- Email: [email protected]
Is the oscillometric blood pressure measuring device in accord with the intra-arterial invasive blood pressure measuring method?
S20
Abstracts
(group A) or low-dose amlodipine + telmisartan (group T). The primary endpoints are composite of non-fatal stroke/myocardial infarction and cardiovascular death. All patients will be followed-up for 4 years. Results: The characteristics of patients between the two groups were similar: mean age (61.5 ± 7.7) yrs with 19% history of cerebrovascular diseases, 12% coronary diseases, 18% diabetes, 42% dyslipidemia, and mean initial blood pressure of 157/93 mm Hg. After 8-week treatment, mean blood pressure in groups A and B was reduced to 133.0 ± 11.0/81.0 ± 7.6 and 132.9 ± 11.6/80.6 ± 7.9 mm Hg respectively. Blood pressure control rates reached 72.1% and 72.6% in groups A and T, respectively. Conclusion: Amlodipine-based antihypertensive combination regimens achieved satisfactory blood pressure control rate in patients with essential hypertension in this patient cohort.
24-h heart rate (HR), 24-h pulse pressure (PP) and 24-h rate-pressure product (RPP) in male hypertensives according to ageing. Methods: Twenty-four ambulatory MSP, MDP, HR, PP and RPP recording (CardioControlWorkstation) were obtained during periodical medical check-ups in 2006 in 67 male (M) sedentary employers with uncomplicated hypertension, divided in two groups: group 1 (54 years and younger) and group 2 (55 years and older). Results: Mean 24-h blood pressure in group M1 was 128/81 mm Hg and in group M2 was 127/81 mm Hg. The data are presented in the table. Conclusion: Twenty-four hour ambulatory average MSP and MDP were higher in younger male hypertensives. 24-h HR decreased with ageing in male hypertensives. 24-h PP did not change with ageing in male hypertensives. 24-h RPP decreased in male hypertensives with ageing.
doi:10.1016/j.ijcard.2009.09.064
doi:10.1016/j.ijcard.2009.09.066
BP000690 Impact of choice of diastolic Korotkoff phase in childhood on the prediction to arterial compliance
BP000775 Correlation between aldosterone and hypertension among resistant hypertensive patients
JIE MI, FANGFANG CHEN Capital Institute of Pediatrics, Beijing, China
LINGLING GAO, DINGLIANG ZHU, PINGJIN GAO Shanghai Institute of Hypertension, China
Objectives: The best approach for blood pressure (BP) measurement in children remains controversial, especially on the choice of Korotkoff phase 4 (K4) vs. Korotkoff phase 5 (K5) for diastolic BP (DBP). The relation between hypertension and Arterial Compliance (AC) has been demonstrated in adults but not in children. To compare the differences between K4 and K5 in school-aged children and their predictions to AC. Methods: Based on a cross-sectional survey, 555 children aged 6 to 18 years were selected from three schools of Dongcheng district in Beijing. Physical examination included height, weight, heart rate, systolic blood pressure (SBP) and DBP. Body mass index (BMI) was calculated. DBP was measured using K4 and K5, respectively. AC was measured using digital pulse wave analyzing method from pulse trace machine, and then stiffness index (SI) was determined (SI has a negative correlation with AC: the higher the SI value, the worse the AC). Partial correlation analysis was performed to describe the association of K4 and K5 with SI. Logistic regression analysis was conducted to examine the impact of choice of K4 and K5 as DBP in childhood on the prediction to SI. Appropriate institutional ethics committee clearance and participants' informed consent were obtained. Results: The value of K4 minus K5 (K4–K5) decreased as age increased. Adjusted for age, gender, heart rate, pubertal development, BMI and SBP, in childhood K4 was better correlated to SI (β = 0.167, P 0.018) than K5 (β = 0.079, P 0.078). K4 seems to be superior to K5 in predicting AC, the odds ratio of SI was 1.50 (95% CI: 1.17–2.07) with K4 which was higher than using K5 (OR = 1.32, 95%CI: 1.05–1.65). Conclusions: There was significant difference between K4 and K5 in Chinese schoolchildren. K4 is superior to K5 when using auscultator technique to measure DBP.
