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Intravenous omeprazole and blindness
age. The committee was unable to conclude that there was a direct causal relation between DPT vaccination and Rochalimaea chronic brain damage since the abnormal-
Cats, fleas, and Rochalimaea in California
ities reported in the UK study might have been due to preexisting cerebral lesions. The NCES data suggest that DPT could trigger an acute neurological illness in children with underlying brain or metabolic abnormalities, although there was no indication of a unique post-DPT syndrome. It is this group of children who are at a small risk of chronic nervous system
dysfunction. Richard Horton 1 Statton KR, Howe CJ, Johnstone RB, eds. DPT vaccine and chronic nervous system
dysfunction:
a new
analysis. Washington,
DC: National Academy Press, 1994. 2 Miller DL, Madge N, Diamond J, Wadsworth J, Ross E. Pertussis immunisation and serious neurological illness in children. BMJ 1993; 307: 1171-76. 3 Howson CP, Howe CJ, Fineberg HV, eds. Adverse effects of pertussis and rubella vaccines. Washington, DC: National 4
Academy Press, 1991. Gale JL, Thapa PB, Wassilak SGF, Bobo JK, Mendelman PM, Foy HM. Risk of serious acute neurological illness after immunisation with DPT vaccine. JAMA
cause of catHIV infection was aged 75 and developed responsible for a bacillary angiomatosis lesion on her bacillary angiomatosis, a potentially fatal neck that subsided after 3 months of treatvascular proliferation, in people with ment with doxycycline. She did not own a AIDS (see Lancet Aug 7, p 359). An cat but had spent 2 weeks with 2 infected investigation into whether domestic cats cats on a visit during which she was . scratched are the reservoir for the organism has by a cat and a kitten and also shown that R henselae is enzootic in cats . bitten by their fleas. 17 months after her visit, the cats were proven to be infected. (Felis domesticus) in the Greater San FranThe potential for transmission of this cisco Bay area of Northern California,
scratch fever,
henselae, the can
also be
and that it also occurs in cat fleas cat infection to man is vast-there are , USA, estimated to be 57000000 cats in the (Ctenocephalides felis). Seven cats were identified as close com: USA-yet it remains unknown whether panions of 4 patients with bacillary the findings from San Francisco apply angiomatosis. 3 of the patients had HIV elsewhere and whether the infection can infection. All the cats had R henselae bacbe spread by the cat flea. A related infecteraemia, and fleas from one cat also cartion, trench fever, is spread by the human ried the bacterium (identified both by body louse (Pediculus humanus), with the culture and polymerase chain reaction). long-tailed vole as a possible reservoir of Of 61 other cats from veterinary practices, infection. private homes, and animal pounds within the area, 25 (41%) also had R henselae : John Bignall bacteraemia. : The message for HIV-positive people is 1 Koehler JE, Glaser, CA, Tappero JW. evident-avoid cats or make sure they Rochalimaea henselae infection: a new have been treated and proven free from . zoonosis with the domestic cats as reservoir. The without evidence 1994; 271: 531-35. JAMA of patient infection.
;
1985, 3-4% of the population in Uruguay infected with Trypanosoma cruzi. June, 1991, saw the launch of the Southern
News in brief
1994; 271: 37-41.
was
Intravenous omeprazole and blindness Bundesgesundheitsamt (BGA), Getmany’s Federal Health Agency, has given
The
Chickenpox and corticosteroids The UK Committee on Safety of Medicines and the Medicine Control Agency have stated (Curr Prob 1994; 20: 1-2) that patients on systemic corticosteroids who have not had chickenpox need to be advised that, if exposed, they should see their doctor urgently. The committee has
Cone Initiative to eliminate transmission of the parasite in Argentina, Bolivia, Brazil, Chile, and Uruguay. By the end of 1992, infection rates in several areas in Uruguay had fallen sharply.
