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Intraoperative digital specimen mammography: The effect on re-excision rates.
648 they were either ‘not at all prepared’ or ‘not very prepared’ to integrate aesthetic surgery to their independent practice. Conclusion: Our current national training programme needs additional dedicated aesthetic surgical training and competency assessments as it currently relies on self-directed learning that is associated with a lack of senior trainee confidence. Recognition of the limitations of the current model should help shape the future of aesthetic surgery national training programmes. http://dx.doi.org/10.1016/j.ejso.2014.02.128
P129. Nipple sensation and function following breast reduction with full thickness free nipple grafting. Julia Henderson, Maria Bramley, Janet Walls North Manchester General Hospital, Manchester, UK Introduction and aims: Women with macromastia and a sternal notch to nipple distance of greater than 40cm are at risk of nipple loss using a pedicled reduction technique. We present our experience of using a breast amputating technique with a dermoglandular flap to reshape the breast and a full thickness free nipple graft. Materials and Methods: All patients who underwent breast reduction with full thickness free nipple grafting (FTFNG) between January 2007 and January 2013 were identified alongside a consecutive group of patients who underwent an inferior pedicle (IP) reduction during the same period. Patient demographics, co-morbidities, operative details and complications were collected from case notes. A postal questionnaire regarding nipple appearance, sensation and function was sent to all patients. Results: 32 patients were identified, 16 had FTFNG reduction. Mean specimen weight was 1036g (range 415-2903g) for FTFNG and 544g (range 268-900g) for IP reductions. Three patients in the FNG group suffered partial nipple loss, three underwent tattoing for loss of pigmentation. No patients suffered complete nipple areolar complex loss. 19 patients responded to the questionnaire, 50% from each group. Half of the FTFNG patients reported normal nipple sensation and function in comparison to all of the respondents in the IP reduction group. Conclusions: Breast reduction with full thickness free nipple grafting is a safe procedure for women with macromastia who might be at risk of nipple loss with a pedicled technique. It can be performed with a low risk of complications and in some cases nipple sensation and function will return post operatively. http://dx.doi.org/10.1016/j.ejso.2014.02.129
P130. The rate of One Step Nucleic Acid Amplification (OSNA) positive micro-metastases and additional histopathological NSLN metastases: Results from a single institution over 53 months Mahwash Babar1, Farrokh Pakzad1, Tracey Irvine1, Mark Kissin1, Graham Layer2, Peter Jackson1 1 Royal Surrey County Hospital, Guildford, UK 2 University of Surrey, Guildford, UK Introduction: OSNA, a highly sensitive assay of cytokeratin 19 mRNA, is used intra-operatively for the detection of sentinel lymph node (SLN) macro- and micro-metastases in breast cancer. The clinical significance of micro-metastases and subsequent axillary surgery is currently under debate. Aim: To review the rate of micro-metastases and further NSLN metastases in our unit over a period of 53 months. Methods: Data was collected prospectively (01/12/2008 to 31/05/ 2013) for all eligible patients (clinical and radiological negative axilla). SLN biopsy was performed using blue dye and radioisotope. Patients with micro-metastases (+) underwent level I and those
ABSTRACTS with macro-metastases (++) had level II/III axillary nodal dissection (AND). Results: 1008 patients had 2151 SLN analysed. 336 (34%) were OSNA positive and had further AND. Of these, 152 (45%) had macrometastases (++) and 184 (55%) had micro-metastases (+). A quarter of OSNA positive (85/336) had positive NSLN, with (++) having 38% (57/152) and (+) having 15% (28/184) further positive NLSNs (p<0.05). The ratio of positive SLN/harvested SLN showed a linear correlation with positive NSLNs in both micro- and macro-metastases. In micro-metastases, 5.4% (10/184) had overall nodal count of >4, needing adjuvant radiotherapy and the positive SLN/SLN ratio in these patients (>4 positive nodes) also showed a linear trend towards positive NSLNs. Conclusion: Our study reflects the tumour burden of NSLNs based on the molecular analysis of the SLN. Prospective long-term follow-up data will facilitate the identification of factors that predict the NSLN metastases, allowing accurate calculation of the axillary tumour burden, particularly in patients with micro-metastases. http://dx.doi.org/10.1016/j.ejso.2014.02.130
