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Introduction to Drug Metabolism
BOOK REVIEW
Advances In Chromatography, Volume 25. Edited by J. Calvin Giddings, Eli Grushka, Jack C a m , and Phyllis R. Brown. Marcel Dekker: New York. 1986.416 pages. 16 x 24 cm. ISBN 0-8247-7546-5. $69.75 (U.S. and Canada). Volume 25 of Advances in Chromatography is a collection of eight contributed chapters covering various topics primarily focusing on HPLC technology. The first chapter reviews the study of HPLC retention behavior and physiochemical properties of solutes. The chapter is thorough and includes an impressive list of references numbering 191 and spanning the period from 1899 to 1983! Most of the references cited are from 1972 to 1982. Chapters 2 and 4 are useful to chromatographers involved in method development, especially with regard to applications of reverse-phase HPLC. Chapter 2 reviews mobile phase optimization strategies, primarily for use with computerized systems. Chapter 4 provides an indepth discussion of the properties of reverse-phase stationary phases, using the retention behavior of polycyclic aromatic hydrocarbons as a meana to describe chromatographic properties of numerous C-18 packing materials. A summary of the recently developing technology of IR detection after HPLC separation is presented in Chapter 3. Chapters 5 through 8 are devoted to the application of HPLC to the analysis of 0x0 acids of phosphorus, oxypurines and related compounds, carbohydrates, and glycosphingolipids and phospholipids. These chapters also provide authoritative reviews and focus on the literature from 1975 to 1983. In most chapters the authors include their own current work, which adds interest to the reviews. An author index is provided, covering all of the literature citations. The subject index will be of most use when included in a cumulative index for this series. As a volume of collected reviews, this book suffers from the same problem as many others of its type: a lack of continuity. However, it does maintain some degree of focus within the broad field of HPLC technology and applications of reversephase HPLC. The book succeeds because of the wealth of data and extensive, authoritative reviews of the subject matter. For instance, several chapters contain well-organized tables summarizing numerous published methods and procedures applicable to the fields being reviewed. This book will be valuable to research and development scientists who employ HPLC methods in the areas of biomedical and environmental science. Because of the chapters of general interest to those involved in analytical method development, Advances in Chromatography will be a useful addition to academic as well as corporate libraries.
examining specialized subjects or emerging issues in the discipline and thus are principally directed to an audience of researchers and specialists. Although several excellent books examine the subject of introductory drug metabolism, the many advances that have taken place during the past decade make the present book a worthwhile and timely contribution to this field. The paperback is divided into five general areas comprising eight chapters. The first two chapters provide a concise but well-illustrated introduction into the various pathways of drug metabolism, focusing on the enzymology and molecular mechanisms of these processes. Chapters 3 through 5 describe the phenomena surrounding induction and inhibition of drug metabolism as well as the influences that internal and external forces exert on metabolism. In Chapter 6 the authors relate drug metabolism to the pharmacologic and toxicologic responses that accompany drug administration, and in Chapter 7 to clinical pharmacokinetic considerations of drug disposition in man. Finally, the book devotes a chapter to describing various techniques and experiments meant to illustrate underlying principles of drug metabolism. Each chapter is complete with a bibliography of suggested readings which includes classical and contemporary monographs, reviews, and original research articles dating through 1985. This primer of drug metabolism should be an excellent textbook for courses that enroll advanced undergraduate students or graduate students not anticipating additional training in this area. A notable strength is the integration of recent advances, such as insights into the spectral properties of P-450, the molecular biology of enzyme induction, and the polymorphism of drug metabolism, into the classical knowledge base. Thoughtful schemes that illustrate current concepta are abundant, as are many useful summary tables. The authors have succeeded in creating a textbook that is well organized, clearly written, and likely to find broad application in programs emphasizing the life sciences. George B. Corcoran Department of Pharmaceutics School of Pharmacy State University of New York Buffalo, NY 14260
Raymond A. Pritchard Syntex Laboratories, Inc. Palo Alto, CA 94303
Rate Control In Drug Therapy. Edited by L. F. Prescott and W. S. Nimmo. Churchill Livingstone: New York. 1985. xii + 315 pp. 16.3 x 24 cm. ISBN 0-443-02998-9. $62.95. It is now feasible to precisely control the rate of drug absorption so as to provide prolonged therapeutic action with minimal dose, side effects, and toxicity. Rate Control in Drug Therapy is the Proceedings of the Second Edinburgh International Conference on Drug Absorption which was held in 1983. The 32 chapters include a fine introductory overview, 15 chapters dealing with general aspects of rate-controlled drug delivery, an equal number of chapters discussing the clinical application of rate-controlled delivery of specific drugs or drug classes, and a chapter with final comments. Unlike some proceedings which are produced from (‘cameraready” typescript, these have been set by the publisher (who could have proofread the galleys once more). The text is
lntroductlon to Drug Metabolism. By G. Gordon Gibson and Paul Skett. Chapman and Hall: London. 1986.305 pages. 23 x 15 x 1.5 cm. ISBN 0-412-26400-5.$25.00 paperback, $60.00clothbound. A host of monographs have appeared over the past several years which address various aspects of drug metabolism. Nearly all of these publications, however, are devoted to 268 /Journal of fhannaceutical Sciences Vol. 76, No. 3, March 1987
