- Email: [email protected]
June 2012
In Context
Ten most wanted June 2012 1 Alzheimer’s disease immunotherapy (Article, July) Winblad B, et al. Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurol 2012; 11: 597–604. 2 Diabetic neuropathy (Review, June) Callaghan BC, et al. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521–534. 3 Neuropathic pain (Review, July) Calvo M, et al. The role of the immune system in the generation of neuropathic pain. Lancet Neurol 2012; 11: 629–42. 4 HIV and CNS infections (Review, July) Tan IL, et al. HIV-associated opportunistic infections of the CNS. Lancet Neurol 2012; 11: 605–17. 5 Polyradiculoneuropathy (Article, June) Nobile-Orazio E, et al. Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial. Lancet Neurol 2012; 11: 493–502. 6 Sporadic human prion diseases (Review, July) Puoti G, et al. Sporadic human prion diseases: molecular insights and diagnosis. Lancet Neurol 2012; 11: 618–28. 7 Alzheimer’s disease (Comment, July) Wisniewski T. Active immunotherapy for Alzheimer’s disease. Lancet Neurol 2012; 11: 571–72. 8 Stroke prevention (Article, June) Easton JD, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol 2012; 11: 503–11. 9 Neuromyelitis optica (Review, June) Papadopoulos MC, Verkman A. Aquaporin 4 and neuromyelitis optica. Lancet Neurol 2012; 11: 534–544. 10 Parkinson’s disease (Article, July) Moreau C, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson’s disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol 2012; 11: 589–96. The top ten Lancet Neurology articles downloaded from ScienceDirect in June, 2012.
www.thelancet.com/neurology Vol 11 September 2012
Lifeline Kees Braun is a Professor of child neurology at Utrecht University, Utrecht, the Netherlands, where he also obtained his MD and PhD and was trained in neurology. He is President of the Dutch Society of Paediatric Neurology. His clinical and research interests are paediatric stroke, refractory epilepsy, epilepsy surgery, and imaging of structural and functional integrity of the epileptic brain. What has been the greatest achievement of your career? Establishing the Time To Stop study together with our colleagues in the European Taskforce for Epilepsy Surgery in Children, whose findings are published in this issue of The Lancet Neurology. It will hopefully change our current, rather conservative, medication-withdrawal policies.
See Articles page 784
If you had not entered your current profession, what would you have liked to do? I used to dream of a career as a professional piano player. After 28 years of medicine, talent seems to have faded. What inspired you? First, being raised by stimulating parents, and second, being surrounded and challenged by talented colleagues from different backgrounds, either basic neuroscientists or clinical specialists. Who was your most influential teacher, and why? Onno van Nieuwenhuizen, my colourful predecessor; a charismatic leader and a tutor in social skills, wit, and public speaking. What is your favourite book? Like People in History by Felice Picano. Picano beautifully describes a previous generation that paved the way to the life I can live now. What would be your advice to a newly qualified doctor? If he or she wants to pursue an academic career: take courses in time management, hire a personal coach, make choices and stick to them, find a niche and a hobby, and learn to play the game. What is your greatest fear? I have a continuing anxiety for serious diseases. If not for myself, then for our dog, which is why my friends diagnosed me with a veterinarian subtype of Münchhausen syndrome by proxy. What is your worst habit? Expressing irritation through body language. What keeps you awake at night? Deliberating on how to respond to 44 critical questions from The Lancet Neurology’s reviewers. Other than that: high temperatures (which are rare in our country) and unfeasible deadlines. Do you believe in ghosts? Definitely not, although my mother-in-law tries to convince me otherwise. 753
Ten most wanted June 2012 1 Alzheimer’s disease immunotherapy (Article, July) Winblad B, et al. Safety, tolerability, and antibody response of active Aβ immunotherapy with CAD106 in patients with Alzheimer’s disease: randomised, double-blind, placebo-controlled, first-in-human study. Lancet Neurol 2012; 11: 597–604. 2 Diabetic neuropathy (Review, June) Callaghan BC, et al. Diabetic neuropathy: clinical manifestations and current treatments. Lancet Neurol 2012; 11: 521–534. 3 Neuropathic pain (Review, July) Calvo M, et al. The role of the immune system in the generation of neuropathic pain. Lancet Neurol 2012; 11: 629–42. 4 HIV and CNS infections (Review, July) Tan IL, et al. HIV-associated opportunistic infections of the CNS. Lancet Neurol 2012; 11: 605–17. 5 Polyradiculoneuropathy (Article, June) Nobile-Orazio E, et al. Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial. Lancet Neurol 2012; 11: 493–502. 6 Sporadic human prion diseases (Review, July) Puoti G, et al. Sporadic human prion diseases: molecular insights and diagnosis. Lancet Neurol 2012; 11: 618–28. 7 Alzheimer’s disease (Comment, July) Wisniewski T. Active immunotherapy for Alzheimer’s disease. Lancet Neurol 2012; 11: 571–72. 8 Stroke prevention (Article, June) Easton JD, et al. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial. Lancet Neurol 2012; 11: 503–11. 9 Neuromyelitis optica (Review, June) Papadopoulos MC, Verkman A. Aquaporin 4 and neuromyelitis optica. Lancet Neurol 2012; 11: 534–544. 10 Parkinson’s disease (Article, July) Moreau C, et al. Methylphenidate for gait hypokinesia and freezing in patients with Parkinson’s disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial. Lancet Neurol 2012; 11: 589–96. The top ten Lancet Neurology articles downloaded from ScienceDirect in June, 2012.
www.thelancet.com/neurology Vol 11 September 2012
Lifeline Kees Braun is a Professor of child neurology at Utrecht University, Utrecht, the Netherlands, where he also obtained his MD and PhD and was trained in neurology. He is President of the Dutch Society of Paediatric Neurology. His clinical and research interests are paediatric stroke, refractory epilepsy, epilepsy surgery, and imaging of structural and functional integrity of the epileptic brain. What has been the greatest achievement of your career? Establishing the Time To Stop study together with our colleagues in the European Taskforce for Epilepsy Surgery in Children, whose findings are published in this issue of The Lancet Neurology. It will hopefully change our current, rather conservative, medication-withdrawal policies.
See Articles page 784
If you had not entered your current profession, what would you have liked to do? I used to dream of a career as a professional piano player. After 28 years of medicine, talent seems to have faded. What inspired you? First, being raised by stimulating parents, and second, being surrounded and challenged by talented colleagues from different backgrounds, either basic neuroscientists or clinical specialists. Who was your most influential teacher, and why? Onno van Nieuwenhuizen, my colourful predecessor; a charismatic leader and a tutor in social skills, wit, and public speaking. What is your favourite book? Like People in History by Felice Picano. Picano beautifully describes a previous generation that paved the way to the life I can live now. What would be your advice to a newly qualified doctor? If he or she wants to pursue an academic career: take courses in time management, hire a personal coach, make choices and stick to them, find a niche and a hobby, and learn to play the game. What is your greatest fear? I have a continuing anxiety for serious diseases. If not for myself, then for our dog, which is why my friends diagnosed me with a veterinarian subtype of Münchhausen syndrome by proxy. What is your worst habit? Expressing irritation through body language. What keeps you awake at night? Deliberating on how to respond to 44 critical questions from The Lancet Neurology’s reviewers. Other than that: high temperatures (which are rare in our country) and unfeasible deadlines. Do you believe in ghosts? Definitely not, although my mother-in-law tries to convince me otherwise. 753