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Investigation of gluten sensitivity
703 A
28-year-old
woman was
admitted
to
hospital in
1965 with
auditory hallucinations and bizarre ideas. She was discharged after 6 months, and in 1967 she was again admitted with the same symptoms.
Since then she has been
hospital. Despite conventional schizophrenic
with
continuously treated in gradually became
treatment, she
auditory hallucinations,
delusions with
pathological physical sensations, paranoid and suicidal ideas, and fits of aggression. The patient lost contact with reality and became more and more autistic. She was sometimes completely Treatment with baclofen was started mute and isolated herself. on Oct. 1, 1974 (5 mg. three times a day) and gradually increased to 20 mg. three times a day. She was also receiving chlorpromazine (200 mg. three times a day [t.i.d.]), pericyazine (20 mg. t.i.d.), and fluphenazine (125 mg. every 2 weeks). After 4 days, the patient spontaneously started conversations and seemed calmer. She still had some auditory hallucinations, but was able to look upon them objectively. After 2 weeks fluphenazine and pericyazine were withdrawn and chlorpromazine reduced to 400 mg. daily because of tiredness. Previous attempts at drug reduction had caused serious signs of psychosis. On Oct. 22 the patient showed me a book. She no longer had difficulties in following the sentences. She recounted previous events, trauma included, but found it difficult to place them in time. Otherwise, she was well oriented in time. She seemed affectively warmer and easier to reach, and adequately. After 9 years of pro-
replied
Obituary SIDNEY CAMPBELL DYKE
B.A.Toronto, D.M.Oxon., F.R.C.P., F.R.C.Path., D.P.H. Dr Sidney C. Dyke, honorary senior research fellow, department of pathology, University of Birmingham, and founder of the Association of Clinical Pathologists, died on March 3 at the age of 88. He was born in 1886 and went to Canada in 1898 when his family emigrated. At the University of Toronto he took a degree in arts with lst-class honours, after which he took up teaching and journalism. In 1910 he won a Rhodes scholarship to Exeter College, Oxford, where he read natural sciences, graduating once again with lst-class honours and winning a scholarship to St. Mary’s Hospital, London. When war broke out he joined King Edward’s Horse as a trooper but returned to St. Mary’s Hospital to complete his medical course, qualifying L.M.S.S.A. in the shortest possible time so that he could rejoin the Army as a captain in the R.A.M.C. in France. After the war he was assistant bacteriologist in the medical school of the University of Durham until 1920, when he returned to London at the invitation of Sir Cuthbert Wallace to set up a laboratory for the clinical units of St. Thomas’ Hospital. He proceeded to the degree of D.M. and became M.R.C.P. in 1924, when he left St. Thomas’ to become pathologist and bacteriologist to the South Staffordshire General Hospital, now the Royal Hospital, Wolverhampton. Retiring from this post in 1952, he was curator of the Regional Histological Collection, University of Birmingham until 1973.
Dyke’s many achievements are too numerous to list, but they show his wide-ranging interest in medicine and his enthusiasm for the part of clinical pathology in medical progress. This was a period when scientific discoveries were beginning to influence the practice of medicine, and the stage was set for the establishment of laboratories in the provincial hospitals. At this time insulin was becoming available for the treatment of diabetes, and pernicious ansemia could be treated with liver extracts. Dyke took a special interest in these fields, and he also introduced blood-transfusion into local hospital practice, publishing
gressive schizophrenia the trend changed radically after 6 weeks of baclofen therapy, and although the patient is certainly not well, personality integration is more and more obvious.
My preliminary results in thirteen patients are so encouraging that I intend to continue using baclofen in schizophrenic patients. Lillhagens Sjukhus, Hisings Backa 3,
422 03
P. K. FREDERIKSEN.
Sweden.
INVESTIGATION OF GLUTEN SENSITIVITY
SIR,—It is proposed
study the effects of gluten on simple questionary has been constructed for completion by those with known or suspected gluten sensitivity. Will any doctor who has patients in this category please aid this project by writing to me for information andindicating the number of questionaries required ?
health.
to
A
Standard Bank Buildings, 28 Northumberland Avenue, London WC2N 5AG.
