John Kenyon Netherton Jones 1912–1977

1912 -1977

JOHN KENYON NETHERTON JONES 1912-1977

Many great men have compelled the admiration of their associates, but few have won the respect and the affection of their colleagues and coworkers to the extent achieved by John Kenyon Netherton Jones. Professor Jones was at all times an educator of the highest rank, and an inspiration to a large number of graduate students, from whom he evoked, as a result of his enthusiasm, sincerity, and gentle character, tremendous fealty and dedication. His life belies the popularly accepted quip “nice guys finish last.” On January 28,1912, J. K. N. Jones was born in Birmingham, England, the eldest son of George Edward Netherton Jones and Florence Jones (n6e Goldchild). His father was a shipping agent for the Elder-Dempster line; during the latter part of his life he was in poor health as a consequence of being badly gassed during World War I, and he died in the early 1920’s from tuberculosis. For the next few years, Jones’s mother strove to secure a pension for herself and her seven children, but because a pension was not granted until 1926, shortly before she died from blood poisoning, hardship characterized the early life of the Jones family. The family, now bereft of both parents, was separated, and the six oldest children were made wards of the Ministry of Pensions, and dispersed among five families of relatives. The youngest, Geoffrey David, who had been born after the end of the war in 1918, was not supported by the Ministry of Pensions, and was sent to an orphanage. Ken Jones had a particularly warm affection for his youngest brother, and experienced enormous grief when Geoffrey, a bomber pilot during World War 11, was killed in action in June, 1944. Ken’s school days were happy ones, and although he lived with several aunts and uncles in Birmingham, they afforded him the security and warm affection so necessary to a growing boy. Hereminisced fiequently of the joyous summer days when he was able to cycle out to the home of a paternal uncle, Jack Jones, who, with his wife Lucy, lived in the country near Ross-on-Wye, Herefordshire. He spent his holidays with them, and these visits engendered in him a life-long interest in gardening and an abiding love of plants and flowers. Between 1917 and 1923, Ken attended the local Bordesley Green Council School. He received a scholarship to the Waverley Grammar 1

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School, an institution noted for the excellence of its science and engineering students, many of whom progressed to Birmingham University. At both Bordesley Green and Waverley Schools, Ken immersed himself in reading and studying as a means of forgetting the harsh times of his childhood and enduring the loneliness occasioned by the prolonged separation from his brothers and sisters. Later, these two activities became a habit and, eventually, a pleasure for him. Ken inherited his mother’s athletic talents and developed into a fine athlete. In 1929, he was both the captain of the school’s association football team and an athletics champion. He was a typical ectomorph, above average in height, seemingly impervious to weight gain, and walking with a characteristic gait that made him stand out in any gathering of scientists. In 1930, Ken entered Birmingham University, having won a Polytechnic Bursary and a Kitchener Scholarship. He began his studies with great enthusiasm, finding particular enjoyment in the laboratory work. Ken had been advised to take a degree in metallurgy, and he studied this subject in his first year at Birmingham, together with chemistry and physics. He found physical chemistry difficult, and his whole interest turned to organic chemistry. During the vacations, he assisted Dr. W. J. Hickinbottom with his researches; this experience presumably persuaded him to become an organic chemist. Ken completed his studies towards the B.Sc. degree, with first-class honours, in 1933,and received the Frankland Medal for having attained the highest standing in his year. The financial constraints imposed by the dire economic conditions of the time thwarted his endeavor to secure financial assistance to work on platinum compounds with Dr. William W. Wardlaw. Happily for carbohydrate chemistry, Ken was offered a research scholarship to study for his Ph.D. with Professor W. N. Haworth and Dr. E. L. Hirst. Under the supervision of this illustrious team, Ken became engaged in studies related to L-ascorbic acid, and he was allocated to Maurice Stacey, at that time a Research Fellow. The Chemistry Department was aglow with excitement because the determination of structure and the synthesis of L-ascorbic acid had just been achieved, and Ken was assigned the topic of repeating on a large scale the synthesis of L-ascorbic acid, and elucidating the structures of some of the intermediates. When Maurice Stacey departed for London, in late 1933, Ken began a happy collaboration with the late Fred Smith, under Edmund Hirst’s general direction. The long hours expended in the laboratory by this team resulted in rapid progress towards the development of a process for the production of L-ascorbic acid on a commercial scale. In 1937, the rights to a patent (with W. N. Haworth, E. L. Hirst, and F. Smith) on the nitric acid oxidation of

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L-sorbose to L-ascorbic acid were sold for a return of $100 sterling to each co-author. The year 1937 was important to Ken Jones both professionally and personally, for, in June of that year, he married Marjorie Ingles Noon, Fred Smith being the best man. The couple first met as teenagers through a family association-Ken’s uncle, Tom, with whom he had lived for a time, had married Majorie’s aunt, Elsie. Later, Ken and Marjorie met at school dances and nurtured their relationship through enjoyable walks and tandem cycling together. Marjorie understood Ken’s commitment to laboratory work, and devotedly spent long evenings, Sundays, and holidays with him in the laboratory, eventually learning enough chemical language to proof-read his writings. Marjorie was an only child; her father was for many years a maintenance and electrical engineer at the offices of the Birmingham Post and Mail,Birmingham’s leading newspaper. In 1936, Ken received the Ph.D. degree. In that same year, when E. L. Hirst was appointed to the Chair of Organic Chemistry at Bristol University, Ken accepted Hirst’s invitation to go with him as an assistant lecturer and to be part of the nucleus of his carbohydrate-research group. Thus began a close and productive partnership that lasted until Hirst moved to Edinburgh in 1948. Jones readily acknowledged that Hirst was his inspiration to diligence in research, and Ken regarded him as a model and a father figure. Ken Jones’s first topic of research at Bristol was the elucidation of the structure of damson gum. Maurice Stacey had collected several pounds of the raw material in Shropshire and had donated it to Hirst. The unravelling of the structure of this complex material was a truly formidable task, but Ken was not daunted by this challenge. He rapidly established himself as a leader, building up, with such colleagues as G. T. Young, a powerful carbohydrate-research team, and they extended their interests to other plant gums, alginates, and unusual starches. Regrettably, the deepening gravity of the war demanded that the major research effort on carbohydrates be suspended in 1940, at which time the Bristol University Chemistry Department, under the headship of Professor W. E. Gamer, was asked to house Professor Bennett of King’s College, London, and his Chemistry Department, and also to find accommodation for sections of the Woolwich Arsenal staff. The organic chemists accepted an invitation to do “war work” with Professors Gamer and Cecil Bawn on problems concerning explosives, such as the use of low-grade toluene to make TNT, and to assist with work on the then-supersecret RDX (hexahydro-l,3,5-trinitro-l,3,5-triazine, a high explosive) and on plastic explosives.

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During this period, Ken supervised the laboratory work at the University, thereby enabling Edmund Hirst to attend to Governmental activities. Under Ken Jones’s leadership, the team, over a period of six years, made a very significant contribution to the war effort, but, because of the nature of the work, received very little publicity. Despite the personal cost to himself, Ken adhered rigidly to the terms of the Official Secrets Act. In 1945, Ken, who was now Lecturer at Bristol University, was again invited by Hirst to move with him to Manchester University, this time as Senior Lecturer in Organic Chemistry. Once more, it became necessary for Hirst to concentrate his efforts on University and Government committee work. Ken Jones, therefore, took charge of the carbohydrate-research group, and supervised the completion of the explosives work. During this interval, Ken enjoyed the able collaboration of Dr. T. G. Halsall in studies on the structures of starch, cellulose, and glycogen, and on the oxidation of carbohydrates by periodate. The close association of Ken with Professor Hirst, which continued at Manchester University until 1948, was a tremendously fruitful one; over 50 joint publications resulted from their research on complex polysaccharides. In 1948, Edmund Hirst moved to Edinburgh University, and Ken returned to Bristol University as Reader in Organic Chemistry. At Bristol, Ken rapidly developed his own carbohydrate-research group and, with great foresight, impressed upon his colleagues the need to apply biochemical methods to the study of natural products, a point of view fully shared by his brilliant assistant (later Professor) Leslie Hough. The decision, in 1951, to accept an invitation to spend six months at the institute of Paper Chemistry, in Appleton, Wisconsin, changed irrevocably the course of Ken’s professional career. i n 1953, he moved to the Chown Research Chair of Chemistry at Queen’s University, Kingston, Ontario, Canada. Of this move, Ken wrote in his Royal Society Record “I stayed (at Appleton) from April to September. The people were very kind and helpful and the weather was hot and sunny. The scenery was good and I liked the large open area. When I saw the advert. for the Chown Research Chair in 1953 I put in for it. I have never regretted moving here. Facilities at first were poor but J. A. McRae, Dean Ettinger and the National Research Council gave me funds to buy apparatus and with the assistance of devoted graduate students we have never looked back.” The Chown Research Chair required the expenditure of a minimum amount of time for administration and teaching, and afforded Ken the maximum possible time for research. One early difficulty in Canada was the restriction of his re-

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search effort occasioned by the lack of available Canadian graduates, but this was soon overcome by Ken’s ability to attract research students and postdoctoral researchers from overseas, particularly from Bristol. His research group grew steadily. In the course of time, he did succeed in attracting Canadian graduates into his research group, amongst them being Walter Szarek. Like E. L. Hirst, Professor Jones throughout his career attracted the close collaboration of a number of University colleagues. Thus, at Bristol University, Dr. (later Professor) L. Hough collaborated with him, and in Canada, at Queen’s University, he found senior collaborators in the persons of Dr. M. B. Perry until 1962, and Dr. (later Professor) W. A. Szarek from 1967 to 1977. Despite Professor Jones’s abiding passion for research in carbohydrate chemistry, his life was much broader than his science alone. It encompassed as well an appreciation of the beauties of Nature in general, and a devotion to family life. Three children, Stephanie Netherton, Stephen Howard, and Jonathan Ingles Netherton were born into their family. These children, from 1953 onwards, rapidly became “real” Canadians, enjoying life to the full. The children chose to follow diverse educational paths. Stephanie graduated as a nurse, Stephen as an engineer from Queen’s University, Kingston, and Jonathan as a biologist from Brock University, St. Catharines, Ontario. The Jones family had a charming home on Treasure Island on the St. Lawrence River near Kingston. From their grounds, they could enjoy swimming, boating, fishing, and partaking of the beautiful scenery of the St. Lawrence River. Ken took much pride and joy in cultivating and displaying his flowers and garden. Together with his wife Marjorie, he had an active interest in the cultural affairs of Kingston, such as the promotion of live theatre and the Symphony Orchestra. He was an experienced and extremely eager traveller. Indeed, his travels took him to countries on five continents. He was on sabbatical leave in Brazil for the period September 1967 to March 1968,in South Africa from March 1968 to June 1968, and again in Brazil from January 1976 to June 1976. Ken’s hobbies, which he could share with the family, were simple -music, photography, foreign stamps, chess, and the collecting of plants. He took a general interest in military affairs. He was quite proud of the active role he played in Bristol, where he was a part-time officer in the Royal Corps of Signals attached to the University Training Corps. At the end of the war, he resigned with the rank of Captain. As Chown Research Professor at Queen’s University, Professor Jones, in addition to the supervision of the research of a large number of graduate students, postdoctoral fellows, and fourth-year undergraduates, taught courses in Natural Products Chemistry and Carbohy-

