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KTI and CEC sign membrane deal
ISSN 0958-2118
February 1992
An International Newsletter
N u m b e r 22
Membrane Technology Membrane-based biosensors
Contents News and Views
1
•
Membrane-based biosensors
•
KTI a n d C E C s i g n m e m b r a n e d e a l
•
Info w a n t e d o n s u r f a c e t r e a t m e n t e f f l u e n t
•
Heavy metal separation and analysis
•
I o n i c s to b u i l d / r u n d e s a l i n a t i o n p l a n t i n California
•
U S A to s e e 9% p.a. g r o w t h ; 10% in E u r o p e
•
Smart biomaterlals
•
Books
*
Lasers test membrane integrity
Features •
Membrane-based biosensors are being developed by V u m a n Ltd of M a n c h e s t e r , UK, for c o n t i n u o u s m o n i t o r i n g or o n l i n e a n a l y s i s in a v a r i e t y of a p p l i c a t i o n a r e a s - - m e d i c a l or v e t e r i n a r y , food control, water quality a n d effluent treatment, process p l a n t c o n t r o l - - t h r o u g h t h e u s e of e n z y m e - b a s e d e l e c t r o d e s . V u m a n h a s to d a t e c o n c e n t r a t e d o n m e d i c a l a p p l i c a t i o n s b u t is i n t e r e s t e d in d i s c u s s i n g j o i n t d e v e l o p m e n t p r o j e c t s for specific n o n - m e d i c a l or medical applications. Th e e l e c t r o d e t e c h n o l o g y e m p l o y e d in t h e m e d i c a l a r e a i n v o l v e s t h e ' m a t c h i n g ' of s u i t a b l e o x i d a s e a n d dehydrogenase enzymes with a microporous m e m b r a n e . T h e m e m b r a n e s a r e c o a t e d to i n h i b i t interference from c o n t a m i n a n t s present in whole blood, f l u i d s a n d t i s s u e s , a n d c o n t r o l t h e s u b s t r a t e a n d c o - s u b s t r a t e m a s s t r a n s f e r to t h e e n z y m e . T h e e l e c t r o d e s a r e s a i d to b e h i g h l y s e l e c t i v e a n d sensitive. Amongst metabolites which can be detected by v e r s i o n s of t h e e n z y m e s y s t e m s a r e g l u c o s e , l a c t a t e , alanine, pyruvate, urea, cholesterol and oxalate. A c c o r d i n g to V u m a n , e l e c t r o d e s c a n b e c o n s t r u c t e d in a ' c o n v e n t i o n a l ' m a n n e r ( t h at is, of n o r m a l size), or b e m i n i a t u r i z e d . M i n i a t u r i z a t i o n of t h e e l e c t r o d e s h a s r e s u l t e d in n e e d l e - t y p e d e s i g n s u s i n g p r e f a b r i c a t e d or d i p - c o a t e d p o l y m e r s a s m e m b r a n e s . At t h e p r e s e n t s t a t e of d e v e l o p m e n t t h e s e p e r m i t 2 4 - h o u r i n- vi vo m o n i t o r i n g for o x y g en , g l u c o s e a n d l a c t a t e . F u r t h e r i n f o r m a t i o n f r o m Dr R Duff, V u m a n Ltd, E n t e r p r i s e H o u s e , M a n c h e s t e r S c i e n c e Park, M a n c h e s t e r M15 4EN, UK. Tel +44 (0)61 2 2 6 87 46. F a x +44 (0)61 2 2 6 58 55.
5
M e m c o r C M F s y s t e m f i n d s +cider a p p l i c a t i o n
Patents
7
Acid a n d a l k a l i r e c o v e r y Cyclodestrin polymer membrane syntheses Hydrophilic polypropylene-based membranes M e m b r a n e s to r e v e r s e t h e g r e e n h o u s e effect... Brine-powered pervaporation process Fluorinated aromatic polyimide O x y g e n - 18 i s o t o p i c e n r i c h m e n t of w a t e r
Events Calendar
12
KTI a n d C E C s i g n membrane deal KTI h a s s i g n e d a n a g r e e m e n t w i t h C h l o r i n e E n g i n e e r s C o r p of J a p a n to m a r k e t C E C ' s C h l o r - a l k a l i m e m b r a n e t e c h n o l o g y for r e v a m p i n g m e r c u r y a n d d i a p h r a g m cell p l a n t s in W e s t e r n a n d E a s t e r n E u r o p e , i n c l u d i n g t h e E u r o p e a n s t a t e s of t h e CIS. In E u r o p e a b o u t 6 5 % of c h l o r i n e p r o d u c t i o n r e l i e s o n m e r c u r y
r~
ELSEVIER ADVANCED TECiiNOLOGY ©1992 Elsevier Science
Publishers Ltd., England./92/$0.00
+ 2.20
No part of this publication may be reproduced, stored in a retrieval system, or transmitted by any form or by a n y m e a n s , electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisbcrs. [Readers In the U.S.A. - - p l e a s e see special regulations lls~ted on back cover.)