P131. Intraoperative digital specimen mammography: The effect on re-excision rates. Catherine Zabkiewicz, Fawad Muhammad, Minn Lwin Betsi Cadwaladr University Health Board, North Wales, UK Introduction: This study examines the effect on re-operation rates with the introduction of Intraoperative Digital Specimen Mammography (IDSM) compared to Standard Specimen Mammography (SSM) in patients undergoing breast conserving surgery. Method: In this retrospective cohort study 218 consecutive patients underwent breast conserving surgery at a single hospital. Data on single and multiple re-operation rates were collected for two surgeons. Results: SSM was used in 99 patients in the year prior to introduction of IDSM, and IDSM was used in 119 patients the year after. Rates of further operation for re-excision of positive margins were similar using SSM and IDSM (22% vs 28% p¼0.35).Re-operative rates were not significantly different between individual surgeons (26% vs 25% p¼0.88). Conclusion: ISDM was introduced in place of SSM at this satellite hospital as part of reconfiguration of radiology services. Previous studies suggest surgeon evaluated IDSM is comparable in accuracy to SSM, and there is postulation that IDSM can reduce the number of positive margins. However, this has not translated to evidence of reduced re operation rates. Our study supports this evidence that the use of ISDM has not significantly reduced re-operation rates. http://dx.doi.org/10.1016/j.ejso.2014.02.131
P132. The use of OSNA in the management of the axilla for DCIS Susan Hignett, Uma Sridharan, Elizabeth Kane, Susanah Shore, Alison Waghorn, Christopher Holcombe The Royal Liverpool University Hospital, Liverpool, UK Aim: With DCIS, metastatic spread to the axilla is unusual. However patients are having to return to theatre for further breast and axillary surgery if an invasive component is identified. Our aim was to review how many patients with DCIS had a positive Sentinel Node. Method: Data was collected retrospectively from Jan 2005 to October 2013 for all patients undergoing sentinel node biopsy with an initial diagnosis of DCIS. All patients with extensive calcification underwent mastectomy with sentinel node biopsy regardless of microinvasion. Results:
P129. Nipple sensation and function following breast reduction with full thickness free nipple grafting. Julia Henderson, Maria Bramley, Janet Walls North Manchester General Hospital, Manchester, UK Introduction and aims: Women with macromastia and a sternal notch to nipple distance of greater than 40cm are at risk of nipple loss using a pedicled reduction technique. We present our experience of using a breast amputating technique with a dermoglandular flap to reshape the breast and a full thickness free nipple graft. Materials and Methods: All patients who underwent breast reduction with full thickness free nipple grafting (FTFNG) between January 2007 and January 2013 were identified alongside a consecutive group of patients who underwent an inferior pedicle (IP) reduction during the same period. Patient demographics, co-morbidities, operative details and complications were collected from case notes. A postal questionnaire regarding nipple appearance, sensation and function was sent to all patients. Results: 32 patients were identified, 16 had FTFNG reduction. Mean specimen weight was 1036g (range 415-2903g) for FTFNG and 544g (range 268-900g) for IP reductions. Three patients in the FNG group suffered partial nipple loss, three underwent tattoing for loss of pigmentation. No patients suffered complete nipple areolar complex loss. 19 patients responded to the questionnaire, 50% from each group. Half of the FTFNG patients reported normal nipple sensation and function in comparison to all of the respondents in the IP reduction group. Conclusions: Breast reduction with full thickness free nipple grafting is a safe procedure for women with macromastia who might be at risk of nipple loss with a pedicled technique. It can be performed with a low risk of complications and in some cases nipple sensation and function will return post operatively. http://dx.doi.org/10.1016/j.ejso.2014.02.129