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drate Chemistry. These were graduate-level courses, but were open to fourth-year undergraduates. Occasionally, Ken gave a series of lectures on Carbohydrate Chemistry to students at the Royal Military College in Kingston. Although he was loath to accept administrative responsibilities beyond those inherent in his research operation, Ken, nevertheless, did fulfil such tasks on occasion, at both the Departmental and Faculty level, but administration was not his forte. During his time at Queen’s University, he served briefly as a Member of the Department of Chemistry Graduate Committee, and one term as Chairman of that Division of the School of Graduate Studies and Research which encompassed the physical sciences (Division IV).The Chairmen of the various Divisions are Members of the Council of the School of Graduate Studies. As well, Ken was Secretary of the Committee on Scientific Research, a committee that considered applications from faculty members for financial support of research. He contributed to the design of some of the laboratory renovations (completed in 1964) in Gordon Hall. Professor Jones’s participation in professional societies and affairs outside the University were as follows: Rapporteur for the Royal Society of Canada (Chemical Section) in 1971, and Convenor in 1972; Member of the Advisory Committee to the Atlantic Regional Laboratories of the National Research Council, Halifax, Nova Scotia; Member of the Board of Governors of the Ontario Research Foundation; Member of the Board of Advisors for the British Commonwealth for Advances in Carbohydrate Chemistry and Biochemistry; Member of the Editorial Advisory Board of Carbohydrate Research; Chairman of the Fourth International Conference on Carbohydrate Chemistry, which was held in Kingston in 1967; and a Corresponding Member of the Nomenclature Committee of the Division of Carbohydrate Chemistry, American Chemical Society. Professor Jones was a member of The Chemical Society, the Biochemical Society, the Royal Institute of Chemistry (Associate),the Chemical Institute of Canada, the American Chemical Society, and the New York Academy of Sciences. Professor Jones’s outstanding achievements in carbohydrate chemistry were recognized by his receipt of numerous awards and honors. In 1957, he was elected a Fellow of the Royal Society of London, and, in 1959, a Fellow of the Royal Society of Canada and a Fellow of the Chemical Institute of Canada. The Division of Carbohydrate Chemistry of the American Chemical Society presented him with the Claude S. Hudson Award in 1969. He was the 1975 recipient of the Anselme Payen Award from the Cellulose, Paper, and Textile Division. In March 1975, he was awarded the third Sir Norman Haworth Memorial Medal of The Chemical Society (London).

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An International Symposium entitled “Perspectives in Carbohydrate Chemistry” was organized in Kingston to honor Professor Jones on the occasion of his 65th birthday and his retirement from the Chair as the Chown Research Professor at Queen’s University. Alas, a few weeks before the Symposium was to commence, he did not survive a second major operation for cancer of the stomach, and the Symposium was held, in May, 1977, as a memorial to him. Over 200 participants attended the Symposium, which was a fitting expression of appreciation of the life and work of a fine scientist and true gentleman. As has already been intimated, J. K.’s earliest publications (with W. N. Haworth and E. L. Hirst) were concerned with L-ascorbic acid (vitamin C) and its analogs. Four papers and one patent resulted from the L-ascorbic acid work at Birmingham. When E. L. Hirst was appointed to the Chair of Organic Chemistry at Bristol University in 1936, he took J. K. with him from Birmingham. At this time, Fred Smith’s work was mainly concerned with the structures of gum arabic and gum tragacanth, topics suggested by Edmund Hirst, and J. K. and Fred agreed to maintain a general collaboration in order to avoid overlap. The early Bristol work indeed owes much to the generous provision by Fred Smith of reference samples of partially methylated sugars. J. K. undertook the major task of elucidating the structures of damson gum and various pectic substances. The next four years was a period of tremendous activity for him, necessitating spending even longer hours than previously in the laboratory, as few research students were available at Bristol. The techniques used for structural determination of the highly complex, acidic carbohydrate polymers were initially those developed by the Birmingham school for the determination of polysaccharide structures : exhaustive methylation of the carbohydrate polymer, or its acid-degraded derivative, followed by partial and complete hydrolysis and then quantitative separation and identification of the constituent methylated mono-, di-, and oligo-saccharides. J. K. realized that new techniques were urgently needed to lessen the enormous amount of labor required for these difficult investigations. J. K. developed new methods of methylation using thallium compounds and methyl iodide, and new oxidative methods for the determination of end groups in saccharide chains. He was quick to perceive the potential of various chromatographictechniques for the separation of complex mixtures of simple saccharides and their methyl ethers. The results were published in a series of papers concerned with the structures of such diverse substances as damson gum, peanut arabinan, pectic acids, cherry gum, slippery-eIm mucilage, and citrus arabinan. The move to Manchester in 1945 made a welcome change, although J. K. had once more to build up a new research team. The cessation of hostilities had

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M. STACEY, A N D G. W. HAY

cleared the way for the resumption of his primary interest, namely, polysaccharide chemistry. Salient among the excellent work performed during this period was the elucidation of further major structural features of the complex macromolecules of damson gum, cherry gum, and peach gum. Damson gum is an exudate gathered in the form of resin-like nodules from the bark of the tree Prunus insitia. It is normally isolated in the form of an ash-free, water-soluble, acidic white powder. Hydrolysis by mineral acid afforded D-xylose, L-arabinose, Dgalactose, D-mannose, and D-glucuronic acid. Damson gum differed from gum arabic in its content of D-mannose and D-xylose, and by its lack of L-rhamnose. As in the case of gum arabic, L-arabinose was liberated by autohydrolysis, and was present in the furanoid form. No fewer than 18 methylated saccharide derivatives were isolated from the hydrolyzed, methylated gum and the methylated, degraded gum. The quantitative separation of these constituents and an examination of their modes of union permitted an assignment of structure to a large part of the highly branched molecule. Similar studies were made on cherry gum, to which periodate-oxidation techniques were applied successfully. In the many gum exudates and mucilages studied, striking similarities, and yet often wide differences, in saccharide constituents and their modes of linkage were disclosed. The work was greatly expedited by J. K.’s development of automated fraction-collectors. Column chromatography and paper partition-chromatography were developed into a fine art at Bristol, owing to J. K.’s skill and that of such of his students as A. E. Flood, F. Brown, W. H. Wadman, and L. Hough. Ken’s geographical transition to the New World was accompanied by a concomitant transition in his research emphasis. Although he maintained an interest in polysaccharide chemistry, the publication record from Queen’s University attests to the universality of his interests in carbohydrate chemistry. J. K. made major contributions to synthetic carbohydrate chemistry, stereochemistry , biosynthetic mechanisms, and metabolism of carbohydrates, and the application of such separational techniques as paper and gas-liquid chromatography in the carbohydrate field. The results of his lifetime of research were documented in over 300 scientific publications. Clearly, it would be impractical to review this number of papers individually, and consequently, only a representative sample will be treated. A list of Professor Jones’s publications is appended to this article. During the 1950’s and early 196O’s, J. K. and his coworkers achieved new syntheses of a number of simple sugars. These included D-tag& tose and mpsicose, 5,&dideoxy-~-xylo-and -h-arubino-hexose, derivatives of Dribitol, 5-S-ethyl-5thio-~threo-2-pentulose, wgZycer0-D-

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rnanno-heptose, l-deoxy-~-arabino-3-hexulose, L-arabinoseS-lC, D apiose, 3-acetamido-3-deoxy-~glucose,L-mycarose, L-cladinose, D glycero-Daltro-, L-glycero-L-galacto-, Dglycero-L-gluco-, and Bglycero-L-galacto-octulose,and 3-hexuloses. The classic problem of disaccharide synthesis also attracted J. K.’s attention. Syntheses of 3-

O-~-D-galactopyranosy~-D-ga~actose, 3-~-~-D-xylopyranosy~-D-xy~ose,

lactose, 2-0- and 5-O-P-D-glUCOpyranOSyl-D-XylOSe,and 4-O-P-D-galactopyranosyl-Dgalactose were included in his achievements. Two accomplishments of particular significance were the synthesis of sugars in which the ring-oxygen atom had been replaced by nitrogen, and the investigation of the reaction of sulfuryl chloride with sugars and their derivatives. The former development was a consequence of J. K.’s study of the microbiological oxidation of sugar derivatives by Acetobacter suboxyans. A series of papers on the oxidation of terminally substituted, polyhydric alcohols was published. In connection with studies of the oxidation of acetamidodeoxyalditols,5-acetamido-5-deoxy-~-arabinose was prepared and, interestingly, was found to exist in two forms, namely, the normal furanoid form, and a pyranoid form in which the ring heteroatom was nitrogen, not oxygen. A number of examples of this new type of compound were methyl synthesized, including 5-acetamido-5-deoxy-~-xylopyranose, 4-acetamido-4-deoxy-~-erythrofuranoside, and methyl 4-acetamido-4deoxy-D and -L-arabinofuranoside. Concomitant with these developments at Queen’s University, researchers in other countries, particularly the United States and West Germany, were synthesizing a variety of analogous compounds in which the oxygen atom of the ring was replaced by nitrogen, phosphorus, selenium, or sulfur. J. K. and his colleagues extensively studied the reaction of sulfuryl chloride with carbohydrates. This work elucidated the stereochemical principles involved in the various transformations, and made available a convenient and effective procedure for the preparation of chlorodeoxy sugars, derivatives that have been found to be extremely valuable intermediates in the synthesis of a wide variety of rare sugars. The synthesis of chlorodeoxy sugars involves the initial formation of chlorosulfuric esters, followed by bimolecular displacement of certain of the chlorosulfonyloxy groups by chloride ion liberated during the chlorosulfation. It is often possible to predict the reactivity of a chlorosulfonyloxy group by a consideration of the steric and polar factors affecting the formation of the transition state. Thus, it has been found that the presence of a vicinal, axial substituent, or of a P-transaxial substituent, on a pyranoid ring inhibits replacement of a chlorosulfonyloxy group; also, a chlorosulfate group at C-2 has been observed to be deactivated to nucleophilic substitution by chloride ion.

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Some of the rare sugars that have been prepared by way of chlorodeoxy derivatives are 4,6-dideoxy-3- 0-methyl-~-xyZo-hexose(D-chalcose), 3,6-dideoxy-D-ribo-hexose (paratose), 3,6-dideoxy-~urabinohexose (tyvelose), methyl 2,3-dideoxy-~-~-glycero-hex-2-enopyranosid-4-ulose, and certain aminodeoxy sugars. Although the bulk of J. K.’s work at Queen’s University concerned reactions of monosaccharides, he nevertheless did not lose interest in polysaccharides and the chemistry of L-ascorbic acid. The polysaccharides examined during the Canadian period included the hemicelluloses of loblolly pine (Pinus taeda) and aspen (PopuEus trernuloides), linseed mucilage from flax (Linurn usztatissimum), the type VIII Pneurnococcus specific polysaccharide, the hemicelluloses and a-cellulose from a specimen of ancient wood from Cedrus penhallowii, an arabinogalactan from Monterey pine (Pinus radiata ), the “gum asafoetida” polysaccharide, a water-soluble arabinogalactan from mountain larch (Larix lylatli, Parl), the glucomannan of bluebell seed (ScyZla n.onsc7ipta L.), polysaccharides from the seeds of the huacra pona palm (friarteauentricosa), cholla gum (Opuntia fulgida),the capsular polysaccharide of Pneumococcus XII, arabinobioses from Acacia nilotica gum, the type-specific polysaccharide from type XIX Pneumococcus, the mucilage from the bark of Ulmus fulua (slipperyelm mucilage), lemon gum (CitrusZiminia), lipopolysaccharides of Proteus, and the galactan from the albumin glands of the snail (Strophocheilus oblongus). In the course of the preparation of C - and 0benzyl derivatives of L-ascorbic acid, it was observed that the L-ascorbate ion acts as an ambident nucleophile; this was the first example of a carbohydrate structure exhibiting this property. The universality of J. K.’s interests was further manifested by his continuing studies of biosynthetic mechanisms and the metabolism of carbohydrates, and the application of such separational techniques as gas-liquid chromatography in the carbohydrate field. In 1961, the mode of the linkage of sugars to amino acids in glycoproteins and “mucoproteins” was obscure. J. K. and his colleagues attempted to determine the nature of the carbohydrate -peptide bonds occurring in natural glycoproteins. In 1967, Walter Szarek returned to Queen’s University as a faculty member, after a three-year absence in the United States, and was asked to direct J. K.’s entire research group while J. K. was on sabbatical leave in Brazil and, subsequently, South Africa. This marked the beginning of the very close association and collaboration between J. K. and Walter Szarek, a partnership that continued until J. K.’s death. The fruit of this close relationship was recorded in the numerous publications that ensued. These were primarily in the area of synthetic carbohydrate chemistry, and involved such topics as synthesis and

