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Is psoriasis an allergic disease?
217
ABSTRACTS The inference is drawn that if one tests with this list of allergens pollens one will secure a positive reaction in a high percentage of which are capable of responding with positive reactions. Is Psoriasis
an Allergic
Disease?
Zcidler,
R. Wien.
med.
as well as with eases of allergy
81: 577, 1931.
Wehnschr.
In a series of patients treated with pollen extracts for hay fever there were It came to the attenseveral individuals who suff’ered also with psoriasis vulgaris. tion of the writer, that in the course of treatments with pollen extract injection, the The question arose as to whether this was simply psoriasis was likewise relieved. a spontaneous remission or an effect attributable to the pollen therapy. Experiments were performed to discover : (1) How a normal skin (no symptoms of hay fever) reacted to tests with pollen extracts. (2) How a psoriasitic skin (no symptoms of hay fever) reacted. Results showed that no normal skin gave a positive reaction to the pollen extracts. From patients with psoriasis vulgaris, however, a positive reaction to the pollen extracts was elicited. It was observed that the course of the psoriasis vulgaris When a cutaneous reaction with the strongest ran parallel with the skin reaction. concentration of pollen extract could no longer be elicited, the psoriasis also diminished to a point where it was practically cured. It was found, further, that 22 per cent of patients with psoriasis showed some nasal symptoms typical of hay fever or rhinitis conditions. The etiology of psoriasis vulgaris has long been a matter of much dispute. The findings of the present writer bring up the possibility of au allergic etiology. Whether the psoriasis is an allergic reaction to the excitant of hay fever and therefore only a symptom of hay fever, or a reaction by hypersensitive individuals to various specific foreign substances, the writer is not prepared to state at the present time.
Passive Anaplhylaxis. Injections Into Rabbits of Human Serum from Hypersensitive Individuals, Miield With the Specific Allmergen. Vallery-Radot, P., Maubic, G., Hugo,
A.,
and
Giroud,
P. Compt.
rend.
fioe.
de biol.
107:
707,
1931.
Having failed to accomplish passive transfer of anaphylaxis by iujecting human serum from hypersensitive individuals into rabbits and at some time thereafter injecting the specific allergen, the authors undertook to mix the serum and allergen Patients giving positive Prausnitz-Kiistner reactions and those with posiin vitro. tive skin reactions were chosen. Fifteen experiments were done. In eight, the serum and allergen were allowed to stand at room temperature for one-half hour; in one, two hours; and in six, twenty-four hours. In some, the mixtures were centrifuged and the supernatant fluid was injected; in others the whole mixtures were administered. In no instance was passive anaphylaxis obtained. In 10 control experiments with normal serum and allergens, no anaphylaxis was obtained. Consequently, passive transfer of anaphyla.xis could not be accomplished by mixtures of reagins and allergens.
ABSTRACTS The inference is drawn that if one tests with this list of allergens pollens one will secure a positive reaction in a high percentage of which are capable of responding with positive reactions. Is Psoriasis
an Allergic
Disease?
Zcidler,
R. Wien.
med.
as well as with eases of allergy
81: 577, 1931.
Wehnschr.
In a series of patients treated with pollen extracts for hay fever there were It came to the attenseveral individuals who suff’ered also with psoriasis vulgaris. tion of the writer, that in the course of treatments with pollen extract injection, the The question arose as to whether this was simply psoriasis was likewise relieved. a spontaneous remission or an effect attributable to the pollen therapy. Experiments were performed to discover : (1) How a normal skin (no symptoms of hay fever) reacted to tests with pollen extracts. (2) How a psoriasitic skin (no symptoms of hay fever) reacted. Results showed that no normal skin gave a positive reaction to the pollen extracts. From patients with psoriasis vulgaris, however, a positive reaction to the pollen extracts was elicited. It was observed that the course of the psoriasis vulgaris When a cutaneous reaction with the strongest ran parallel with the skin reaction. concentration of pollen extract could no longer be elicited, the psoriasis also diminished to a point where it was practically cured. It was found, further, that 22 per cent of patients with psoriasis showed some nasal symptoms typical of hay fever or rhinitis conditions. The etiology of psoriasis vulgaris has long been a matter of much dispute. The findings of the present writer bring up the possibility of au allergic etiology. Whether the psoriasis is an allergic reaction to the excitant of hay fever and therefore only a symptom of hay fever, or a reaction by hypersensitive individuals to various specific foreign substances, the writer is not prepared to state at the present time.
Passive Anaplhylaxis. Injections Into Rabbits of Human Serum from Hypersensitive Individuals, Miield With the Specific Allmergen. Vallery-Radot, P., Maubic, G., Hugo,
A.,
and
Giroud,
P. Compt.
rend.
fioe.
de biol.
107:
707,
1931.
Having failed to accomplish passive transfer of anaphylaxis by iujecting human serum from hypersensitive individuals into rabbits and at some time thereafter injecting the specific allergen, the authors undertook to mix the serum and allergen Patients giving positive Prausnitz-Kiistner reactions and those with posiin vitro. tive skin reactions were chosen. Fifteen experiments were done. In eight, the serum and allergen were allowed to stand at room temperature for one-half hour; in one, two hours; and in six, twenty-four hours. In some, the mixtures were centrifuged and the supernatant fluid was injected; in others the whole mixtures were administered. In no instance was passive anaphylaxis obtained. In 10 control experiments with normal serum and allergens, no anaphylaxis was obtained. Consequently, passive transfer of anaphyla.xis could not be accomplished by mixtures of reagins and allergens.