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Intracranial nasal dermoid sinus cysts: Computed tomographic scan findings and surgical results
Abstracts /Int.
256
J. Pediatr.
Otorhinolaryngol.
30 (1994) 253-267
significant lod score values for linkage to either USHIB or USHIC were found in this group. With regard to US1 families of other geographic origin (Normandy and Northern France, 11 families), nonsignificant lod scores for linkage to chromosome llq13.5 were observed (Z(max) = 1.83 and Z(max) = 2.23 at lgq = IO for probes Zd5 and AFMl85ya1, respectively, at loci DllS527 and Dl lS916, respectively). However, the HOMOG test suggested that USHIB might account for the disease in 9/l 1 families in our series (families IO- 19), the latter two families possibly being accounted for by USHIC (maximum likelihood for heterogeneity = 7.91 in In L; heterogeneity versus homogeneity, P = 0.01; heterogeneity versus nonlinkage, P < 0.01). The present study supports the view that Usher syndrome type 1 is a genetically heterogeneous condition that is caused by at least three genes and possibly many more. Intracranial nasal dermoid sinus cysts: Computed tomographic scan fiadiogs nod surgical results Posnick J.C.; RortoluxxiP.; Armstrong D.C.; Drake J.M.; Bartlett S.P. PLAST.
RECONSTR.
SURG.
(USA)
(1994) 9314 (745-756)
From July 1987 to January 1991, 14 patients, ages 1 to 19 years (mean 6 years), were seen with nasal dermoid sinus cysts, a congenital lesion with the potential for intracranial extension. Each patient was assessed clinically for cyst location, symptoms, associated craniofacial deformity and other congenital anomalies. In 5 (36%) of the 14 patients, ages 4 to 48 months (mean 25 months), computed tomographic scans indicated indirect signs of intracranial extension, which were confirmed intraoperatively and histologically in all 5 patients. After neurosurgical consultation, a combined single-stage intracranialextracranial approach was used to excise the lesion. No perioperative complications occurred. Clinical assessment (follow-up 20 to 40 months, mean 31 months), confirmed by postoperative CT scan 1 year after surgery, indicated no evidence of recurrence, residual skeletal contour defects, or deformity; forehead and nasal growth were qualitatively normal, and scar appearance was satisfactory. Our experience indicates that intracranial extension of nasal dermoid sinus cysts seen at a tertiary care referral center are not rare, that computed tomography scan permits accurate diagnosis, and that the single-stage intracranial-extracranial approach to resection is effective and results in minimal morbidity. Clinical efficacy of antimicrobial drugs for acute otitis media: Metaaaalysis of 5400 children from tkirtythree randomized trials Rosenfeld R.M.; Vertrees A.J.E.; Carr J.; Cipoile R.J.; Uden D.L.; Giebiok G.S.; Canafax D.M. J. PEDIATR.
(USA)
(1994) 124/3 (355-367)
Objective: To reconcile conflicting published reports concerning the absolute and comparative clinical efficacy of antimicrobial drugs for acute otitis media in children. Study selection: Articles were identitied by MEDLINE search, Current Contents, and references from review articles, textbook chapters, and retrieved reports. Randomized, controlled trials of therapeutic antimicrobial drugs used in the initial empiric therapy for simple acute otitis media were selected by independent, blinded observers, and scored on 11 measures of study validity. Thirty English and three foreign-language articles met all inclusion criteria. Data extraction: Data were abstracted for an end point of complete clinical resolution (primary control), exclusive of middle ear effusion, within 7 to 14 days after therapy started. Data synthesis: The spontaneous rate of primary control - without antibiotics or tympanocentesis - was 81% (95”/0confidence interval, 69 to 94%). Compared with placebo or no drug, antimicrobial therapy increased primary control by 13.7% (95% confidence interval, 8.2% to 19.2%). No significant differences were found in the comparative efficacy of various antimicrobial agents. Extending antimicrobial coverage to include, fl-lactamase-producing organisms did not significantly increase the rates of primary control or resolution of middle ear effusion. Pretreatment tympanocentesis was positively associated with individual group primary control rates, negatively associated with the ability to detect differences in clinical efficacy and unassociated with resolution of MEE. Conclusions: Antimicrobial drugs have a modest but significant impact on the primary control of acute otitis media. Treatment with &lactamase-stable agents does not increase resolution of acute symptoms or middle ear effusion; initial therapy should be guided by considerations of safety, tolerability, and affordability, and not by the theoretical advantage of an extended antibacterial spectrum. Facial growth and developmentduring puberty in unilateral cleft lip and palate: A longitudinal study Smakel Z.; Mullerova Z. J. CRANIOFAC.
GENET.
DEV. MOL.
(CZE)
(1994) 14/l (57-68)
Roentgencephalometry was used for longitudinal assessment of facial growth and development in 20 boys
256
J. Pediatr.
Otorhinolaryngol.
30 (1994) 253-267
significant lod score values for linkage to either USHIB or USHIC were found in this group. With regard to US1 families of other geographic origin (Normandy and Northern France, 11 families), nonsignificant lod scores for linkage to chromosome llq13.5 were observed (Z(max) = 1.83 and Z(max) = 2.23 at lgq = IO for probes Zd5 and AFMl85ya1, respectively, at loci DllS527 and Dl lS916, respectively). However, the HOMOG test suggested that USHIB might account for the disease in 9/l 1 families in our series (families IO- 19), the latter two families possibly being accounted for by USHIC (maximum likelihood for heterogeneity = 7.91 in In L; heterogeneity versus homogeneity, P = 0.01; heterogeneity versus nonlinkage, P < 0.01). The present study supports the view that Usher syndrome type 1 is a genetically heterogeneous condition that is caused by at least three genes and possibly many more. Intracranial nasal dermoid sinus cysts: Computed tomographic scan fiadiogs nod surgical results Posnick J.C.; RortoluxxiP.; Armstrong D.C.; Drake J.M.; Bartlett S.P. PLAST.
RECONSTR.
SURG.
(USA)
(1994) 9314 (745-756)
From July 1987 to January 1991, 14 patients, ages 1 to 19 years (mean 6 years), were seen with nasal dermoid sinus cysts, a congenital lesion with the potential for intracranial extension. Each patient was assessed clinically for cyst location, symptoms, associated craniofacial deformity and other congenital anomalies. In 5 (36%) of the 14 patients, ages 4 to 48 months (mean 25 months), computed tomographic scans indicated indirect signs of intracranial extension, which were confirmed intraoperatively and histologically in all 5 patients. After neurosurgical consultation, a combined single-stage intracranialextracranial approach was used to excise the lesion. No perioperative complications occurred. Clinical assessment (follow-up 20 to 40 months, mean 31 months), confirmed by postoperative CT scan 1 year after surgery, indicated no evidence of recurrence, residual skeletal contour defects, or deformity; forehead and nasal growth were qualitatively normal, and scar appearance was satisfactory. Our experience indicates that intracranial extension of nasal dermoid sinus cysts seen at a tertiary care referral center are not rare, that computed tomography scan permits accurate diagnosis, and that the single-stage intracranial-extracranial approach to resection is effective and results in minimal morbidity. Clinical efficacy of antimicrobial drugs for acute otitis media: Metaaaalysis of 5400 children from tkirtythree randomized trials Rosenfeld R.M.; Vertrees A.J.E.; Carr J.; Cipoile R.J.; Uden D.L.; Giebiok G.S.; Canafax D.M. J. PEDIATR.
(USA)
(1994) 124/3 (355-367)
Objective: To reconcile conflicting published reports concerning the absolute and comparative clinical efficacy of antimicrobial drugs for acute otitis media in children. Study selection: Articles were identitied by MEDLINE search, Current Contents, and references from review articles, textbook chapters, and retrieved reports. Randomized, controlled trials of therapeutic antimicrobial drugs used in the initial empiric therapy for simple acute otitis media were selected by independent, blinded observers, and scored on 11 measures of study validity. Thirty English and three foreign-language articles met all inclusion criteria. Data extraction: Data were abstracted for an end point of complete clinical resolution (primary control), exclusive of middle ear effusion, within 7 to 14 days after therapy started. Data synthesis: The spontaneous rate of primary control - without antibiotics or tympanocentesis - was 81% (95”/0confidence interval, 69 to 94%). Compared with placebo or no drug, antimicrobial therapy increased primary control by 13.7% (95% confidence interval, 8.2% to 19.2%). No significant differences were found in the comparative efficacy of various antimicrobial agents. Extending antimicrobial coverage to include, fl-lactamase-producing organisms did not significantly increase the rates of primary control or resolution of middle ear effusion. Pretreatment tympanocentesis was positively associated with individual group primary control rates, negatively associated with the ability to detect differences in clinical efficacy and unassociated with resolution of MEE. Conclusions: Antimicrobial drugs have a modest but significant impact on the primary control of acute otitis media. Treatment with &lactamase-stable agents does not increase resolution of acute symptoms or middle ear effusion; initial therapy should be guided by considerations of safety, tolerability, and affordability, and not by the theoretical advantage of an extended antibacterial spectrum. Facial growth and developmentduring puberty in unilateral cleft lip and palate: A longitudinal study Smakel Z.; Mullerova Z. J. CRANIOFAC.
GENET.
DEV. MOL.
(CZE)
(1994) 14/l (57-68)
Roentgencephalometry was used for longitudinal assessment of facial growth and development in 20 boys