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chemical modification of carbohydrate antibiotics, design of biologically active nucleosides, development of new routes to those sugars and their derivatives that are of interest to biochemistry and chemotherapy, conformationaland mechanistic studies of carbohydrate reactions, microbiological oxidation of sugars and their derivatives, chemical modification of polysaccharides, photochemistry of carbohydrates, stereochemistry, and heterocyclic conformational analysis. In 1976, the long tradition of excellence in carbohydrate chemistry at Queen’s University led to the formation of the Carbohydrate Research Institute. J. K. was a very strong supporter of such an interface between the University, Government, and Industry and was, with Walter Szarek and G. W. Hay, a Founding Member. Regrettably, his deteriorating health at this period obviated his active involvement in the formation and subsequent development of the Institute, which came into being through the efforts, and under the directorship, of Walter Szarek. Professor Jones died on April 13, 1977, after a 10-month struggle with cancer. His family and friends, his carbohydrate chemistry, and his love and appreciation of the beauties of Nature were, for him, his life. His genuine humility precluded any inclination towards extensive eulogizing or ceremony. He was indeed “one among a thousand” (Job, 33: 23). The character of the man was accurately portrayed by the University Chaplain during the Memorial Service at Queen’s University in the words ‘‘. . . our friend, highly regarded and greatly beloved among us . . . cared for all living and growing things and cherished the beauty and wonder of woods and fields, rocks and water flowing by. His loyalty and thoughtfulness toward others taught us that a faithful friend is the medicine of life.” WALTERA. SZAREK MAURICE STACEY GEORGEW. HAY

APPENDIX

The following is a chronological list of the scientific publications of Professor J. K. N. Jones and his colleagues. “Synthesis of Ascorbic Acid and its Analogues: The Addition of Hydrogen Cyanide to Osones,” W. N. Haworth, E. L. Hirst, J. K. N. Jones, and F. SmithJ. Chem. SOC. (1934) 1192- 1197. “Ascorbic Acid and its Analogs,” W. N. Haworth, E. L. Hirst, J. K. N. Jones, and F. Smith, Br. Pat. 443,901 (1936).

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“Gluco-ascorbic Acid,” W. N. Haworth, E. L. Hirst, and J, K. N. Jones,]. Chem. Soc., (1937)549-556. “Pectic Substances. Part I. The Araban and Pectic Acid of the Peanut,” E. L. Hirst and J. K. N. Jones,]. Chem. Soc., (1938)496-505. “Analogues of Ascorbic Acid Containing Six-membered Rings,” W. N. Haworth, E. L. Hirst, and J. K. N. Jones,]. Chem. SOC., (1938) 710-715. “The Constitution of Damson Cum. Part I. Composition of Damson Gum and Structure of an Aldobionic Acid (Clycuronosido-2-mannose)Derived from It,” E. L. Hirst and J. K. N. Jones,-/. Chem. Soc., (1938) 1174-1180. “Methylation of a-Methylglucoside by Thallous Hydroxide and Methyl Iodide,” C. C. Barker, E. L. Hirst, and J. K. N. Jones,J. C h m . Soc., (1938) 1695-1698. “Methyl Ethers of Arab-ascorbic Acid and Their Isomerism,” E. G. E. Hawkins, E. L. Hirst, and J. K. N. Jones,J. Chem. Soc., (1939) 246-248. “Pectic Substances. Part 11. Isolation of an Araban from the Carbohydrate Constituents of the Peanut,” E. L. Hirst and J. K. N. Jones,]. Chem. Soc., (1939) 452-453. “Pectic Substances. Part 111. Composition of Apple Pectin and the Molecular Structure of the Araban Component of Apple Pectin,” E. L. Hirst and J. K. N. Jones,J. Chem. SOC.,(1939)454-460. “The Constitution of Cherry Gum. Part I. Composition,” J. K. N. Jones,]. Chem. Soc., (1939) 558-563. “Constitution ofthe Mucilage from the Bark of Ulmusfuloa (Slippery Elm Mucilage). Part I. The Aldobionic Acid Obtained by Hydrolysis of the Mucilage,” R. E. Gill, E. L. Hirst, and J. K. N. Jones,]. Chem. Soc., (1939) 1469-1471. “The Constitution of Damson Cum. Part 11. Hydrolysis Products from Methylated Degraded (Arabinose-free) Damson Grim,” E. L. Hirst and J. K. N. JonesJ. Chem. Soc., (1939) 1482- 1490. “Pectic Substances. Part IV. Citrus Araban,” G. H. Beaven, E. L. Hirst, and J. K. N. Jones,]. Chem. S o c . , (1939) 1865-1868. “2:3:4-Trimethyl Mannose,” W. N. Haworth, E. L. Hirst, F. A. Isherwood, and J. K. N. Jones,]. Chem. Soc., (1939) 1878-1880. “The Structure of Alginic Acid. Part I,” E. L. Hirst, J. K. N. Jones, and (Miss) W. 0. Jones,]. Chem. Soc., (1939) 1880-1885. “Structure of Alginic Acid,” E. L. Hirst, J. K. N. Jones, and W. 0.Jones, Nnture, 143 (1939) 857. “Molecular Structure of Pectic Acid,” C. H. Beaven and J. K. N. Jones, Chem. Znd. (London),(1939) 363. “The Constitution of Banana Starch,” E. G. E. Hawkins, J. K. N. Jones, and G. T. Young, J . Chem. Soc., (1940)390-394. “The €-Galactan of Larch Wood,” E . L. Hirst, J. K. N. Jones, and W. G. Campbell, Nature, 147 (1941)25-26. “Separation of Methylated Methylglycosides by Adsorption on Alumina. A New Method for End-group Determinations in Methylated Polysaccharides,” J. K. N. Jones, 1. Chein. Soc., (1944) 333-334. “The Condensation of Glucose and p-Diketones,” J. K. N. Jones,]. Chem. Soc., (1945) 116- 119. “The Quantitative Estimation of Xyiose,” L. J. Breddy and J. K. N. Jones,]. Chem. SOC., (1945)738-739. “Nitrogenous Substances Synthesized by Moulds,” A. H. Campbell, M. E. Foss, E. L. Hirst, and J. K. N. Jones, Nature, 155 (1945) 141. “Application of New Methods of End-group Determination to Structural Problems in the Polysaccharides,” F. Brown, S. Dunstan, T. C. Halsall, E. L. Hirst, and J. K. N. Jones, Nature, 156 (1945) 785-786.

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“The Constitution of Damson Gum. Part 111. Hydrolysis Products from Methylated Damson Gum,” E. L. Hirst and J. K. N. Jones,]. Chem. SOC., (1946) 506-512. “Methylation of B-Methylglucopyranoside and ap-Methylxylopyranosidesby Thallous Hydroxide and Methyl Iodide,” C. C. Barker, E. L. Hirst, and J. K. N. Jones,]. Chem. SOC., (1946) 783-784. “Constitution of the Mucilage from the Bark of Ulmusfulua (Slippery Elm Mucilage). Part 11. The Sugars Formed in the Hydrolysis of the Methylated Mucilage,” R. E. Gill, E. L. Hirst, and J. K. N. Jones, J. Chem. SOC., (1946) 1025-1029. “The Chemistry of Pectic Materials,” E. L. Hirst and J. K. N. Jones,Adu. Carbohydr. Chem., 2 (1946) 235-251. “Structure of Starch and Cellulose,” T. G. Halsall, E. L. Hirst, and J. K. N. Jones, Nature, 159 (1947) 97. “Quantitative Estimation of Mixtures of Sugars by the Paper Chromatogram Method,” A. E. Flood, E. L. Hirst, and J. K. N. Jones, Nature, 160 (1947) 86-87. “The Chemistry of Some Plant Gums and Mucilages,” E. L. Hirst and J. K. N. Jones, J . SOC. Dyers Colour., 63 (1947) 249-254. “The Quantitative Determination of Galactose, Mannose, Arabinose, and Rhamnose,” E. L. Hirst, J. K. N. Jones, and E. A. Woods,]. Chem. SOC., (1947) 1048-1051. “The Constitution of Cherry Gum. Part 11. The Products of Hydrolysis of Methylated Cherry Gum,” J. K. N. Jones, J. Chem. SOC., (1947) 1055-1059. “The Synthesis of 3-Methyl and 3:5-Dimethyl L-Arabinose,” E. L. Hirst, J. K. N. Jones, and (Miss) E. Williams,J. Chem. SOC., (1947) 1062-1064. “The Constitution of Egg-plum Gum. Part I,” E. L. Hint and J. K. N. Jones,]. Chem. SOC., (1947) 1064-1068.

“Pectic Substances. Part V. The Molecular Structure of Strawberry and Apple Pectic Acids,” G. H. Beaven and J. K. N. Jones,]. Chem. SOC., (1947) 1218-1221. “Pectic Substances. Part VI. The Structure of the Araban from Arachis hypogea,” E. L. Hirst and J. K. N. Jones,]. Chem. SOC., (1947) 1221-1225. “Pectic Substances. Part VII. The Constitution of the Galactan from Lupinus albus,” E. L. Hirst, J. K. N. Jones, and (MIS.) W. 0. Walder,]. Chem. SOC., (1947) 1225-1229. “Some Derivatives of DGalacturonic Acid,” J. K. N. Jones and M. Stacey,]. Chem.

SOC., (1947) 1340-1341.

“Synthesis of Some Derivatives of D and L-Arabinose,” J. K. N. Jones, P. W. Kent, and M. Stacey,]. Chem. Soc., (1947) 1341-1344. “The Quantitative Separation of Methylated Sugars,” F. Brown and J. K. N. Jones,]. Chem. SOC., (1947) 1344-1347. “The Structure of Glycogen. Ratio of Non-terminal to Terminal Glucose Residues,” T. G. Halsall, E. L. Hirst, and J. K. N. Jones,]. Chem. SOC., (1947) 1399-1400. “Oxidation of Carbohydrates by the Periodate Ion,” T. G. Halsall, E. L. Hirst, and J. K. N. Jones,]. Chem. SOC., (1947) 1427-1432. “The Galactomannan of the Lucerne Seed,” E. L. Hirst, J. K. N. Jones, and (MIS.)W. 0. Walder, J . Chem. SOC., (1947) 1443-1446. “The Structure of Starch. The Ratio of Non-terminal to Terminal Groups,” F. Brown, T. G. Halsall, E. L. Hirst, and J. K. N. Jones,J. Chem. Soc., (1948) 27-32. “The Structure of Egg-plum Gum. Part 11. The Hydrolysis Products Obtained from the Methylated Degraded Gum,” E. L. Hirst and J. K. N. Jones,]. Chem. SOC., (1948) 120- 128.

