99
In conclusion, we suggest that ferritin loses a part of its iron on passage from the liver cell to the blood. This might happen not only in iron overload and liver cell leakage but also in other circumstances, because almost always serum ferritin seems to be a modified product of the tissue (blood cell) ferritins [3]. This principle might be overruled in some cases of severe liver cell (perhaps other cell) leakage. Then, ferritin with a higher iron content will enter the blood. Of course in cases with a low iron content in liver (or other tissue) ferritins, as in advanced iron mobilization, serum ferritin will always be low in its mean iron content. Acknowledgement The authors wish to thank Professor Dr. J. van Go01 for his interest in and support of this study. References 1
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