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Iris Vessel Involvement in Iris-Nevus Syndrome
447
ABSTRACTS
in the subepithelial layer was observed as bright, highly refractive tissue interspersed with small spaces void of cells, and was especially evident at the wound edges of the peripheral side. The center of the cornea was slightly damaged by the excimer laser, but proliferative changes were not observed there. Conclusion: The results of this study revealed that the damage to the center of the cornea caused by PRK for hyperopia was not very severe. But it is important to evaluate further the efficacy and safety of PRK for hyperopia. (J Jpn Ophthalmol Soc 103:243– 251, 1999) Yuji Hosoda and Kiyoo Nakayasu Department of Ophthalmology, Juntendo University School of Medicine PII S0021-5155(99)00075-1
Comparison With Indocyanine Green Angiography and Immunohistochemical Study of Choroidal Neovascular Membrane in Age-related Macular Degeneration Purpose: We classified choroidal neovascular membranes (CNMs) (48 eyes) in age-related macular degeneration (AMD) into four types using indocyanine green angiography. Methods: Surgically extracted CNMs were examined immunohistochemically. Specimens were stained with glial fibrillary acidic protein (GFAP), von Willebrand factor, Ki-67 antigen, actin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), and transforming growth factor (TGF-b1). Results: All types of CNM were positively stained with GFAP on the side opposite the retinal pigment epithelial (RPE) cells. This suggests the adherence of neurosensory retina to the CNM. Type I membranes that showed hyperfluorescence in the early and late phase of ICG angiography were significantly stained with Ki-67 antigen. Conclusion: These results indicate that CNMs in AMD are extracted with neurosensory retina and RPE cells during surgery. Type I membranes have a high capability for proliferation. (J Jpn Ophthalmol Soc 103:252–258, 1999) Masami Nakajima,* Hiroyuki Shimada,† Misao Sato† and Mitsuko Yuzawa† Department of Ophthalmology, Inatori Hospital of Nihon University PII S0021-5155(99)00076-3
Iris Vessel Involvement in Iris-Nevus Syndrome Purpose: To report a case of iris-nevus syndrome accompanied by disruption of the blood-aqueous barrier in the iris, which was confirmed angiographically and histopathologically. Case: The patient was a 39-year-old woman. She noticed blurred vision in the left eye, which was diagnosed as left glaucoma. Specular microscopy revealed low endothelial cell density in the left cornea. The left iris showed atrophy with clusters of nodular iris nevus and distorted pupil. The left iridocorneal angle was closed with peripheral anterior synechia. Findings: Indocyanine green iris angiography revealed more vessels on the surface of the left iris than on the right. In fluorescein iris angiography, the dye leaked from the iris vessels in areas where the iris showed advanced atrophy. The trabecular tissue obtained by trabeculectomy from the patient’s left eye showed histopathologically a lining of corneal endothelial cells on the surface of the iris. The density of the vessels was high in the iris stroma. Some cells covering the vessel wall showed degeneration with opening of the zonula occludens. Schlemm’s canal had narrowed lumina, and the intertrabecular spaces were closed. Conclusion: Disruption of the blood-aqueous barrier may occur in iris-nevus syndrome. (J Jpn Ophthalmol Soc 103:259–267, 1999) Akihiko Tawara,* Takao Nakamura,† Ayako Yoshida,† Toshiaki Kubota,† Yoshitaka Ohnishi* and Hajime Inomata† *Department of Ophthalmology, Wakayama Medical College; †Department of Ophthalmology, Faculty of Medicine, Kyushu University PII S0021-5155(99)00077-5
Expression of Brain-derived Neurotrophic Factor Gene in Retina Following Vitreous Tap Purpose: Mechanical injuries to the retina following vitreous tap are reported to protect photoreceptor cells in a rat model of the retinal degeneration and enhance the survival rate of retinal ganglion cells in the optic nerve transection. Neurotrophic factors are presumably involved in the protective mechanisms. In order to see whether neurotrophic factors are synthesized in the retina, we studied the expression of neurotrophic factors in the retina following vitreous tap in rats.