“The +Galactan of Larch Wood (Larix decidua),” W. G. Campbell, E. L. Hirst, and J. K. N. Jones,]. Chem. Soc., (1948) 774-777. “The Galactomannan of Carob-seed Gum (Gum Gatto),” E. L. Hirst and J. K. N. Jones, J . Chem. SOC., (1948) 1278-1282. “The Structure of Almond-tree Gum. Part I. The Constitution of the Aldobionic Acid

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Derived from the Gum,” F. Brown, E. L. Hirst, and J. K. N. Jones,]. Chem. SOC., (1948) 1677-1679. “Quantitative Analysis ofMixtures of Sugars by the Method of Partition Chromatography. Part I. Standardisation of Procedure,” A. E. Flood, E. L. Hirst, and J. K. N.Jones,]. Chem. SOC., (1948)1679-1683. “Structure of Acorn Starch,” E. L. Hirst, J. K. N. Jones, and A. J. Roudier,]. Chem. SOC., (1948)1779-1783. “Pectic Substances. Part VIII. The Araban Component of Sugar-beet Pectin,” E. L. Hirst and J. K. N. Jones,]. Chem. SOC., (1948)2311-2313. “Separation and Identification of Methylated Sugars on the Paper Chromatogram,” F. Brown, E. L. Hirst, L. Hough, J. K. N. Jones, and H. Wadman, Nature, 161 (1948)720. “Application of Paper Partition Chromatography to the Separation of Sugars and their Methylated Derivatives on a Column of Powdered Cellulose,” L. Hough, J. K. N. Jones, and W. H. Wadman, Nature, 162 (1948)448. “The Amylose Content of the Starch Present in the Growing Potato Tuber,” T. G. Halsall, E. L. Hirst, J. K. N. Jones, and F. W. Sansome, Biochem.]., 43 (1948)70-72. “Quantitative Analysis of Mixtures of Sugars by the Method of Partition Chromatography. Part 11. The Separation and Determination of Methylated Aldoses,” E. L. Hirst, L. Hough, and J. K. N. Jones,]. Chern. SOC., (1949)928-933. “The Polysaccharides ofthe Florideae. Floridean Starch,” V. C. Barry, T. G. Halsall, E. L. Hirst, and J. K. N. Jones,J. Chem. SOC.,(1949)1468-1470. “Quantitative Analysis of Mixtures of Sugars by the Method of Partition Chromatography. Part 111. Determination of the Sugars by Oxidation with Sodium Periodate,” E. L. Hirst and J. K. N. Jones,]. Chem. SOC., (1949)1659-1662. “The Constitution of Egg-plum Gum. Part 111. The Hydrolysis Products Obtained from the Methylated Gum,” F. Brown, E. L. Hirst, and J. K. N. Jones,]. Chen. SOC., (1949)1757-1761. “Cholla Gum,” F. Brown, E. L. Hirst, and J. K. N. Jones,], Chem. SOC., (1949)17611766. “Reactions of Nitroparaffins. Part XI. The Reaction of 2-Nitropropane with Formaldehyde and Ammonin,” J. K. N. Jones and T. Urbariski,J. Chem. SOC., (1949)17661767. “Quantitative Analysis of Mixtures of Sugars by the Method of Partition Chromatography. Part IV. The Separation of the Sugars and Their Methylated Derivatives on Columns of Powdered Cellulose,” L. Hough, J. K. N. Jones, and W. H. Wadman,J. Chem. SOC., (1949)2511-2516. “Cherry Gum. Part 111. An Examination of the Products of Hydrolysis of Methylated Degraded Cherry Gum, Using the Method of Paper Partition Chromatography,” J. K. N. Jones,J. Chem. Soc., (1949)3141-3145. “The Action ofp-Amylase on Amylopectin and on Glycogen,” T. G. Halsall, E. L. Hirst, L. Hough, and J. K. N. Jones,]. Chern. SOC., (1949)3200-3207. “Pear Cell-wall Cellulose,” E. L. Hirst, F. A. Isherwood, M. A. Jermyn, and J. K. N. Jones,J. Chem. SOC., (1949)s182-sl84. “Composition of the Gum of Sterculia setigera: Occurrence of D-Tagatose in Nature,” E. L. Hirst, L. Hough, and J. K. N. Jones, Nature, 163 (1949)177. “Chromatographic Analysis. The Application of Partition Chromatography to the Separation of the Sugars and their Derivatives,” E. L. Hirst and J. K. N. Jones, Discuss. Faraday SOC., 7 (1949)268-274. “Plant Gums and Mucilages,” J. K. N. Jones and F. Smith,Ado. Carbohydr. Chem., 4 (1949)243-291. “The Structure of Peach Gum. Part I. The Sugars Produced on Hydrolysis of the Gum,” J. K. N. Jones,J. Chem. SOC., (1950)534-537.

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“On the Structure of Knudsen’s Base and of Related Compounds. Part I,” M. E. Foss, E. L. Hirst, J. K. N. Jones, H. D. Springall, A. T. Thomas, and T. Urbairski,]. Chem. SOC.,(1950) 624-628. “The Synthesis of 2:bDimethyl L-Rhamnose; The Action of Sodium Metaperiodate on 2:3- and 3:4-Dimethyl L-Rhamnoses,” F. Brown, L. Hough, and J. K. N. Jones, J. Chem. Soc., (1950) 1125-1127. “The Constitution of Xylan from Esparto Grass (Stipa tenacissima, L.),” S. K. Chanda, E.L. Hirst, J. K. N.Jones, and E. G. V. Percivd,]. Chem. SOC.,(1950) 12891297. “On the Structure of Knudsen’s Base and of Related Compounds. Part 11,”M. E. Foss, E. L. Hirst, J. K. N. Jones, H. D. Springall, A. T. Thomas, and T. Urbairski,]. Chem. SOC.,(1950) 1691-1695. “Grapefruit and Lemon Gums. Part I. The Ratio of Sugars Present in the Gums and the Structure of the AIdobionic Acid (4-~-Glucuronosido-~-galactose) Isolated by Graded Hydrolysis of the Polysaccharides,” J. J. Connell, (Miss) R. M. Hainsworth, E. L. Hirst, and J. K. N. Jones,]. Chem. Soc., (1950) 1696-1700. “Quantitative Analysis of Mixtures of Sugars by the Method of Partition Chromatography. Part V. Improved Methods for the Separation and Detection of the Sugars and their Methylated Derivatives on the Paper Chromatogram,”L. Hough, J. K. N. Jones, and W. H. Wadman,]. Chem. Soc., (1950) 1702-1706. “Frog-spawn Mucin,” B. F.Folkes, R. A. Grant, and J. K. N. Jones,]. Chem. Soc., (1950) 2136-2140. “The Structure of the Mannan Present in Porphyra umbiliculis,” J. K. N. Jones, J . Chem. SOC.,(1950) 3292-3295. “Composition of Linseed Mucilage,” D. G. Easterby and J. K. N. Jones, Nature, 165 (1950) 614. “Constitution of the Mucilage from the Bark of Ulmu~fuloa (Slippery Elm Mucilage). Part 111. The Isolation of 3-Monomethyl &Galadose from the Products of Hydrolysis,” E. L. Hirst, L. Hough, and J. K. N. Jones,]. Chem.SOC.,(1951) 323-325. “The Synthesis of Sugars from Simpler Substances. Part I. The in oitro Synthesis of the Pentoses,” L. Hough and J. K. N. Jones,]. Chem. Soc., (1951) 1122-1126. “The Synthesis of Sugars from Simpler Substances. Part 11. The Synthesis of DL-Ribose in oitro from D-Glyceraldehyde and Glycollic Aldehyde,” L. Hough and J. K. N. Jones,]. Chem. SOC.,(1951)3191-3192. “Toluene+-sulphonylhydrazones of the Pentose Sugars, with Particular Reference to the Characterisationand Determination of Ribose,” D. G. Easterby, L. Hough, and J. K. N. Jones,]. Chem. SOC.,(1951) 3416-3418. “The Colorimetric Determination of Methylated Sugars: An Improved Micromethod of End-group Assay,” J. K. Bartlett, L. Hough, and J. K. N.Jones, Chem. Ind. (London), (1951) 76. “The Chemical Composition and Properties of Pectins,” J. K. N. Jones, Chem. Ind. (London),(1951) 430-431. “The Origin of the Sugars,” L. Hough and J. K. N. Jones, Nature, 167 (1951) 180. “Some Observations on the Constitution of Gum Myrrh,” L. Hough, J. K. N. Jones, and W. H. Wadman,]. Chem. SOC.,(1952) 796-800. “Methylene Derivatives of &Galactose and &Glucose,” L. Hough, J. K. N. Jones, and M. S. Magson,]. Chem. SOC.,(1952) 1525-1527. “Mannose-containing Polysaccharides. Part 11. The Gdactomannan of Fenugreek Seed (Trigonellafoenurngraecum),” P. Andrews, L. Hough, and J. K. N. Jones,]. Chem. SOC.,(1952) 2744-2750. “The Hemicelluloses Present in Aspen Wood (Populus tremulotdes).Part I,” J. K. N. Jones and L. E. Wise,J. Chem. Soc., (1952) 2750-2756.

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“The Hemicelluloses Present in Aspen Wood (Populus tremuloides). Part 11,” J. K. N. Jones and L. E. Wise,]. Chem. Soc., (1952)3389-3393. “An Investigation of the Polysaccharide Components of Certain Fresh-water Algae,” L. Hough, J. K. N. Jones, and W. H. Wadman,]. Chem. Soc., (1952)3393-3399. “The Reaction of Amino-compounds with Sugars. Part I. The Action of Ammonia on ~ G l u c o s e , ”L. Hough, J. K. N. Jones, and E. L. Richards,]. Chem. Soc., (1952) 38543857. “The Synthesis of Sugars from Simpler Substances. Part 111. Enzymic Synthesis of a Pentose,” L. Hough and J. K. N. Jones,]. Chem. SOC., (1952)4047-4052. “The Synthesis of Sugars from Simpler Substances. Part IV. Enzymic Synthesis of 6-Deoxy-D-fructose and 6-Deoxy-L-sorbose,” L. Hough and J. K. N. Jones, ]. Chem. SOC., (1952)4052-4055. “A Synthesis of 3:4-Dimethyl D-Xylose and 4-Methyl D-Xylose,” L. Hough and J: K. N. Jones,j. Chern. Soc., (1952)4349-4351. “Methylation of Carbohydrate Using Diazomethane,” L. Hough and J. K. N. Jones, Chem. Znd. (London), (1952) 380. “The Enzymatic Synthesis of Methylpentose,” L. Hough and J. K. N. Jones, Chem. Ind. (London), (1952)715. “The Enzymic Synthesis of Heptose Sugars,” L. Hough and J. K. N. Jones, Chem. lnd. (London),(1952)907. “Arabopyranose Residues in Larch E-Galactan,” J. K. N. Jones, Chem. lnd. (London), (1952)954. “Mannose-containing Polysaccharides. Part I. The Galactomannans of Lucerne and Clover Seeds,” L. Hough and J. K. N. Jones,]. Am. Chem. Soc., 74 (1952) 40294032. “Identification of L-Rhamnose in Aspen Wood,” J. K. N. Jones and J. R. Schoettler, Tappi, 35 (1952) 1mA. “Pentahydric Alcohols and their Oxidation Products,’’ J. K. N. Jones, in E. H. Rodd (Ed.), Chemistry of Carbon Compounds, Val. IB, Chap. XIX, Elsevier, Amsterdam, 1952, pp. 1197-1223. “Hexa- and Poly-hydric Alcohols and their Oxidation Products. Carbohydrates and Related Compounds,” J. K. N. Jones, in E. H. Rodd (Ed.), Chemistry of Carbon Compounds, Vol. IB, Chap. XX,Elsevier, Amsterdam, 1952, pp. 1224-1286. “The Synthesis of Sugars from Simpler Substances. Part V. Enzymic Sypthesis of Sedoheptulose,” L. Hough and J. K. N. Jones, j . C h . Soc., (1953) 342-345. “Mannose-containing Polysaccharides. Part 111. The Polysaccharides in the Seeds of In’s achroleuca and I. sibirca,” P. Andrews, L. Hough, and J. K. N. JonesJ. Chem. Soc., (1953) 1186-1192. “The Synthesis of Sugars from Simpler Substances. Part VI. Enzymic Synthesis of D-Idoheptulose,” P. A. J. Gorin and J. K. N. Jones,]. Chem. Soc., (1953) 1537-1538. “The Reaction of Amino-compounds with Sugars. Part 11. The Action of Ammonia on Glucose, Maltose, and Lactose,” L. Hough, J. K. N. Jones, and E. L. Richards,]. Chem. SOC., (1953)2005-2009. “The Synthesis of Sugars from Simpler Substances. Part VII. Enzymic Synthesis of 5-Deoxy-~-xylulose,”P. A. J. Gorin, L. Hough, and J. K. N. Jones,]. Chem. Soc., (1953) 2140-2142. “The Isolation of Oligosaccharides from Gums and Mucilages. Part I,” P. Andrews, D. H. Ball, and J. K. N. Jones,]. Chem.SOC., (1953) 4090-4095. “Structure of the ‘Triuronide’ from Pectic Acid,” J. K.N. Jones, Chem. Ind. (London), (1953)303. “The Galactan of Strychnos nux-uomica Seeds,” P. Andrews, L. Hough, and J. K. N. Jones, ]. Chem. Soc., (1954) 806-810.

