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Intraoral Schwannoma: Case Report
ORAL AND MAXILLOFACIAL PATHOLOGY e62 Abstracts history of ulcerated lesions in the oral mucosa and perioral region. The medical history included congenital immunodeficiency. Clinical examination revealed an extensive ulcer on the buccal mucosa extending to the skin. The diagnostic hypothesis was herpetic ulceration, and an incisional biopsy was performed. The diagnosis of HZ manifestation was confirmed, and the patient was initially treated with acyclovir (800 mg 5/day), without clinical response. Intravenous administration of acyclovir resulted in partial healing of the skin ulceration. The patient was then treated with ganciclovir (250 mg 12/12 hours), which resulted in complete healing of the skin lesion, although some ulcerations were observed on the hard palate. Despite the various treatments, the patient died.
PCC-191 - HIV-ASSOCIATED ORAL BURKITT’S LYMPHOMA: A CASE REPORT. VINICIUS RABELO TORREGROSSA, RAFAELA MAIA CARDOSO ALMENDRA, LEONARDO FRANCISCO PROVEDEL DE SOUSA, LUIZA CAVALCANTI FADUL, LUCIANO ESPINHEIRA FONSECA JUNIOR, PATRÍCIA LEITE RIBEIRO LAMBERTI, VIVIANE ALMEIDA SARMENTO. UNIVERSIDADE FEDERAL DA BAHIA/UNIVERSIDADE ESTADUAL DE CAMPINAS. Burkitt’s lymphoma (BL) is an aggressive B-cell lymphoma and the second most common HIV-associated non-Hodgkin’s lymphoma. A 20-year-old male admitted to the hospital with a painful intraoral swelling associated with tooth mobility. The patient was referred from another hospital with a diagnosis of odontogenic infection, which had been treated unsuccessfully with surgical drainage and antibiotic therapy. Computed tomography showed an expansive lesion, with bone infiltration and erosion, in the right maxilla. An incisional biopsy was performed, and the histopathological evaluation indicated BL. Immunophenotyping and immunohistochemical findings confirmed the diagnosis. The patient underwent intensive cytoreductive chemotherapy, together with the cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine regimen, as well as highly active antiretroviral therapy. Total remission was observed after 4 chemotherapy cycles.
PCC-192 - INTRAORAL SCHWANNOMA: CASE REPORT. NIKEILA CHACON DE OLIVEIRA CONDE, LARISSA ALVES DE LIMA E SOUZA, NAOMY TAVARES CISNEROS, RAFAELA SANT ANA ALBUQUERQUE, LUCILEIDE CASTRO DE OLIVEIRA, MAX EDUARDO BARROSO DE AMORIM, JULIANA VIANNA PEREIRA. UNIVERSIDADE FEDERAL DO AMAZONAS. Schwannoma or neurilemmoma is a rare benign neoplasm of the neural sheath derived from the Schwann cells. A 24-year-old male was referred to our school of dentistry complaining of a painless swelling in the right side of the lower lip. The patient had first noticed the swelling approximately 3 years earlier. The diagnostic hypothesis was mucocele. Surgery was performed, and 3 excised specimens were obtained. Microscopic examination revealed a benign encapsulated tumor of neural origin characterized by streaming fascicles of spindle-shaped cells (Antoni A). These cells were in a palisade arrangement around central eosinophilic areas (Verocay bodies). Another pattern observed was a poorly organized distribution of less spindle-shaped cells in a myxomatous stroma (Antoni B). The diagnosis of Schwannoma was established. The patient is being followed-up with no recurrence.
OOOO August 2015 PCC-193 - NONPIGMENTED INTRAMUCOSAL MELANOCYTIC NEVUS OF THE ORAL CAVITY. FLÁVIO RODRIGUES SOARES JÚNIOR, DL CORTIZO, LF DUARTE, R TUCCI, RC BORGES, LL DIB. UNIVERSIDADE PAULISTA. Nevi are benign proliferations of nevus cells either in the epithelium or in the subepithelial stroma. Oral mucosal nevi typically present as a well-circumscribed, intense dark papules or plaque, of variable size and with smooth surfaces. Nonpigmented intramucosal nevus rarely occurs in the oral cavity. A 31-year-old male presented to an oral medicine service with a 1-cm asymptomatic nodular lesion of the hard palate. The lesion, whose coloration was similar to that of the normal mucosa, had been growing slowly over the last years. Radiography and computed tomography reveal no bone abnormalities, except for a discrete bulging. The diagnostic hypothesis was pleomorphic adenoma, and an excisional biopsy was performed. Histopathological analysis revealed an intramucosal melanocytic nevus. The nevus cells were immunohistochemically positive for S-100 protein, and isolated cells were positive for HMB-45. The patient is under periodic clinical follow-up and is asymptomatic.