ABSTRACTS
in the subepithelial layer was observed as bright, highly refractive tissue interspersed with small spaces void of cells, and was especially evident at the wound edges of the peripheral side. The center of the cornea was slightly damaged by the excimer laser, but proliferative changes were not observed there. Conclusion: The results of this study revealed that the damage to the center of the cornea caused by PRK for hyperopia was not very severe. But it is important to evaluate further the efficacy and safety of PRK for hyperopia. (J Jpn Ophthalmol Soc 103:243– 251, 1999) Yuji Hosoda and Kiyoo Nakayasu Department of Ophthalmology, Juntendo University School of Medicine PII S0021-5155(99)00075-1
Comparison With Indocyanine Green Angiography and Immunohistochemical Study of Choroidal Neovascular Membrane in Age-related Macular Degeneration Purpose: We classified choroidal neovascular membranes (CNMs) (48 eyes) in age-related macular degeneration (AMD) into four types using indocyanine green angiography. Methods: Surgically extracted CNMs were examined immunohistochemically. Specimens were stained with glial fibrillary acidic protein (GFAP), von Willebrand factor, Ki-67 antigen, actin, vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), and transforming growth factor (TGF-b1). Results: All types of CNM were positively stained with GFAP on the side opposite the retinal pigment epithelial (RPE) cells. This suggests the adherence of neurosensory retina to the CNM. Type I membranes that showed hyperfluorescence in the early and late phase of ICG angiography were significantly stained with Ki-67 antigen. Conclusion: These results indicate that CNMs in AMD are extracted with neurosensory retina and RPE cells during surgery. Type I membranes have a high capability for proliferation. (J Jpn Ophthalmol Soc 103:252–258, 1999) Masami Nakajima,* Hiroyuki Shimada,† Misao Sato† and Mitsuko Yuzawa† Department of Ophthalmology, Inatori Hospital of Nihon University PII S0021-5155(99)00076-3
Iris Vessel Involvement in Iris-Nevus Syndrome Purpose: To report a case of iris-nevus syndrome accompanied by disruption of the blood-aqueous barrier in the iris, which was confirmed angiographically and histopathologically. Case: The patient was a 39-year-old woman. She noticed blurred vision in the left eye, which was diagnosed as left glaucoma. Specular microscopy revealed low endothelial cell density in the left cornea. The left iris showed atrophy with clusters of nodular iris nevus and distorted pupil. The left iridocorneal angle was closed with peripheral anterior synechia. Findings: Indocyanine green iris angiography revealed more vessels on the surface of the left iris than on the right. In fluorescein iris angiography, the dye leaked from the iris vessels in areas where the iris showed advanced atrophy. The trabecular tissue obtained by trabeculectomy from the patient’s left eye showed histopathologically a lining of corneal endothelial cells on the surface of the iris. The density of the vessels was high in the iris stroma. Some cells covering the vessel wall showed degeneration with opening of the zonula occludens. Schlemm’s canal had narrowed lumina, and the intertrabecular spaces were closed. Conclusion: Disruption of the blood-aqueous barrier may occur in iris-nevus syndrome. (J Jpn Ophthalmol Soc 103:259–267, 1999) Akihiko Tawara,* Takao Nakamura,† Ayako Yoshida,† Toshiaki Kubota,† Yoshitaka Ohnishi* and Hajime Inomata† *Department of Ophthalmology, Wakayama Medical College; †Department of Ophthalmology, Faculty of Medicine, Kyushu University PII S0021-5155(99)00077-5
Expression of Brain-derived Neurotrophic Factor Gene in Retina Following Vitreous Tap Purpose: Mechanical injuries to the retina following vitreous tap are reported to protect photoreceptor cells in a rat model of the retinal degeneration and enhance the survival rate of retinal ganglion cells in the optic nerve transection. Neurotrophic factors are presumably involved in the protective mechanisms. In order to see whether neurotrophic factors are synthesized in the retina, we studied the expression of neurotrophic factors in the retina following vitreous tap in rats.