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Intradermal tests with recall antigens in acne patients
Sl88
Posters -Acne
and related
in 6, Staphylococcus albus in 2 and Staphylococcus epidermidis in 4 patients. Patients with severe forms of acne-who failed former cures were treated with the Corynebacterium parvum vaccine, for 6 weeks, every other 3 days. Good and efficient long-term results were found after this treatment, as compared with prior cures. 0P5
The results of intermittent isotretinoin treatment in adults with acne vulgaris
G. Broniarczyk-Dyta, C. Arkuszewska, E. Joss-Wichman. of Dernratology arrd Veneomlogy, Medical of Mdi Poland
Departmeat University
Acne vulgaris is a common problem not only among young people but also for persons aged over 25. 30 patients (I8 women and I2 men) over the age of 25 were included in the study. They were all previously treated with antibiotics or continuous isotretinoin. We decided to administer isotretinoin in an intermittent way because of unsatisfactory results of previous treatment or recurrence of lesions. The patients received isotretinoin in daily dose of 0.5 mg/kg for 7 consecutive days of a month. Such treatment was repeated 6 times with 3 week intervals between each course of therapy. In 22 (73%) from 30 treated patients very good and good results of therapy were obtained. It should be stressed that the drug was very well tolerated by all patients. The only side effect observed was cheilitis, without any deviations in laboratory tests. This study suggests that intermittent isotrtinoin can be used in treatment of acne vulgaris in adults. Further observation is necessary in order to prove a long term efficacy of this method. 0 P6
An experimental model of skin irritation with benzoyl peroxide: Effect of anti-irritant skin care for skin prone to acne
P Msika’, M.A. Alonso2, F. M&ot2, P Masson2. ‘Lab. Pharmascience,
Courbevoie;
2Evic-Ceba.
Blanqaefort,
France
Skin irritation related to treatment with topical acne preparations was studied in vitro in an experimental model with application of 10% benzoyl peroxide on reconstituted human epidermis (Episkin R). The latter is characterized by extensive release of ILlAlpha in the supematant medium (170 pg/ml) and by significantly reduced cell viability (4%). “Iwo products, A (anti-shine lotion) and B (cleansing cream) containing Dimethyl Oxobenzo Dioxasilane (DOD), an immunomodulator cytoprotective active ingredient were tested. Observations of pre and post-treatment findings with product A in pure form and diluted to 50% concentration, revealed an increase in cell viability (23 and 29% respectively) and a major reduction in levels of ILlAlpha release produced by benzoyl peroxide (52 and 55 pg/ml respectively). Product B diluted to 0.5 and 0.1% concentration acted only on a decrease in IL I Alpha levels ( I22 and 96 pg/ml). Conclusion: this study confrms the anti-irritant action of the two products tested and improved compliance with topical acne medications may be anticipated.
IP7
disorders
lntradermal patients
tests with recall antigens
J. RaEovski, V. Semridova. Is!. Dept. of Dertnalology, Hospital
St. Ann,
Brtlo,
Czech
in acne Facalty
Republic
The aim of the study is to judge the state of cellular immunity in vivo in approachable way of intradermal tests with recall antigens in the group of patients with the various forms of acne vulg. and conglobata. We used the set of antigens (Immunoskin tests SEVAC, Prague) contained tuberculin, toxoplasmin. candidin, tetanic and diphteric antigens. The index of “intradermal cutaneous testing-ICY was calculated. Generally we examined 216 patients. In the group of patients with acne papulopustulosa (n = 96) was average ICT 1.22 ZIZ1.13, with acne cystica (n = 48) 1.08 f 0.93, with acne conglobata mild form (n = 43) 0.70 f 0.10 and with acne conglobata severe form (n = 29) 0.30 f 0.10. Decreasing of the index value corresponded with the severity of the disease. The average value of ICT in the select group of healthy people was 2.21 f 0.72. The differences between healthy controls and all groups of acne patients are significant (p < 0.01; ANOVA). 0 P8 Treatment of acne scars with glycolic acid 70% Th. Koussidou, F. Boutli. G. Chaidemenos, G. Karakatsanis. 0. Mourellou. Stare Hospital for Skin and Venereal Diseases, Thessalotliki,
Greece
During one year period (January 1977-98) 80 patients were treated for acne scars in our Hospital. The majority of the patients were. female between I6 and 25 years of age. The scars were mostly located on the cheeks. All the patients were treated with sessions of peelings every two weeks. Full strength 70% glycolic acid caused epidermolysis in 3 to 7 minutes, depending on skin and thickness of the stratum comeum. The number of the sessions that were necessary to get the desired effect oscillated between 5 to I2 sessions. Marked improvement was noticed by the proper patient between the 3ti and the 51h session. The desired improvement was depending on the depth and the number of the scars as well as the degree of satisfaction of the patients. The majority required 6 to I2 sessions. References [I] Brody J.H. Chemical peeling. Mosby-year book Inc. St. Louis, 1922; p 66-68. [2] Van Scott E.J. Alpha hydroxy acids. Procedures for the use in clinical practice. Cutis, 1989: 43: 222-228. 0P9
Treatment of acne with intermittent isotretinoin, cohort study
F. Boutli, Th. Koussidou, G.Ch. Chaidemenos. 0. Mourellou, I. Lefaki, G. Karakatsanis. State Hospital for Skin aad Venereal Diseases,
Thessaloniki,
Greece
Isotretinoin has completely changed the treatment of acne. Its principal use was the treatment of severe nodular acne. In recent years isotretinoin is also prescribed to treat patients with moderate and mild acne unresponsive to antibiotic therapy and especially when associated with dysmor-phophobia or scaring. 80 patients in our dermatological department suffered mild aone
