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I.P2 Prevalence of non motor symptoms in Parkinson's Disease: An international survey using NMSQuest in 525 patients
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POSTER PRESENTATIONS
Section I: Basic concepts and (Early) Non-Motor Manifestations I.P1 Depression and cognitive impairment in patiens with Parkinson’s Disease in university clinical centre of Belgrade E. Dzoljic° , H. Vlajinac, S. Sipetic, J. Maksimovic, I. Ratkov, V. Kostic Institute of Neurology and Epidemiology, School of Medicine, University of Belgrade, Serbia and Montenegro Introduction: Depression and dementia in association with PD have recently gained increasing attention because of their significant impact on quality of life as well as on response to anti-parkinsonian medication. Objective: To assess the major non-motor symptoms in patients with Parkinson’s Disease (PD). Methods: This case–control study comprises 110 patients with PD and 220 age, gender matched control subjects in University Clinical Centre of Serbia, Belgrade, during 2002–2005. All participants were assessed using questionnaire, including Mini Mental Score Examination (MMSE) and Hamilton Depression Rating Scale (HDRS). Results: There were 63 (57.27%) males, 47 (42.72%) females, with average age: 60.75±8.64 years in PD patients and 126 (57.27%) male, 94 (42.72%) female, with average age: 60.57±8.78 years in control. HDRS 17 had 85 (72.27%) PD patients and 199 (90.91%) of controls, while 18 HDRS was found in 25 (27.73%) patients with PD and 21 (9.09%) controls (PD vs. control: p 0.05). Additionally, MMSE 24 was found in majority 106 (96.36%) PD patients and 216 (98.18%) controls, while MMSE 23 had only 4 (3.64%) PD patients and 4 (1.82%) controls. (PD vs. control: NS). Conclusion: In our survey symptoms of depression were significantly more frequent in patients with PD than in controls, while cognitive impairment was not prominent, neither in PD patients nor in controls. I.P2 Prevalence of non motor symptoms in Parkinson’s Disease: An international survey using NMSQuest in 525 patients L. Clayton1° , P. Martinez-Martin2 , P. Odin3 , F. Stocchi4 , U. Bonuccelli5 , K. Sethi6 , A.H.V. Schapira7 , R. Brown8 , J.M. Rabey9 , K.R. Chaudhuri10,1 Parkinson’s Disease Non Motor Group. 1 Guy’s, King’s and St Thomas’ School of Medicine, King’s College London, UK; 2 National Centre for Epidemiology. Carlos III Institute of Health, Madrid, Spain; 3 Central Hospital, Bremerhaven, Germany; 4 Institute of Neurology, IRCCS NEUROMED, Pozzilli (IS), Italy; 5 Dipartimento di Neuroscienze Universit`a di Pisa, Italy; 6 Medical College of Georgia, USA; 7 Royal Free Hospital Medical School and National Hospital for Neurology, Neurosurgery, Queen Square, London, 8 Department of Psychology, Institute of Psychiatry, King’s College London, UK; 9 Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University, Zerifin, Israel; 10 King’s College and Lewisham Hospitals, London, UK Introduction: Non motor symptoms (NMS) are becoming increasingly recognised as an integral part of Parkinson’s Disease (PD) and a key determinant of quality of life (QoL). NMSQuest is a recently validated, self completing questionnaire with 30 items, allowing a comprehensive assessment of NMS in PD. Objective: To asses the prevalence and pattern of NMS across an international setting reflective of a “real life” population of PD (neurological and geriatric centres) using the NMSQuest.
Methods: 525 PD patients (57.9% male, mean age 67.7±10.5yrs (34−91), mean disease duration 6.9±5.3 (0.5–38yrs), median Hoehn and Yahr (HY) score 2.5 (1−5), from Germany, Italy, Israel, Japan, UK and USA, completed the NMSQuest. Data was compared with demographic details. Results: The mean number of NMS experienced was 10±5.3(0–28), with >30% of patients experiencing dribbling, constipation, urgency, nocturia, memory, loss of interest, concentration, blues, anxiety, sex drive, sex difficulties, dizziness, sleep problems, insomnia, vivid dreams, acting out dreams, restless legs and swelling. These symptoms were consistently present in each international centres and across the countries. The NMS scores correlated positively with HY stage. Conclusion: NMS is common in PD and most may have up to 10 different NMS. Across an international setting NMS related to urinary, gastrointestinal, cognitive and sleep domains are most prominent and the number of NMS increases with advancing PD. References Chaudhuri KR, Martinez-Martin P, Schapira AHV et al. An international multicentre pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s Disease: The NMSQuest study. Mov Disord, in press.