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“The Structure of the Oligosaccharides Produced by the Enzymic Breakdown of Pectic Acid. Part I,” J. K. N. Jones and W. W. Reid,]. Chem. SOC., (1954)1361-1365. “The Isolation of Oligosaccharides from Gums and Mucilages. Part 11,” P. Andrews and J. K. N. Jones,]. Chem. SOC., (1954)1724-1726. “The Hemicelluloses of Scots Pine (Pinus syloestris) and Black Spruce (Picea nigru) Woods,” A. R. N. Gorrod and J. K. N. Jones,]. Chem. SOC., (1954)2522-2525. “The Synthesis of Sugars from Smaller Fragments. Part VIII. The Synthesis of D-Idoheptulosan from D-Xylose,” J. K. N. Jones,]. Chem. SOC., (1954)3643-3644. “The Isolation ofOligosaccharides from Gums and Mucilages. Part 111. Golden Apple Gum,” P. Andrews and J. K. N. Jones,]. Chem. Soc., (1954)4134-4138. “A Synthesis of 4-Deoxy-~-erythrohexulose,” P. A. J. Gorin, L. Hough, and J. K. N. Jones,]. Chem. SOC., (1954)4700-4701. “Some Observations on the Browning Reaction Between Glucose and Ammonia,” L. Hough, J. K. N. Jones, and E. L. Richards, Chem. Ind. (London),(1954)545-546. “Colorimetric Estimation of Sugars with Benzidine,” J. K.N. Jones and J. B. Pridham, Biochem. 1..58 (1954) 288-290. “Hemicellulose of Esparto (Stipa tenucissima L.). Part I,” J. K. N. Jones and G. Guzman, An. R. Soc. Esp. Fts. Qutm., Ser. B , 50 (1954)505-516. “An Improved Synthesis of D-Xylose 5-(Barium Phosphate),” P. A. J. Gorin, L. Hough, and J. K. N. JonesJ. Chem. Soc., (1955)582-583. “The Isolation of Oligosaccharides from Gums and Mucilages. Part IV. The Isolation of 3-O-~-~-Arabopyranosyl-~-arabinose from Lemon Cum,” P. Andrews and J. K. N. Jones,]. Chem. SOC., (1955)583-584. “The Synthesis of L-Glycerotetrulose and Related Compounds,” P. A. J. Gorin, L. Hough, and J. K. N. Jones,J. Chem. SOC., (1955)2699-2705. “The Constitution of Gum Myrrh. Part 11,” J. K. N. Jones and J. R. Nunn,J. Chem. Soc., (1955)3001-3004. “The Epimerization of Sugars,” J. K. N. Jones and W. H. Nicholson,]. Chem. Soc., (1955)3050-3053. “The Synthesis of Sugars from Simpler Substances. Part IX.The Enzymic Synthesis P. A. J. Gorin, L. Hough, and J. K. N. Jones,]. Chem. of 5:6-Dideoxy-~threohexulose,” SOC., (1955)3843-3845. “Methylene Derivatives of L-Rhamnose,” P. Andrews, L. Hough, and J. K. N. Jones, J. Am. Chem. Soc., 77 (1955)125-130. “The Structure of Frankincense Gum,” J. K. N. Jones and J. R. Nunn,]. Am. Chem. SOC., 77 (1955)5745-5764. “Chemistry ofthe Carbohydrates,” J. K. N. Jones,Annu. Reo. Biochem., 24 (1955)113 - 134. “A Synthesis of D-Tagatose from D-Galacturonic Acid,” P. A. J. Gorin, J. K. N. Jones, and W. W . Reid, Can.]. Chem., 33 (1955)1116-1118. “Preparation of L-Sorbose from 5-Keto-D-gluconic Acid (L-Sorburonic Acid),” J. K. N. Jones and W . W. Reid, Can. ]. Chem., 33 (1955)1682-1683. “The Analysis of Plant Gums and Mucilages,” J. K. N. Jones and E. L. Hirst, in K. Peach and M. V. Tracey (Eds.), Modern Methods of Plant Anulysis, Vol. 11, SpringerVerlag, Berlin, 1955,p. 275. “Properties of Dextrans Extracted from Plasma and Urine of Dogs,” R. E. Semple, B. J. Excell, and J. K. N. Jones, Fed. Proc., Fed. Am. Soc. Erp. Biol., 14 (1955)443. “The Structure ofthe Oligosaccharides Produced by the Enzymic Breakdown of P e e tic Acid. Part 11,” J. K. N. Jones and W. W. Reid,]. Chem. Soc., (1955)1890-1891. “The Separation ofan Essential Oil and of Methylated Sugars by Thermal Diffusion,” D. H. Ball, R. M. Butler, W. H. Cook, and J. K. N. Jones, Chem. Ind. (London),(1955) 1740-1741.

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“The Synthesis of Sugars from Smaller Fragments. Part X. Synthesis of LClucoheptulose,” J. K. N. Jones and R. B. Kelly, Can. I . Chem., 34 (1956)95-97. “A Synthesis of 5-0-Methyl =Glucose and of2-0-Methyl D-Glyceronamide,” J. K. N. Jones, Can.]. Chem., 34 (1956)310-312. “Fractionation of Polysaccharides,” A. J. Erskine and J. K. N. Jones, Can.].Chem., 34 (1956)821-826. “The Hemicellulose of the Fossilized Wood of Cedrus penhallawii,” J. K. N. Jones and E. Merler, Can. J. Chem., 34 (1956)840. “4-6-OisoPropylidene-rnethyl-a-~-glucoside,” J. K. N. Jones, Can. J . Chern., 34 (1956) 840-842. “The Action of Alkali Containing Metaborates on Wood Cellulose,” J. K. N. Jones, L. E. Wise, and J. P. Jappe, Tappi, 39 (1956)139-141. “The Synthesis of 3-Hexuloses. Part 1.2O-Methyl-~-rylo-3-hexulose,”J. K. N. Jones, J. Am. Chem. SOC., 78 (1956)2855-2857. “The Structure of the Hemicelluloses of Loblolly Pine,” D. H. Ball, J. K. N. Jones, W. H. Nicholson, and T. J. Painter, Tappi, 39 (1956) 438-443. “Reactions of Aliphatic Nitro Compounds. Formation of a Derivative of 1,5-Diazabicyclo(3.3.3)undecane from 1-Nitropropane, Formaldehyde and Ammonia,” J. K. N. Jones, R.Kosinski, H. Piotrowska, and T. Urbariski, Bull. Acad. Pol. Sci. Cl. 3,4 (1956) 509-510. “Reactions of Aliphatic Nitro Compounds. XXVII. On Formation of a Derivative of 1,5-Diazabicyclo(3.3.3}undecane from 1-Nitropropane, Formaldehyde and Ammonia,” J. K. N. Jones, R. Kolinski, €1. Piotrowska, and T. Urbdski, Ron. Chem.,31 (1957) 101109. “The Synthesis ofo-DeoxywS-ethylpoIyols,”J. K. N. Jones and D. L. Mitchell, Can. I. Chem., 36 (1957) 206-211. “The Hemicelluloses of Loblolly Pine (Pinus taeda) Wood. Part I. The Isolation of Five Oligosaccharide Fragments,” J. K. N. Jones and T. J. Painter,]. Chem. Soc., (1957) 669-6’73. “The Hemicelluloses Present in Aspen Wood (Populus tremuloides). Part 111. The Constitution of Pentosan and Hexosan Fractions,” J. K. N. Jones, E. Merler, and L. E. Wise, Can. J . Chem., 35 (1957) 634-645. “The Fractionation of Polysaccharides by the Method of Ultrafiltration,” K. C. B. Wilkie, J. K. N. Jones, B. J. Excell, and R. E. Sernple, Can. l. Ckm.,35 (1957) 7957%. “A Synthesis of 5,6Dideoxy-~-xylohexose(5-Deoxy-X-methyl-D-xylose),”J. K. N. Jones and J. L. Thompson, Can.J . Chem., 35 (1957) 955-959. “The Structure of the Type VIII Pneumococcus Specific Polysaccharide,” J. K. N. Jones and M. B. Perry,J. Am. Chem. SOC., 79 (1957) 2787-2793. ‘‘The Structure of Linseed Mucilage. Part I,” A. J. Erskine and J. K. N. Jones, Can.J. Chem., 35 (1957) 1174-1182. “The Synthesis of Disaccharides,” D. H. Ball and J. K. N. JonesJ. Chem. Soc., (1957) 4871-4873. “Isolation of Disaccharides from Golden Apple Cum,” J. K. N. Jones and B. 0. Lindgren,Acta Chem. S c a d . , 11 (1957) 1365. “The Acidcatalyzed Reversion of L-Arabinose and of DMannose,” J. K. N. Jones and W. H. Nicholson,J. Chem. Soc., (1958) 27-33. “The Acid-catalyzed Reversion of DXylose,” D. H. Ball and J. K. N. Jones,J. Chem. SOC., (1958)33-36. “A Synthesis of3-0-j3-DCalactopyranosyl-~galactose,” D. H. Ball and J. K. N. Jones, 1. Chem. SOC.,(1958)905-907.