PCC-194 - OROFACIAL MANIFESTATIONS OF PEMPHIGUS VULGARIS: ROLE OF THE DENTIST IN DIAGNOSIS. LILIANA APARECIDA PIMENTA DE BARROS, ROSA MARIA LOURENÇO CARLOS MAIA, DANIELLE REZENDE CAMISASCA BARROSO, ROSSIENE MOTTA BERTOLLO, TERESA CRISTINA RANGEL PEREIRA, DANIELA NASCIMENTO SILVA, TÂNIA REGINA GRÃO VELLOSO. UNIVERSIDADE FEDERAL DO ESPÍRITO SANTO. Pemphigus vulgaris (PV) is a rare autoimmune disease of the skin and mucous membranes. The usual oral clinical sign is gingival desquamation. However, it can be the result of various pathological processes, thus becoming a challenge in the diagnosis. In addition, oral manifestation of PV can be the first sign of this severe disease. A young female complained of gingival desquamation accompanied by nasal bleeding. After clinical examination and biopsy, the diagnosis of PV was confirmed by morphologic findings in hematoxylin and eosin-stained samples. The therapeutic steps and follow-up of the case are discussed. Early diagnosis of PV is important in order to start treatment as soon as possible and to halt the progression of the disease. It is important for the dentist to recognize oral manifestations of PV, thus playing a significant role in the early diagnosis and management of the disease.
PCC-195 - PEUTZeJEGHERS SYNDROME: CASE REPORT. ISRAEL ALEXANDRE DE ARAUJO SENA, EMANUELLE LOUYDE FERREIRA DE LIMA, BRUNA RAFAELA MARTINS DOS SANTOS, ROBERTO TIAGO ALVES PINHEIRO, ISABELA PINHEIRO CAVALCANTI LIMA. UNIVERSIDADE DO ESTADO DO RIO GRANDE DO NORTE. PeutzeJeghers syndrome is a rare genetic condition, characterized by intestinal hamartomatous polyps and melanocytic pigmentations in the skin and mucous membranes. The polyps can undergo malignant transformation to adenocarcinomas, causing ulceration and hemorrhage, leading to abdominal pain and melena. The participation of the dental surgeon in the suspicion/diagnosis of this condition, through the association of mucocutaneous pigmentation with polyposis, allows early treatment and minimizes the risk of malignancy. A 23-year-old male
PCC-191 - HIV-ASSOCIATED ORAL BURKITT’S LYMPHOMA: A CASE REPORT. VINICIUS RABELO TORREGROSSA, RAFAELA MAIA CARDOSO ALMENDRA, LEONARDO FRANCISCO PROVEDEL DE SOUSA, LUIZA CAVALCANTI FADUL, LUCIANO ESPINHEIRA FONSECA JUNIOR, PATRÍCIA LEITE RIBEIRO LAMBERTI, VIVIANE ALMEIDA SARMENTO. UNIVERSIDADE FEDERAL DA BAHIA/UNIVERSIDADE ESTADUAL DE CAMPINAS. Burkitt’s lymphoma (BL) is an aggressive B-cell lymphoma and the second most common HIV-associated non-Hodgkin’s lymphoma. A 20-year-old male admitted to the hospital with a painful intraoral swelling associated with tooth mobility. The patient was referred from another hospital with a diagnosis of odontogenic infection, which had been treated unsuccessfully with surgical drainage and antibiotic therapy. Computed tomography showed an expansive lesion, with bone infiltration and erosion, in the right maxilla. An incisional biopsy was performed, and the histopathological evaluation indicated BL. Immunophenotyping and immunohistochemical findings confirmed the diagnosis. The patient underwent intensive cytoreductive chemotherapy, together with the cyclophosphamide, doxorubicin, high-dose methotrexate/ifosfamide, etoposide, and high-dose cytarabine regimen, as well as highly active antiretroviral therapy. Total remission was observed after 4 chemotherapy cycles.
PCC-192 - INTRAORAL SCHWANNOMA: CASE REPORT. NIKEILA CHACON DE OLIVEIRA CONDE, LARISSA ALVES DE LIMA E SOUZA, NAOMY TAVARES CISNEROS, RAFAELA SANT ANA ALBUQUERQUE, LUCILEIDE CASTRO DE OLIVEIRA, MAX EDUARDO BARROSO DE AMORIM, JULIANA VIANNA PEREIRA. UNIVERSIDADE FEDERAL DO AMAZONAS. Schwannoma or neurilemmoma is a rare benign neoplasm of the neural sheath derived from the Schwann cells. A 24-year-old male was referred to our school of dentistry complaining of a painless swelling in the right side of the lower lip. The patient had first noticed the swelling approximately 3 years earlier. The diagnostic hypothesis was mucocele. Surgery was performed, and 3 excised specimens were obtained. Microscopic examination revealed a benign encapsulated tumor of neural origin characterized by streaming fascicles of spindle-shaped cells (Antoni A). These cells were in a palisade arrangement around central eosinophilic areas (Verocay bodies). Another pattern observed was a poorly organized distribution of less spindle-shaped cells in a myxomatous stroma (Antoni B). The diagnosis of Schwannoma was established. The patient is being followed-up with no recurrence.
OOOO August 2015 PCC-193 - NONPIGMENTED INTRAMUCOSAL MELANOCYTIC NEVUS OF THE ORAL CAVITY. FLÁVIO RODRIGUES SOARES JÚNIOR, DL CORTIZO, LF DUARTE, R TUCCI, RC BORGES, LL DIB. UNIVERSIDADE PAULISTA. Nevi are benign proliferations of nevus cells either in the epithelium or in the subepithelial stroma. Oral mucosal nevi typically present as a well-circumscribed, intense dark papules or plaque, of variable size and with smooth surfaces. Nonpigmented intramucosal nevus rarely occurs in the oral cavity. A 31-year-old male presented to an oral medicine service with a 1-cm asymptomatic nodular lesion of the hard palate. The lesion, whose coloration was similar to that of the normal mucosa, had been growing slowly over the last years. Radiography and computed tomography reveal no bone abnormalities, except for a discrete bulging. The diagnostic hypothesis was pleomorphic adenoma, and an excisional biopsy was performed. Histopathological analysis revealed an intramucosal melanocytic nevus. The nevus cells were immunohistochemically positive for S-100 protein, and isolated cells were positive for HMB-45. The patient is under periodic clinical follow-up and is asymptomatic.
PCC-194 - OROFACIAL MANIFESTATIONS OF PEMPHIGUS VULGARIS: ROLE OF THE DENTIST IN DIAGNOSIS. LILIANA APARECIDA PIMENTA DE BARROS, ROSA MARIA LOURENÇO CARLOS MAIA, DANIELLE REZENDE CAMISASCA BARROSO, ROSSIENE MOTTA BERTOLLO, TERESA CRISTINA RANGEL PEREIRA, DANIELA NASCIMENTO SILVA, TÂNIA REGINA GRÃO VELLOSO. UNIVERSIDADE FEDERAL DO ESPÍRITO SANTO. Pemphigus vulgaris (PV) is a rare autoimmune disease of the skin and mucous membranes. The usual oral clinical sign is gingival desquamation. However, it can be the result of various pathological processes, thus becoming a challenge in the diagnosis. In addition, oral manifestation of PV can be the first sign of this severe disease. A young female complained of gingival desquamation accompanied by nasal bleeding. After clinical examination and biopsy, the diagnosis of PV was confirmed by morphologic findings in hematoxylin and eosin-stained samples. The therapeutic steps and follow-up of the case are discussed. Early diagnosis of PV is important in order to start treatment as soon as possible and to halt the progression of the disease. It is important for the dentist to recognize oral manifestations of PV, thus playing a significant role in the early diagnosis and management of the disease.
PCC-195 - PEUTZeJEGHERS SYNDROME: CASE REPORT. ISRAEL ALEXANDRE DE ARAUJO SENA, EMANUELLE LOUYDE FERREIRA DE LIMA, BRUNA RAFAELA MARTINS DOS SANTOS, ROBERTO TIAGO ALVES PINHEIRO, ISABELA PINHEIRO CAVALCANTI LIMA. UNIVERSIDADE DO ESTADO DO RIO GRANDE DO NORTE. PeutzeJeghers syndrome is a rare genetic condition, characterized by intestinal hamartomatous polyps and melanocytic pigmentations in the skin and mucous membranes. The polyps can undergo malignant transformation to adenocarcinomas, causing ulceration and hemorrhage, leading to abdominal pain and melena. The participation of the dental surgeon in the suspicion/diagnosis of this condition, through the association of mucocutaneous pigmentation with polyposis, allows early treatment and minimizes the risk of malignancy. A 23-year-old male