I.P3 A study of sensorimotor filtering in “de novo” Parkinson Disease M.P. Perriol° , Ph. Derambure, A. Dest´ee, L. Defebvre, K. Dujardin Lille University Hospital, Lille, France Introduction: Pre-pulse inhibition (PPI) is considered to mirror sensorimotor gating, an organism’s ability to filter out irrelevant sensory or cognitive information. The disruption of PPI has been investigated in several neurological and psychiatric basal ganglia disorders characterized by a disruption of attention (Huntington disease, Tourette’s syndrome and schizophrenia). PPI is thought to reflect the early stages of attentional processing, allowing selection of relevant information. It was shown to be deficient in dementia with Lewy bodies and Parkinson’s Disease with dementia while preserved in Alzheimer’s disease. The issue of the disruption of PPI in the early stages of Parkinson’s Disease (PD) has not been investigated yet. Methods: PPI of the N1/P2 component of auditory evoked potentials was used to investigate the early stages of attention selectivity in 10 untreated PD patients early in the course of the disease and 10 healthy controls (HC). The PPI paradigm consisted of the presentation of sound pulses (40 ms, 115 dB) proceeded by a pre-pulse (40 ms, 80 dB). Sound stimuli were presented in a total of 80 trials (20 with the pulse alone, and three groups of 20 with a pre-pulse–pulse time interval of 60, 120 and 300 ms respectively) in a pseudo-random order. Results: Untreated PD patients showed no significant disruption of PPI compared to HC. Conclusion: The present study evidences no significant disturbance of PPI early in the course of the disease in patients with no cognitive impairment and no dopatherapy.
POSTER PRESENTATIONS
Section I: Basic concepts and (Early) Non-Motor Manifestations I.P1 Depression and cognitive impairment in patiens with Parkinson’s Disease in university clinical centre of Belgrade E. Dzoljic° , H. Vlajinac, S. Sipetic, J. Maksimovic, I. Ratkov, V. Kostic Institute of Neurology and Epidemiology, School of Medicine, University of Belgrade, Serbia and Montenegro Introduction: Depression and dementia in association with PD have recently gained increasing attention because of their significant impact on quality of life as well as on response to anti-parkinsonian medication. Objective: To assess the major non-motor symptoms in patients with Parkinson’s Disease (PD). Methods: This case–control study comprises 110 patients with PD and 220 age, gender matched control subjects in University Clinical Centre of Serbia, Belgrade, during 2002–2005. All participants were assessed using questionnaire, including Mini Mental Score Examination (MMSE) and Hamilton Depression Rating Scale (HDRS). Results: There were 63 (57.27%) males, 47 (42.72%) females, with average age: 60.75±8.64 years in PD patients and 126 (57.27%) male, 94 (42.72%) female, with average age: 60.57±8.78 years in control. HDRS 17 had 85 (72.27%) PD patients and 199 (90.91%) of controls, while 18 HDRS was found in 25 (27.73%) patients with PD and 21 (9.09%) controls (PD vs. control: p 0.05). Additionally, MMSE 24 was found in majority 106 (96.36%) PD patients and 216 (98.18%) controls, while MMSE 23 had only 4 (3.64%) PD patients and 4 (1.82%) controls. (PD vs. control: NS). Conclusion: In our survey symptoms of depression were significantly more frequent in patients with PD than in controls, while cognitive impairment was not prominent, neither in PD patients nor in controls. I.P2 Prevalence of non motor symptoms in Parkinson’s Disease: An international survey using NMSQuest in 525 patients L. Clayton1° , P. Martinez-Martin2 , P. Odin3 , F. Stocchi4 , U. Bonuccelli5 , K. Sethi6 , A.H.V. Schapira7 , R. Brown8 , J.M. Rabey9 , K.R. Chaudhuri10,1 Parkinson’s Disease Non Motor Group. 