J. CROUCHE.
several papers on these and other subjects. In 1927 under his leadership, the growing number of pathologists in the provinces banded together to form the British Pathologists’ Association, later to be known as the Association of Clinical Pathologists. During its formative years Dyke was elected secretary, and with his far-sighted guidance the Association has exerted its influence not only on pathology but on the whole of medical practice in this country-and, indeed, on the Continent, where the European Association of Clinical Pathologists was founded in 1943, which was to develop into the International Society in 1947, and then into the World Association of Societies of Pathology. No-one can really know the work which must have gone into Dr Dyke’s efforts to establish and maintain the highest standards of applied pathology, but as early as 1929 he was awarded the Radcliffe prize for the advancement of medicine. He edited all 6 editions of Recent Advances in Clinical Pathology from 1946 to 1973, and he received honours and appreciation from all over the world. It is indeed sad
realise that the dominant but kindly no longer be found in the front row of A.C.P. meetings. For many years he never missed a meeting, and he soon got to know everyone there, including the youngest members of the Association. Dr C. E. Dukes, in a tribute to Dyke on his 80th birthday, said that in its early years the success of the A.C.P. owed much to Dyke’s eloquence, especially when more or less impromptu. " He of illustrating his remarks was fond, " Dukes wrote, with Biblical quotations and allusions to theological controversies of bygone days. But he always endeavoured to be precise and exact in his choice of words. Le mot juste pleased him greatly." His erudition was remarkable, and his knowledge of literature, the scriptures, music, and the arts was extensive. He was, as Dukes put it, " a far-sighted man, but not a mere visionary. He was always a man of action with the courage of his convictions". There can be no more fitting epitaph for S. C. Dyke than the continuing vitality and influence of his own creation-the Association of Clinical Pathologists. A. G. M. to
figure of Sidney Dyke will
"
A memorial service for Sir Aubrey Lewis will be held at the Liberal Synagogue, 28 St. John’s Wood Road, London NW8, at 12.30 P.M. on Thursday, April 17.
28-year-old
woman was
admitted
to
hospital in
1965 with
auditory hallucinations and bizarre ideas. She was discharged after 6 months, and in 1967 she was again admitted with the same symptoms.
Since then she has been
hospital. Despite conventional schizophrenic
with
continuously treated in gradually became
treatment, she
auditory hallucinations,
delusions with
pathological physical sensations, paranoid and suicidal ideas, and fits of aggression. The patient lost contact with reality and became more and more autistic. She was sometimes completely Treatment with baclofen was started mute and isolated herself. on Oct. 1, 1974 (5 mg. three times a day) and gradually increased to 20 mg. three times a day. She was also receiving chlorpromazine (200 mg. three times a day [t.i.d.]), pericyazine (20 mg. t.i.d.), and fluphenazine (125 mg. every 2 weeks). After 4 days, the patient spontaneously started conversations and seemed calmer. She still had some auditory hallucinations, but was able to look upon them objectively. After 2 weeks fluphenazine and pericyazine were withdrawn and chlorpromazine reduced to 400 mg. daily because of tiredness. Previous attempts at drug reduction had caused serious signs of psychosis. On Oct. 22 the patient showed me a book. She no longer had difficulties in following the sentences. She recounted previous events, trauma included, but found it difficult to place them in time. Otherwise, she was well oriented in time. She seemed affectively warmer and easier to reach, and adequately. After 9 years of pro-
replied
Obituary SIDNEY CAMPBELL DYKE
B.A.Toronto, D.M.Oxon., F.R.C.P., F.R.C.Path., D.P.H. Dr Sidney C. Dyke, honorary senior research fellow, department of pathology, University of Birmingham, and founder of the Association of Clinical Pathologists, died on March 3 at the age of 88. He was born in 1886 and went to Canada in 1898 when his family emigrated. At the University of Toronto he took a degree in arts with lst-class honours, after which he took up teaching and journalism. In 1910 he won a Rhodes scholarship to Exeter College, Oxford, where he read natural sciences, graduating once again with lst-class honours and winning a scholarship to St. Mary’s Hospital, London. When war broke out he joined King Edward’s Horse as a trooper but returned to St. Mary’s Hospital to complete his medical course, qualifying L.M.S.S.A. in the shortest possible time so that he could rejoin the Army as a captain in the R.A.M.C. in France. After the war he was assistant bacteriologist in the medical school of the University of Durham until 1920, when he returned to London at the invitation of Sir Cuthbert Wallace to set up a laboratory for the clinical units of St. Thomas’ Hospital. He proceeded to the degree of D.M. and became M.R.C.P. in 1924, when he left St. Thomas’ to become pathologist and bacteriologist to the South Staffordshire General Hospital, now the Royal Hospital, Wolverhampton. Retiring from this post in 1952, he was curator of the Regional Histological Collection, University of Birmingham until 1973.
