=2564>prealbumin. XBD=1550 XBD=1744 XBD=1848 XHG=1410 XHG=1567 XHG=1762 YBD=2603 YHG=2565>albumin YHG=2565>(r=0’609, YHG=2566>p<0 XBD=279 XHG=896 XBD=317 XBD=414 XBD=477 XBD=659 XBD=704 XBD=845 XBD=886 XBD=973 XBD=1092 XBD=1212 XBD=1303 XHG=167 XHG=289 XHG=329 XHG=424 XHG=488 XHG=672 XHG=714 XHG=854 XHG=982YBD=2615 XHG=1104 XHG=1222 YBD=2616 YBD=2620 YBD=2614 YBD=2620 YBD=2614 YHG=2585>looked YHG=2592>at YHG=2585>since YHG=2585>the YHG=2584>incidence, YHG=2585>in YHG=2585>relation YHG=2592>to YHG=2585>total YHG=2585>births, YHG=2584>differs YHG=2584>from XBD=1514 XBD=1665 XBD=1801 XBD=1879 XBD=2024 XBD=2106 XBD=2222 XBD=2303 XBD=2349 XBD=2528 XHG=1410 XHG=1526 XHG=1677 XHG=1813 XHG=1891 XHG=2035 XHG=2118 XHG=2234 XHG=2312 XHG=2361 YBD=2647 YBD=2639 YBD=2648 YBD=2640 YHG=2611>These YHG=2610>findings YHG=2617>suggest YHG=2611>that YHG=2610>amerlex YHG=2610>FT4 YHG=2611>values YHG=2619>may YHG=2611>be YHG=2609>influenced XBD=252 XHG=518 XBD=296 XBD=395 XBD=440 XBD=506 XBD=636 XHG=166 YBD=2667 XHG=264 XHG=309 XHG=407 XHG=452 YBD=2661 YHG=2631>region. YBD=2660 YHG=2638>to YHG=2638>town YHG=2631>in YHG=2631>the XBD=1450 XHG=2425 XBD=1567 XBD=1830 XBD=1882 XBD=2027 XBD=2071 XBD=2153 XBD=2197 XBD=2330 XBD=2412 XBD=2527 XHG=1409 YBD=2685 XHG=1463 XHG=1580 XHG=1843 XHG=1888 XHG=2040 XHG=2084 XHG=2166 XHG=2209 XHG=2344 YBD=2693 YHG=2655>results YBD=2684 YBD=2692 YHG=2656>by YHG=2664>serum YHG=2655>concentrations YHG=2655>of YHG=2655>albumin YHG=2655>well YHG=2665>as YHG=2655>NEFA. YHG=2655>FT4 of Paediatrics,YBD=2729 Department XBD=1556 XBD=1606 XBD=1750 XBD=1831 XBD=1916 XBD=2039 XBD=2085 XBD=2243 XBD=2435 XBD=2526 XHG=1409 XHG=1565 XHG=1616 XHG=1760 XHG=1843 XHG=1925 XHG=2047 XHG=2095 XHG=2251 XHG=2443 YBD=2737 YBD=2730 YBD=2738 YHG=2700>obtained YHG=2700>by YHG=2700>amerlex YHG=2700>FT4 YHG=2700>RIA YHG=2700>should YHG=2700>be YHG=2700>carefully YHG=2700>interpreted YHG=2701>when Ponce School of Medicine, XBD=1461 XBD=1590 XBD=1655 XBD=1682 XBD=1827 XBD=1930 XBD=1979 XBD=2087 XBD=2245 XBD=2287 XBD=2329 XBD=2528 XHG=1408 XHG=1471 XHG=1600 XHG=1666 XHG=1692 XHG=1837 XHG=1940 XHG=1983 XHG=2096 XHG=2256 XHG=2297 XHG=2338 YBD=2781 YBD=2775 YBD=2774 YBD=2783 YHG=2746>the YHG=2745>patient YHG=2745>has YHG=2755>a YHG=2745>reduced YHG=2745>levels YHG=2745>of YHG=2754>serum YHG=2745>albumin, YHG=2755>as YHG=2746>in YHG=2744>non-thyroid ADOLFO PÉREZ COMAS Puerto Rico 00709 Mayaguez,
00 I)
" XBD=1641 XBD=1514 XHG=1527 XHG=1409 YBD=2820 YHG=2790>illness. YHG=2800>severe
ANABOLIC STEROIDS IN MEAT AND PREMATURE TELARCHE
