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Jumping to conclusions in obsessive compulsive disorder
S334
P.1.j. Basic and clinical neuroscience − Cognitive neuroscience
P.1.j.019 Jumping to conclusions in obsessive compulsive disorder M.E. Ortigosa Luque1 , M. Valverde Barea2 , F. Cartas Moreno2 ° Princesa de Espa˜na, Jaen, Spain; 2 Hosp. Princesa de Espa˜na, psychiatry, Jaen, Spain
1 Hosp.
Introduction: In Obsessive compulsive disorder, sometimes, observed symptoms that could be psychotic. These observations make us wonder if there is a continuum between obsession, overvalued idea and delirium. There is a cognitive bias called Jumping to conclusions in psychosis. We think it is necessary to explore whether this bias is present in Obsessive compulsive disorder [1]. Objectives: We want to show the presence or not of a cognitive bias in obsessive compulsive disorder; jump to conclusions, present in psychosis, by testing The picture to decision task (TDT). Methods: 20 patients diagnosed with Obsessive compulsive disorder (according DSM-5 criteria) attended the Community care center of Ja´en (Spain). 12 men and 8 women. Test were passed: OCI-R, Community assesment of psychic experiences (CAPE), Beads task and The picture to decision task (TDT). Pearson‘s correlation was performed by relating the different variables studied, after this we made the linear regression where the dependent variable is TDT and independent CAPE negative and OCI-R accumulation. Results: First we studied the relationship between the dimensions of the CAPE and the OCI-R finding that the positive dimension of the CAPE had a positive relationship with the subscale order OCI-R (Pearson = 0.61, p = 0.005) and neutralization subscale (Pearson = 0.51, p = 0.05). In the case of the negative dimension of CAPE related to the accumulation subscale of OCI-R (Pearson = 0.55, p = 0.05). No relation between the depressive dimension with any of the subdivisions obtained from OCI-R was found. As for the possible relationship between OCI-R subscales and measures to jump to conclusions (Draw to decision; DTD) It shows that only the accumulation dimension relate negatively with DTD without tracks (Pearson = −0.052, p = 0.05) and the DTD with tracks (Pearson = −0.59, p = 0.005). The relationship between the dimensions of the CAPE and the DTD showed that only the negative side of the CAPE was associated with DTD without tracks (Pearson = −0.49, p = 0.05) and with the DTD with tracks (Pearson = −0.48, p = 0.05). To determine which dimensions are independently associated with DTD a linear regression was performed where the dependent variable was DTD and the independent variables were negative CAPE and OCI-R accumulation. Once we showed that only the accumulation dimension was associated independently with the DTD with tracks (beta = −0.47, p = 0.05). Partnering with free DTD was lost and none of the dimensions associated with free DTD. Conclusions: In the results obtained an association between dimensions CAPE observed with OCI-R subscales, that is, we see a possible association between what could be signs of psychotic symptoms manifested, or rather, with experiences that could enter into what the psychotic spectrum. Added to this it is that jumping to conclusions is present in obsessive compulsive disorder and a higher score on the item accumulation jump to conclusions was greater. Although this was done with the Beads task and was not positive jump to conclusions in patients suffering from Obsessive compulsive disorder [2].
References [1] Rubio, J.l., Ruiz-Veguilla, M., Hernandez, L., Barrig´on, M.L., Salcedo, M.D., Moreno, J.M., G´omez, E., Moritz, S., Ferrin, M., 2011. Jumping to conclusions in psychosis: a faulty appraisal. Schizophr Res 133(1−3), 199–204. [2] Jacobsen, P., Freeman, D., Salkovskis, P., 2012. Reasoning bias and belief conviction in obsessive compulsive disorder and delusions: jumping to conclusions across disorders? Br J Clin Psychol 51(1), 84−99.