1 Guy’s, King’s and St Thomas’ School of Medicine, King’s College London, UK; 2 National Centre for Epidemiology. Carlos III Institute of Health, Madrid, Spain; 3 Central Hospital, Bremerhaven, Germany; 4 Institute of Neurology, IRCCS NEUROMED, Pozzilli (IS), Italy; 5 Dipartimento di Neuroscienze Universit`a di Pisa, Italy; 6 Medical College of Georgia, USA; 7 Royal Free Hospital Medical School and National Hospital for Neurology, Neurosurgery, Queen Square, London, 8 Department of Psychology, Institute of Psychiatry, King’s College London, UK; 9 Assaf Harofeh Medical Center, School of Medicine, Tel-Aviv University, Zerifin, Israel; 10 King’s College and Lewisham Hospitals, London, UK Introduction: Non motor symptoms (NMS) are becoming increasingly recognised as an integral part of Parkinson’s Disease (PD) and a key determinant of quality of life (QoL). NMSQuest is a recently validated, self completing questionnaire with 30 items, allowing a comprehensive assessment of NMS in PD. Objective: To asses the prevalence and pattern of NMS across an international setting reflective of a “real life” population of PD (neurological and geriatric centres) using the NMSQuest.
Methods: 525 PD patients (57.9% male, mean age 67.7±10.5yrs (34−91), mean disease duration 6.9±5.3 (0.5–38yrs), median Hoehn and Yahr (HY) score 2.5 (1−5), from Germany, Italy, Israel, Japan, UK and USA, completed the NMSQuest. Data was compared with demographic details. Results: The mean number of NMS experienced was 10±5.3(0–28), with >30% of patients experiencing dribbling, constipation, urgency, nocturia, memory, loss of interest, concentration, blues, anxiety, sex drive, sex difficulties, dizziness, sleep problems, insomnia, vivid dreams, acting out dreams, restless legs and swelling. These symptoms were consistently present in each international centres and across the countries. The NMS scores correlated positively with HY stage. Conclusion: NMS is common in PD and most may have up to 10 different NMS. Across an international setting NMS related to urinary, gastrointestinal, cognitive and sleep domains are most prominent and the number of NMS increases with advancing PD. References Chaudhuri KR, Martinez-Martin P, Schapira AHV et al. An international multicentre pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson’s Disease: The NMSQuest study. Mov Disord, in press.
I.P3 A study of sensorimotor filtering in “de novo” Parkinson Disease M.P. Perriol° , Ph. Derambure, A. Dest´ee, L. Defebvre, K. Dujardin Lille University Hospital, Lille, France Introduction: Pre-pulse inhibition (PPI) is considered to mirror sensorimotor gating, an organism’s ability to filter out irrelevant sensory or cognitive information. The disruption of PPI has been investigated in several neurological and psychiatric basal ganglia disorders characterized by a disruption of attention (Huntington disease, Tourette’s syndrome and schizophrenia). PPI is thought to reflect the early stages of attentional processing, allowing selection of relevant information. It was shown to be deficient in dementia with Lewy bodies and Parkinson’s Disease with dementia while preserved in Alzheimer’s disease. The issue of the disruption of PPI in the early stages of Parkinson’s Disease (PD) has not been investigated yet. Methods: PPI of the N1/P2 component of auditory evoked potentials was used to investigate the early stages of attention selectivity in 10 untreated PD patients early in the course of the disease and 10 healthy controls (HC). The PPI paradigm consisted of the presentation of sound pulses (40 ms, 115 dB) proceeded by a pre-pulse (40 ms, 80 dB). Sound stimuli were presented in a total of 80 trials (20 with the pulse alone, and three groups of 20 with a pre-pulse–pulse time interval of 60, 120 and 300 ms respectively) in a pseudo-random order. Results: Untreated PD patients showed no significant disruption of PPI compared to HC. Conclusion: The present study evidences no significant disturbance of PPI early in the course of the disease in patients with no cognitive impairment and no dopatherapy.