" XBD=1303 XBD=392 XHG=875 XBD=541 XBD=706 XBD=754 XBD=805 XBD=867 XBD=931 XBD=1122 XBD=1261 XHG=201 XHG=401 XHG=551 XHG=715 XHG=763 XHG=815 XHG=940YBD=3061 XHG=1131 XHG=1271 YBD=3068 YBD=3062 YBD=3062 YBD=3062 YHG=3032>SIR,-Your YHG=3033>editorial YHG=3032>of YHG=3033>27 YHG=3042>on YHG=3033>the YHG=3041>use YHG=3032>of YHG=3032>steroids YHG=3033>in March anabolic
" " " " " " "
Laboratory for Clinical Investigation and Departments of Laboratory Medicine and Obstetrics and Gynaecology, Osaka University Medical School, Osaka 553, Japan Central
XBD=1304XHG=904 XBD=219 XBD=310 XBD=509 XBD=581 XBD=629 XBD=716 XBD=853 XBD=895 XBD=951 XBD=1019 XBD=1079 XBD=1163 XHG=166 XHG=229 XHG=320 XHG=518 XHG=591 XHG=632 XHG=727 XHG=863 XHG=963YBD=3106 XHG=1029 XHG=1089 XHG=1171 YBD=3114 YBD=3107 YBD=3106 YBD=3115 YBD=3107 YHG=3079>the YHG=3084>meat YHG=3078>production YHG=3087>was YHG=3076>of YHG=3084>great YHG=3078>interest YHG=3084>to YHG=3087>us. YHG=3076>We YHG=3087>are YHG=3087>very YHG=3078>worried XBD=261 XHG=917 XBD=346 XBD=512 XBD=560 XBD=638 XBD=741 XBD=894 XBD=958 XBD=1032 XBD=1164 XBD=1303 XHG=165 XHG=283 XHG=368 XHG=537 XHG=584 XHG=661 XHG=763 XHG=980YBD=3159 XHG=1055 XHG=1186 YBD=3153 YBD=3160 YBD=3151 YBD=3152 YBD=3151 YBD=3152 YHG=3123>about YHG=3122>this YHG=3122>practice: YHG=3123>it YHG=3123>has YHG=3122>been YHG=3122>allowed YHG=3122>by YHG=3122>the YHG=3122>World YHG=3122>Health XBD=387 XHG=915 XBD=451 XBD=515 XBD=687 XBD=833 XBD=905 XBD=970 XBD=1017 XBD=1146 XBD=1303 XHG=166 XHG=396 XHG=462 XHG=525 XHG=696 XHG=842 XHG=979YBD=3197 XHG=1027 XHG=1156 YBD=3205 YBD=3196 YBD=3197 YBD=3204 YBD=3197 YHG=3167>Organisation YHG=3168>but YHG=3167>the YHG=3176>necessary YHG=3167>controls YHG=3167>will YHG=3174>not YHG=3167>be YHG=3167>strictly YHG=3166>enforced XBD=198 XHG=832 XBD=337 XBD=545 XBD=629 XBD=788 XBD=910 XBD=1103 XBD=1226 XBD=1301 XHG=165 XHG=243 XHG=379 XHG=593 XHG=673 XHG=955YBD=3242 XHG=1148 XHG=1269 YBD=3251 YBD=3243 YBD=3250 YBD=3242 YHG=3213>in YHG=3222>many YHG=3213>countries. YHG=3213>In YHG=3212>Puerto YHG=3212>Rico YHG=3213>products YHG=3212>such YHG=3222>as XBD=473 XHG=917 XBD=600 XBD=681 XBD=825 XBD=895 XBD=985 XBD=1078 XBD=1151 XBD=1302 XHG=164 XHG=494 XHG=620 XHG=701 XHG=845 XHG=1005 XHG=1098 XHG=1172 YBD=3296 YBD=3288 YBD=3287 YBD=3288 YBD=3287 YHG=3257>diethylstilboestrol YHG=3257>(DES) YHG=3258>and YHG=3259>zeranol YHG=3267>are YHG=3258>sold YHG=3267>over YHG=3258>the YHG=3264>counter XBD=297 XHG=916 XBD=327 XBD=513 XBD=742 XBD=813 XBD=903 XBD=995 XBD=1227 XBD=1301 XHG=164 XHG=310 XHG=339 XHG=525 XHG=757 XHG=826 XHG=1008 XHG=1238 YBD=3333 YBD=3340 YBD=3332 YBD=3339 YBD=3332 YHG=3303>without YHG=3312>a YHG=3303>veterinary YHG=3303>prescription. YHG=3303>We YHG=3303>have YHG=3303>been YHG=3302>investigating YHG=3303>this XBD=275 XHG=880 XBD=421 XBD=475 XBD=523 XBD=689 XBD=865 XBD=919 XBD=1104 XBD=1253 XBD=1301 XHG=164 XHG=290 XHG=436 XHG=484 XHG=538 XHG=704 XHG=928YBD=3377 XHG=1118 XHG=1268 YBD=3384 YBD=3385 YBD=3376 YBD=3377 YHG=3355>matter YHG=3348>because YHG=3357>an YHG=3348>alarming YHG=3348>incidence YHG=3347>of YHG=3355>premature YHG=3347>telarche YHG=3348>in