P130. The rate of One Step Nucleic Acid Amplification (OSNA) positive micro-metastases and additional histopathological NSLN metastases: Results from a single institution over 53 months Mahwash Babar1, Farrokh Pakzad1, Tracey Irvine1, Mark Kissin1, Graham Layer2, Peter Jackson1 1 Royal Surrey County Hospital, Guildford, UK 2 University of Surrey, Guildford, UK Introduction: OSNA, a highly sensitive assay of cytokeratin 19 mRNA, is used intra-operatively for the detection of sentinel lymph node (SLN) macro- and micro-metastases in breast cancer. The clinical significance of micro-metastases and subsequent axillary surgery is currently under debate. Aim: To review the rate of micro-metastases and further NSLN metastases in our unit over a period of 53 months. Methods: Data was collected prospectively (01/12/2008 to 31/05/ 2013) for all eligible patients (clinical and radiological negative axilla). SLN biopsy was performed using blue dye and radioisotope. Patients with micro-metastases (+) underwent level I and those
ABSTRACTS with macro-metastases (++) had level II/III axillary nodal dissection (AND). Results: 1008 patients had 2151 SLN analysed. 336 (34%) were OSNA positive and had further AND. Of these, 152 (45%) had macrometastases (++) and 184 (55%) had micro-metastases (+). A quarter of OSNA positive (85/336) had positive NSLN, with (++) having 38% (57/152) and (+) having 15% (28/184) further positive NLSNs (p<0.05). The ratio of positive SLN/harvested SLN showed a linear correlation with positive NSLNs in both micro- and macro-metastases. In micro-metastases, 5.4% (10/184) had overall nodal count of >4, needing adjuvant radiotherapy and the positive SLN/SLN ratio in these patients (>4 positive nodes) also showed a linear trend towards positive NSLNs. Conclusion: Our study reflects the tumour burden of NSLNs based on the molecular analysis of the SLN. Prospective long-term follow-up data will facilitate the identification of factors that predict the NSLN metastases, allowing accurate calculation of the axillary tumour burden, particularly in patients with micro-metastases. http://dx.doi.org/10.1016/j.ejso.2014.02.130
P131. Intraoperative digital specimen mammography: The effect on re-excision rates. Catherine Zabkiewicz, Fawad Muhammad, Minn Lwin Betsi Cadwaladr University Health Board, North Wales, UK Introduction: This study examines the effect on re-operation rates with the introduction of Intraoperative Digital Specimen Mammography (IDSM) compared to Standard Specimen Mammography (SSM) in patients undergoing breast conserving surgery. Method: In this retrospective cohort study 218 consecutive patients underwent breast conserving surgery at a single hospital. Data on single and multiple re-operation rates were collected for two surgeons. Results: SSM was used in 99 patients in the year prior to introduction of IDSM, and IDSM was used in 119 patients the year after. Rates of further operation for re-excision of positive margins were similar using SSM and IDSM (22% vs 28% p¼0.35).Re-operative rates were not significantly different between individual surgeons (26% vs 25% p¼0.88). Conclusion: ISDM was introduced in place of SSM at this satellite hospital as part of reconfiguration of radiology services. Previous studies suggest surgeon evaluated IDSM is comparable in accuracy to SSM, and there is postulation that IDSM can reduce the number of positive margins. However, this has not translated to evidence of reduced re operation rates. Our study supports this evidence that the use of ISDM has not significantly reduced re-operation rates. http://dx.doi.org/10.1016/j.ejso.2014.02.131
P132. The use of OSNA in the management of the axilla for DCIS Susan Hignett, Uma Sridharan, Elizabeth Kane, Susanah Shore, Alison Waghorn, Christopher Holcombe The Royal Liverpool University Hospital, Liverpool, UK Aim: With DCIS, metastatic spread to the axilla is unusual. However patients are having to return to theatre for further breast and axillary surgery if an invasive component is identified. Our aim was to review how many patients with DCIS had a positive Sentinel Node. Method: Data was collected retrospectively from Jan 2005 to October 2013 for all patients undergoing sentinel node biopsy with an initial diagnosis of DCIS. All patients with extensive calcification underwent mastectomy with sentinel node biopsy regardless of microinvasion. Results: