Clinics in Dermatology (2006) 24, 61 – 65
CONGRESS REPORT Edited by Marcia Ramos-e-Silva, MD, PhD
IV World Congress of the International Academy of Cosmetic Dermatology July 2 to 5, 2005, Paris, France Lawrence Charles Parish, MDa,*, Marcia Ramos-e-Silva, MD, PhDb, Howard A. Epstein, MSc a
Department of Dermatology and Cutaneous Biology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19103, USA b Sector of Dermatology, School of Medicine and HUCFF/UFRJ, Federal University of Rio de Janeiro, 22271-110 Rio de Janeiro, Brazil c Kao Brands Company, Cincinnati, OH 45214, USA With more than 900 physicians in attendance and representing over 70 countries, the IV World Congress of the International Academy of Cosmetic Dermatology was a resounding success. Daniel Wallach (Paris, France), the president of the Congress, and his committees, created a spectacular program that incorporated recent advances in investigational dermatology with cosmetic dermatology (Fig. 1). The Palais des Congre`s de Paris, where the 21st World Congress of Dermatology was held just 3 years prior, proved to be an excellent venue, and Philippe Fournier and his staff from MCI France anticipated almost every need for a memorable congress (Fig. 2).
Plenary sessions Albert Kligman (Philadelphia, PA) gave the opening address, bPerspectives of the Past and Future of Cosmetic DermatologyQ (Fig. 3). He reflected on how cosmetic dermatology has become an integral part of dermatology in general and how there are so many options available today for improving the patient’s appearance. Thomas Luger (Mqnster, Germany) discussed bNeurophysiology of the Skin,Q in which he pointed out that the * Corresponding author. 1760 Market Street, Suite 301, Philadelphia, PA 19103. Tel.: +1 215 563 8333; fax: +1 215 563 3044. E-mail address:
[email protected] (L.C. Parish). 0738-081X/$ – see front matter D 2006 Elsevier Inc. All rights reserved. doi:10.1016/j.clindermatol.2005.11.005
components of neurogenic inflammation include neuropeptides, neuropeptide receptors, endopeptidases, and protease-activated receptors. Neuropeptides are involved in the neurogenic inflammation found in psoriasis, contact dermatitis, atopic dermatitis, urticaria, pruritus, wound healing, and tumor formation. bRetinoids in Dermatology and CosmetologyQ by JeanHilaire Saurat (Geneva, Switzerland) (Fig. 4) included a discussion of the retinoids for dermatoporosis, which is parallel to osteoporosis and can be treated with topical retinoids. Isotretinoin is not necessarily an active suppressant of sebaceous gland activity but rather a prodrug that generates active oxo-metabolites. Jean-Paul Ortonne (Nice, France) emphasized the role of pigmentation and the consternation felt by patients with abnormal skin coloring in his plenary lecture entitled, bBasic Research for the Future of Cosmetic Dermatology.Q The genetic makeup of normal skin color is controlled by melanocortin receptor 1, agouti signaling protein, pink-eyed, and membrane-associated protein. For example, melanocortin receptor 1 plays a role in red hair, freckles, nonmelanoma skin cancers, and melanomas, whereas membrane-associated protein mutations permit oculocutaneous albinism type 4. Lowell Goldsmith (Chapel Hill, NC) gave the II Eugene J. Van Scott Lecture (Figs. 5 and 6) discussing bCosmetic Dermatology and Genetics: The New Paradigm.Q He
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Fig. 1 Daniel Wallach (Paris, France), president, inaugurated the Congress.
Fig. 3 Albert Kligman (Philadelphia, PA) delivered the opening address.
emphasized that there will be a radical paradigm shift in cosmetics with the recognition that the closer a cosmetic is like a drug the better it will be (ie, cosmeceutical). To benefit fully from the advances in genetics, more attention needs to be paid to role of the environment, particularly UV radiation. In considering the role of genetics in a disease process, one needs to distinguish between a Mendelian process that is strongly deterministic and a multigenic and polygenic effect that probably occurs more often. Sylvie Consoli (Paris, France) (Fig. 5), a dermatologist and a psychoanalyst, made a very important point about the cosmetic patient: bWhy does the patient want a change and what is the reason?Q
Pigmentation disorders: therapeutic advances
Major sessions The major sessions are shown in Figs. 4-6.
Fig. 2 Left to right, Lawrence Charles Parish (Philadelphia, PA), Philippe Fournier (Paris, France), and Daniel Wallach (Paris, France) at the opening of the Congress.
Solar lentigines and freckles can be reduced and even eliminated by the use of nonablative resurfacing, according to Henry Chan (Hong Kong, China), whereas Doris Hexsel (Porto Alegre, Brazil) has excellent results using resurfacing procedures for eliminating leukodermas, a major problem in South America. Shaomin Zhong (Beijing, China) studied 85 herbs and 5 formulations of traditional Chinese medicines. His group found that several herbs, including rhizoma chuanxiong, radix clematidis, and semen ginkgo, could reduce cellular melanin.