Advances In Chromatography, Volume 25. Edited by J. Calvin Giddings, Eli Grushka, Jack C a m , and Phyllis R. Brown. Marcel Dekker: New York. 1986.416 pages. 16 x 24 cm. ISBN 0-8247-7546-5. $69.75 (U.S. and Canada). Volume 25 of Advances in Chromatography is a collection of eight contributed chapters covering various topics primarily focusing on HPLC technology. The first chapter reviews the study of HPLC retention behavior and physiochemical properties of solutes. The chapter is thorough and includes an impressive list of references numbering 191 and spanning the period from 1899 to 1983! Most of the references cited are from 1972 to 1982. Chapters 2 and 4 are useful to chromatographers involved in method development, especially with regard to applications of reverse-phase HPLC. Chapter 2 reviews mobile phase optimization strategies, primarily for use with computerized systems. Chapter 4 provides an indepth discussion of the properties of reverse-phase stationary phases, using the retention behavior of polycyclic aromatic hydrocarbons as a meana to describe chromatographic properties of numerous C-18 packing materials. A summary of the recently developing technology of IR detection after HPLC separation is presented in Chapter 3. Chapters 5 through 8 are devoted to the application of HPLC to the analysis of 0x0 acids of phosphorus, oxypurines and related compounds, carbohydrates, and glycosphingolipids and phospholipids. These chapters also provide authoritative reviews and focus on the literature from 1975 to 1983. In most chapters the authors include their own current work, which adds interest to the reviews. An author index is provided, covering all of the literature citations. The subject index will be of most use when included in a cumulative index for this series. As a volume of collected reviews, this book suffers from the same problem as many others of its type: a lack of continuity. However, it does maintain some degree of focus within the broad field of HPLC technology and applications of reversephase HPLC. The book succeeds because of the wealth of data and extensive, authoritative reviews of the subject matter. For instance, several chapters contain well-organized tables summarizing numerous published methods and procedures applicable to the fields being reviewed. This book will be valuable to research and development scientists who employ HPLC methods in the areas of biomedical and environmental science. Because of the chapters of general interest to those involved in analytical method development, Advances in Chromatography will be a useful addition to academic as well as corporate libraries.
examining specialized subjects or emerging issues in the discipline and thus are principally directed to an audience of researchers and specialists. Although several excellent books examine the subject of introductory drug metabolism, the many advances that have taken place during the past decade make the present book a worthwhile and timely contribution to this field. The paperback is divided into five general areas comprising eight chapters. The first two chapters provide a concise but well-illustrated introduction into the various pathways of drug metabolism, focusing on the enzymology and molecular mechanisms of these processes. Chapters 3 through 5 describe the phenomena surrounding induction and inhibition of drug metabolism as well as the influences that internal and external forces exert on metabolism. In Chapter 6 the authors relate drug metabolism to the pharmacologic and toxicologic responses that accompany drug administration, and in Chapter 7 to clinical pharmacokinetic considerations of drug disposition in man. Finally, the book devotes a chapter to describing various techniques and experiments meant to illustrate underlying principles of drug metabolism. Each chapter is complete with a bibliography of suggested readings which includes classical and contemporary monographs, reviews, and original research articles dating through 1985. This primer of drug metabolism should be an excellent textbook for courses that enroll advanced undergraduate students or graduate students not anticipating additional training in this area. A notable strength is the integration of recent advances, such as insights into the spectral properties of P-450, the molecular biology of enzyme induction, and the polymorphism of drug metabolism, into the classical knowledge base. Thoughtful schemes that illustrate current concepta are abundant, as are many useful summary tables. The authors have succeeded in creating a textbook that is well organized, clearly written, and likely to find broad application in programs emphasizing the life sciences. George B. Corcoran Department of Pharmaceutics School of Pharmacy State University of New York Buffalo, NY 14260
Raymond A. Pritchard Syntex Laboratories, Inc. Palo Alto, CA 94303
Rate Control In Drug Therapy. Edited by L. F. Prescott and W. S. Nimmo. Churchill Livingstone: New York. 1985. xii + 315 pp. 16.3 x 24 cm. ISBN 0-443-02998-9. $62.95. It is now feasible to precisely control the rate of drug absorption so as to provide prolonged therapeutic action with minimal dose, side effects, and toxicity. Rate Control in Drug Therapy is the Proceedings of the Second Edinburgh International Conference on Drug Absorption which was held in 1983. The 32 chapters include a fine introductory overview, 15 chapters dealing with general aspects of rate-controlled drug delivery, an equal number of chapters discussing the clinical application of rate-controlled delivery of specific drugs or drug classes, and a chapter with final comments. Unlike some proceedings which are produced from (‘cameraready” typescript, these have been set by the publisher (who could have proofread the galleys once more). The text is
lntroductlon to Drug Metabolism. By G. Gordon Gibson and Paul Skett. Chapman and Hall: London. 1986.305 pages. 23 x 15 x 1.5 cm. ISBN 0-412-26400-5.$25.00 paperback, $60.00clothbound. A host of monographs have appeared over the past several years which address various aspects of drug metabolism. Nearly all of these publications, however, are devoted to 268 /Journal of fhannaceutical Sciences Vol. 76, No. 3, March 1987