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Large solitary fibrous tumor of the oral cavity – report of a case
OOOO Volume 114, Number 4 LARGE SOLITARY FIBROUS TUMOR OF THE ORAL CAVITY – REPORT OF A CASE Oliveira DHIP1, Nonaka CFW2, Germano AR3, Silva JSP3, Assis GM3, Queiroz LMG1 - 1UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE - PROGRAMA DE PÓS-GRADUAÇÃO EM PATOLOGIA ORAL, 2UNIVERSIDADE ESTADUAL DA PARAÍBA - ODONTOLOGIA, 3UNIVERSIDADE FEDERAL DO RIO GRANDE DO NORTE - CIRURGIA E TRAUMATOLOGIA BUCO-MAXILO-FACIAL Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm of uncertain histogenesis which most often occurs in the pleura. SFT is a rare tumor of the head and neck region and, to date, most lesions have been observed in the buccal mucosa, nasal cavity, pharyngeal area, and tongue. This case refers to a 44-year-old man which presented for evaluation of a painless mass located in the left buccal mucosa. The mass measured 4.0 cm in diameter and had been noted by the patient 10 years earlier. Histopathologic analysis revealed a well circumscribed lesion characterized by a patternless pattern of round- to spindle-shaped cells in a collagenous background. Focally prominent staghorn vessels could also be observed. Immunohistochemical analysis disclosed positivity for CD34 (diffuse) and Bcl-2 (focal). There was no immunoreactivity to ␣-smooth muscle actin, desmin, or S-100 protein. The definitive diagnosis was SFT. The patient continues to be under careful follow-up.
ORAL CANCER SCREENING: A SUCCESSFUL EXPERIENCE Cavalcanti D1, Oliveira R2, Alves JC3, Alves ME3 - 1CENTRO DE ESPECIALIDADES ODONTOLÓGICAS DE SUZANO - ESTOMATOLOGIA, 2SECRETARIA DA SAUDE DE SUZANO - SAUDE BUCAL, 3SECRETARIA MUNICIPAL DE SAÚDE DE SUZANO - COORDENAÇÃO DE SAÚDE BUCAL Background/objective: Suzano is a city in the State of São Paulo, with a population of 304.414 inhabitants. In this city, the Screening for the Prevention and Early Detection of Oral cancer have been held since the year 2005, as part of the Annual Campaign Against Influenza in the Elderly. The main objective of these campaigns is to identify patients with oral cancer, and the diagnosis and preservation of potentially malignant disorders of the oral mucosa. Study design: Were presented details of these screenings in the period of 2005 to 2011 and comparing them on the index examined and confirmed cases observed in the State of Sao Paulo. Results: In Suzano, 9247 patients were evaluated in 2010 (6 confirmed cases of oral cancer, 76 cases of potentially malignant disorders) and 9310 patients in 2011 (70 cases of potentially malignant disorders). Conclusion: We conclude that the oral cancer screenings are important for prevention and early detection of oral cancer.
BETA-2 ADRENERGIC RECEPTOR EXPRESSION IN SURGICAL MARGINS OF ORAL SQUAMOUS CELL CARCINOMA Bravo-Calderón DM1, Lauand GA1, Nonogaki S2, Carvalho AL3, Kowalski LP4, Marana AN5, Oliveira DT1 - 1BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO, BAURU, BRAZIL - DEPARTMENT OF STOMATOLOGY, AREA OF PATHOLOGY, 2 ADOLFO LUTZ INSTITUTE, SÃO PAULO, BRAZIL - PA-
ORAL ABSTRACTS Abstracts e83 THOLOGY DIVISION, 3FUNDAÇÃO PIO XII-CANCER HOSPITAL OF BARRETOS, BARRETOS, BRAZIL - DEPARTMENT OF HEAD AND NECK SURGERY, 4CANCER HOSPITAL A. C. CAMARGO, SÃO PAULO, BRAZIL - DEPARTMENT OF HEAD AND NECK SURGERY AND OTORHINOLARYNGOLOGY, 5SÃO PAULO STATE UNIVERSITY (UNESP), BAURU, BRAZIL - DEPARTMENT OF COMPUTING, SCHOOL OF SCIENCES Objectives: Evaluate the expression of the 2-adrenergic receptor (2-AR) in surgical margins of oral squamous cell carcinoma (OSCC). Study design: The immunohistochemical expression of 2-AR in the surgical margins and in the invasive tumor front of 62 OSCC was statically analyzed relative to the clinicopathologic variables using the Chi-square test. Results: 2-AR expression was observed in all surgical margins. A comparative analysis revealed that in 29% of the invasive tumor front there was a decrease of the 2-AR expression when compared to the surgical margin. The strong 2-AR expression in the surgical margins was significantly associated with simultaneous consumption of alcohol and tobacco (p⫽0.046) and T stage (p⫽0.03). Conclusions: These results suggest that the 2-AR is constitutively expressed in oral epithelium and that its expression can be decrease in OSCC, reinforcing the warranty of further studies to elucidate the functions of this protein by malignant cells in oral cancer. Financial support: FAPESP:2011/11630-0 and CNPq 142790/2011-7.