" XBD=380 XBD=278 XHG=292 XHG=164 YBD=3421 YBD=3422 YHG=3392>Rico. YHG=3392>Puerto
" XBD=1153 XBD=1300XHG=886 XBD=323 XBD=389 XBD=471 XBD=537 XBD=648 XBD=724 XBD=872 XBD=963 XHG=198 XHG=336 XHG=403 XHG=485 XHG=550 XHG=664 XHG=738 XHG=976YBD=3467 XHG=1165 YBD=3473 YBD=3466 YBD=3474 YBD=3474 YBD=3467 YHG=3436>During YHG=3437>the YHG=3444>past YHG=3443>ten YHG=3446>years, YHG=3438>375 YHG=3437>patients YHG=3437>with YHG=3444>premature YHG=3437>telarche " XBD=1300 XBD=241 XHG=867 XBD=331 XBD=496 XBD=539 XBD=610 XBD=766 XBD=855 XBD=906 XBD=997 XBD=1090 XBD=1174 XHG=911 XHG=163 XHG=254 XHG=345 XHG=508 XHG=552 XHG=622 XHG=780 XHG=1009 XHG=1102 XHG=1187 YBD=3510 YBD=3519 YBD=3511 YBD=3511 YBD=3520 YHG=3481>have YHG=3482>been YHG=3481>observed YHG=3481>in YHG=3491>our YHG=3481>practice: YHG=3482>85% YHG=3481>of YHG=3482>these YHG=3491>were YHG=3491>seen YHG=3482>during " XBD=1294 XBD=215 XHG=783 XBD=310 XBD=488 XBD=555 XBD=666 XBD=689 XBD=776 XBD=945 XBD=1119 XBD=1210 XBD=1250 XHG=162 XHG=224 XHG=323 XHG=500 XHG=565 XHG=674 XHG=699 XHG=953YBD=3563 XHG=1128 XHG=1218 XHG=1259 YBD=3556 YBD=3562 YBD=3554 YBD=3555 YBD=3556 YBD=3564 YBD=3556 YHG=3526>the YHG=3535>years YHG=3526>1979 YHG=3525>We YHG=3525>found YHG=3536>a YHG=3526>high YHG=3527>incidence YHG=3526>of YHG=3534>cysts YHG=3527>in YHG=3528>61 ovarian - 81.
NOBUYUKI AMINO KEIKO NISHI KIYOSHI MIYAI OSAMU TANIZAWA
1. Block E. Quantitative morphological investigation of follicular system in woman: Variations in different phases of sexual cycle. Acta Endocrinol 1951; 8: 33. 2. Burt RL. Plasma nonesterified fatty acids in normal pregnancy and the puerperium. Obstet Gynecol 1960; 15: 460-64. 3. Yamamoto T, Amino N, Tanizawa O, Doi K, Ichihara K, Azukizawa M, Miyai K. Longitudinal study of serum thyroid hormones, chorionic gonadotrophin and thyrotrophin during and after normal pregnancy. Clin Endocrinol 1979; 10: 459-68 4. Ammo N, Yamada T, Mitsuma T, Nogimori T, Tanizawa O, Kawashima M, Kurachi K, Miyai K Increase in plasma thyrotropin-releasing hormone in normal human pregnancy. J Clin Endocrinol Metab 1981; 53: 1288-90. 5. Midgley JEM, Wilkins TA The direct estimation of free hormones by a simple equilibrium radioimmunoassay. Amersham, Bucks: Amersham International Ltd, 1981