The aim of the present study was to assess the correlation between aldosterone and blood pressure levels among 575 resistant hypertensive patients depending on office BP, who were diagnosed as essential hypertensive patients after extensive examination. All the patients were recruited from the Department of Hypertension in Ruijin Hospital, Shanghai. The 24 h ambulatory blood pressure was measured under drug taking. Therefore, the ambulatory blood pressure remained normal for 85 patients after administrating just three kinds of antihypertensive drugs. Plasma aldosterone was measured in the supine position and after standing for 2 h. The supine and standing plasma aldosterone levels were consistently associated with both average daytime and nighttime ambulatory blood pressures (P = 0.05). Moreover, the patients with normal ambulatory blood pressure (n = 85) showed relatively lower plasma aldosterone compared to those with high ambulatory blood pressure (P = 0.05). Furthermore, there was obvious relationship of supine and standing plasma aldosterone with average daytime and nighttime blood pressures. Taken together, our results documented strong association of daytime blood pressure with supine plasma aldosterone, as well as that of nighttime blood pressure with standing plasma aldosterone, which further indicated that aldosterone might serve as a major risk factor for the elevated blood pressure.
doi:10.1016/j.ijcard.2009.09.065
JANG-WHAN BAE, HYE JIN JOO, WON-YIK LEE, SANG YEOB LEE, JU-HEE LEE, DONG-WOON KIM, MYEONG-CHAN CHO, CHUNG-SUK LEE, EUN-KYONG KIM Chungbuk National University Hospital, South Korea
BP000722 Morning blood pressure, heart rate, pulse pressure and rate pressure product in male hypertensives according to ageing RADMILA ZIVKOVIC, MIRA UGLJESIC, OLJA MILOVIC, BISERKA OBRADOVIC Medical Center Stari Grad, Yugoslavia Objective: The aim was to evaluate the relationship between morning systolic (MSP) and morning diastolic blood pressure (MDP),
doi:10.1016/j.ijcard.2009.09.067
BP000791 Is the oscillometric blood pressure measuring device in accord with the intra-arterial invasive blood pressure measuring method?
Objectives: The use of automatic blood pressure measuring devices with oscillometric method is popular in home and clinics. Although the protocol for evaluating the accuracy of devices was known, subject of validation was not real user who has cardiovascular risk factor. In this study, we try to verify the BP measured with automatic oscillometric device with invasively measured intra-atrial blood pressure especially in older and multiple cardiovascular risk
Abstracts
factors. Design and methods: From September 2007 to April 2008 in Chungbuk National University Hospital 104 men and women between 35 and 82 years of age with coronary angiography approached with radial artery were included. Blood pressure measured by automatic device (manufactured by Omron HEM747IC, Japan) in the right arm was compared with one after that measured by invasive inserted catheter to radial artery. The agreement between these methods was analyzed with Bland–Altman method. Results: As might be expected patients have some cardiovascular risk factor. Their median age is 60 ± 11 years, 52 (52%) of this group suffer from hypertension, 20 (19%) from DM, 40 (48%) from dyslipidemia, and 46 (44%) from ischemic heart disease. All bias of SBP, DBP, and MBP is less than 5 mm Hg. Variability of SBP is 8.8 mm Hg that is out of AAMI criteria. 95% CI of bias and LOA (limit of agreement) in SBP, DBP, and MBP are within 25% of normal each BP: 30 (SBP), 20 (DBP), and 22.5 (MBP). According to JNC7 classification of BP or age is not correlated with disagreement of each BP measured by two methods. Conclusions: Oscillometric automatic blood pressure measured device can replace with mercury sphygmomanometer. But more larger studies including old, hypertensive patient are necessary for evidence of agreement between automatic measured BP and intra-arterial BP. doi:10.1016/j.ijcard.2009.09.068 BP000797 Blood pressure self-measurement and hypertension self-management via smart-phones, web and Bluetooth-enabled monitors XIAOWEI YANG, ERIC WEN, KAI WANG, SHIQUAN WU, JINGYI LIU, HUAN ZENG, BO HONG Bayessoft, Inc, United States Objective: Demonstrate the feasibility of self-measurement of blood pressure (BP) and self-management of hypertension (HTN) by using wireless and web technologies. Design and method: A wireless personal area network (WPAN) was developed to connect smartphones with oscillometric BP monitors using the Bluetooth (BT) protocol for the purpose of BP self-measurement. The applications running on smart-phones and the Web Server jointly provide functions enabling forms of HTN self-management. Results: So far, we have implemented the WPAN with two BT-enabled BP monitors (upper-arm Stabil-O-Graph and wrist HPL-108) and three applications running over Windows Mobile, iPhone, and Symbian operating systems: (1) iMeasure sets up the connection between a smart-phone and a BP monitor for automatically measuring BP. It also provides an interface for users to enter certain behavioral