Posters -Acne
and related
in 6, Staphylococcus albus in 2 and Staphylococcus epidermidis in 4 patients. Patients with severe forms of acne-who failed former cures were treated with the Corynebacterium parvum vaccine, for 6 weeks, every other 3 days. Good and efficient long-term results were found after this treatment, as compared with prior cures. 0P5
The results of intermittent isotretinoin treatment in adults with acne vulgaris
G. Broniarczyk-Dyta, C. Arkuszewska, E. Joss-Wichman. of Dernratology arrd Veneomlogy, Medical of Mdi Poland
Departmeat University
Acne vulgaris is a common problem not only among young people but also for persons aged over 25. 30 patients (I8 women and I2 men) over the age of 25 were included in the study. They were all previously treated with antibiotics or continuous isotretinoin. We decided to administer isotretinoin in an intermittent way because of unsatisfactory results of previous treatment or recurrence of lesions. The patients received isotretinoin in daily dose of 0.5 mg/kg for 7 consecutive days of a month. Such treatment was repeated 6 times with 3 week intervals between each course of therapy. In 22 (73%) from 30 treated patients very good and good results of therapy were obtained. It should be stressed that the drug was very well tolerated by all patients. The only side effect observed was cheilitis, without any deviations in laboratory tests. This study suggests that intermittent isotrtinoin can be used in treatment of acne vulgaris in adults. Further observation is necessary in order to prove a long term efficacy of this method. 0 P6
An experimental model of skin irritation with benzoyl peroxide: Effect of anti-irritant skin care for skin prone to acne
P Msika’, M.A. Alonso2, F. M&ot2, P Masson2. ‘Lab. Pharmascience,
Courbevoie;
2Evic-Ceba.
Blanqaefort,
France
Skin irritation related to treatment with topical acne preparations was studied in vitro in an experimental model with application of 10% benzoyl peroxide on reconstituted human epidermis (Episkin R). The latter is characterized by extensive release of ILlAlpha in the supematant medium (170 pg/ml) and by significantly reduced cell viability (4%). “Iwo products, A (anti-shine lotion) and B (cleansing cream) containing Dimethyl Oxobenzo Dioxasilane (DOD), an immunomodulator cytoprotective active ingredient were tested. Observations of pre and post-treatment findings with product A in pure form and diluted to 50% concentration, revealed an increase in cell viability (23 and 29% respectively) and a major reduction in levels of ILlAlpha release produced by benzoyl peroxide (52 and 55 pg/ml respectively). Product B diluted to 0.5 and 0.1% concentration acted only on a decrease in IL I Alpha levels ( I22 and 96 pg/ml). Conclusion: this study confrms the anti-irritant action of the two products tested and improved compliance with topical acne medications may be anticipated.
IP7
disorders
lntradermal patients
tests with recall antigens
J. RaEovski, V. Semridova. Is!. Dept. of Dertnalology, Hospital
St. Ann,
Brtlo,
Czech
in acne Facalty
Republic
The aim of the study is to judge the state of cellular immunity in vivo in approachable way of intradermal tests with recall antigens in the group of patients with the various forms of acne vulg. and conglobata. We used the set of antigens (Immunoskin tests SEVAC, Prague) contained tuberculin, toxoplasmin. candidin, tetanic and diphteric antigens. The index of “intradermal cutaneous testing-ICY was calculated. Generally we examined 216 patients. In the group of patients with acne papulopustulosa (n = 96) was average ICT 1.22 ZIZ1.13, with acne cystica (n = 48) 1.08 f 0.93, with acne conglobata mild form (n = 43) 0.70 f 0.10 and with acne conglobata severe form (n = 29) 0.30 f 0.10. Decreasing of the index value corresponded with the severity of the disease. The average value of ICT in the select group of healthy people was 2.21 f 0.72. The differences between healthy controls and all groups of acne patients are significant (p < 0.01; ANOVA). 0 P8 Treatment of acne scars with glycolic acid 70% Th. Koussidou, F. Boutli. G. Chaidemenos, G. Karakatsanis. 0. Mourellou. Stare Hospital for Skin and Venereal Diseases, Thessalotliki,
Greece
During one year period (January 1977-98) 80 patients were treated for acne scars in our Hospital. The majority of the patients were. female between I6 and 25 years of age. The scars were mostly located on the cheeks. All the patients were treated with sessions of peelings every two weeks. Full strength 70% glycolic acid caused epidermolysis in 3 to 7 minutes, depending on skin and thickness of the stratum comeum. The number of the sessions that were necessary to get the desired effect oscillated between 5 to I2 sessions. Marked improvement was noticed by the proper patient between the 3ti and the 51h session. The desired improvement was depending on the depth and the number of the scars as well as the degree of satisfaction of the patients. The majority required 6 to I2 sessions. References [I] Brody J.H. Chemical peeling. Mosby-year book Inc. St. Louis, 1922; p 66-68. [2] Van Scott E.J. Alpha hydroxy acids. Procedures for the use in clinical practice. Cutis, 1989: 43: 222-228. 0P9
Treatment of acne with intermittent isotretinoin, cohort study
F. Boutli, Th. Koussidou, G.Ch. Chaidemenos. 0. Mourellou, I. Lefaki, G. Karakatsanis. State Hospital for Skin aad Venereal Diseases,
Thessaloniki,
Greece
Isotretinoin has completely changed the treatment of acne. Its principal use was the treatment of severe nodular acne. In recent years isotretinoin is also prescribed to treat patients with moderate and mild acne unresponsive to antibiotic therapy and especially when associated with dysmor-phophobia or scaring. 80 patients in our dermatological department suffered mild aone