P.1.j.021 Magnesium enhances the effects of reboxetine on cognitive functions in rats L. Mititelu Tartau1 , G. Rusu1 , A.C. Cristofor1 , R. Chirita2 , R.V. Lupusoru3 , E.G. Popa4 ° 1 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- PharmacologyAlgesiology, Iasi, Romania; 2 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- Psychiatry, Iasi, Romania; 3 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- Patho-Physiology, Iasi, Romania; 4 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Pharmacy - Pharmaceutical Technology, Iasi, Romania The antidepressant drug reboxetine is a norepinephrine reuptake inhibitor used especially in the treatment of major and unipolar depressions [1]. Magnesium is one of the most wide-spread elements in the environment, being the fourth major cation in the organism (after sodium, potassium and chloride), and the second most abundant within the cells. It plays a pivotal role in the homeostasis, being involved as enzyme co-factor in more than 300 biochemical reactions in the body [2]. Aim: Experimental researches on the effects of reboxetine and magnesium chloride association on the cognitive functions in old rats. Material and Method: The experiment was carried out on white male Wistar old rats (300–350 g, 15 months), distributed into 4 groups of 6 animals each, treated orally (using an eso-gastric device) one daily consecutive administration, for one month, as follows: group I (Control): distilled water 0.3 ml/100 g weight; group II (RBX): reboxetine 5 mg/kbw; group III (Mg): magnesium chloride 1 mmol/kbw, group IV (RBX+Mg): reboxetine 5 mg/kbw + magnesium chloride 1 mmol/kbw. The animal spatial memory performance was assessed by recording spontaneous alternation behavior in a single session in the T-maze test. Each animal was placed at the end of one arm and allowed to move freely through the maze during an eight minutes session. The following parameters were counted: number of arm visits, the percent of time spent inside the arms, the number of the returns inside the same arm, the number of alternations, the alternation percentage. The alternation percentage was calculated according the following formula: [(number of alternations)/(total number of arm visits − 2)] × 100 [3]. Data were presented as ± standard deviation and significance was tested by SPSS 17.0 for Windows statistics software, with ANOVA method and Newman–Keuls test as post-hoc. P-values less than 0.05 were considered statistically significant comparing with those of control group. Experimental protocol was implemented, according to recommendations of the ‘Grigore T. Popa’ University Committee for Research and Ethical Issues. Results: In our experimental conditions the administration of reboxetine (2 mg/kbw) determined an increase of spontaneous alternation rate, statistically significant comparing with control group, but did not influence the period latency to choose a goal arm. The chronic use of magnesium chloride (1 mmol/kbw)
P.1.j. Basic and clinical neuroscience − Cognitive neuroscience
P.1.j.019 Jumping to conclusions in obsessive compulsive disorder M.E. Ortigosa Luque1 , M. Valverde Barea2 , F. Cartas Moreno2 ° Princesa de Espa˜na, Jaen, Spain; 2 Hosp. Princesa de Espa˜na, psychiatry, Jaen, Spain
1 Hosp.
Introduction: In Obsessive compulsive disorder, sometimes, observed symptoms that could be psychotic. These observations make us wonder if there is a continuum between obsession, overvalued idea and delirium. There is a cognitive bias called Jumping to conclusions in psychosis. We think it is necessary to explore whether this bias is present in Obsessive compulsive disorder [1]. Objectives: We want to show the presence or not of a cognitive bias in obsessive compulsive disorder; jump to conclusions, present in psychosis, by testing The picture to decision task (TDT). Methods: 20 patients diagnosed with Obsessive compulsive disorder (according DSM-5 criteria) attended the Community care center of Ja´en (Spain). 12 men and 8 women. Test were passed: OCI-R, Community assesment of psychic experiences (CAPE), Beads task and The picture to decision task (TDT). Pearson‘s correlation was performed by relating the different variables studied, after this we made the linear regression where the dependent variable is TDT and independent CAPE negative and OCI-R accumulation. Results: First we studied the relationship between the dimensions of the CAPE and the OCI-R finding that the positive dimension of the CAPE had a positive relationship with the subscale order OCI-R (Pearson = 0.61, p = 0.005) and neutralization subscale (Pearson = 0.51, p = 0.05). In the case of the negative dimension of CAPE related to the accumulation subscale of OCI-R (Pearson = 0.55, p = 0.05). No relation between the depressive dimension with any of the subdivisions obtained from OCI-R was found. As for the possible relationship between OCI-R subscales and measures to jump to conclusions (Draw to decision; DTD) It shows that only the accumulation dimension relate negatively with DTD without tracks (Pearson = −0.052, p = 0.05) and the DTD with tracks (Pearson = −0.59, p = 0.005). The relationship between the dimensions of the CAPE and the DTD showed that only the negative side of the CAPE was associated with DTD without tracks (Pearson = −0.49, p = 0.05) and with the DTD with tracks (Pearson = −0.48, p = 0.05). To determine which dimensions are independently associated with DTD a linear regression was performed where the dependent variable was DTD and the independent variables were negative CAPE and OCI-R accumulation. Once we showed that only the accumulation dimension was associated independently with the DTD with tracks (beta = −0.47, p = 0.05). Partnering with free DTD was lost and none of the dimensions associated with free DTD. Conclusions: In the results obtained an association between dimensions CAPE observed with OCI-R subscales, that is, we see a possible association between what could be signs of psychotic symptoms manifested, or rather, with experiences that could enter into what the psychotic spectrum. Added to this it is that jumping to conclusions is present in obsessive compulsive disorder and a higher score on the item accumulation jump to conclusions was greater. Although this was done with the Beads task and was not positive jump to conclusions in patients suffering from Obsessive compulsive disorder [2].