and psychosocial data. (2) iAnalyze displays user's historical data, calculate normal ranges and time-trends, and reports abnormal measures. (3) IManage provides an interface for behavioral therapy of HTN, guiding users to reduce breathing rate to < 10 times/min, eat less fat, and/or do more exercise. On the server-side, a database management system was developed using JAVA, PHP, R, and MySQL. Several web applications are available to coordinate with the above mobile-phone applications (via 3G cellular networks) mainly for self-evaluation, self-education, and selfcontrol of HTN. Currently, the performances of the system are being assessed using HTN patients, physicians, and public health researchers. The study results are expected to be available in September 2009. Conclusions: Utilization of mobile-phones in BP self-measurement and HTN self-management outside clinics has been proved a promising solution. It can greatly enhance the accuracy in HTN diagnosis and improve the effectiveness and compliance of HTN control. doi:10.1016/j.ijcard.2009.09.069
S21
BP000816 Ambulatory blood pressure registry for the evaluation of the prognostic threshold in hypertension patients in Korea (Kor-ABP registry) YU-MI KIMa, JINHO SHINb, WOOK BEOM PYUNc, WOO-SHK KIMd, JU HAN KIMe, SOON KIL KIMb, BO YOUL CHOIa a Preventive Medicine, Hanyang University College of Medicine, South Korea b Department of Internal Medicine, Hanyang University College of Medicine, South Korea c Department of Internal Medicine, School of Medicine, Ewha Women's University, South Korea d Department of Internal Medicine, School of Medicine, Kyung Hee University, South Korea e Department of Internal Medicine, Chonnam National University College of Medicine, South Korea Background: Ambulatory blood pressure monitoring provides prognostically better information. But the prognostic threshold for untreated or treated hypertension is not clearly defined. So we designed an ambulatory blood pressure monitoring registry for prospective follow up to determine prognostic threshold in secondary or tertiary referral hospital setting. Methods: The sample size was determined according to the average clinical risks provided by ESC/ESH hypertension guideline. For each low or moderate clinical risk group, hazard ratio of 1.5 will be detected with the power of 0.8. For the high or very high risk group, hazard ratio of 1.2 will be detected with the power of 0.8. The Kor-ABP registry will be web-based. Clinical follow up will be 6 month interval for 3 years. And the end points are major adverse cardiovascular events including stroke, myocardial infarction, congestive heart failure, newonset diabetes, and body mass index. Clinic BP will be measured using automated device and the information for antihypertensive medication will also be collected. Results: The registry is scientifically supported by the Korean Society of Hypertension. Total sample size is 22,000 considering the 20% loss during follow-up. Until 30th June, 2009, volunteering 43 secondary and tertiary referral hospitals were participating in the registry program. Through web-site simulation for 1 month, Kor-ABP registry will be launched in 1st August, 2009. Conclusion: Kor-ABP registry is expected to contribute in developing prognostic thresholds for treated hypertension patients. doi:10.1016/j.ijcard.2009.09.070 BP000856 Sex-specific relative and absolute risks associated with the conventional and ambulatory blood pressures in 9357 subjects from 11 populations JOSE BOGGIA, LUTGARDE THIJS, TINE WILLUM HANSEN, YAN LI, MASAHIRO KIKUYA, KRISTINA BJORKLUND-BODEGARD, TOM RICHART, TAKAYOSHI OHKUBO, JORGEN JEPPESEN, CHRISTIAN TORP PEDERSEN, EAMON DOLAN, TATIANA KUZNETSOVA, KATARZYNA STOLARZ-SKRZYPEK, VALÉRIE TIKHONOFF, SOFIA MALYUTINA, EDOARDO CASIGLIA, YURI NIKITIN, LARS LIND, EDGARDO SANDOYA, KALINA KAWECKA-JASZCZ, YUTAKA IMAI, JIGUANG WANG, HANS IBSEN, EOIN O'BRIEN, JAN A. STAESSEN Manuel Quintela Hospital, University of the Republic, Uruguay Objectives: To analyze the sex-specific risk associated with the SBP on conventional and ambulatory measurements. Methods: We performed conventional BP measurement and 24-h ABPM in 9357 subjects (mean age 52.8, 47% women) recruited from 11 population
Abstracts
(group A) or low-dose amlodipine + telmisartan (group T). The primary endpoints are composite of non-fatal stroke/myocardial infarction and cardiovascular death. All patients will be followed-up for 4 years. Results: The characteristics of patients between the two groups were similar: mean age (61.5 ± 7.7) yrs with 19% history of cerebrovascular diseases, 12% coronary diseases, 18% diabetes, 42% dyslipidemia, and mean initial blood pressure of 157/93 mm Hg. After 8-week treatment, mean blood pressure in groups A and B was reduced to 133.0 ± 11.0/81.0 ± 7.6 and 132.9 ± 11.6/80.6 ± 7.9 mm Hg respectively. Blood pressure control rates reached 72.1% and 72.6% in groups A and T, respectively. Conclusion: Amlodipine-based antihypertensive combination regimens achieved satisfactory blood pressure control rate in patients with essential hypertension in this patient cohort.
