LB010 EFFECTS OF ENTERAL NUTRITION ENRICHED WITH EICOSAPENTAENOIC ACID (EPA) IN GASTRIC CANCER PATIENTS UNDERGOING GASTRECTOMY

Late Breaking Abstracts I screening tool such as NRS 2002 is simplified enough to be structurally educated to all level of hospital staffs. The locally developed screening and assessment tools may be beneficial in some countries. Disclosure of Interest: Pongtorn Kietdumrongwong, MD, receives honorarium from Nestle, Baxter Healthcare, Covidien, B Braun AVM. Dr. Vibool Trakulhun, MD, receives honorarium from ThaiOtsuka, Baxter. Buccha Bramanavisuth, RN, receives honorarium from Covidien, Thai-Otsuka.

LB010 EFFECTS OF ENTERAL NUTRITION ENRICHED WITH EICOSAPENTAENOIC ACID (EPA) IN GASTRIC CANCER PATIENTS UNDERGOING GASTRECTOMY ¨ . Sakrak1 , K. Dikmen1 . A. Bedirli1 , M. Kerem1 , O 1 General Surgery Department, Gazi University Faculty of Medicine, Ankara, Turkey Rationale: Protein energy malnutrition is recognized as an important risk factor for the occurence of postoperative complications in gastric cancer patients. This study evaluated the effects of perioperative enteral nutrition enriched with eicosapentaenoic acid (EPA) support for severely malnourished patients with gastric cancer undergoing gastrectomy. Methods: Forty-six registered malnourished patients (weight loss >10% over 6 months) who were underwent for major elective surgery for gastric cancer. These patients were classified into two groups, those without EPA (Ensure, Abbott Nutrition) use and those with EPA (Prosure, Abbott Nutrition) use. Correlation with the postoperative outcome was then made. Results: Twenty patients who underwent total gastrectomy and 26 patients who underwent subtotal gastrectomy had severe malnutrition preoperatively. Differences were detected in weight (58.5±11.5 kg vs. 64.4±11.1 kg; p < 0.05) with a significant increase in fat mass in Prosure group. The postoperative infectious complications were similar in both groups. Perioperative enteral nutrition enriched with EPA is associated with reduced length of hospital stay; the mechanism is unclear as other outcomes were not improved. Conclusion: Enteral nutrition enriched with EPA help to improve weight and fat mass without reduction in clinical complications in gastric cancer patients. Disclosure of Interest: None declared.

LB011 THE EFFECT OF HYPERICUM PERFORATUM EXTRACT ON HEPATIC ISCHEMIA REPERFUSION INJURY IN RATS ¨ . Sakrak1 , A. Aydin1 , M. Kerem1 , H. Pasaoglu2 , O M. Alper3 , E. Akkol4 , A. Bedirli1 . 1 General Surgery, 2 Clinic Biochemistry, Gazi University, Medical Faculty, 3 Pathology, Diskapi Training and Education Hospital, 4 Pharmacy, Gazi University, Pharmacy Faculty, Ankara, Turkey Rationale: Ischemia reperfusion (I/R) injury of the liver is a significant problem which occurs in situations such as interruption of blood flow to the liver as in transplantation or resection of it. In this study we investigated the effect of crude extract of the Hypericum

171 perforatum (HP), a medicinal plant species containing many compounds which have high antioxidant properties on hepatic I/R injury. Methods: In the experiment, Wistar-Albino male rats were used. Animals were divided into four group: First group (sham) given standard lab chow followed by sham operation; Second group (I/R) given standard lab chow followed by partial (70%) liver ischemia for 45 min; Third group (CMC+I/R) given 0.5% carboxymethyl cellulose (CMC) for a week followed by I/R just like the second group; Fourth group (CMC+HP+I/R) given 0.5% CMC supplemented with the crude extract of HP (400 mg/kg/d) for a week followed by I/R. Blood samples were obtained before ischemia, and 1, 2, and 4 after reperfusion. Results: Blood levels of ALT, TNF-a, IL-6 and MDA were significantly lower in the fourth group compared with second and third groups (p < 0.05). However, no differences were observed between the other two groups (second and third groups). Similarly, HP treatment significantly reduced liver injury scores and number of PNL adherent to second (I/R) and third (CMC) groups respectively. Conclusion: This study indicates that use of HP extract can be considered to protect the liver against I/R injury. Disclosure of Interest: No conflict of interest

LB012 ORAL ADMINISTRATION OF A NATURAL EXTRACT RICH IN HYALURONIC ACID FOR THE TREATMENT OF KNEE OA WITH SYNOVITIS: A RETROSPECTIVE COHORT STUDY I. Moller1 , D. Martinez-Puig2 , C. Chetrit2 . 1 Instituto Poal de Reumatología, Barcelona, 2 Bioiberica S.A., Palafolls, Spain Rationale: The objective of the study is to obtain preliminary information about the effectiveness of oral administration with a natural extract rich in hyaluronic acid (Hyal-Joint) in patients with moderate to severe osteoarthritis of the knee presenting with persistent knee pain and joint effusion Methods: An observational retrospective cohort study involving 70 consecutive outpatients with KOA and synovitis fulfilling ACR criteria who had started the selected treatments at least in the previous 3 months were included in this retrospective study. Selected treatments were Hyal-Joint (Bioiberica, Spain; HA; n = 35) and Paracetamol (PCT; n = 36). Data were collected after 1, 2 and 3 months follow-up. The clinical outcome was the course of synovitis in the suprapatellar recess using ultrasonography (US). Results: Pre-treatment synovial effusion was similar between the 2 groups (mean±SD, 5.7±1.79 mm in HA group and 6.2±1.22 mm in PCT group; P = 0.437). Both treatment groups experienced a decrease in synovitis over a 3 month time. However, patients treated with HA reached physiological mean values after the first month of treatment (2.9±1.22 mm) but not patients in PCT group (5.6±2.05 mm; P > 0.05). At 3 months followup differences between groups were more pronounced (0.18±0.84 mm for HA group compared to 4.2±2.82 mm for PCT group; P > 0.0001). Pre-treatment the number of patients with severe synovial effusion was not different between groups (16 vs. 15 for HA and PCT groups