- Email: [email protected]
Intravenous adenosine echocardiography, a new pharmacologic stress test: Preliminary results and comparison with simultaneous thallium scintigraphy
234A
jACC Vol. 15, No. 2 February 1990234A
ABSTRACTS
ECHOCARDIOGRAPHY,
NEW
A
AMIODARONE INDUCED RA Alan K
Woclfel,
.A.C
sley,
?? .
University of NorthCarolina a!
inregard IOage,leflventicukuejection amiodaronc dasage(2&19vs 13&3 g
._. _. _
20 and SPECT versus angiography(n-42),using scar or respectively. Thus adenosine were 83% and 7 ischemia, stresstest that is 20 is a promisingnew pharmacologic comparable to adenosine SPECT in the detectionof CAD.
andti ETT(12&R vs 1Qt4days),QT
UTAMINE STRESSECROCARDIOORAI%~Y 8 CORREtATION DOSE PONSNENESS ANDQUANTITATIVE MIICGRAPHY da, ND,, Stephen E:.
Ryan,
William F.
dioine, Indianapolis,
IN
ry disease (CAD). The purpose of ate the dose of’Dobutamine and a regional wall motion abnormal-
) appeared with CADseverity.
Forty-four
aonaeoutive patients (pts) were identified who had a P s W
stenosis with &late
low dose of <20 mog/k&min resulted in 8 studiesbeingstopped prematurely. Of
ease (SVD). A new UHA at a
pts 7 had multivessel diaeasct (MfD) and 1 had a >7 proximal left anterior descending lesion. The new
ON OF IS FAMlOD
Antiarrhythmic agents acting on sodium channels do so in a use-dependent fashion which may be reversed by catacholamine administration.The purposeof this study was 10assess use-dependent effectsof chronicoral amiodarone(A) before and afteradministrationof isoproterenol(I). After oral amiodaroneloading (@am/day x 2weeks) dogs (n=4) underwent a baseline electrophysiologic study involving selective His-bundlepacing at paced cycle lengthsjust below the sinus rate to a maximal paced cycle length of 200msec. Isoproterenol was then infused at Sug/m.inuntil a stable sinus rate was achieved and the pacing protocol was repeated.The stimulus to ventricular electrogram interval (SV) for each pacedcycle length (CL) was comparedlo the SV of the longestpacedCL at baseline.Data a~ representedas themean% change(*SE) in SV as compared to the SV at the longest paced CL during the baseline study. CYCLELENGTH(msec) llfl
lesions and collaterals (al (all SVD) and 1 with a 75-90 (!JVD)- Of the pts with MIDmd no collaterala 22123 had a * DSB at a BR <125. We conclude that a +DSEat a lau dose or a flR
>I25 indleaka
mderate disease or collateral flow.
USE-DEPE
icheal C. Chin,BS Bertram G. Katzung, University of California,San Francisco.
ons supplied by vessels with >70
1 with luminal diameter 1.09 e 9 pta with a + DSEat a HR >125
NOL ON
17&3 23&3 23s
( *pa.01 #pa.05 )
27s
31f3 :!ti
35&3 38+2 14s 12&4
The mean serum amiodaronelevel was 2.Mo.8 mgldl. Conclusion: Isoproterenol significantly attenuates the use-dependent effect of chronically administered a~od~o~e in t canine model. These findings may help to explain how changes in neuro-humeraltone may alter clinical drug efficacy.
jACC Vol. 15, No. 2 February 1990234A
ABSTRACTS
ECHOCARDIOGRAPHY,
NEW
A
AMIODARONE INDUCED RA Alan K
Woclfel,
.A.C
sley,
?? .
University of NorthCarolina a!
inregard IOage,leflventicukuejection amiodaronc dasage(2&19vs 13&3 g
._. _. _
20 and SPECT versus angiography(n-42),using scar or respectively. Thus adenosine were 83% and 7 ischemia, stresstest that is 20 is a promisingnew pharmacologic comparable to adenosine SPECT in the detectionof CAD.
andti ETT(12&R vs 1Qt4days),QT
UTAMINE STRESSECROCARDIOORAI%~Y 8 CORREtATION DOSE PONSNENESS ANDQUANTITATIVE MIICGRAPHY da, ND,, Stephen E:.
Ryan,
William F.
dioine, Indianapolis,
IN
ry disease (CAD). The purpose of ate the dose of’Dobutamine and a regional wall motion abnormal-
) appeared with CADseverity.
Forty-four
aonaeoutive patients (pts) were identified who had a P s W
stenosis with &late
low dose of <20 mog/k&min resulted in 8 studiesbeingstopped prematurely. Of
ease (SVD). A new UHA at a
pts 7 had multivessel diaeasct (MfD) and 1 had a >7 proximal left anterior descending lesion. The new
ON OF IS FAMlOD
Antiarrhythmic agents acting on sodium channels do so in a use-dependent fashion which may be reversed by catacholamine administration.The purposeof this study was 10assess use-dependent effectsof chronicoral amiodarone(A) before and afteradministrationof isoproterenol(I). After oral amiodaroneloading (@am/day x 2weeks) dogs (n=4) underwent a baseline electrophysiologic study involving selective His-bundlepacing at paced cycle lengthsjust below the sinus rate to a maximal paced cycle length of 200msec. Isoproterenol was then infused at Sug/m.inuntil a stable sinus rate was achieved and the pacing protocol was repeated.The stimulus to ventricular electrogram interval (SV) for each pacedcycle length (CL) was comparedlo the SV of the longestpacedCL at baseline.Data a~ representedas themean% change(*SE) in SV as compared to the SV at the longest paced CL during the baseline study. CYCLELENGTH(msec) llfl
lesions and collaterals (al (all SVD) and 1 with a 75-90 (!JVD)- Of the pts with MIDmd no collaterala 22123 had a * DSB at a BR <125. We conclude that a +DSEat a lau dose or a flR
>I25 indleaka
mderate disease or collateral flow.
USE-DEPE
icheal C. Chin,BS Bertram G. Katzung, University of California,San Francisco.
ons supplied by vessels with >70
1 with luminal diameter 1.09 e 9 pta with a + DSEat a HR >125
NOL ON
17&3 23&3 23s
( *pa.01 #pa.05 )
27s
31f3 :!ti
35&3 38+2 14s 12&4
The mean serum amiodaronelevel was 2.Mo.8 mgldl. Conclusion: Isoproterenol significantly attenuates the use-dependent effect of chronically administered a~od~o~e in t canine model. These findings may help to explain how changes in neuro-humeraltone may alter clinical drug efficacy.