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JID VisualDx Quiz: October 2013
JID VisualDx Quiz
JID VisualDx Quiz: October 2013 Caroline Y. Winslow1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2013) 133, e9. doi:10.1038/jid.2013.333
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Venous leg ulcer. b. Arterial ulcer. c. Pyoderma gangrenosum. d. Vasculitis. e. Cryoglobulinemia.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
1
Journal of Investigative Dermatology (2013), Volume 133
© 2013 The Society for Investigative Dermatology
JID VisualDx Quiz
2. Macrophages involved with healing are: a. Classically activated (M1). b. Alternatively activated (M2). c. Proinflammatory. d. Anti-inflammatory. e. All of the above.
3. All of the following data were found to support a role of arginase in wound healing except: a. Pharmacologic inhibition delayed healing. b. Pharmacologic inhibition reduced macrophage numbers. c. Pharmacologic inhibition increased inflammation. d. Deletion of the gene Arg1 delayed healing. e. Deletion of the gene Arg1 led to increased influx of inducible nitric oxide synthase.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Campbell L, Saville CR, Murray PJ et al. (2013) Local arginase 1 activity is required for cutaneous wound healing. J Invest Dermatol 133:2461–70
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2013.333. Additional images related to this condition and the differential diagnosis may be found at http://info.visualdx.com/l/11412/2013-08-01/t4wh3.
2
Journal of Investigative Dermatology (2013), Volume 133
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
JID VisualDx Quiz: October 2013 Caroline Y. Winslow1 and Robert S. Kirsner1 Journal of Investigative Dermatology (2013) 133, e9. doi:10.1038/jid.2013.333
JID and Logical Images, Inc., have cooperated to offer the JID VisualDx Quiz, incorporating diagnostic images from VisualDx’s vast database. Questions relate to the image as well as to selected articles in JID, which are listed after the questions. Answers will be posted as supplementary material. We hope you enjoy this challenge.
Image appears with permission from VisualDx. © Logical Images, Inc.
QUESTIONS 1. What is your diagnosis? a. Venous leg ulcer. b. Arterial ulcer. c. Pyoderma gangrenosum. d. Vasculitis. e. Cryoglobulinemia.
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA
1
1
Journal of Investigative Dermatology (2013), Volume 133
© 2013 The Society for Investigative Dermatology
JID VisualDx Quiz
2. Macrophages involved with healing are: a. Classically activated (M1). b. Alternatively activated (M2). c. Proinflammatory. d. Anti-inflammatory. e. All of the above.
3. All of the following data were found to support a role of arginase in wound healing except: a. Pharmacologic inhibition delayed healing. b. Pharmacologic inhibition reduced macrophage numbers. c. Pharmacologic inhibition increased inflammation. d. Deletion of the gene Arg1 delayed healing. e. Deletion of the gene Arg1 led to increased influx of inducible nitric oxide synthase.
TOPIC ARTICLE Questions 2 and 3 refer to the following article: Campbell L, Saville CR, Murray PJ et al. (2013) Local arginase 1 activity is required for cutaneous wound healing. J Invest Dermatol 133:2461–70
Answers are available as supplementary material at http://dx.doi.org/10.1038/jid.2013.333. Additional images related to this condition and the differential diagnosis may be found at http://info.visualdx.com/l/11412/2013-08-01/t4wh3.
2
Journal of Investigative Dermatology (2013), Volume 133
Copyright of Journal of Investigative Dermatology is the property of Nature Publishing Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.