- Email: [email protected]
LB025-SUN: Home Parenteral Nutrition is Beneficial in Systemic Sclerosis Patients with Gastrointestinal Dysfunction
S248 LB024-SUN IS THERE A RELATIONSHIP BETWEEN SERUM 25 HYDROXYVITAMIN D AND OSTEOCALCIN? A CROSSSECTIONAL STUDY WITH BRAZILIAN ADOLESCENTS K.V. Giudici1 , M.A.P. Lopes1 , D.M.L. Marchioni1 , R.M. Fisberg1 , L.A. Martini1 . 1 School of Public Health/Department of Nutrition, University of S˜ ao Paulo, S˜ ao Paulo, Brazil Rationale: Vitamin D (VD) insufficiency and deficiency are related to bone homeostasis and nutritional status. Osteocalcin (OC) is a bone protein found in two circulating forms, and undercarboxylated osteocalcin (ucOC) has positive effects on energy homeostasis. This study aimed to evaluate if 25 hydroxyvitamin D [25(OH)D] correlated with OC measures among adolescents. Methods: Cross-sectional study with 198 subjects 14 18 years old from S˜ ao Paulo, Brazil. Serum 25(OH)D was measured by high-performance liquid chromatography (HPLC) and carboxylated osteocalcin (cOC) and ucOC were measured by enzyme-linked immunosorbent assay (ELISA). T-student test, Pearson’s correlation and multiple linear regression were conducted, and p < 0.05 was considered significant. Results: 25(OH)D correlated positively with ucOC (r = 0.326; p < 0.0001) but not with cOC (p = 0.667). The predictive effect of 25(OH)D in ucOC was also observed by multiple regression (r2 = 0.144; p < 0.0001), after adjusting for age and BMI. Overweight/obese subjects (42.6%) presented lower 25(OH)D (22.0 ng/mL, SD = 13.5 vs 27.5 ng/mL, SD = 12.9; p < 0.0001), cOC (36.9 ng/mL, SD = 46.7 vs 58.6 ng/mL, SD = 75.0; p = 0.036) and ucOC (0.67 ng/mL, SD = 1.07 vs 0.76 ng/mL, SD = 0.94; p = 0.006) concentrations than normal weight people. Over 70% participants were considered VD deficient (<20 ng/mL) or insufficient (20 30 ng/mL). Those with 25(OH)D >30 ng/mL presented higher ucOC (0.85 ng/mL, SD = 1.05 vs 0.67 ng/mL, SD = 0.97; p = 0.017). Conclusion: These findings confirm the link between 25(OH)D and ucOC. Correcting VD status through stimulating safe sun exposure and the intake of natural sources of this vitamin or fortified foods may also contribute to higher ucOC concentrations and its positive metabolic effects. More studies, especially experimental ones, are needed with this population. Disclosure of Interest: None Declared.
LB025-SUN HOME PARENTERAL NUTRITION IS BENEFICIAL IN SYSTEMIC SCLEROSIS PATIENTS WITH GASTROINTESTINAL DYSFUNCTION C. Aeberhard1 , P. Pl¨ uss1 , Z. Stanga1,2 , P. Villiger3 . 1 Department of Endocrinology, Diabetes and Clinical Nutrition, 2 Department of General Internal Medicine, 3 Department of Rheumatology, Clinical Immunology and Allergology, University Hospital, Bern, Switzerland Rationale: Systemic sclerosis (SSc) is a systemic connective tissue disease, which can affect the gastrointestinal tract (GIT). Symptoms associated with GIT dysfunction generally become manifest as gastro-esophageal reflux, pseudoobstruction and malabsorption causing weight loss and subsequent malnutrition. The progressive deterioration of the nutritional state and body functions require an adequate and
Late Breaking Abstracts early nutritional therapy as complementary home parenteral nutrition (HPN). The purpose of the current study was to assess the quality of life in malnourished, catabolic patients affected by SSc before and after complementary HPN. Methods: Observational, single-center, pilot study, approved by the ethics committee. Anthropometric and clinical data were collected between 2008 and 2013 and extracted from paper and electronic medical records. Quality of life (QoL) scores were assessed by the SF-36v2 questionnaire. The data were assessed with descriptive statistical methods. Results: We studied five malnourished SSc patients with a mean age of 62.2 years needing complementary HPN. During the observational period of 12 months anthropometrics, body function and QoL improved. All components of the SF-36 questionnaire like physical functioning in the everyday life, general health, vitality, emotional and social competence as well as mental health showed a benefit from the nutritional therapy. Conclusion: In this pilot study we could demonstrate, that complementary HPN was safe, lead to a health benefit in terms of improved anthropometric parameters and QoL in patients affected by SSc and manifest GIT dysfunction. HPN should be considered for malnourished, catabolic patients unable to maintain their nutritional state because of severe gastrointestinal involvement. Despite these encouraging results, there is still a need to verify the present findings with a randomized prospective study. Disclosure of Interest: None Declared.