24-h heart rate (HR), 24-h pulse pressure (PP) and 24-h rate-pressure product (RPP) in male hypertensives according to ageing. Methods: Twenty-four ambulatory MSP, MDP, HR, PP and RPP recording (CardioControlWorkstation) were obtained during periodical medical check-ups in 2006 in 67 male (M) sedentary employers with uncomplicated hypertension, divided in two groups: group 1 (54 years and younger) and group 2 (55 years and older). Results: Mean 24-h blood pressure in group M1 was 128/81 mm Hg and in group M2 was 127/81 mm Hg. The data are presented in the table. Conclusion: Twenty-four hour ambulatory average MSP and MDP were higher in younger male hypertensives. 24-h HR decreased with ageing in male hypertensives. 24-h PP did not change with ageing in male hypertensives. 24-h RPP decreased in male hypertensives with ageing.
doi:10.1016/j.ijcard.2009.09.064
doi:10.1016/j.ijcard.2009.09.066
BP000690 Impact of choice of diastolic Korotkoff phase in childhood on the prediction to arterial compliance
BP000775 Correlation between aldosterone and hypertension among resistant hypertensive patients
JIE MI, FANGFANG CHEN Capital Institute of Pediatrics, Beijing, China
LINGLING GAO, DINGLIANG ZHU, PINGJIN GAO Shanghai Institute of Hypertension, China
Objectives: The best approach for blood pressure (BP) measurement in children remains controversial, especially on the choice of Korotkoff phase 4 (K4) vs. Korotkoff phase 5 (K5) for diastolic BP (DBP). The relation between hypertension and Arterial Compliance (AC) has been demonstrated in adults but not in children. To compare the differences between K4 and K5 in school-aged children and their predictions to AC. Methods: Based on a cross-sectional survey, 555 children aged 6 to 18 years were selected from three schools of Dongcheng district in Beijing. Physical examination included height, weight, heart rate, systolic blood pressure (SBP) and DBP. Body mass index (BMI) was calculated. DBP was measured using K4 and K5, respectively. AC was measured using digital pulse wave analyzing method from pulse trace machine, and then stiffness index (SI) was determined (SI has a negative correlation with AC: the higher the SI value, the worse the AC). Partial correlation analysis was performed to describe the association of K4 and K5 with SI. Logistic regression analysis was conducted to examine the impact of choice of K4 and K5 as DBP in childhood on the prediction to SI. Appropriate institutional ethics committee clearance and participants' informed consent were obtained. Results: The value of K4 minus K5 (K4–K5) decreased as age increased. Adjusted for age, gender, heart rate, pubertal development, BMI and SBP, in childhood K4 was better correlated to SI (β = 0.167, P 0.018) than K5 (β = 0.079, P 0.078). K4 seems to be superior to K5 in predicting AC, the odds ratio of SI was 1.50 (95% CI: 1.17–2.07) with K4 which was higher than using K5 (OR = 1.32, 95%CI: 1.05–1.65). Conclusions: There was significant difference between K4 and K5 in Chinese schoolchildren. K4 is superior to K5 when using auscultator technique to measure DBP.
