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KMP040 Disseminated Trichosporon asahii infection in a dog
Wissenschaftliches Programm 55. DGHM-Tagung 29. September-l. Oktober 2003 in Dresden Abstracts - Poster
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Disseminated Trichosporon asahfi infection in a dog L0bke-Becker, A.1; Schwegler, K.2; AIIgoewer, I. 3
~Freie Universit~t Berlin; Institut fDr Mikrobiologie und Tierseuchen 2Freie Universit~t Berlin; Institut fDr VeterinarPathologie 3Berlin; Animal Eye Practise Trichosporon spp. are widely distributed in nature. In humans Trichosporon spp. infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial cutaneous infections and hypersensitive pneumonia in immunocompetent individuals to severe systemic disease in immunocompromised patients. There are only very few case reports of Trichosporon spp. infections in animals which are classically associated with intramammary infections in cows. We report the clinical signs as well as the pathological and mycological findings of a disseminated Trichosporon asahii infection in a 4-year-old German shepherd dog. The most prominent clinical features were unilateral panuveitis with secondary glaucoma, posterior uveitis with subretinal exsudate in the other eye and generalized lymphadenopathy. At necropsy, greyish granulomas of different size were present in lymphnodes, spleen, thymus, heart muscle and kidneys. The aortical lumbal lymphnodes were enlarged up to 5 cm in diameter. With the periodic acid-Schiff reaction fungal structures were detected inside the granulomas. The hypertrophic and dilated heart showed calcification and a fibrinous endocarditis in the left atrium in which the periodic acid-Schiff reaction revealed fungal structures as well. To our knowledge, this is the first report of an invasive infection caused by Trichosporon asahii in a dog
Recurrent meningitis caused by Bacillus species Hochauf, K.1; Alex, H.2; Gahn, G.2; Jacobs, E. 1
1Dresden University of Technology; Institute of Medical Microbiology and Hygiene 2Dresden University of Technology; Department of Neurology A 68-year old female patient was admitted to the neurological department after a one year history of recurrent bacterial meningitis following a neurosurgical operation for the resection of a cavernoma and implantation of a Rickham reservoir. During the first postoperative episode of bacterial meningitis, 5 months after the operative intervention, Bacillus sp. was isolated from a sample of cerebrospinal fluid (CSF). The Rickham reservoir has been removed. According to susceptibility test results the patient was treated with ciprofloxacin and piperacillin intravenously. After initial improvement more than 5 periods of meningitis with altered cellular and biochemical CSF parameters as well as unspecific intrathecal antibody production occurred. No focus and no infectious agent were found.
http://www.dghm.org
391
G~ GESELL~
/. %
o~°
Disseminated Trichosporon asahfi infection in a dog L0bke-Becker, A.1; Schwegler, K.2; AIIgoewer, I. 3
~Freie Universit~t Berlin; Institut fDr Mikrobiologie und Tierseuchen 2Freie Universit~t Berlin; Institut fDr VeterinarPathologie 3Berlin; Animal Eye Practise Trichosporon spp. are widely distributed in nature. In humans Trichosporon spp. infections are rare but have been associated with a wide spectrum of clinical manifestations, ranging from superficial cutaneous infections and hypersensitive pneumonia in immunocompetent individuals to severe systemic disease in immunocompromised patients. There are only very few case reports of Trichosporon spp. infections in animals which are classically associated with intramammary infections in cows. We report the clinical signs as well as the pathological and mycological findings of a disseminated Trichosporon asahii infection in a 4-year-old German shepherd dog. The most prominent clinical features were unilateral panuveitis with secondary glaucoma, posterior uveitis with subretinal exsudate in the other eye and generalized lymphadenopathy. At necropsy, greyish granulomas of different size were present in lymphnodes, spleen, thymus, heart muscle and kidneys. The aortical lumbal lymphnodes were enlarged up to 5 cm in diameter. With the periodic acid-Schiff reaction fungal structures were detected inside the granulomas. The hypertrophic and dilated heart showed calcification and a fibrinous endocarditis in the left atrium in which the periodic acid-Schiff reaction revealed fungal structures as well. To our knowledge, this is the first report of an invasive infection caused by Trichosporon asahii in a dog
Recurrent meningitis caused by Bacillus species Hochauf, K.1; Alex, H.2; Gahn, G.2; Jacobs, E. 1
1Dresden University of Technology; Institute of Medical Microbiology and Hygiene 2Dresden University of Technology; Department of Neurology A 68-year old female patient was admitted to the neurological department after a one year history of recurrent bacterial meningitis following a neurosurgical operation for the resection of a cavernoma and implantation of a Rickham reservoir. During the first postoperative episode of bacterial meningitis, 5 months after the operative intervention, Bacillus sp. was isolated from a sample of cerebrospinal fluid (CSF). The Rickham reservoir has been removed. According to susceptibility test results the patient was treated with ciprofloxacin and piperacillin intravenously. After initial improvement more than 5 periods of meningitis with altered cellular and biochemical CSF parameters as well as unspecific intrathecal antibody production occurred. No focus and no infectious agent were found.
http://www.dghm.org
391