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“Carbohydrate Chemistry at Queen’s University,” J. K. N. Jones, Pulp Pap. Mag. Can. Tech. Sect., 59 (1958) 145-147. “The Preparation of Some Derivatives of DRibono-14-lactone and DRibitol,” L. Hough, J. K. N. Jones, and D. L. Mitchell, Can. J. Chem., 36 (1958) 1720-1728. “The Hemicellulosas of Loblolly Pine (Pintts taedu) Wood. Part 11.The Constitution of Hexosan and Pentosan Components,” J. K. N. Jones and T. J. Painter,]. Chem. SOC., (1959) 573-580. “Structural Studies on Clinical Dextrans. Part I. Methylation and Pcriodate Oxidation Studies,” J. K. N. Jones and K. C. B. Wilkie, CanJ. Biochem. Physiol., 37 (1959) 377390. “The Characterization of TriO-tosyl Sucrose,” P. D. Bragg and J. K. N. Jones, Can. J. Chem., 37 (1959)575-578. “The Oxidation of Some Terminal-substituted Polyhydric Alcohols by Acetobacter suboxydans,” L. Hough, J. K. N. Jones, and D. L. Mitchell, Can. J . Chem., 37 (1959) 725-730. “Structure of Some Water-soluble Polysaccharides from Wood,” D. J. Brasch, J. K. N. Jones, T. J. Painter, and P. E. Reid, Proc. Cellul. Con$, 2nd, Syracuse, 1959, 3-15. “Structure of Some Water-soluble Polysaccharides from Wood,” D. J. Brasch, T. J. Painter, P. E. Reid, and J. K. N. Jones, Pulp Pap. Mag. Can., Tech. Sect., 60 (1959)T342T345. “5,6-Dideoxy-~arabino-hexose (S-Deoxy-5C-methyl-L--arabinose),” D. H. Bali, A. E. Flood, and J. K. N. Jones, Can. J. Chem., 37 (1959) 1018-1021. “The Reaction of Sulphuryl Chloride with Glycosides and Sugar Alcohols. Part I,” P. D. Bragg, J.K. N. Jones, and J. C. Turner, Can. J. Chem., 37 (1959) 1412-1416. “The Structure of an Arabogalactan From Monterey Pine (Pinus radiata),” D. J . Brasch and J. K. N. Jones, Can.J. Chem., 37 (1959) 1538-1545. “The Synthesis of S-Deoxy-5S-ethyl-D-threo-pentulose,” J. K. N. Jones and D. L. Mitchell, Can. J. Chem., 37 (1959) 1561-1566. “Separation of Sugars on Ion Exchange Resins,” J. K. N. Jones, R. A. Wall, and A. 0. Pittet, Chem. Ind. (London),(1959) 1196. “Synthesis of Sugars from Smaller Fragments. Part XI. Synthesis of L-Galactoheptulose,” J. K. N. Jones and N. K. Matheson, Can. J. Chem., 37 (1959) 1754-1756. “Investigation of Some Ancient Woods,” D. J. Brasch and J. K. N. Jones, Tappi, 42 (1959) 913-920. “The Reaction of Sodium Metaperiodate with Some Nitrogen Derivatives of Carbohydrates,” M. J. Abercrombie and J. K. N. Jones, Can. J. Chem., 38 (1960)308-309. “Synthesis of Sugars from Smaller Fragments. Part XII. Synthesis of SGlycero-D altro-, cGEycero-Lgalacto-, DClycero-Ggluco-, and DGlycero-cgalacto-odulose,” J . K. N. Jones and H. H. Sephton, Can. J. Chem., 38 (1960) 753-760. “Some Open-chain Derivatives of Glucose and Mannose,” E. J. C. Curtis and J. K. N. Jones, Can. J. Chem., 38 (1980) 890-895. “The Synthesis of 2O-~-~-Glucopyranosyl-~-xylose,” J. K. N. Jones and P. E. Reid, Can.]. Chem., 38 (1960) 944-949. “The Reaction of Sulphuryl Chloride with Glycosides and Sugar Alcohols. Part 11,” J. K. N. Jones, M. B. Peny, and J. C. Turner, Can.]. Chem., 38 (1960) 1122-1129. “The Synthesis of 3O-~-~-Xylopyranosyl-~-xylose and the Recharacterization of Some Benzylidene Derivatives of ~Xylose,”E. J. C.Curtis and J. K. N. Jones, Can.]. Chem., 38 (1960) 1305-1315. “The Polysaccharides of Cryptococcus laurentii (NRRL Y-1401). Part I,” M. J. Abercrombie, J. K. N. Jones, M. V. Lock, M. B. Perry, and R.J. Stoodley, Can.]. Chem., 38 (1960) 1617-1624.

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W. A. SZAREK, M. STACEY, AND G. W. HAY

“A Chemical Procedure for Determination of the C“ Distribution in Some Labelled Carbohydrates,” M. J. Abercrombie and J. K. N. Jones, Can.J . Chem., 38 (1960)1999-

2006.

“The Polysaccharides of Cryptococcus laurentii (Y1401).Part 11. Biosynthesis of the Carbohydrates Found in the Acidic Polysaccharide,” M. J. Abercrombie, J. K. N. Jones, and M. B. Perry, Can. J . Chem., 38 (1960)2007-2014. “The Separations of Sugars on Ion-exchange Resins. Part I,” J. K. N. Jones, R. A. Wall, and (in part) A. 0.Pittet, Can. J . Chem., 38 (1960)2285-2289. “The Separations ofSugars on Ion-exchange Resins. Part 11,” J. K. N. Jones and R. A. Wall, Can. J. Chem., 38 (1960)2290-2294. “The Structure of the ‘Gum Asafoetida’ Polysaccharide,” J. K. N. Jones and G. H. S. Thomas, Can. J . Chem., 39 (1961)192-202. “Analysis of Sugar Mixtures by Gas-Liquid Partition Chromatography,” S. W. Gunner, J. K. N. Jones, and M. B. Perry, Chem. Ind. (London), (1961)255-256. “The Demethylation of Sugars with Hydrogen Peroxide,” B. Fraser-Reid, J. K. N. Jones, and M. B. Perry, Can. J . Chem., 39 (1961)555-563. “The Synthesis ofhcetamido-deoxy Ketoses b y Acetobacter suboxydans. Part I,” J. K. N. Jones, M. B. Perry, and J. C. Turner, Can./. Chem., 39 (1961)965-972. “The Carbohydrate-Protein Linkage in Glycoproteins. Part I. The Syntheses of Some Model Substituted Amides and an L-Seryl-Sglucosaminide,” J, K. N. Jones, M. B. Perry, B. Shelton, and D. J. Walton, Can. J . Chem., 39 (1961)1005-1016. “Constitution of a 4-O-Methylglucuronoxylan From the Wood of Trembling Aspen (Populus tremuloides Michx.),” J. K. N. Jones, C. B. Purves, and T. E. Timell, Can. J. Chem., 39 (1961)1059-1066. “The Gas-Liquid Partition Chromatography of Carbohydrate Derivatives. Part I. The Separation of Glycitol and Glycose Acetates,” S. W. Gunner, J. K. N. Jones, and M. B. Perry, C a n . J .Chem., 39 (1961)1892-1899. “The Synthesis of Acetamido-deoxy Ketoses by Acetobacter suboxyduns. Part 11,” J. K. N. Jones, M. B. Perry, and J. C. Turner, Can./. Chem., 39 (1961)2400-2410. “Biogenesis of Carbohydrates in Wood,” J. K. N. Jones, Pure Appl. Chem., 5 (1962)

21 -35.

“The Synthesis of Acetamido-deoxy Ketoses by Acetobacter suboxydans. Part 111,” J. K. N. Jones, M. B. Perry, and J. C. Turner, Can.]. Chem., 40 (1962)503-510. “Biosynthesis of Sugars Found in Bacterial Polysaccharides. Part I. Biosynthesis of L-Rhamnose,” J. K. N. Jones, M. B. Perry, and R. J. Stoodley, C a n . ] . Chem., 40 (1962) 856-863. “The Biological and Chemical Synthesis of Polysaccharides,” J. K. N. Jones, Pure Appl. Chem., 5 (1962)469-482. “The Structure of Linseed Mucilage. Part 11,” K. Hunt and J. K. N. Jones, Can. J .

Chem., 40 (1962)1266-L279. “The Reaction of Sulphuryl Chloride with Reducing Sugars. Part I,” H. J. Jennings and J. K. N . Jones, Can. j . Chem., 40 (1962)1408-1414. “The Gas-Liquid Partition Chromatography of Carbohydrate Derivatives. Part 111. The Separation of Amino Glycose Derivatives and of Carbohydrate Acetal and Ketal Derivatives,” H. G. Jones, J. K. N. Jones, and M. B. Perry, Can.]. Chem.,40 (1962)1559 -1563. “Biosynthesis of Sugars Found in Bacterial Polysaccharides. Part 11. Biosynthesis of D-#lycero-D-manno-Heptose,”J. K. N. Jones, M. B. Perry, and R. J. Stoodley, Can. J . Chem., 40 (1962)1798-1804. “The Carbohydrate-Protein Linkage in Glycoproteins. Part 11. The Synthesis ofN-LSeryt-D-glucosamine andN-L-Threonyl-Sglucosamine,” J. K. N. Jones, J. P. Millington, and M. B. Perry, Can. /. Chem., 40 (1962)2229-2233.

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“5-Acetamido-5-deoxyy-~-arabinose: A Sugar Derivative Containing Nitrogen as the Hetero-atom in the Ring,” J. K. N. Jones and J. C. Turner,./. Chem. SOC., (1962)46994703. “Recent Progress in Polysaccharide Chemistry,” J. K. N. Jones, An. Assoc. Bras. Quim., Numero Expec., 21 (1962) 41-55. “Chromatography on Paper,” L. Hough and J. K. N. Jones, Methods Carbohydr. Chem., 1 (1962) 21-31. “Enzymic Methods for Determination of DGlucose. Quantitative Determination of D-Glucose by Oxidation with D-Glucose Aerodehydrogenase,” L. Hough and J. K. N. Jones, Methods Carbohydr. Chern., 1 (1962)400-404. “Determination of isotopic Carbon Distribution in Aldoses. Chemical Oxidation to Carbon Dioxide,” J. K. N. Jones and R. J. Stoodley, Methods Carbohydr. Chem., 2 (1963)489-493. “Structural Studies on the Water-Soluble Arabinogalactans of Mountain and European Larch,” J. K. N. Jones and P. E. Reid,J. Polym. Sci., Part C , (1963) 63-71. “Synthesis of a Sugar Derivative with Nitrogen in the Ring,” J. K. N. Jones and W. A. Szarek, Can.J . Chem., 41 (1963) 636-640. “The Reaction of Chlorosulphate Esters of Sugars with Pyridine,” H. J. Jennings and J. K. N. Jones, Can.J.Chem., 41 (1963) 1151-1159. “The Synthesis of D-glycero-Dmanno-Heptose,”R. K. Hulyalkar. J. K.N. Jones, and M. B. Perry, Can. J. Chem., 41 (1963) 1490-1492. “The Synthesis of 3-Hexuloses. Part 11. Derivatives of 1-Deoxy-Lurabo-3-hexulose (Syn. 6-Deoxy-~-Zyxo4-hexulose),”J. W. Bird and J. K. N. Jones, Can. J . Chem., 41 (1963) 1877-1881. “Synthesis of ~-Arabinose-5-C’~,” R. K. Hulyalkar and J. K. N. Jones, Can. J. Chem., 41 (1963) 1898-1904. “Carbon-Oxygen Fission: Degradation of Polysaccharides,” J. K.N. Jones and M. B. Perry, in K. W. Bentley (Ed.), Elucidation of Structures b y Physical and Chemical Methods, Part 11, Technique of Organic Chemistry, Vol. X I , Interscience Publishers, New York, 1963, pp. 707-750. “The Synthesis of 5#-~-D-Glucopyranosy1-Dxylose and 3,5-Di.0-P-~-glucopyranosyl-D-xylose,” J. K. N. Jones and P. E. Reid, Can. J . Chem., 41 (1963) 2382-2387. “The Occurrence of Dglycero-D.manno-Heptosein the Extracellular Polysaccharide Produced by Azotobacter indicum,” J. K. N. Jones, M. B. Perry, and W. Sowa, Can. J. Chem., 41 (1963)2712-2715. “The Structure of the Extracellular Polysaccharide of Azotobacter indicum,” V. M. Parikh and J. K. N. Jones, Can. J . Chem., 41 (1963)2826-2835. “Synthesis of Methyl 4-Acetamido4-deoxy-~-erythrofuranoside: A Sugar with Nitrogen in a Five-membered Ring,” W. A. Szarek and J. K. N. Jones, Can. /. Chem., 42 (1964)20-24. “The Chemistry of Apiose. Part I,” D. T. Williams and J. K. N. Jones, Can. J . Chem., 42 (1964)69-72. “The Glucomannan of Bluebell Seed (Scylla nonscripta L.),” J. L. Thompson and J. K. N. Jones, Can.]. Chem., 42 (1964) 1088-1091. “Hindered Internal Rotation in Carbohydrates Containing Nitrogen in the Ring,” W. A. Szarek, S. Wolfe, and J. K. N. Jones, Tetrahedron Lett., (1964)2743-2750. “Polysaccharides From the Seeds of the Huacra Pona Palm (Zriartea uentricosa),” W. Sowa and J. K. N. Jones, Can. J . Chem., 42 (1964) 1751-1754. “The L-Ascorbate Ion as an Ambident Nucleophile,” E. Buncel, K.G. A. Jackson, and J. K. N. Jones, Chem. Ind. (London), (1965)89. “Structure of Cholla Gum (Opuntia fulgida),” V. M. Parikh and J. K. N. Jones, J . Polym. Sci., Part C , (1965) 139-148.