Antioxidants in France A large placebocontrolled study is about to be undertaken Astra Pharmaceuticals notice of intent to of deaths received 2 in children reports in France to measure the protective effect withdraw the licence for intravenous became infected with chickenpox who of vitamins and antioxidant minerals has notified Astra Pharmaomeprazole. It while on systemic corticosteroids. it is aware of 19 cases that ceuticals of (betacarotene, vitamin C, vitamin E, zinc, draw attention to a case-control study and selenium) on mortality from cardio4 cases vision and blindness and impaired (Pediatrics 1993; 92: 223-28) that suggests vascular disease and cancer. A feasibility of impaired hearing and deafness associatthat systemic corticosteroids substantially study on 1000 volunteers has been comed with omeprazole, mostly with parenteral use of the drug. (The need for increase the risk of severe chickenpox. pleted and an appeal was launched on March 2 to recruit 100 000 people. From intravenous administration is doubtful.) The first two cases were reported in: Necropsy tissue The German Society of this pool 15 000 representatives of the Pathology is urging politicians to draw up French population will be selected. The March and May, 1993, by clinical pharmacologists from Bremen, and the others regulations on the removal of tissues at study is being coordinated by Dr Serge after warning notices in the drug bulletin necropsies. The request follows publicity Hercberg (INSERM) and financially supArznei-telegramm and by the agency. : about how tissues are being removed for ported by the food and drug industry. The BGA says that product information commercial purposes without the necesfor omeprazole should include a warning sary legal backing. 91 German hospitals ’Flu and fetal loss When the UK Comare supplying Braun/Melsungen, one of municable Disease Surveillance Centre on blindness and deafness as well as allerthe main firms preparing meninges for was alerted by a group of primary care vasculitis and fever. It gic drug-induced has also demanded animal studies into the . brain surgery, with tissue in this way. physicians to an unusual number of stillSome assistants have admitted births and spontaneous abortions during mechanism of the pathology possible immunogenic ’., vasculitis that is thought to cause the receiving a small fee from Braun for the winter, a case-control investigation’ blindness and deafness, as well as possible meninges. A representative from Braun was conducted (CDR Rev 1994; 4: renal and cardiac damage. : and a neurosurgeon have emphasised that R28-32). It showed that women affected were much more likely to have had a fluThe theory that a vasculitis may be the prepared meninges are needed for lifelike illness at the time of the event and to saving purposes. causing the observed events has been suphave serological evidence of influenza A ported by reports in the German press of necrotising arteritis in dogs that had been Elimination of Chagas’ disease The infection (A H3N2, Christchurch/4/85World Health Organisation is confident like strain). Influenza has not hitherto given lansoprazole. that Uruguay will be the first endemic been thought to be a hazard to pregnant Peter S Schönhöfer country to rid itself of Chagas’ disease. In women. .
They
;
665
Cats, fleas, and Rochalimaea in California
ities reported in the UK study might have been due to preexisting cerebral lesions. The NCES data suggest that DPT could trigger an acute neurological illness in children with underlying brain or metabolic abnormalities, although there was no indication of a unique post-DPT syndrome. It is this group of children who are at a small risk of chronic nervous system
dysfunction. Richard Horton 1 Statton KR, Howe CJ, Johnstone RB, eds. DPT vaccine and chronic nervous system
dysfunction:
a new
analysis. Washington,
DC: National Academy Press, 1994. 2 Miller DL, Madge N, Diamond J, Wadsworth J, Ross E. Pertussis immunisation and serious neurological illness in children. BMJ 1993; 307: 1171-76. 3 Howson CP, Howe CJ, Fineberg HV, eds. Adverse effects of pertussis and rubella vaccines. Washington, DC: National 4
Academy Press, 1991. Gale JL, Thapa PB, Wassilak SGF, Bobo JK, Mendelman PM, Foy HM. Risk of serious acute neurological illness after immunisation with DPT vaccine. JAMA
cause of catHIV infection was aged 75 and developed responsible for a bacillary angiomatosis lesion on her bacillary angiomatosis, a potentially fatal neck that subsided after 3 months of treatvascular proliferation, in people with ment with doxycycline. She did not own a AIDS (see Lancet Aug 7, p 359). An cat but had spent 2 weeks with 2 infected investigation into whether domestic cats cats on a visit during which she was . scratched are the reservoir for the organism has by a cat and a kitten and also shown that R henselae is enzootic in cats . bitten by their fleas. 17 months after her visit, the cats were proven to be infected. (Felis domesticus) in the Greater San FranThe potential for transmission of this cisco Bay area of Northern California,
scratch fever,
henselae, the can
also be
and that it also occurs in cat fleas cat infection to man is vast-there are , USA, estimated to be 57000000 cats in the (Ctenocephalides felis). Seven cats were identified as close com: USA-yet it remains unknown whether panions of 4 patients with bacillary the findings from San Francisco apply angiomatosis. 3 of the patients had HIV elsewhere and whether the infection can infection. All the cats had R henselae bacbe spread by the cat flea. A related infecteraemia, and fleas from one cat also cartion, trench fever, is spread by the human ried the bacterium (identified both by body louse (Pediculus humanus), with the culture and polymerase chain reaction). long-tailed vole as a possible reservoir of Of 61 other cats from veterinary practices, infection. private homes, and animal pounds within the area, 25 (41%) also had R henselae : John Bignall bacteraemia. : The message for HIV-positive people is 1 Koehler JE, Glaser, CA, Tappero JW. evident-avoid cats or make sure they Rochalimaea henselae infection: a new have been treated and proven free from . zoonosis with the domestic cats as reservoir. The without evidence 1994; 271: 531-35. JAMA of patient infection.