Surgical approaches to adipose tissue disorders Gilbert Zakine (Paris, France) presented methods of reducing the appearance of fat atrophy in AIDS patients by using various filler materials. Abraham Glicksman (Tel Aviv, Israel) introduced the use of ultrasound as a noninvasive means for body contouring.
Fig. 4 Left to right, Daniel Wallach (Paris, France), Jean Saurat (Geneva, Switzerland), and Jean Civatte (Paris, France).
IV World Congress of the International Academy of Cosmetic Dermatology
Fig. 5 Left to right, Sylvie Consoli (Paris, France) and Lowell Goldsmith (Chapel Hill, NC) just before their plenary lectures.
The red face patient Aleksandra Basta-Juzbasic (Zagreb, Croatia) advocates the term dermatitis rosaceiformis steroidica over steroidinduced rosacea. She has found oral tetracycline and bland creams can reduce the damage to the face from 1 to 6 months and even up to 20 years of topical steroid application. Hana Zelenkova (Bratislava, Slovakia) noted that Bizzozer first described Helicobacter pylori in the stomach in 1893. She believes these bacteria can be associated with rosacea, acne, perioral dermatitis, seborrheic dermatitis, and chronic urticaria. Jasna Lipozencˇic´ (Zagreb, Croatia) (Fig. 7) discussed cases of resistant seborrheic dermatitis. These patients are usually on short or prolonged use of topical steroid, and the resistance to appropriate therapy is possibly influenced by application of long-term steroid. This can lead to intense growth of Malassezia furfur (Plasmodium ovale) and allergic reactions to the corticosteroid that can be confirmed by a positive patch test. The demodex mite, according to Smaranda Gotia (Timisoara, Romania), may be the cause of facial dermatitis in up to 36% of the 250 patients that she and her group studied.
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Fig. 7 Seen at the exhibits were (left to right) Jennifer Parish (Philadelphia, PA), Marcia Ramos-e-Silva (Rio de Janeiro, Brazil), Erin Boh and Larry Millikan (New Orleans, LA), and Jasna Lipozencˇic´ (Zagreb, Croatia).
Tulane Session The session organized by Larry Millikan and Erin Boh from Tulane University (New Orleans, LA) (Fig. 7) featured very important and new issues. During this symposium, Elizabeth McBurney (Slidell, LA) showed the audience her experience with new laser technology, using Fraxel phothermolysis. She has had very good results with laser resurfacing but emphasized that although this is one more option for rejuvenation, it has its limitation and the patient must be evaluated for the best therapeutic option. Jennifer Parish (Philadelphia, Pa) (Fig. 7) presented her very interesting and equally funny work entitled, bOops.Q All of the procedures in cosmetic dermatology that enable us to rejuvenate our patients have potential side effects, complications, or boops.Q There are even boopsQ for the dermatologist. For example, there is increased risk of glove perforation among the surgical specialties, with the puncture rates being as high as 50%, especially in longer procedures.
Ethnic skins and their special problems
Fig. 6 The gong presented to Lowell Goldsmith by the International Academy of Cosmetic Dermatology.
Important subjects related to ethnic speakers from around the world discussed skins and their special problems. This symposium included, among others, Chee-Leok Goh (Singapore), commenting on the pigmentation problems of the Asian patients, who very frequently need help for their hyperpigmented lesions on the face, such as melasma and postinflammatory macules. The hyperpigmentation phenomenon in Asian skin leads to epidermal damage, increase of melanocytic activity, and pigment incontinence. Sometimes, it is very difficult to reverse. Flavia Addor (Rio de Janeiro, Brazil), speaking about characteristics of skin permeation, discussed the differences in the barrier function between black and white skins. Although they have equal thickness, black skin has
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Fig. 8 Left, Howard Epstein (Cincinnati, OH); right, Daniel Wallach (Paris, France).
increased number of cell layers and is more resistant to stripping, as well as increased lipid content and increased electrical resistance. Black skin shows greater cohesiveness of corneocytes, greater resistance to many substances, and usually in irritant reactions, erythema is harder to observe. Ncoza Dlova (Durban, South Africa) spoke about the cosmetic habits of black South Africans for skin, nails, and hair and discussed the very important issue related to skin bleaching, a habit black South Africans, especially women, still have nowadays and that promotes a wide range of adverse reactions that dermatologists have to deal with in her country and vicinities.
Cosmetic dermatology around the world Juan Honeyman (Santiago, Chile) conducted a doubleblind study in which patients diagnosed with male pattern baldness received either Proscar (5 mg) once a week or Propecia (1 mg) daily. Several months into the study, it became apparent that both groups did equally well.