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“The C- and 0-Benzylation of L-Ascorbic Acid,” K. G. A. Jackson and J. K. N. Jones, Can. J . Chem., 43 (1965)450-457. “The Oxidation of Sugar Acetals and Thioacetals by Acetobacter suborydans,” D. T. Williams and J. K. N. Jones, Can.]. Chem., 43 (1965)955-959. “Synthesis of 4-Acetamido4-deoxy-sugars,” A. J. Dick and J. K. N. Jones, Can. J.

Chem., 43 (1965)977-982. “The Reaction of Galactose with Hydrazine at Elevated Temperature,” J. K. N. Jones, P. Reid, and J. R. Turvey, Can.]. Chem., 43 (1965)983-985. “The Chemistry of D-Apiose. Part 11. The Configuration of D-Apiose in Apiin,” R. K. Hulydkar, J. K. N. Jones, and M. B. Perry, Can.]. Chem., 43 (1965)2085-2091. “Carbohydrates Containing Nitrogen in a Five-membered Ring and an Attempted Synthesis of a Carbohydrate with Nitrogen in a Seven-membered Ring,” W. A. Szarek and J. K. N. Jones, Can .J. Chem., 43 (1965)2345-2356. “Reactions of Sugar Chlorosulfates. Part V. The Synthesis of Chlorodeoxy Sugars,” H. J. Jennings and J. K. N. Jones, Can.J . Chem., 43 (1965)2372-2386. “Synthesis of 40-~-D-Galactopyranosyl-D-galactose,” E. J. C. Curtis and J. K. N. Jones, Can. J . Chem., 43 (1965)2508-2511. “Reactions of Sugar Chlorosulfates. Part VI. The Structure of Unsaturated Chlorodeoxy Sugars,” H. J. Jennings and J. K. N. Jones, Can.J. Chem., 43 (1965)3018-3025. “Synthesis of 5-Benzamido-5-deoxy-~-xylopyranose,” M. S. Patel and J. K. N. Jones, Cun. J . Chem., 43 (1965)3105-3108. “Direct Displacement of a Primary Tolyl-p-sulfonyloxy Group by the Methoxide Ion: A More Direct Route to 5-0-Methyl-L-arabinose and 3,5-Di4l-methyl-~-arabinose,” S. C. Williams and J. K. N. Jones, Can. J. Chem., 43 (1965)3440-3442. “Oxidation of Sugars with Ruthenium Dioxide-Sodium Periodate: A Simple Method for the Preparation of Substituted Keto Sugars,” V. M. Parikh and J . K. N. Jones, Can.J . Chern., 43 (1965)3452-3453. “Selective Nucleophilic Substitution and Preferential Epoxide Formation,” A. J. Dick and J. K. N. Jones, Can. J . Chem., 44 (1966)79-87. “Cholla Gum. Part I. Structure of the Degraded Cholla Gum,” V. M. Parikh and J. K. N. Jones, Can. J . Chem., 44 (1966)327-333. “The Separation of Aldopentose and Aldohexose Diethyl Dithioacetal Derivatives by Gas-Liquid Partition Chromatography,” D. T. Williams and J. K. N. Jones, Can. J . Chem., 44 (1966) 412-415. “Chlorosulphate as a Leaving Group: The Synthesis of a Methyl Tetrachloro-tetradeoxy-hexoside,” A. G. Cottrell, E. Buncel, and J. K. N. Jones, Chem. Ind. (London), (1%) 552. “Reactions of Sugar Chlorosulfates. Part VII. Some Confonnational Aspects,” A. G. Cottrell, E. Buncel, and J. K. N. Jones, Can.]. C h m . , 44 (1966)1483-1491. “Cholla Gum. Part 11. Structure of the Undegraded Cholla Gum,” V. M. Parikh and J. K. N. Jones, C a n . J .Chem., 44 (1966) 1531-1539. “The Capsular Polysaccharide of Pneumococcus Type XII, SXII,” J. A. Cifonelli, P. Rebers, M. B. Perry, and J. K. N. Jones, Biochemistry, 5 (1966)3066-3072. “A One-step Conversion of Cyclohexene Oxide into cis-l&Dichlorocyclohexane,” J. R. Campbell, J. K. N. Jones, and S. Wolfe, Can.J . Chem., 44 (1966)2339-2342. “A New Synthesis of 3-Acetamido3-deoxy-~glucose,” D. T. Williams and J. K. N. Jones, Cun. J . Chem., 45 (1967)7-9. “A Synthesis of Dihydroxyacetone Phosphate From Dihydroxyacetone,” R. L. Colbran, J. K. N. Jones, N. K. Matheson, and I. Rozema, Carbohydr. Res., 4 (1967)355-358. “The Synthesis, Separation, and Identification of the Methyl Ethers of Arabinose and ‘Their Derivatives,” S. C. Williams and J. K. N. Jones, Can.J.Chem., 45 (1967)275-290.

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“Further Experiments on the Oxidation of Sugar Acetals and Thioacetals by Acetobacter suborydans,” D. T. Williams and J. K. N. Jones, Can.]. Chem., 45 (1967)741744. “Acetonation of D-Xylose Diethyl Dithioacetal,” D. G. Lance and J. K. N. Jones, Can. .J. Chem., 45 (1967)1533-1538. “Reactions of Sugar Chlorosulfates. Part VIII. @Ribose and Its Derivatives,” S. S. Ali, T. J. Mepham, (Miss) I. M. E. Thiel, E. Buncel, and J. K. N. Jones, Carbohydr. Res., 5 (1967)118-125. “Gas Chromatography of Derivatives of the Methyl Ethers of D-Xylose,” D. G. Lance and J. K. N. Jones, Can. 3. Chem., 45 (1967)1995-1998. “The Synthesis of L-Mycarose and L-Cladinose,” G. B. Howarth and J. K. N. Jones, Can. ]. Chem., 45 (1967)2253-2256. “Selective Benzoylation of Benzyl P-L-Arabinopyranoside and Benzyl a-~-Xylopyranoside,” T. Sivakumaran and J. K. N. Jones, Can. 1.Chem., 45 (1967)2493-2500. “Epoxide Ring Opening of Methyl 2,3-Anhydro4-azido4-deoxy-pentopyranosides,” A. J. Dick and J. K. N. Jones, Can.]. Chem., 45 (1967)2879-2885. “The Synthesis of ~-Arcanose,” G. B. Howarth, W. A. Szarek, and J. K. N. Jones, Chem. Commun., (1968)62-63. “Isolation of Two kabinobioses From Acacia nilotica Gum,” R. C . Chalk, J. F. Stoddart, W. A. Szarek, and J. K. N. Jones, Con.]. Chem., 46 (1968)2311-2313. “Synthesis of 6-Deoxy3-C-methyl-2-0-methyl-@a~lose,” G. B. Howarth, W. A. Szarek, and J. K. N. Jones, Can. 3. Chem., 46 (1968)3375-3379. “Synthesis of 6-Chloro-4(6’-deoxy-3’C-methyl-2‘,3‘,4‘-~-0-methyl-~-@allopyranosy1)purine: A Branched-chain Sugar Nucleoside,” G. B. Howarth, W.A. Szarek, and J. K. N. Jones, Can. J. Chem., 46 (1968)3691-3694. “Photolysis of Carbohydrate Nitro-olefins,” G. B. Howarth, D. G. Lance, W. A. Szarek, and J. K. N. Jones, Chem. Commun., (1968)1349. “Branched-chain Sugar Nucleosides. Synthesis of a Purine Nucleoside of 4-0-AcetylL-arcanose,” G. B. Howarth, W. A. Szarek, and J. K. N. Jones,]. Org. Chem., 34 (1969) 476-477. “Syntheses Related to the Carbohydrate Moiety in Lincomycin,” G. B. Howarth, D. G . Lance, W. A. Szarek, and J. K. N. Jones, Can.]. Chem., 47 (1969)75-79. “Photolysis of a Carbohydrate Nibbolefin,” G. B. Howarth, D. G. Lance, W. A. Szarek, and J. K. N. Jones, Can. J. Chem., 47 (1969)81-87. “Some Structural Features of the Mucilage From the Bark of Ulmus fulua (Slippery Elm Mucilage),” R. J. Beveridge, J. F. Stoddart, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 9 (1969)429-439. “An Improved Procedure for Oxidation of Carbohydrate Derivatives with Ruthenium Tetraoxide,” B. T. Lawton, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 10 (1969) 456-458. “Synthesis of 8-Deoxy-D+rythro-D-galacto-octose.Determination of the Configuration of Two Octenoses,” D. G. Lance, W. A. Szarek, J. K. N. Jones, and G. B. Howarth, Can.]. Chem., 47 (1969)2871-2874. “Some 0-Isopropylidene Derivatives of @Ribose Diethyl Dithioacetal,” D. G. Lance, W. A. Szarek, and J. K. N. Jones, Can.]. Chem., 47 (1969)2889-2891. “Synthesis of DChalcose,” B. T. Lawton, D. J. Ward, W. A. Szarek, and J. K. N. Jones, Can. ]. Chem., 47 (1969)2899-2901. “Large Heterocyclic Rings From Carbohydrate Precursors,” J. F. Stoddart, W. A. Szarek, and J. K. N. Jones, Can.]. Chem., 47 (1969)3213-3215. “A Simple Synthesis of Azidodeoxy-sugars uia Chlorodeoxy-sugars,” B. T. Lawton, W. A. Szarek, and J. K. N. Jones, Chem. Commun., (1969)787-788.

