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Iotaderma #161
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IOTADERMA #161 What is Texier’s syndrome, and what is its cause? Robert I. Rudolph, MD, FACP Answer will appear in the July issue of the Journal.
MAY IOTADERMA (#160) What is emperipolesis, and in what disease with cutaneous manifestations is it constantly present? Answer: Emperipolesis is a pathologic finding in which histiocytes contain whole, or fragments of, lymphocytes, neutrophils, eosinophils, and plasma cells. It is a constant finding in RosaieDorfman disease (sinus histiocytosis with massive lymphadenopathy), but can be detected in other conditions, such as chronic lymphatic leukemia, CreutzfeldteJakob disease, and Schimke immuno-osseous dysplasia, and many other organ systems, such as the brain, kidney, and bone marrow. REFERENCES Pitamber HV, Grayson W. Five cases of cutaneous RosaieDorfman disease. Clin Exp Dermatol 2003;28:17-21. RosaieDorfman disease. In: Pathology of the skin (3rd ed). McKee PH, Calonje E, Granter SR, editors. Philadelphia (PA): Elsevier Mosby, 2005. Shintaku M, Yutani C. Oligodendrocytes within astrocytes (‘‘emperipolesis’’) in the white matter in CreutzfeldteJakob disease. Acta Neuropathol 2004;108:201-6.
Robert I. Rudolph, MD, FACP
1058
NOTES
IOTADERMA #161 What is Texier’s syndrome, and what is its cause? Robert I. Rudolph, MD, FACP Answer will appear in the July issue of the Journal.
MAY IOTADERMA (#160) What is emperipolesis, and in what disease with cutaneous manifestations is it constantly present? Answer: Emperipolesis is a pathologic finding in which histiocytes contain whole, or fragments of, lymphocytes, neutrophils, eosinophils, and plasma cells. It is a constant finding in RosaieDorfman disease (sinus histiocytosis with massive lymphadenopathy), but can be detected in other conditions, such as chronic lymphatic leukemia, CreutzfeldteJakob disease, and Schimke immuno-osseous dysplasia, and many other organ systems, such as the brain, kidney, and bone marrow. REFERENCES Pitamber HV, Grayson W. Five cases of cutaneous RosaieDorfman disease. Clin Exp Dermatol 2003;28:17-21. RosaieDorfman disease. In: Pathology of the skin (3rd ed). McKee PH, Calonje E, Granter SR, editors. Philadelphia (PA): Elsevier Mosby, 2005. Shintaku M, Yutani C. Oligodendrocytes within astrocytes (‘‘emperipolesis’’) in the white matter in CreutzfeldteJakob disease. Acta Neuropathol 2004;108:201-6.
Robert I. Rudolph, MD, FACP
1058