The aim of the present study was to assess the correlation between aldosterone and blood pressure levels among 575 resistant hypertensive patients depending on office BP, who were diagnosed as essential hypertensive patients after extensive examination. All the patients were recruited from the Department of Hypertension in Ruijin Hospital, Shanghai. The 24 h ambulatory blood pressure was measured under drug taking. Therefore, the ambulatory blood pressure remained normal for 85 patients after administrating just three kinds of antihypertensive drugs. Plasma aldosterone was measured in the supine position and after standing for 2 h. The supine and standing plasma aldosterone levels were consistently associated with both average daytime and nighttime ambulatory blood pressures (P = 0.05). Moreover, the patients with normal ambulatory blood pressure (n = 85) showed relatively lower plasma aldosterone compared to those with high ambulatory blood pressure (P = 0.05). Furthermore, there was obvious relationship of supine and standing plasma aldosterone with average daytime and nighttime blood pressures. Taken together, our results documented strong association of daytime blood pressure with supine plasma aldosterone, as well as that of nighttime blood pressure with standing plasma aldosterone, which further indicated that aldosterone might serve as a major risk factor for the elevated blood pressure.
doi:10.1016/j.ijcard.2009.09.065
JANG-WHAN BAE, HYE JIN JOO, WON-YIK LEE, SANG YEOB LEE, JU-HEE LEE, DONG-WOON KIM, MYEONG-CHAN CHO, CHUNG-SUK LEE, EUN-KYONG KIM Chungbuk National University Hospital, South Korea
BP000722 Morning blood pressure, heart rate, pulse pressure and rate pressure product in male hypertensives according to ageing RADMILA ZIVKOVIC, MIRA UGLJESIC, OLJA MILOVIC, BISERKA OBRADOVIC Medical Center Stari Grad, Yugoslavia Objective: The aim was to evaluate the relationship between morning systolic (MSP) and morning diastolic blood pressure (MDP),
doi:10.1016/j.ijcard.2009.09.067
BP000791 Is the oscillometric blood pressure measuring device in accord with the intra-arterial invasive blood pressure measuring method?
Objectives: The use of automatic blood pressure measuring devices with oscillometric method is popular in home and clinics. Although the protocol for evaluating the accuracy of devices was known, subject of validation was not real user who has cardiovascular risk factor. In this study, we try to verify the BP measured with automatic oscillometric device with invasively measured intra-atrial blood pressure especially in older and multiple cardiovascular risk
Abstracts
factors. Design and methods: From September 2007 to April 2008 in Chungbuk National University Hospital 104 men and women between 35 and 82 years of age with coronary angiography approached with radial artery were included. Blood pressure measured by automatic device (manufactured by Omron HEM747IC, Japan) in the right arm was compared with one after that measured by invasive inserted catheter to radial artery. The agreement between these methods was analyzed with Bland–Altman method. Results: As might be expected patients have some cardiovascular risk factor. Their median age is 60 ± 11 years, 52 (52%) of this group suffer from hypertension, 20 (19%) from DM, 40 (48%) from dyslipidemia, and 46 (44%) from ischemic heart disease. All bias of SBP, DBP, and MBP is less than 5 mm Hg. Variability of SBP is 8.8 mm Hg that is out of AAMI criteria. 95% CI of bias and LOA (limit of agreement) in SBP, DBP, and MBP are within 25% of normal each BP: 30 (SBP), 20 (DBP), and 22.5 (MBP). According to JNC7 classification of BP or age is not correlated with disagreement of each BP measured by two methods. Conclusions: Oscillometric automatic blood pressure measured device can replace with mercury sphygmomanometer. But more larger studies including old, hypertensive patient are necessary for evidence of agreement between automatic measured BP and intra-arterial BP. doi:10.1016/j.ijcard.2009.09.068 BP000797 Blood pressure self-measurement and hypertension self-management via smart-phones, web and Bluetooth-enabled monitors XIAOWEI YANG, ERIC WEN, KAI WANG, SHIQUAN WU, JINGYI LIU, HUAN ZENG, BO HONG Bayessoft, Inc, United States Objective: Demonstrate the feasibility of self-measurement of blood pressure (BP) and self-management of hypertension (HTN) by using wireless and web technologies. Design and method: A wireless personal area network (WPAN) was developed to connect smartphones with oscillometric BP monitors using the Bluetooth (BT) protocol for the purpose of BP self-measurement. The applications running on smart-phones and the Web Server jointly provide functions enabling forms of HTN self-management. Results: So far, we have implemented the WPAN with two BT-enabled BP monitors (upper-arm Stabil-O-Graph and wrist HPL-108) and three applications running over Windows Mobile, iPhone, and Symbian operating systems: (1) iMeasure sets up the connection between a smart-phone and a BP monitor for automatically measuring BP. It also provides an interface for users to enter certain behavioral and psychosocial data. (2) iAnalyze displays user's historical data, calculate normal ranges and time-trends, and reports abnormal measures. (3) IManage provides an interface for behavioral therapy of HTN, guiding users to reduce breathing rate to < 10 times/min, eat less fat, and/or do more exercise. On the server-side, a database management system was developed using JAVA, PHP, R, and MySQL. Several web applications are available to coordinate with the above mobile-phone applications (via 3G cellular networks) mainly for self-evaluation, self-education, and selfcontrol of HTN. Currently, the performances of the system are being assessed using HTN patients, physicians, and public health researchers. The study results are expected to be available in September 2009. Conclusions: Utilization of mobile-phones in BP self-measurement and HTN self-management outside clinics has been proved a promising solution. It can greatly enhance the accuracy in HTN diagnosis and improve the effectiveness and compliance of HTN control. doi:10.1016/j.ijcard.2009.09.069
S21
BP000816 Ambulatory blood pressure registry for the evaluation of the prognostic threshold in hypertension patients in Korea (Kor-ABP registry) YU-MI KIMa, JINHO SHINb, WOOK BEOM PYUNc, WOO-SHK KIMd, JU HAN KIMe, SOON KIL KIMb, BO YOUL CHOIa a Preventive Medicine, Hanyang University College of Medicine, South Korea b Department of Internal Medicine, Hanyang University College of Medicine, South Korea c Department of Internal Medicine, School of Medicine, Ewha Women's University, South Korea d Department of Internal Medicine, School of Medicine, Kyung Hee University, South Korea e Department of Internal Medicine, Chonnam National University College of Medicine, South Korea Background: Ambulatory blood pressure monitoring provides prognostically better information. But the prognostic threshold for untreated or treated hypertension is not clearly defined. So we designed an ambulatory blood pressure monitoring registry for prospective follow up to determine prognostic threshold in secondary or tertiary referral hospital setting. Methods: The sample size was determined according to the average clinical risks provided by ESC/ESH hypertension guideline. For each low or moderate clinical risk group, hazard ratio of 1.5 will be detected with the power of 0.8. For the high or very high risk group, hazard ratio of 1.2 will be detected with the power of 0.8. The Kor-ABP registry will be web-based. Clinical follow up will be 6 month interval for 3 years. And the end points are major adverse cardiovascular events including stroke, myocardial infarction, congestive heart failure, newonset diabetes, and body mass index. Clinic BP will be measured using automated device and the information for antihypertensive medication will also be collected. Results: The registry is scientifically supported by the Korean Society of Hypertension. Total sample size is 22,000 considering the 20% loss during follow-up. Until 30th June, 2009, volunteering 43 secondary and tertiary referral hospitals were participating in the registry program. Through web-site simulation for 1 month, Kor-ABP registry will be launched in 1st August, 2009. Conclusion: Kor-ABP registry is expected to contribute in developing prognostic thresholds for treated hypertension patients. doi:10.1016/j.ijcard.2009.09.070 BP000856 Sex-specific relative and absolute risks associated with the conventional and ambulatory blood pressures in 9357 subjects from 11 populations JOSE BOGGIA, LUTGARDE THIJS, TINE WILLUM HANSEN, YAN LI, MASAHIRO KIKUYA, KRISTINA BJORKLUND-BODEGARD, TOM RICHART, TAKAYOSHI OHKUBO, JORGEN JEPPESEN, CHRISTIAN TORP PEDERSEN, EAMON DOLAN, TATIANA KUZNETSOVA, KATARZYNA STOLARZ-SKRZYPEK, VALÉRIE TIKHONOFF, SOFIA MALYUTINA, EDOARDO CASIGLIA, YURI NIKITIN, LARS LIND, EDGARDO SANDOYA, KALINA KAWECKA-JASZCZ, YUTAKA IMAI, JIGUANG WANG, HANS IBSEN, EOIN O'BRIEN, JAN A. STAESSEN Manuel Quintela Hospital, University of the Republic, Uruguay Objectives: To analyze the sex-specific risk associated with the SBP on conventional and ambulatory measurements. Methods: We performed conventional BP measurement and 24-h ABPM in 9357 subjects (mean age 52.8, 47% women) recruited from 11 population