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KMS introduces Spirapro TFC and RO elements
NEWS measuring molecules using electronic signals, the Eagle approach achieves a 1000-fold higher sensitivity by using the FETs embedded in the structure. ‘A rapid, cost-effective and portable molecular detection device has the potential to advance a wide range of important life science applications,’ says Dennis Gilbert, Chief Scientific Officer of Applied Biosystems. ‘While it is still in early stages, we are excited about exploring this technology’s ability to achieve these goals by identifying molecules directly by electronic charge signatures – a capability which could also represent the future of label-free molecule detection.’ Applied Biosystems intends to focus its initial development support and feasibility testing for applications in protein identification and the detection of proteinbinding events. Provided that the ability to electronically profile the individual four nucleotides in DNA is further developed, the company believes the Eagle technology has the potential to identify and measure both DNA and proteins in a single sample at the same time. Contact: Applied Biosystems, Division Headquarters, 850 Lincoln Centre Drive, Foster City, CA 94404, USA. Tel: +1 650 638 5800, www.appliedbiosystems.com
Multi-well plate sustains cell mono-layers Now available from Millipore Corporation of Billerica, Massachusetts is a 96-well Millicell plate that is optimized to grow and sustain high integrity cell mono-layers. Cells grown on Millicell plate membranes grow better than on plastic because the cells are nourished from both the apical and basolateral sides, says Millipore. Furthermore, cell growth and function more closely mimic in vivo conditions. The Millicell 96-well plates are designed for analysis as well as cell growth, and can be used manually or with
automated cell seeding, feeding and washing systems. During 2005, Millipore introduced both 24-well Millicell plates and single-well Millicell hanging inserts. The 96-well plate further extends the firm’s product range, and enhances its usability in a range of laboratory environments. Like the 24-well and singlewell versions, the 96-well Millicell plate incorporates track-etched thin-film membranes for reliable mono-layer formation; microscopically transparent membranes for easy cell visualization; and fluorescence-compatible plastics and membranes. The device is available with a 1.0 µm polyethylene terephthalate (PET) membrane. To reduce the risk of monolayer contamination, the device uses ‘feet’ to elevate the plate above the work surface when disassembled from the feeder tray. Teardrop-shaped receiver wells eliminate air bubbles as the plates are assembled. Contact: Millipore Corporation, 290 Concord Road, Billerica, MA 01821, USA. Tel: +1 978 715 4321, www.millipore.com
KMS introduces Spirapro TFC and RO elements Koch Membrane Systems Inc (KMS) of Wilmington, Massachusetts has introduced its Fluid Systems Spirapro TFC line of SR3 and reverse osmosis (RO) elements for pharmaceutical and fine chemicals applications. According to the company, these significantly lower the operating costs for a wide variety of applications, including selective rejection, desalting and organics concentration. Ideally suited to desalting and separating antibiotics and active pharmaceutical ingredients (APIs), the Fluid Systems Spirapro TFC elements use a proprietary, polyamide thin-film composite membrane with a sanitary spiral-wound net outerwrap. The molecular weight
cut-off for the TFC SR3 allows the membrane to pass monovalent salts, such as sodium chloride, yet it provides high retention of multivalent ions and uncharged organic solutes. The retention of sugars, such as lactose, typically exceeds 99%. These elements can be useful for separating small molecules from chromatography effluent or other intermediate purification processes. The TFC RO elements are ideal for concentrating compounds which have a molecular weight of 100–2000 daltons, such as antibiotics, radiopaque contrast agents and polypeptides, says KMS. These RO elements are specifically designed to increase efficiency and reduce costs by providing high rejection at low pressure. Typically, they achieve better than 99.95% rejection of protein and lactose and achieve chloride rejection of 99.3%. Both TFC SR3 and TFC RO elements can be used to replace Nanomax membranes, originally supplied by Millipore Corporation, or Desal membranes originally supplied by GE Osmonics. All element components pass USP Class VI toxicity testing guidelines. The maximum operating pressure for all of the Fluid Systems Spirapro TFC elements is 4 MPa (600 psi), while the actual operating pressure depends on the system flux rate as well as feed, recovery and temperature conditions. These spiral elements are available in 10 cm (3.8 inch) and 20 cm (7.9 inch) diameters, at the standard 97 cm (38 inch) and 102 cm (40 inch) lengths. Feed channel spacers are also available in the N1 standard or the N2 custom sizes. In addition, KMS offers a range of anti-scalants, cleaners and maintenance chemicals for all of the Spirapro TFC membranes. Kochtreat anti-scalants and Kochkleen membrane cleaners help prolong membrane service life and reduce the cleaning cycle time. Contact: Koch Membrane Systems Inc, 850 Main Street, Wilmington, MA 01887-3388, USA. Tel: +1 978 694 7000, www.kochmembrane.com
In Brief Dow raises price of ion-exchange resins US-based Dow Water Solutions has raised the price of all Dowex ion-exchange resin, adsorbent and catalyst products. The company says the increase – an average of 5% across the line – reflects the need to offset the higher costs of energy and raw materials. Customers will be contacted by their local Dow sales representatives with the specific product and price details. Pentair names President and Chief Operating Officer US-based Pentair Inc has revised its leadership structure, and appointed Michael Schrock to the newly created role of President and Chief Operating Officer. Schrock will report to Randall Hogan, the firm’s Chairman and Chief Executive Officer. ‘This new structure streamlines our leadership communication channels and provides for broader coordination of operations with more direct cost controls across the company, which is critical as we face shifting market conditions,’ says Hogan. Schrock will assume responsibility for all of Pentair’s operating segments. He will continue to lead the Technical Products Group, which he has led since October 2001, and the Filtration business, for which he has been responsible since October 2005, while gaining responsibility for the remaining Water businesses. NSF helps to improve water quality in the Philippines US-based NSF International has entered into an agreement with the Philippines National Government. The move will allow NSF to use its standards for drinking water treatment units as the basis for all devices tested, certified and evaluated in the Philippines. It will also allow NSF technical experts to work directly with the Philippines Bureau of Health Devices and Technology, Department of Health, and is a key step that will lead to the development of standards for raising the quality of drinking water for the consuming public.
