- Email: [email protected]
Introduction to toxicology (2nd edn)
B
0
0
K
s
agonist that is an antagonist at the two other receptor subtypes? Or is the best potential drug one that is selective for p,-adrenoceptors? While this may sound like the best altemative, it has been reported that noradrenaline may first have to act on P,-adrenoceptors to promote development of brown adipose tissue before stimulating P,-adrenoceptors expressed on this tissue. One issue that is inadequately discussed in this book concerns the numerous reports, most of them prior to cloning of the genes, of the
presence of atypical P-adrenoceptors in tissues other than fat, e.g. muscle, heart, brain. While a number of these findings may be explained by the presence of adipocytes in the locations studied, others remain unexplained, especially where the very sensitive polymerase chain reaction, RNAse protection, or in situ hybridization failed to detect any p,-adrenoceptor message (as is the case in various parts of the brain). Few, if any, investigators still retain the possibility of the existence of yet another P-adlrenoceptor subtype (h- or
p,-adrenoceptor?) but a discussion of these apparent discrepancies would have been welcomed. In this book Goldberg and Frishman have provided an overview of P,-adrenoceptor agonism; however, for the reasons mentioned above, they may have missed the opportunity of writing the definitive book on p,-adrenoceptor agonism.
New editions
Pharmacological and Chemical Synonyms (10th edition)
names used for drugs, pesticides and other chemicals (such as vitamins) that are of pharmacological or biochemical significance. The alphabetical listing (using American spelling) provides main headings consisting of non-proprietary names followed by chemical names, pharmacological names, abbreviated chemical names, trivial names, salt names, research codes and proprietary (trade) names. There is careful cross referencing for proprietary names of established drugs.
Introduction to Toxicology (2nd edn) by John A. Timbrell, Taylor & Francis, 1995. E13.95 (xiii + 167 pages) ISBN 0 7484 0241 1 This second edition, published seven years after the original text, is not a major overhaul of the book but a simple update revision. New details have been added to examples used in the first edition and some completely new examples have been included. There are 11 chapters, the first of which is a general introduction (the historical aspects of toxicology and types of toxic substance and exposure). The other chapters cover a wide range of subjects including disposition of toxic compounds, types of toxic exposure and response, drugs as toxic substances, industrial chemicals, food additives and contaminants, toxic natural products, and toxicity testing. Unlike the original text, each chapter concludes with several questions addressing topics that have been discussed in that particular chapter but specimen answers are not included. The bibliography has been extensively revised and the book contains a glossary of toxicological terms. The book is an introductory text for beginners in the field of toxicology rather than an encyclopaedic toxicology text for the specialist.
1 7 6
TiPS - May 1995 (Vol. 16)
compiled by E. E. J. Marler, Elsevier Science, 1994. Dfl450.00 (viii + 593 pages) ISBN 0 444 820817
This reference directory to pharmacological and chemical names has reached its tenth edition. The volume is an alphabetical compilation of
A. Donny Strosberg
Laboratoire d’lmmuno-Pharmacologic Mokulaire,
lnstitut Cochin de GBn&ique MoKxulaire, CNRS UPR-0415, 22 rue MBchain, Paris, France.
Books received Books featured in the Books received in Pharmacological
section will not be reviewed
in Trends
Sciences.
S. Araki (ed.) Neurobehavioral Methods and Effects in Occupational and Environmental Health Academic Press, 1994. $49.00 (xxxii + 1020 pages) ISBN 0 12 059785 3 H. Bergman and H. Sinzinger (eds) Radioactive Isotopes in Clinical Medicine und Research Birkhsuser, 1995. E68.00 (xviii + 454 pages) ISBN 3 7643 5082 2 B. B. Biswas and S. Roy (eds) Subcellular Biochemistry Volume24. Proteins: Structure, Function and Engineering Plenum, 1995. $120.00 (xx + 436 pages) ISBN 0 306 44846 7 B. A. Brody (au.) Ethical Issues in Drug Testing, Approval and Pricing. The CIot-Dissolving Drugs Oxford University Press, 1995. E30.00 (x + 268 pages) ISBN 0 19 508831 X I’. R. Brown and E. Grushka (eds) Advances in Chromatography Dekker, 1995.
$165.00 (xviii + 425 pages) ISBN 0 8247 9361 7 G. Darcourt, J. Mendlewicz, G. Racagni and N. Brunello (eds) Current Therapeutic Approaches to Panic and Other Anxiety Disorders Karger, 1994. $180.00 (vi + 206 pages) ISBN 3 8055 5989 5 G. Gregoriadis, B. McCormack and G. Paste (eds) Turgeting of Drugs 4. Advances in System Constructs Plenum, 1994. $75.00 (viii + 207 pages) ISBN 0 306 44910 2 S. Moncada, M. Feelisch, R. Busse and E. A. Higgs (eds) The Biology ofNitric Oxide Part 3: Physiological and Clinical Aspects Portland Press, 1994. E132.00 (xvii + 451 pages) ISBN 185578 063 1 S. Neidle and M. Waring (eds) Molecular Anticuncer Aspects of Drug-DNA Interactions (Vol. 2) Macmillan, 1994.
0
0
K
s
agonist that is an antagonist at the two other receptor subtypes? Or is the best potential drug one that is selective for p,-adrenoceptors? While this may sound like the best altemative, it has been reported that noradrenaline may first have to act on P,-adrenoceptors to promote development of brown adipose tissue before stimulating P,-adrenoceptors expressed on this tissue. One issue that is inadequately discussed in this book concerns the numerous reports, most of them prior to cloning of the genes, of the
presence of atypical P-adrenoceptors in tissues other than fat, e.g. muscle, heart, brain. While a number of these findings may be explained by the presence of adipocytes in the locations studied, others remain unexplained, especially where the very sensitive polymerase chain reaction, RNAse protection, or in situ hybridization failed to detect any p,-adrenoceptor message (as is the case in various parts of the brain). Few, if any, investigators still retain the possibility of the existence of yet another P-adlrenoceptor subtype (h- or
p,-adrenoceptor?) but a discussion of these apparent discrepancies would have been welcomed. In this book Goldberg and Frishman have provided an overview of P,-adrenoceptor agonism; however, for the reasons mentioned above, they may have missed the opportunity of writing the definitive book on p,-adrenoceptor agonism.
New editions
Pharmacological and Chemical Synonyms (10th edition)
names used for drugs, pesticides and other chemicals (such as vitamins) that are of pharmacological or biochemical significance. The alphabetical listing (using American spelling) provides main headings consisting of non-proprietary names followed by chemical names, pharmacological names, abbreviated chemical names, trivial names, salt names, research codes and proprietary (trade) names. There is careful cross referencing for proprietary names of established drugs.
Introduction to Toxicology (2nd edn) by John A. Timbrell, Taylor & Francis, 1995. E13.95 (xiii + 167 pages) ISBN 0 7484 0241 1 This second edition, published seven years after the original text, is not a major overhaul of the book but a simple update revision. New details have been added to examples used in the first edition and some completely new examples have been included. There are 11 chapters, the first of which is a general introduction (the historical aspects of toxicology and types of toxic substance and exposure). The other chapters cover a wide range of subjects including disposition of toxic compounds, types of toxic exposure and response, drugs as toxic substances, industrial chemicals, food additives and contaminants, toxic natural products, and toxicity testing. Unlike the original text, each chapter concludes with several questions addressing topics that have been discussed in that particular chapter but specimen answers are not included. The bibliography has been extensively revised and the book contains a glossary of toxicological terms. The book is an introductory text for beginners in the field of toxicology rather than an encyclopaedic toxicology text for the specialist.
1 7 6
TiPS - May 1995 (Vol. 16)
compiled by E. E. J. Marler, Elsevier Science, 1994. Dfl450.00 (viii + 593 pages) ISBN 0 444 820817
This reference directory to pharmacological and chemical names has reached its tenth edition. The volume is an alphabetical compilation of
A. Donny Strosberg
Laboratoire d’lmmuno-Pharmacologic Mokulaire,
lnstitut Cochin de GBn&ique MoKxulaire, CNRS UPR-0415, 22 rue MBchain, Paris, France.
Books received Books featured in the Books received in Pharmacological
section will not be reviewed
in Trends
Sciences.
S. Araki (ed.) Neurobehavioral Methods and Effects in Occupational and Environmental Health Academic Press, 1994. $49.00 (xxxii + 1020 pages) ISBN 0 12 059785 3 H. Bergman and H. Sinzinger (eds) Radioactive Isotopes in Clinical Medicine und Research Birkhsuser, 1995. E68.00 (xviii + 454 pages) ISBN 3 7643 5082 2 B. B. Biswas and S. Roy (eds) Subcellular Biochemistry Volume24. Proteins: Structure, Function and Engineering Plenum, 1995. $120.00 (xx + 436 pages) ISBN 0 306 44846 7 B. A. Brody (au.) Ethical Issues in Drug Testing, Approval and Pricing. The CIot-Dissolving Drugs Oxford University Press, 1995. E30.00 (x + 268 pages) ISBN 0 19 508831 X I’. R. Brown and E. Grushka (eds) Advances in Chromatography Dekker, 1995.
$165.00 (xviii + 425 pages) ISBN 0 8247 9361 7 G. Darcourt, J. Mendlewicz, G. Racagni and N. Brunello (eds) Current Therapeutic Approaches to Panic and Other Anxiety Disorders Karger, 1994. $180.00 (vi + 206 pages) ISBN 3 8055 5989 5 G. Gregoriadis, B. McCormack and G. Paste (eds) Turgeting of Drugs 4. Advances in System Constructs Plenum, 1994. $75.00 (viii + 207 pages) ISBN 0 306 44910 2 S. Moncada, M. Feelisch, R. Busse and E. A. Higgs (eds) The Biology ofNitric Oxide Part 3: Physiological and Clinical Aspects Portland Press, 1994. E132.00 (xvii + 451 pages) ISBN 185578 063 1 S. Neidle and M. Waring (eds) Molecular Anticuncer Aspects of Drug-DNA Interactions (Vol. 2) Macmillan, 1994.