Dyke’s many achievements are too numerous to list, but they show his wide-ranging interest in medicine and his enthusiasm for the part of clinical pathology in medical progress. This was a period when scientific discoveries were beginning to influence the practice of medicine, and the stage was set for the establishment of laboratories in the provincial hospitals. At this time insulin was becoming available for the treatment of diabetes, and pernicious ansemia could be treated with liver extracts. Dyke took a special interest in these fields, and he also introduced blood-transfusion into local hospital practice, publishing
gressive schizophrenia the trend changed radically after 6 weeks of baclofen therapy, and although the patient is certainly not well, personality integration is more and more obvious.
My preliminary results in thirteen patients are so encouraging that I intend to continue using baclofen in schizophrenic patients. Lillhagens Sjukhus, Hisings Backa 3,
422 03
P. K. FREDERIKSEN.
Sweden.
INVESTIGATION OF GLUTEN SENSITIVITY
SIR,—It is proposed
study the effects of gluten on simple questionary has been constructed for completion by those with known or suspected gluten sensitivity. Will any doctor who has patients in this category please aid this project by writing to me for information andindicating the number of questionaries required ?
health.
to
A
Standard Bank Buildings, 28 Northumberland Avenue, London WC2N 5AG.
J. CROUCHE.
several papers on these and other subjects. In 1927 under his leadership, the growing number of pathologists in the provinces banded together to form the British Pathologists’ Association, later to be known as the Association of Clinical Pathologists. During its formative years Dyke was elected secretary, and with his far-sighted guidance the Association has exerted its influence not only on pathology but on the whole of medical practice in this country-and, indeed, on the Continent, where the European Association of Clinical Pathologists was founded in 1943, which was to develop into the International Society in 1947, and then into the World Association of Societies of Pathology. No-one can really know the work which must have gone into Dr Dyke’s efforts to establish and maintain the highest standards of applied pathology, but as early as 1929 he was awarded the Radcliffe prize for the advancement of medicine. He edited all 6 editions of Recent Advances in Clinical Pathology from 1946 to 1973, and he received honours and appreciation from all over the world. It is indeed sad
realise that the dominant but kindly no longer be found in the front row of A.C.P. meetings. For many years he never missed a meeting, and he soon got to know everyone there, including the youngest members of the Association. Dr C. E. Dukes, in a tribute to Dyke on his 80th birthday, said that in its early years the success of the A.C.P. owed much to Dyke’s eloquence, especially when more or less impromptu. " He of illustrating his remarks was fond, " Dukes wrote, with Biblical quotations and allusions to theological controversies of bygone days. But he always endeavoured to be precise and exact in his choice of words. Le mot juste pleased him greatly." His erudition was remarkable, and his knowledge of literature, the scriptures, music, and the arts was extensive. He was, as Dukes put it, " a far-sighted man, but not a mere visionary. He was always a man of action with the courage of his convictions". There can be no more fitting epitaph for S. C. Dyke than the continuing vitality and influence of his own creation-the Association of Clinical Pathologists. A. G. M. to
figure of Sidney Dyke will
"
A memorial service for Sir Aubrey Lewis will be held at the Liberal Synagogue, 28 St. John’s Wood Road, London NW8, at 12.30 P.M. on Thursday, April 17.