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“Reachon of Methyl 4,6C)-Benzy~idene3C-methyl-2-O-p-tolylsulfonyl-a-~-allopyranoside with Sodium Methoxide in Methyl Sulfoxide: Synthesis of 6-Deoxy-34methyl3-O-methyl-aallose (2-Hydroxy-~-cladinose),”G. B. Howarth, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 11 (1969)257-262. “The Synthesis of N-Acetyl-lincosamine (6-Acetamido-6,8-dideoxy-D+rythro-~-galacto-octose), a Derivative of the Free Carbohydrate Moiety in Lincomycin,” G. B. How&, W. A. Szarek, and J. K. N. Jones, Chem. Commun., (1969) 1339-1340. “Synthesis of 3-Hexuloses,” K. G. A. Jackson and J. K. N. Jones, Can.J . Chem., 47 (1969)2498-2501. “Separation and Identification of Methyl Ethers of DGlucose and D-Glucitol by GasLiquid Chromatography,” H. G. Jones and J. K. N. Jones, Can.]. Chem., 47 (1969)3269 -3271. “Synthesis of Olivomycose (2,6-Dideoxy3C-methyl-~-arabino-hexose),” E. H. Wi1liams, W. A. Szarek, and J. K. N. Jones, Can.]. Chem., 47 (1969) 4467-4471. “Addition of Pseudohalogens to Unsaturated Carbohydrates. Part 111. Synthesis of 3DeoxySE-nitromethyl-&allose, a Branchedchain Nitro Sugar,” W. A. Szarek, J. S. Jewell, 1. Szczerek, and J. K. N. Jones, Can.J. Chem., 47 (1969)4473-4476. “Carbohydrate Fluorosulfates,” E. Buncel, H. J. Jennings, J. K. N. Jones, and I. M. E. Thiel, Carbohydr. Res., 10 (1969)331-332. “Structural Feature of Pneumococcus Type XIX Specific Polysaccharide,” T. Miyazaki and J. K. N. Jones, Chem. Pham. Bull., 17 (1969) 1531-1533. “The Isolation and Properties of the Skin-reactive Substance in Aedes aegypti Oral Secretion,” W. H. Newsome, J. K. N. Jones, F. E. French, and A. S. West, Can.J. Biochem., 47 (1969) 1129-1136. ‘?V-(4,6-O-Benzylidene-l-O-methyl-3-oximino-a-~-ribohexopyranos-2-y1)pyridinium p-Toluenesulfonate. A Novel Versatile Carbohydrate Substrate,” W. A. Szarek, B. T. Lawton, and J. K. N. Jones, Tetrahedron Lett., (1970) 4867-4870. “A Facile Synthesis of 4,6-Dideoxy-~-xylo-hexose,” B. T. Lawton, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 14 (1970) 255-258. “The Synthesis of Lincomycin,” G. B. Howarth, W. A. Szarek, and J. K. N. Jones, 1. C h . SOC., C, (1970) 2218-2224. “Synthesis of Deoxy and Aminodeoxy Sugars by Way of Chlorodeoxy Sugars,” B. T. Lawton, W. A. Szarek, and J. K. N.Jones, Carbohydr. Res., 15 (1970) 397-402. “Polysaccharides of Type XIX Pneumococcus. Part I. Isolation of Type Specific Polysaccharide,” T. Miyazaki,T. Yadomae, and J. K. N. Jones,]. Biochem. (Tokyo), 68 (1970) 755-758. “Synthesis of Paratose (3,6-Dideoxy-D.ribo-hexose)and Tyvelose (3,6-Dideoxy-~arabino-hexose),” E. H. Williams, W. A. Szarek, and J. K. N. Jones, Can. ]. Chem., 49 (1971) 796-799. “Some Structural Studies on the Galactan from the Albumen Glands of‘the Snail, Strophocheilus oblongus,” J. H. Duarte and J. K. N. Jones, Carbohydr. Res., 16 (1971) 327-335. “Reaction of Methyl 4,6-Dichloro4,6-dideoxy-a-D-galactopyranoside2,3-Di(chlorosulfate) with Sodium Azide, and with Sodium Bromide, in N,N-Dimethylformamide,” H. Parolis, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 19 (1975) 97-105. “Isolation of Three Oligosaccharides from the Mucilage from the Bark of Ulmusfulua (Slippery-Elm Mucilage). Synthesis of O-(30-Methyl-~-~-galactopyranosyl)-(14)-~rhaanose,” R. J. Beveridge, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 19 (1971) 107-1 16. “Reactions of‘Carbohydrate a-Keto Toluene*-sulphonates. Reaction of Methyl 4,6O-Benzylidene-20-toluenep-suIphonyl-a-D-ribo-hexop~~nosid~-ulose with Triethyl-

OBlTUARY- JOHN KENYON NETHERTON JONES

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amine-Methanol,” A. Dmytraczenko, W. A. Szarek, and J. K. N. Jones, Chem. Com-

mun., (1971) 1220-1222.

“Preparation of Unsaturated Carbohydrates from Methyl 4,W-Benzylidene-3chIoro-3-deoxy-pDallopyranoside,and Their Utility in the Synthesis of Sugars of Biological Importance,” E. H. Williams, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 20 (1971) 49-57. ‘‘Structure of Slippery Elm Mucilage (Ulmusfulua),” R. J. Beveridge, J. K. N. Jones, R. W.Lowe, and W . A. Szarek,]. PoZym. Sci., Part C,36 (1971) 461-466. “Studies on Lipopolysaccharides of Proteus,” B. A. Dmitriev, N. A. Hinton, R. W. Lowe, and J. K. N. Jones, Can.]. MicrobioZ., 17 (1971) 1385-1394. “An Evaluation of Methods for the Preparation of 1,2:3,4-Di-O-isopropylidene-a-~galacto-hexodialdo-1,Spyranose. Oxidation of 1,2:3,4DiO-isopropylidene-a-~galactopyranose with Lead Tetraacetate-Pyridine,” D. J. Ward, W.A. Szarek, and J. K. N. Jones, Carbohydr. Res., 21 (1972) 305-308. “Addition of Pseudohalogens to Unsaturated Carbohydrates. Part V. Addition of Iodine Trifluororoacetate,” R. G. S. Ritchie and W. A. Szarek, Can. J. Chem., 50 (1972)

507-511. “Some Reactions of Unsaturated Carbohydrates in the Presence of Iodine,” I. Szczerek, J. S. Jewell, R. G. S. Ritchie, W.A. Szarek, and J. K. N. Jones, Carbohydr. Res., 22 (1972) 163-172. “Amination of Sugar Derivatives with a Mixture of Phthalimide, Triphenylphosphine, and Diethyl Azodicarboxylate,” A. Zamojski, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 23 (1972) 460-462. “Selective Oxidation of a Diol with Methyl Sulfoxide-Acetic Anhydride,” T. B. Grindley, J. W. Bird, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 24 (1972) 212215. “Synthesis of Carbohydrate Furoxan Derivatives,” C. S. Wu, W. A. Szarek, and J. K. N. Jones, Chem. Commun., (1972) 1117-1118. “Ethers of Sugars,” J. K. N. Jones and G. W. Hay, in W. Pigman and D. Horton (Eds.), The Carbohydrates, Vol. IA, Academic Press, New York, 1972, pp. 403-422. “Reaction of Some Die-isopropylidenehexoseswith Cyanuric Chloride,” A. Zamojski, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 26 (1973) 208-214. “Reaction of Methyl 2,3-O-lsopropylidene-6~~-tolylsulfonyl-a-DEyxo-hexofuranosid-5-ulose with Triethylamine-Methanol,” A. Dmytraczenko, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 26 (1973) 297-303. “Reductive Cleavage of Carbohydrate p-Toluenesulfonates with Sodium Naphthalene,” H. C. Jarrell, R. G. S. Ritchie, W. A. Szarek, and J. K. N. Jones, Can.]. Chem., 51 (1973) 1767-1770. “Conversion of 2-Hexuloses into 3-Heptuloses: Synthesis of D-manno3-Heptulose,” R. W. Lowe, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 28 (1973) 281-293. “The Total Synthesis of Carbohydrates,” W. A. Szarek and J. K. N. Jones, in J. W. ApSimon (Ed.), The Total Synthesis of Natural Products, Wiley-Interscience, New York, 1973, pp. 1-80. “Lipopolysaccharides of Proteus,” J. K. N. Jones, in Mbthodologie de la Structure et du Mbtabolisme des Glycoconjuguk, Colloques Internationaux du Centre National de la Recherche Scientifique, No. 221, June 20-27, 1973, Villeneuve d’Ascq, Vol. 1, pp. 533-543. “A Reinvestigation of the Reaction of Methyl 8-DGlucopyranoside with Sulfuryl Chloride,” D. M. Dean, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 33 (1974) 383-386. “Reaction of Hexopyranoside a-Keto Toluene-p-sulfonates with Triethylamine-

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W. A. SZAREK, M. STACEY, AND G . W. HAY

Methanol,” W. A. Szarek, A. Dmytraczenko, and J . K. N. Jones, Carbohydr. Res., 35 (1974)203-219. “Reaction o f Methyl Yentofuranosides with Sulfiiryl Chloride,” B. Achmatowicz, W. A. Szarek, J. K. N. Jones, and E. H. Williams, Carbohydr. Res., 36 (1974) c14-c16. “Arthur Charles Neish, 1916-1973,” J. K. N. Jones, Biogr. Mem. Fellows R . Soc., 20 (1974)294-315. “Synthesis of Nucleosides by Direct Replacement of the Anomeric Hydroxy-group,” W. A. Szarek, C. Depew, H.C. Jarrell, and J. K. N. Jones,]. Chem. Soc., Chem. Commum, (1975)648-649. “Syntheses Related to Dendroketose,” H. C. Jarrell, W. A. Szarek, J. K. N. Jones, A. Dmytraczenko, and E. B. Rathbone, Carbohydr. Res., 45 (1975) 151-159. “Decarhonylation of Aldehydo Sugar Derivatives with Chlorotris(methyldipheny1phosphine)rhodium(I),” D. J. Ward, W. A. Szarek, and J. K. N. Jones, Chem. Ind. (London), (1976) 162-163. “Syntheses Towards the Carbohydrate Moiety of Lincomycin,” G. R. Woolard, E. B. Rathbone, W. A. Szarek, and J. K. N. Jones,/. Chem. SOC. Perkin Trans. 1 , (1976)950954.

“Synthesis of Carbohydrate-Saccharin Conjugates,” W. A. Szarek, C. Depew, and J. K. N. Jones,/. Heterocycl. Chem., 13 (1976) 1131-1133. “Selective, Reductive Dechlorination of Chlorodeoxy Sugars. Structural Determination of Chlorodeoxy and Deoxy Sugars by I3C Nuclear Magnetic Resonance Spectroscopy,” W. A. Szarek, A. Zamojski, A. R. Gibson, D. M. Vyas, and J. K. N. Jones, Can./. Clnem., 54 (1976)3783-3793. “Oxidation of a Branched-chain Alditol by Acetobocter suboxydans: a Stereospecific Synthesis of L-Dendroketose,” W. A. Szarek, G. W. Schnarr, H. C. Jarrell, and J. K. N. Jones,Carbohydr. Res., 53 (1977)101-108. “Preparation and Activity of Immobilized Acetobacter suboxydans Cells,” G . W. Schnarr, W. it. Szarek, and J. K. N. Jones,AppL Enoiron. Microbiol., 33 (1977)732-734. “Synthesis of Glymsides: Reactions of the Anomeric Hydroxyl Group with NitrogenPhosphorus Betaines,” W. A. Szarek, H. C. Jarrell, and J. K. N. Jones, Carbohydr. Res., 57 (1977) c13-cI6. “Stereospecific Chemical Synthesis of L-Dendroketose Derivatives,” H. C. Jarrell, W. A. Szarek, and J. K. N. Jones, Carbohydr. Res., 64 (1978)283-288.