JAAD game changers: Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement

Journal Pre-proof Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement Adam Friedman PII:

S0190-9622(19)32486-7

DOI:

https://doi.org/10.1016/j.jaad.2019.07.093

Reference:

YMJD 13704

To appear in:

Journal of the American Academy of Dermatology

Received Date: 26 July 2019 Accepted Date: 26 July 2019

Please cite this article as: Friedman A, Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement, Journal of the American Academy of Dermatology (2019), doi: https://doi.org/10.1016/j.jaad.2019.07.093. This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2019 Published by Elsevier on behalf of the American Academy of Dermatology, Inc.

Title Page Author: (Corresponding Author) Adam Friedman George Washington School of Medicine and Health Sciences Department of Dermatology 2150 Pennsylvania Avenue, NW Bronx, NY 10467 202-741-2600 [email protected] Funding: None Conflicts: None Words: 217 Article Title: Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement.

Game Changer Information Game Changer Category: General Derm Game Changer Title: Game Changer: Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement Game Changer Author: Adam J. Friedman, MD Game Changer: • TMEP is a clinically inoccuous and histopathologically vanilla condition that is often written off as a banal form of cutaneous mastocytosis with minimal evidence to support this claim. • Investigators demonstrated that systemic disease may be much more likely then previously anticipated, therefore warranting further investigation when we see these patients. • The take home - low mast cell burden in the skin may not corrlate with systemic involvement • Original authors: Severino M, Chandesris MO, Barete S, Tournier E, Sans B, Laurent C, Apoil PA, Lamant L, Mailhol C, Laroche M, Fraitag S, Hanssens K, Dubreuil P, Hermine O, Paul C, Bulai Livideanu C. Original Article Title: Telangiectasia macularis eruptiva perstans (TMEP): A form of cutaneous mastocytosis with potential systemic involvement. Original Capsule Summary: • There is limited information on systemic involvement in telangiectasia macularis eruptiva perstans, a form of cutaneous mastocytosis. • Telangiectasia macularis eruptiva perstans accounted for 14% of adult patients with cutaneous mastocytosis at 2 referral centers for mastocytosis. Systemic mastocytosis was present in 47% of these patients. • Although selection bias may have affected our analysis, evaluation for systemic involvement should be undertaken in patients with telangiectasia macularis eruptiva perstans. Link to the original article: https://www.jaad.org/article/S0190-9622(15)02510-4/fulltext