February 1992
An International Newsletter
N u m b e r 22
Membrane Technology Membrane-based biosensors
Contents News and Views
1
•
Membrane-based biosensors
•
KTI a n d C E C s i g n m e m b r a n e d e a l
•
Info w a n t e d o n s u r f a c e t r e a t m e n t e f f l u e n t
•
Heavy metal separation and analysis
•
I o n i c s to b u i l d / r u n d e s a l i n a t i o n p l a n t i n California
•
U S A to s e e 9% p.a. g r o w t h ; 10% in E u r o p e
•
Smart biomaterlals
•
Books
*
Lasers test membrane integrity
Features •
Membrane-based biosensors are being developed by V u m a n Ltd of M a n c h e s t e r , UK, for c o n t i n u o u s m o n i t o r i n g or o n l i n e a n a l y s i s in a v a r i e t y of a p p l i c a t i o n a r e a s - - m e d i c a l or v e t e r i n a r y , food control, water quality a n d effluent treatment, process p l a n t c o n t r o l - - t h r o u g h t h e u s e of e n z y m e - b a s e d e l e c t r o d e s . V u m a n h a s to d a t e c o n c e n t r a t e d o n m e d i c a l a p p l i c a t i o n s b u t is i n t e r e s t e d in d i s c u s s i n g j o i n t d e v e l o p m e n t p r o j e c t s for specific n o n - m e d i c a l or medical applications. Th e e l e c t r o d e t e c h n o l o g y e m p l o y e d in t h e m e d i c a l a r e a i n v o l v e s t h e ' m a t c h i n g ' of s u i t a b l e o x i d a s e a n d dehydrogenase enzymes with a microporous m e m b r a n e . T h e m e m b r a n e s a r e c o a t e d to i n h i b i t interference from c o n t a m i n a n t s present in whole blood, f l u i d s a n d t i s s u e s , a n d c o n t r o l t h e s u b s t r a t e a n d c o - s u b s t r a t e m a s s t r a n s f e r to t h e e n z y m e . T h e e l e c t r o d e s a r e s a i d to b e h i g h l y s e l e c t i v e a n d sensitive. Amongst metabolites which can be detected by v e r s i o n s of t h e e n z y m e s y s t e m s a r e g l u c o s e , l a c t a t e , alanine, pyruvate, urea, cholesterol and oxalate. A c c o r d i n g to V u m a n , e l e c t r o d e s c a n b e c o n s t r u c t e d in a ' c o n v e n t i o n a l ' m a n n e r ( t h at is, of n o r m a l size), or b e m i n i a t u r i z e d . M i n i a t u r i z a t i o n of t h e e l e c t r o d e s h a s r e s u l t e d in n e e d l e - t y p e d e s i g n s u s i n g p r e f a b r i c a t e d or d i p - c o a t e d p o l y m e r s a s m e m b r a n e s . At t h e p r e s e n t s t a t e of d e v e l o p m e n t t h e s e p e r m i t 2 4 - h o u r i n- vi vo m o n i t o r i n g for o x y g en , g l u c o s e a n d l a c t a t e . F u r t h e r i n f o r m a t i o n f r o m Dr R Duff, V u m a n Ltd, E n t e r p r i s e H o u s e , M a n c h e s t e r S c i e n c e Park, M a n c h e s t e r M15 4EN, UK. Tel +44 (0)61 2 2 6 87 46. F a x +44 (0)61 2 2 6 58 55.
5
M e m c o r C M F s y s t e m f i n d s +cider a p p l i c a t i o n
Patents
7
Acid a n d a l k a l i r e c o v e r y Cyclodestrin polymer membrane syntheses Hydrophilic polypropylene-based membranes M e m b r a n e s to r e v e r s e t h e g r e e n h o u s e effect... Brine-powered pervaporation process Fluorinated aromatic polyimide O x y g e n - 18 i s o t o p i c e n r i c h m e n t of w a t e r
Events Calendar
12
KTI a n d C E C s i g n membrane deal KTI h a s s i g n e d a n a g r e e m e n t w i t h C h l o r i n e E n g i n e e r s C o r p of J a p a n to m a r k e t C E C ' s C h l o r - a l k a l i m e m b r a n e t e c h n o l o g y for r e v a m p i n g m e r c u r y a n d d i a p h r a g m cell p l a n t s in W e s t e r n a n d E a s t e r n E u r o p e , i n c l u d i n g t h e E u r o p e a n s t a t e s of t h e CIS. In E u r o p e a b o u t 6 5 % of c h l o r i n e p r o d u c t i o n r e l i e s o n m e r c u r y
r~
ELSEVIER ADVANCED TECiiNOLOGY ©1992 Elsevier Science
Publishers Ltd., England./92/$0.00
+ 2.20
No part of this publication may be reproduced, stored in a retrieval system, or transmitted by any form or by a n y m e a n s , electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisbcrs. [Readers In the U.S.A. - - p l e a s e see special regulations lls~ted on back cover.)