L.C. Parish et al. must be converted to the active vitamin E. Hydrolysis of vitamin E acetate by skin-related esterases in human skin has been suggested based on experimental studies in animals. Bioconversion of vitamin E acetate in human skin has been challenged for the absence of free vitamin E in human skin biopsies. The cleavage of vitamin E acetate to free active vitamin E by skin-related enzymes has been shown in excised human skin, where it was found to be carrier-dependent. Enzo Berardesca (Rome, Italy) discussed oral supplement in the management of cutaneous aging. Oral fish cartilage as a food supplement was found to improve the appearance of aging skin in a panel of women with signs of aging skin. Clinical evaluation and biophysical parameters related to skin function and wrinkle severity were used in the study. Andreas Schepky (Hamburg, Germany) spoke on the influence of cleansing on stratum corneum tryptic enzyme. He noted that desquamation in human skin is a wellbalanced process of corneocyte production and, eventually, shedding from the skin surface. The proteolysis of corneodesmosomes is an important step in the final desquamation process. Stratum corneum tryptic enzymes play a key role in this process. Tryptic enzyme activity can be reduced by low concentrations of some surfactants, whereas activity can be improved with other surfactant systems in cleansing formulations.
Workshops Fernando Stengel (Buenos Aires, Argentina), Ruggero Caputo (Milan, Italy), Mauro Barbareschi (Bologna, Italy), and Philippe Deshayes (Caen, France) discussed recent advances in the emerging field of clinical cosmetology in their respective countries. Dermatologists and cosmetic
Tattoos and other body adornments An important and update theme was presented in this symposium. Psychological aspects were discussed by John Coterill (Leeds, UK) and Danielle Marcoux (Montreal, Quebec, Canada) (Fig. 12) discussed body art in adolescents, which is increasingly popular and is no longer an exclusivity of prisoners and sailors. Up to 20% of students in some parts of Canada have either permanent or temporary tattoos. She showed many types of tattoos and body piercing, commenting on their complications, including infections that may occur with this practice.
Satellite symposia Werner Baschong (Basel, Switzerland) noted that delivery to the epidermis of prodrugs such as vitamin E acetate
Fig. 9 Left to right, Marcia Ramos-e-Silva (Rio de Janeiro, Brazil), Lawrence Charles Parish (Philadelphia, PA), and Sarah Brenner (Tel Aviv, Israel).
IV World Congress of the International Academy of Cosmetic Dermatology
Fig. 10 The opening ceremonies concluded with a jazz concert by Wendy Lee Taylor and the Manuel Rocheman Trio.
surgeons are working with cosmetologists and estheticians to teach patients with facial disfigurements how to use corrective makeup. Pictures of patients’ preapplication and postapplication of camouflage makeup demonstrated a dramatic improvement in image and self-esteem.
Free communications Michael Gold (Nashville, TN) is a firm advocate of using aminolevulinic acid HCl photodynamic therapy for actinic keratoses, acne, and sebaceous gland hyperplasia.
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Fig. 12 Left to right, Danielle Marcoux (Montreal, Quebec, Canada), Andre´ Rougier (Asnieres, France), Marcia Ramose-Silva (Rio de Janeiro, Brazil), and Miche`le Verschoore (Clichy, France).
Jan Faergemann (Gothenburg, Sweden) reported that Recapeen, a mixture of several components, plus vitamins and minerals, produces up to 50% regrowth in patients with male pattern baldness in a 4-month trial. Botulin toxin A is useful in treating anterior chest wall flushing syndrome. E. Pierzchala (Wroclaw, Poland) found that 100 MU for two sessions greatly reduced the erythema. Antidolor, a device comprised of blunt plastic pins, can reduce the pain associated with botulin toxin A injections, according to E. Cecca (Milan, Italy). Y. Yoshida (Sumida, Japan) and her group have observed that freckles vary in appearance during various seasons, suggesting different systems of color adaptation during the year.
Exhibits There was one floor of technical exhibits (Figs. 7-9), and the poster exhibits provided diverse picture of cosmetic dermatology, ranging from acne to laser applications.
Social events
Fig. 11 On board for the dinner cruise were (left to right) Torleif Roykenes (Basel, Switzerland), Marcia Ramos-e-Silva (Rio de Janeiro, Brazil), Anthony Benedetto and Lawrence Charles Parish (Philadelphia, PA), and Paula Karam (Beirut, Lebanon).
The opening ceremonies on Saturday evening included an outstanding jazz concert by Wendy Lee Taylor and the Manuel Rocheman Trio (Fig. 10). This was followed by an elegant reception in honor of the opening of the exhibits. On Monday evening, there was an elegant dinner at the Eiffel Tour, and the concluding event on Tuesday evening was the dinner cruise in the River Seine (Figs. 11 and 12). We all look forward to the Vth World Congress of the International Academy of Cosmetic Dermatology to be held in Melbourne, Australia, December 10 to 13, 2006.