References [1] Rubio, J.l., Ruiz-Veguilla, M., Hernandez, L., Barrig´on, M.L., Salcedo, M.D., Moreno, J.M., G´omez, E., Moritz, S., Ferrin, M., 2011. Jumping to conclusions in psychosis: a faulty appraisal. Schizophr Res 133(1−3), 199–204. [2] Jacobsen, P., Freeman, D., Salkovskis, P., 2012. Reasoning bias and belief conviction in obsessive compulsive disorder and delusions: jumping to conclusions across disorders? Br J Clin Psychol 51(1), 84−99.
P.1.j.021 Magnesium enhances the effects of reboxetine on cognitive functions in rats L. Mititelu Tartau1 , G. Rusu1 , A.C. Cristofor1 , R. Chirita2 , R.V. Lupusoru3 , E.G. Popa4 ° 1 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- PharmacologyAlgesiology, Iasi, Romania; 2 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- Psychiatry, Iasi, Romania; 3 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Medicine- Patho-Physiology, Iasi, Romania; 4 University of Medicine and Pharmacy Iasi Gr. T. Popa, Faculty of Pharmacy - Pharmaceutical Technology, Iasi, Romania The antidepressant drug reboxetine is a norepinephrine reuptake inhibitor used especially in the treatment of major and unipolar depressions [1]. Magnesium is one of the most wide-spread elements in the environment, being the fourth major cation in the organism (after sodium, potassium and chloride), and the second most abundant within the cells. It plays a pivotal role in the homeostasis, being involved as enzyme co-factor in more than 300 biochemical reactions in the body [2]. Aim: Experimental researches on the effects of reboxetine and magnesium chloride association on the cognitive functions in old rats. Material and Method: The experiment was carried out on white male Wistar old rats (300–350 g, 15 months), distributed into 4 groups of 6 animals each, treated orally (using an eso-gastric device) one daily consecutive administration, for one month, as follows: group I (Control): distilled water 0.3 ml/100 g weight; group II (RBX): reboxetine 5 mg/kbw; group III (Mg): magnesium chloride 1 mmol/kbw, group IV (RBX+Mg): reboxetine 5 mg/kbw + magnesium chloride 1 mmol/kbw. The animal spatial memory performance was assessed by recording spontaneous alternation behavior in a single session in the T-maze test. Each animal was placed at the end of one arm and allowed to move freely through the maze during an eight minutes session. The following parameters were counted: number of arm visits, the percent of time spent inside the arms, the number of the returns inside the same arm, the number of alternations, the alternation percentage. The alternation percentage was calculated according the following formula: [(number of alternations)/(total number of arm visits − 2)] × 100 [3]. Data were presented as ± standard deviation and significance was tested by SPSS 17.0 for Windows statistics software, with ANOVA method and Newman–Keuls test as post-hoc. P-values less than 0.05 were considered statistically significant comparing with those of control group. Experimental protocol was implemented, according to recommendations of the ‘Grigore T. Popa’ University Committee for Research and Ethical Issues. Results: In our experimental conditions the administration of reboxetine (2 mg/kbw) determined an increase of spontaneous alternation rate, statistically significant comparing with control group, but did not influence the period latency to choose a goal arm. The chronic use of magnesium chloride (1 mmol/kbw)