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Is language ability related to the extent of hemispheric language lateralization?
NeuroImage
11, Number
5, 2000, Part 2 of 2 Parts ID
E al@
LANGUAGE
Is language ability related to the extent of hemispheric language lateralization? K. Anneken, H. Lohmann,
A. Floeel, C. Konrad, Chr. Buchinger, M. Deppe, S. Knecht of Neurology,
Department
University
of Muenster,
Germany
Introduction: It has been assumed that the functional linguistic potential (1,2). “Hemispheric present study we addressed the question of hemispheric language lateralization. language lateralization (4).
lateralization of the human brain may be a prerequisite for the full realization of our indecision” has been related to deficits in a number of intellectual domains (3). In the whether linguistic and non-linguistic abilities in healthy subjects correlate with the extent We used functional transcranial Doppler sonography (ffCD) to quantify hemispheric
Methods: So far, in 30 healthy volunteers (13 male, 17 woman) hemispheric language lateralization was determined by ITCD using a word generation task. A laterality index LI was calculated using the AVERAGE program (5). Linguistic and non-linguistic abilities were assessed by the Leistungsprtlfsystem-kurz (LPS-k). The LPS-k, a test with proven sensitivity and validity, is one of the most widely used measures for intelligence testing in Germany (6). The test is subdevided in two sections, a linguistic and a non-linguistic performance. The three linguistic subtests include “verbal factor” [subtest 1 plus 21, “wordfluency” [subtest 51, “ability to guess” [subtest 121. The three non-linguistic subtests consist of “reasoning” [subtest 41 and “technical abilities” [subtest 9, subtest lo]. Age-adjusted t-values for linguistic and non-linguistic subtests of the LPS-k were correlated with LI. Profile level of linguistic and non-linguistic subtests of the LPS-k and the linear contrast between these two parameters were also correlated with LI (6). Results: 1. The overall linguistic performance as assessed by LPS-k did not correlate with the LI (r = -0.09). 2. The three linguistic subtests [subtests 1 plus 25,121 did not correlate significantly with the LI (r= -0.24, r= -0.6, r= -0.32). 3. Furthermore, we could not find a significant correlation between the overall non-linguistic performance as assessed by LPS-k and the LI (r= 0.18). The non-linguistic subtests [subtests 4,9,10] did not correlate significantly with the LI as well (r= 0.12, r= 0.34, r= -0.8). Conclusion: There is no straightforward relation standard linguistic performance.
between
the extent
of hemispheric
language
lateralization
(using
a word generation
task) and
References: (1) Luria AR. The working brain. New York:Basic Books, 1973 (2) Geschwind N, Galaburda AM. Cerebral lateralization. Biological mechanisms associations, and pathology: I. A hypothesis and a program for research. Arch Neurol 1985; 42:428-459. (3) Crow TJ, Crow LR, Done DJ, Leask S. Relative hand skill predicts academic ability: global deficits at the point of hemispheric indecision. Neuropsychologia 1998;36:1275-1282. (4) Knecht S, Deppe M, Ebner A, et al. Non-invasive determination of hemispheric language dominance using functional transcranial Doppler sonography: A comparison with the Wada test. Stroke 1998;29:82-86. (5) Deppe M. Knecht S, Henningsen H, Ringelstein E-B. Average: A Windows program for automated analysis of event related cerebral blood flow. J Neurosci Methods 1997;75: 147-154. (6) Sturm W, Willmes K, LPS-K eine LPS-Kurzform fur himgeschadigte Patienten: mit Anleitung zui- p\ychometrischen Einzelfalldiagnosttk. Diagnostica 1983, Band 29, Heft 4: 346-358.
S327
11, Number
5, 2000, Part 2 of 2 Parts ID
E al@
LANGUAGE
Is language ability related to the extent of hemispheric language lateralization? K. Anneken, H. Lohmann,
A. Floeel, C. Konrad, Chr. Buchinger, M. Deppe, S. Knecht of Neurology,
Department
University
of Muenster,
Germany
Introduction: It has been assumed that the functional linguistic potential (1,2). “Hemispheric present study we addressed the question of hemispheric language lateralization. language lateralization (4).
lateralization of the human brain may be a prerequisite for the full realization of our indecision” has been related to deficits in a number of intellectual domains (3). In the whether linguistic and non-linguistic abilities in healthy subjects correlate with the extent We used functional transcranial Doppler sonography (ffCD) to quantify hemispheric
Methods: So far, in 30 healthy volunteers (13 male, 17 woman) hemispheric language lateralization was determined by ITCD using a word generation task. A laterality index LI was calculated using the AVERAGE program (5). Linguistic and non-linguistic abilities were assessed by the Leistungsprtlfsystem-kurz (LPS-k). The LPS-k, a test with proven sensitivity and validity, is one of the most widely used measures for intelligence testing in Germany (6). The test is subdevided in two sections, a linguistic and a non-linguistic performance. The three linguistic subtests include “verbal factor” [subtest 1 plus 21, “wordfluency” [subtest 51, “ability to guess” [subtest 121. The three non-linguistic subtests consist of “reasoning” [subtest 41 and “technical abilities” [subtest 9, subtest lo]. Age-adjusted t-values for linguistic and non-linguistic subtests of the LPS-k were correlated with LI. Profile level of linguistic and non-linguistic subtests of the LPS-k and the linear contrast between these two parameters were also correlated with LI (6). Results: 1. The overall linguistic performance as assessed by LPS-k did not correlate with the LI (r = -0.09). 2. The three linguistic subtests [subtests 1 plus 25,121 did not correlate significantly with the LI (r= -0.24, r= -0.6, r= -0.32). 3. Furthermore, we could not find a significant correlation between the overall non-linguistic performance as assessed by LPS-k and the LI (r= 0.18). The non-linguistic subtests [subtests 4,9,10] did not correlate significantly with the LI as well (r= 0.12, r= 0.34, r= -0.8). Conclusion: There is no straightforward relation standard linguistic performance.
between
the extent
of hemispheric
language
lateralization
(using
a word generation
task) and
References: (1) Luria AR. The working brain. New York:Basic Books, 1973 (2) Geschwind N, Galaburda AM. Cerebral lateralization. Biological mechanisms associations, and pathology: I. A hypothesis and a program for research. Arch Neurol 1985; 42:428-459. (3) Crow TJ, Crow LR, Done DJ, Leask S. Relative hand skill predicts academic ability: global deficits at the point of hemispheric indecision. Neuropsychologia 1998;36:1275-1282. (4) Knecht S, Deppe M, Ebner A, et al. Non-invasive determination of hemispheric language dominance using functional transcranial Doppler sonography: A comparison with the Wada test. Stroke 1998;29:82-86. (5) Deppe M. Knecht S, Henningsen H, Ringelstein E-B. Average: A Windows program for automated analysis of event related cerebral blood flow. J Neurosci Methods 1997;75: 147-154. (6) Sturm W, Willmes K, LPS-K eine LPS-Kurzform fur himgeschadigte Patienten: mit Anleitung zui- p\ychometrischen Einzelfalldiagnosttk. Diagnostica 1983, Band 29, Heft 4: 346-358.
S327