6 Membrane Technology December 2006
Multi-well plate sustains cell mono-layers Now available from Millipore Corporation of Billerica, Massachusetts is a 96-well Millicell plate that is optimized to grow and sustain high integrity cell mono-layers. Cells grown on Millicell plate membranes grow better than on plastic because the cells are nourished from both the apical and basolateral sides, says Millipore. Furthermore, cell growth and function more closely mimic in vivo conditions. The Millicell 96-well plates are designed for analysis as well as cell growth, and can be used manually or with
automated cell seeding, feeding and washing systems. During 2005, Millipore introduced both 24-well Millicell plates and single-well Millicell hanging inserts. The 96-well plate further extends the firm’s product range, and enhances its usability in a range of laboratory environments. Like the 24-well and singlewell versions, the 96-well Millicell plate incorporates track-etched thin-film membranes for reliable mono-layer formation; microscopically transparent membranes for easy cell visualization; and fluorescence-compatible plastics and membranes. The device is available with a 1.0 µm polyethylene terephthalate (PET) membrane. To reduce the risk of monolayer contamination, the device uses ‘feet’ to elevate the plate above the work surface when disassembled from the feeder tray. Teardrop-shaped receiver wells eliminate air bubbles as the plates are assembled. Contact: Millipore Corporation, 290 Concord Road, Billerica, MA 01821, USA. Tel: +1 978 715 4321, www.millipore.com
KMS introduces Spirapro TFC and RO elements Koch Membrane Systems Inc (KMS) of Wilmington, Massachusetts has introduced its Fluid Systems Spirapro TFC line of SR3 and reverse osmosis (RO) elements for pharmaceutical and fine chemicals applications. According to the company, these significantly lower the operating costs for a wide variety of applications, including selective rejection, desalting and organics concentration. Ideally suited to desalting and separating antibiotics and active pharmaceutical ingredients (APIs), the Fluid Systems Spirapro TFC elements use a proprietary, polyamide thin-film composite membrane with a sanitary spiral-wound net outerwrap. The molecular weight
cut-off for the TFC SR3 allows the membrane to pass monovalent salts, such as sodium chloride, yet it provides high retention of multivalent ions and uncharged organic solutes. The retention of sugars, such as lactose, typically exceeds 99%. These elements can be useful for separating small molecules from chromatography effluent or other intermediate purification processes. The TFC RO elements are ideal for concentrating compounds which have a molecular weight of 100–2000 daltons, such as antibiotics, radiopaque contrast agents and polypeptides, says KMS. These RO elements are specifically designed to increase efficiency and reduce costs by providing high rejection at low pressure. Typically, they achieve better than 99.95% rejection of protein and lactose and achieve chloride rejection of 99.3%. Both TFC SR3 and TFC RO elements can be used to replace Nanomax membranes, originally supplied by Millipore Corporation, or Desal membranes originally supplied by GE Osmonics. All element components pass USP Class VI toxicity testing guidelines. The maximum operating pressure for all of the Fluid Systems Spirapro TFC elements is 4 MPa (600 psi), while the actual operating pressure depends on the system flux rate as well as feed, recovery and temperature conditions. These spiral elements are available in 10 cm (3.8 inch) and 20 cm (7.9 inch) diameters, at the standard 97 cm (38 inch) and 102 cm (40 inch) lengths. Feed channel spacers are also available in the N1 standard or the N2 custom sizes. In addition, KMS offers a range of anti-scalants, cleaners and maintenance chemicals for all of the Spirapro TFC membranes. Kochtreat anti-scalants and Kochkleen membrane cleaners help prolong membrane service life and reduce the cleaning cycle time. Contact: Koch Membrane Systems Inc, 850 Main Street, Wilmington, MA 01887-3388, USA. Tel: +1 978 694 7000, www.kochmembrane.com
In Brief Dow raises price of ion-exchange resins US-based Dow Water Solutions has raised the price of all Dowex ion-exchange resin, adsorbent and catalyst products. The company says the increase – an average of 5% across the line – reflects the need to offset the higher costs of energy and raw materials. Customers will be contacted by their local Dow sales representatives with the specific product and price details. Pentair names President and Chief Operating Officer US-based Pentair Inc has revised its leadership structure, and appointed Michael Schrock to the newly created role of President and Chief Operating Officer. Schrock will report to Randall Hogan, the firm’s Chairman and Chief Executive Officer. ‘This new structure streamlines our leadership communication channels and provides for broader coordination of operations with more direct cost controls across the company, which is critical as we face shifting market conditions,’ says Hogan. Schrock will assume responsibility for all of Pentair’s operating segments. He will continue to lead the Technical Products Group, which he has led since October 2001, and the Filtration business, for which he has been responsible since October 2005, while gaining responsibility for the remaining Water businesses. NSF helps to improve water quality in the Philippines US-based NSF International has entered into an agreement with the Philippines National Government. The move will allow NSF to use its standards for drinking water treatment units as the basis for all devices tested, certified and evaluated in the Philippines. It will also allow NSF technical experts to work directly with the Philippines Bureau of Health Devices and Technology, Department of Health, and is a key step that will lead to the development of standards for raising the quality of drinking water for the consuming public.
6 Membrane Technology December 2006