PARACOCCIDIOIDOMYCOSIS IN WOMEN: A CASE REPORT Capella DL1, Tenuti JGB1, Pensin LA1, Durigon A.S.1, Bortoluzzi MC1 - 1UNOESC Paracoccidioidomycosis (PCM) is the most important systemic mycosis in Brazil. The mortality rate is the eighth most common cause of death among infectious diseases1,2. Epidemiological studies indicate that PMC is about 11 to 30 times more common in adult males despite equal frequencies of exposure to this fungus by both genders3. Studies suggest that female hormones inhibit the transition of Paracoccidioides brasiliensis of mycelia or conidia to yeasts, thus making females less susceptible4,5. This report describes a rare case of PMC in a nonmenopause female patient, 32 years old, with the blood tests within normal limits and HIV negative. Clinical examination revealed multiple ulcerative lesions in hard palate and left gingiva that ranged 2 cm in diameter and are presented for about 5 months. There are no signs of important systemic damage. The diagnosis was confirmed through incisional biopsy (H&E and PAS). The patient is under treatment with fluconazole. Bibliography 1. Coutinho ZF, Silva D, Lazera M, Petri V, Oliveira RM, Sabroza PC et al. Paracoccidioidomycosis mortality in Brazil (1980-1995). Cad Saude Publica. 2002.Sep-Oct;18(5):1441-54. 2. Meneses-García A, Mosqueda-Taylor A, Morales-de la Luz R, Rivera LM. Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Nov;94(5):609-13 3. Shankar J, Restrepo A, Clemons KV, Stevens DA. Hormones and the resistance of women to paracoccidioidomycosis. Clin Microbiol Rev. 2011 Apr;24(2):296-313.
ORAL CANCER SCREENING: A SUCCESSFUL EXPERIENCE Cavalcanti D1, Oliveira R2, Alves JC3, Alves ME3 - 1CENTRO DE ESPECIALIDADES ODONTOLÓGICAS DE SUZANO - ESTOMATOLOGIA, 2SECRETARIA DA SAUDE DE SUZANO - SAUDE BUCAL, 3SECRETARIA MUNICIPAL DE SAÚDE DE SUZANO - COORDENAÇÃO DE SAÚDE BUCAL Background/objective: Suzano is a city in the State of São Paulo, with a population of 304.414 inhabitants. In this city, the Screening for the Prevention and Early Detection of Oral cancer have been held since the year 2005, as part of the Annual Campaign Against Influenza in the Elderly. The main objective of these campaigns is to identify patients with oral cancer, and the diagnosis and preservation of potentially malignant disorders of the oral mucosa. Study design: Were presented details of these screenings in the period of 2005 to 2011 and comparing them on the index examined and confirmed cases observed in the State of Sao Paulo. Results: In Suzano, 9247 patients were evaluated in 2010 (6 confirmed cases of oral cancer, 76 cases of potentially malignant disorders) and 9310 patients in 2011 (70 cases of potentially malignant disorders). Conclusion: We conclude that the oral cancer screenings are important for prevention and early detection of oral cancer.
