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LB026-MON THE RELATIONSHIP BETWEEN 25-HYDROXYVITAMIN D AND HbA1c IN TYPE 2 DIABETES
LATE BREAKING ABSTRACTS II confounding factors. In women with diabetes, those with habitual drinking 2 or more cups of coffee per day had significantly lower risk of CKD (OR, 0.135; 95% CI, 0.021 0.882; P = 0.037) compared with less than 1 cup per day after adjustment, but not among women without diabetes. Conclusion: In a representative sample of Korean women, habitual coffee consumption of 2 or more cups per day was significantly associated with a decreased risk of CKD compared with less than 1 cup per day, especially in women with diabetes. References [1] Coffee consumption & risk of type 2 diabetes a systematic review. JAMA 2005. 294(1): p. 97 104. [2] Coffee consumption and markers of inflammation and endothelial dysfunction in healhty and diabetic women. AJCN, 2006 Oct. 84(4): p. 888 93. Disclosure of Interest: None Declared
LB025-MON QUALITY OF LIFE, COGNITION AND PHYSICAL FUNCTIONING BETWEEN HIGHER AND LOWER INTAKES OF NUTRIENTS OF HOME-DWELLING OLDER AD PATIENTS S. Jyv¨ akorpi1 , T. Puranen1 , M.H. Suominen1 . 1 Society For Memory Disorders Expertise in Finland, Helsinki, Finland Rationale: Sufficient energy and nutrient intake is important in maintaining nutritional status, health and quality of life of AD patients. Aim of this study is to describe differences in quality of life, cognition and physical functioning of home dwelling AD patients between higher and lower intakes of energy, protein and other nutrients. Methods: AD patients (age <65 years) were tested for cognition (MMSE) and the spouse was questioned of AD patients’ physical functioning (IADL) and depression (Cornell). AD patients completed health related quality of life (HRQoL) form independently or assisted by spouse. The spouse filled a 3-day food diary. Nutritional intakes of energy, protein, calcium, folate, vitamin C and E were categorized into two groups using medians or RDAs for the nutrients. In female medians were used for categorizing all nutrients. In males RDAs were used for Calcium and vitamin C and medians for other nutrients. Males and females were analyzed separately. Higher and lower nutrient intake groups were compare with MMSE, Cornell, IADL, and the 15D-HRQoL scores. This data is part of a baseline data of nutritional treatment RCT Results: In male (n = 65) higher intake of protein was associated with less depression (p = 0.045) and Vitamin-E intake was positively associated with higher IADL scores (p = 0.035). In female (n = 31) with higher vitamin C intake scored better on HRQoL (p = 0.025). Other nutrients examined were not significantly associated with measured parameters. Conclusion: These results suggest that sufficient nutrient intake may have positive effect on AD patients’ quality of life and physical functioning. Interventions aimed at improving nutrient intakes and diet quality in older individuals with AD, are needed. Disclosure of Interest: None Declared
275 LB026-MON THE RELATIONSHIP BETWEEN 25-HYDROXYVITAMIN D AND HbA1c IN TYPE 2 DIABETES J.Y. Nam1 , S.Y. Nam2 , E. Kang3 . 1 Endocrinology and metabolism, National Health Insurance Cooperation, Ilsan Hospital, Koyang Shi, 2 Obstetrics and gynecology, Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, 3 Nephrology, National Health Insurance Cooperation, Koyang Shi, