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INTRACORONARY STEM CELL TRANSPLANTATION AFTER ACUTE MYOCARDIAL INFARCTION: A METAANALYSIS OF RANDOMIZED TRIALS
E536 JACC March 27, 2012 Volume 59, Issue 13
Acute Coronary Syndromes INTRACORONARY STEM CELL TRANSPLANTATION AFTER ACUTE MYOCARDIAL INFARCTION: A METAANALYSIS OF RANDOMIZED TRIALS ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 11:00 a.m.-Noon
Session Title: Acute Coronary Syndromes: Clinical XI Abstract Category: 4. Acute Coronary Syndromes: Therapy Presentation Number: 1170-350 Authors: Param Puneet Singh, Sasikanth Adigopula, Mukesh Singh, Vamsi Kodumuri, Rohit Arora, Sandeep Khosla, Chicago Medical School/RFUMS, North Chicago, IL, USA Background: Over the past decade, many trials have suggested that intracoronary stem cell transplantation therapy can improve cardiac function after acute myocardial infarction (AMI). However, many clinical studies evaluating the role of intracoronary stem cells in post-AMI patients have yielded mixed Results: Hence, a meta-analysis was done to ascertain the influence of intracoronary stem cell transplantation in patients after AMI on left ventricular function and volumes. Methods: A total of 17 randomized trials involving 969 patients (control group, 437 patients; stem cell group, 532 patients) were identified. Primary end point analyzed was change in global left ventricular ejection fraction (LVEF) comparing baseline and follow up measurements. Secondary end point was change in left ventricular end-diastolic volume (LVEDV). Standard difference in means (SDIM) across all studies and 95% confidence intervals (CI) were computed. A two-sided alpha error of less than 0.05 was considered to be statistically significant. Results: The baseline characteristics were similar in both groups. The intracoronary stem cell transplantation therapy in post-AMI patients significantly increased LVEF (SDIM: 0.598, CI: 0.304-0.892; p value <0.001). Also, LVEDV was significantly decreased in patients receiving stem cell therapy (SDIM: -0.267, CI: -0.47 to -0.06; p value = 0.01).
Conclusions: Intracoronary stem cell transplantation therapy after AMI significantly improves cardiac function.
Acute Coronary Syndromes INTRACORONARY STEM CELL TRANSPLANTATION AFTER ACUTE MYOCARDIAL INFARCTION: A METAANALYSIS OF RANDOMIZED TRIALS ACC Moderated Poster Contributions McCormick Place South, Hall A Sunday, March 25, 2012, 11:00 a.m.-Noon
Session Title: Acute Coronary Syndromes: Clinical XI Abstract Category: 4. Acute Coronary Syndromes: Therapy Presentation Number: 1170-350 Authors: Param Puneet Singh, Sasikanth Adigopula, Mukesh Singh, Vamsi Kodumuri, Rohit Arora, Sandeep Khosla, Chicago Medical School/RFUMS, North Chicago, IL, USA Background: Over the past decade, many trials have suggested that intracoronary stem cell transplantation therapy can improve cardiac function after acute myocardial infarction (AMI). However, many clinical studies evaluating the role of intracoronary stem cells in post-AMI patients have yielded mixed Results: Hence, a meta-analysis was done to ascertain the influence of intracoronary stem cell transplantation in patients after AMI on left ventricular function and volumes. Methods: A total of 17 randomized trials involving 969 patients (control group, 437 patients; stem cell group, 532 patients) were identified. Primary end point analyzed was change in global left ventricular ejection fraction (LVEF) comparing baseline and follow up measurements. Secondary end point was change in left ventricular end-diastolic volume (LVEDV). Standard difference in means (SDIM) across all studies and 95% confidence intervals (CI) were computed. A two-sided alpha error of less than 0.05 was considered to be statistically significant. Results: The baseline characteristics were similar in both groups. The intracoronary stem cell transplantation therapy in post-AMI patients significantly increased LVEF (SDIM: 0.598, CI: 0.304-0.892; p value <0.001). Also, LVEDV was significantly decreased in patients receiving stem cell therapy (SDIM: -0.267, CI: -0.47 to -0.06; p value = 0.01).
Conclusions: Intracoronary stem cell transplantation therapy after AMI significantly improves cardiac function.