BETA-2 ADRENERGIC RECEPTOR EXPRESSION IN SURGICAL MARGINS OF ORAL SQUAMOUS CELL CARCINOMA Bravo-Calderón DM1, Lauand GA1, Nonogaki S2, Carvalho AL3, Kowalski LP4, Marana AN5, Oliveira DT1 - 1BAURU SCHOOL OF DENTISTRY, UNIVERSITY OF SÃO PAULO, BAURU, BRAZIL - DEPARTMENT OF STOMATOLOGY, AREA OF PATHOLOGY, 2 ADOLFO LUTZ INSTITUTE, SÃO PAULO, BRAZIL - PA-
ORAL ABSTRACTS Abstracts e83 THOLOGY DIVISION, 3FUNDAÇÃO PIO XII-CANCER HOSPITAL OF BARRETOS, BARRETOS, BRAZIL - DEPARTMENT OF HEAD AND NECK SURGERY, 4CANCER HOSPITAL A. C. CAMARGO, SÃO PAULO, BRAZIL - DEPARTMENT OF HEAD AND NECK SURGERY AND OTORHINOLARYNGOLOGY, 5SÃO PAULO STATE UNIVERSITY (UNESP), BAURU, BRAZIL - DEPARTMENT OF COMPUTING, SCHOOL OF SCIENCES Objectives: Evaluate the expression of the 2-adrenergic receptor (2-AR) in surgical margins of oral squamous cell carcinoma (OSCC). Study design: The immunohistochemical expression of 2-AR in the surgical margins and in the invasive tumor front of 62 OSCC was statically analyzed relative to the clinicopathologic variables using the Chi-square test. Results: 2-AR expression was observed in all surgical margins. A comparative analysis revealed that in 29% of the invasive tumor front there was a decrease of the 2-AR expression when compared to the surgical margin. The strong 2-AR expression in the surgical margins was significantly associated with simultaneous consumption of alcohol and tobacco (p⫽0.046) and T stage (p⫽0.03). Conclusions: These results suggest that the 2-AR is constitutively expressed in oral epithelium and that its expression can be decrease in OSCC, reinforcing the warranty of further studies to elucidate the functions of this protein by malignant cells in oral cancer. Financial support: FAPESP:2011/11630-0 and CNPq 142790/2011-7.
PARACOCCIDIOIDOMYCOSIS IN WOMEN: A CASE REPORT Capella DL1, Tenuti JGB1, Pensin LA1, Durigon A.S.1, Bortoluzzi MC1 - 1UNOESC Paracoccidioidomycosis (PCM) is the most important systemic mycosis in Brazil. The mortality rate is the eighth most common cause of death among infectious diseases1,2. Epidemiological studies indicate that PMC is about 11 to 30 times more common in adult males despite equal frequencies of exposure to this fungus by both genders3. Studies suggest that female hormones inhibit the transition of Paracoccidioides brasiliensis of mycelia or conidia to yeasts, thus making females less susceptible4,5. This report describes a rare case of PMC in a nonmenopause female patient, 32 years old, with the blood tests within normal limits and HIV negative. Clinical examination revealed multiple ulcerative lesions in hard palate and left gingiva that ranged 2 cm in diameter and are presented for about 5 months. There are no signs of important systemic damage. The diagnosis was confirmed through incisional biopsy (H&E and PAS). The patient is under treatment with fluconazole. Bibliography 1. Coutinho ZF, Silva D, Lazera M, Petri V, Oliveira RM, Sabroza PC et al. Paracoccidioidomycosis mortality in Brazil (1980-1995). Cad Saude Publica. 2002.Sep-Oct;18(5):1441-54. 2. Meneses-García A, Mosqueda-Taylor A, Morales-de la Luz R, Rivera LM. Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Nov;94(5):609-13 3. Shankar J, Restrepo A, Clemons KV, Stevens DA. Hormones and the resistance of women to paracoccidioidomycosis. Clin Microbiol Rev. 2011 Apr;24(2):296-313.