;
1985, 3-4% of the population in Uruguay infected with Trypanosoma cruzi. June, 1991, saw the launch of the Southern
News in brief
1994; 271: 37-41.
was
Intravenous omeprazole and blindness Bundesgesundheitsamt (BGA), Getmany’s Federal Health Agency, has given
The
Chickenpox and corticosteroids The UK Committee on Safety of Medicines and the Medicine Control Agency have stated (Curr Prob 1994; 20: 1-2) that patients on systemic corticosteroids who have not had chickenpox need to be advised that, if exposed, they should see their doctor urgently. The committee has
Cone Initiative to eliminate transmission of the parasite in Argentina, Bolivia, Brazil, Chile, and Uruguay. By the end of 1992, infection rates in several areas in Uruguay had fallen sharply.
Antioxidants in France A large placebocontrolled study is about to be undertaken Astra Pharmaceuticals notice of intent to of deaths received 2 in children reports in France to measure the protective effect withdraw the licence for intravenous became infected with chickenpox who of vitamins and antioxidant minerals has notified Astra Pharmaomeprazole. It while on systemic corticosteroids. it is aware of 19 cases that ceuticals of (betacarotene, vitamin C, vitamin E, zinc, draw attention to a case-control study and selenium) on mortality from cardio4 cases vision and blindness and impaired (Pediatrics 1993; 92: 223-28) that suggests vascular disease and cancer. A feasibility of impaired hearing and deafness associatthat systemic corticosteroids substantially study on 1000 volunteers has been comed with omeprazole, mostly with parenteral use of the drug. (The need for increase the risk of severe chickenpox. pleted and an appeal was launched on March 2 to recruit 100 000 people. From intravenous administration is doubtful.) The first two cases were reported in: Necropsy tissue The German Society of this pool 15 000 representatives of the Pathology is urging politicians to draw up French population will be selected. The March and May, 1993, by clinical pharmacologists from Bremen, and the others regulations on the removal of tissues at study is being coordinated by Dr Serge after warning notices in the drug bulletin necropsies. The request follows publicity Hercberg (INSERM) and financially supArznei-telegramm and by the agency. : about how tissues are being removed for ported by the food and drug industry. The BGA says that product information commercial purposes without the necesfor omeprazole should include a warning sary legal backing. 91 German hospitals ’Flu and fetal loss When the UK Comare supplying Braun/Melsungen, one of municable Disease Surveillance Centre on blindness and deafness as well as allerthe main firms preparing meninges for was alerted by a group of primary care vasculitis and fever. It gic drug-induced has also demanded animal studies into the . brain surgery, with tissue in this way. physicians to an unusual number of stillSome assistants have admitted births and spontaneous abortions during mechanism of the pathology possible immunogenic ’., vasculitis that is thought to cause the receiving a small fee from Braun for the winter, a case-control investigation’ blindness and deafness, as well as possible meninges. A representative from Braun was conducted (CDR Rev 1994; 4: renal and cardiac damage. : and a neurosurgeon have emphasised that R28-32). It showed that women affected were much more likely to have had a fluThe theory that a vasculitis may be the prepared meninges are needed for lifelike illness at the time of the event and to saving purposes. causing the observed events has been suphave serological evidence of influenza A ported by reports in the German press of necrotising arteritis in dogs that had been Elimination of Chagas’ disease The infection (A H3N2, Christchurch/4/85World Health Organisation is confident like strain). Influenza has not hitherto given lansoprazole. that Uruguay will be the first endemic been thought to be a hazard to pregnant Peter S Schönhöfer country to rid itself of Chagas’ disease. In women. .
They
;
665