LB026-SUN A REFERENCE POPULATION TO DEFINE MUSCLE MASS AND FUNCTION CUT-OFF POINTS IN TURKEY FOR SARCOPENIA G. Bahat1 , A. Tufan1 , C. Kılı¸ c1 , F. Tufan1 , T.S. Akpinar1 , 1 1 M.A. Karan . Istanbul University, Istanbul, Turkey Rationale: The reported prevalence of sarcopenia ranges widely depending on the adopted definition for such condition. European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria to correct the confusion in its prevalence and define its natural course, develop and define effective treatment. They recommend use of normative healthy young adults’ data of the study population rather than other predictive reference populations, with cut-off points at two standard deviations below the mean reference value. No data in this respect is available in our setting. We aimed to define the reference cut-off values in Turkey. Methods: Healthy Turkish young adults between 18 and 39 years of age with no known chronic disease and chronic drug usage were asked to participate in our study. Body composition was assessed with bioimpedance-analysis. Muscle strength was assessed by measurement of hand grip-strength with hydraulic hand dynamometer. The cut-off thresholds of the studied parameters were defined as the mean 2SD of the values of the reference study population. Results: The young reference group included a total of 301 participants (187 male, 114 female). Mean ages were 26.8±4.5, 25.9±4.7 years; mean body mass indexes were 25.5±3.6 and 22.4±3.4 kg/m2 ; skeletal muscle masses were 33.6±3.6 kg and 23.5±1.7 kg. The cut-off thresholds for skeletal muscle mass indexes were designated as 9.2 kg/m2
LB025-SUN HOME PARENTERAL NUTRITION IS BENEFICIAL IN SYSTEMIC SCLEROSIS PATIENTS WITH GASTROINTESTINAL DYSFUNCTION C. Aeberhard1 , P. Pl¨ uss1 , Z. Stanga1,2 , P. Villiger3 . 1 Department of Endocrinology, Diabetes and Clinical Nutrition, 2 Department of General Internal Medicine, 3 Department of Rheumatology, Clinical Immunology and Allergology, University Hospital, Bern, Switzerland Rationale: Systemic sclerosis (SSc) is a systemic connective tissue disease, which can affect the gastrointestinal tract (GIT). Symptoms associated with GIT dysfunction generally become manifest as gastro-esophageal reflux, pseudoobstruction and malabsorption causing weight loss and subsequent malnutrition. The progressive deterioration of the nutritional state and body functions require an adequate and
Late Breaking Abstracts early nutritional therapy as complementary home parenteral nutrition (HPN). The purpose of the current study was to assess the quality of life in malnourished, catabolic patients affected by SSc before and after complementary HPN. Methods: Observational, single-center, pilot study, approved by the ethics committee. Anthropometric and clinical data were collected between 2008 and 2013 and extracted from paper and electronic medical records. Quality of life (QoL) scores were assessed by the SF-36v2 questionnaire. The data were assessed with descriptive statistical methods. Results: We studied five malnourished SSc patients with a mean age of 62.2 years needing complementary HPN. During the observational period of 12 months anthropometrics, body function and QoL improved. All components of the SF-36 questionnaire like physical functioning in the everyday life, general health, vitality, emotional and social competence as well as mental health showed a benefit from the nutritional therapy. Conclusion: In this pilot study we could demonstrate, that complementary HPN was safe, lead to a health benefit in terms of improved anthropometric parameters and QoL in patients affected by SSc and manifest GIT dysfunction. HPN should be considered for malnourished, catabolic patients unable to maintain their nutritional state because of severe gastrointestinal involvement. Despite these encouraging results, there is still a need to verify the present findings with a randomized prospective study. Disclosure of Interest: None Declared.
LB026-SUN A REFERENCE POPULATION TO DEFINE MUSCLE MASS AND FUNCTION CUT-OFF POINTS IN TURKEY FOR SARCOPENIA G. Bahat1 , A. Tufan1 , C. Kılı¸ c1 , F. Tufan1 , T.S. Akpinar1 , 1 1 M.A. Karan . Istanbul University, Istanbul, Turkey Rationale: The reported prevalence of sarcopenia ranges widely depending on the adopted definition for such condition. European Working Group on Sarcopenia in Older People (EWGSOP) developed a practical clinical definition and consensus diagnostic criteria to correct the confusion in its prevalence and define its natural course, develop and define effective treatment. They recommend use of normative healthy young adults’ data of the study population rather than other predictive reference populations, with cut-off points at two standard deviations below the mean reference value. No data in this respect is available in our setting. We aimed to define the reference cut-off values in Turkey. Methods: Healthy Turkish young adults between 18 and 39 years of age with no known chronic disease and chronic drug usage were asked to participate in our study. Body composition was assessed with bioimpedance-analysis. Muscle strength was assessed by measurement of hand grip-strength with hydraulic hand dynamometer. The cut-off thresholds of the studied parameters were defined as the mean 2SD of the values of the reference study population. Results: The young reference group included a total of 301 participants (187 male, 114 female). Mean ages were 26.8±4.5, 25.9±4.7 years; mean body mass indexes were 25.5±3.6 and 22.4±3.4 kg/m2 ; skeletal muscle masses were 33.6±3.6 kg and 23.5±1.7 kg. The cut-off thresholds for skeletal muscle mass indexes were designated as 9.2 kg/m2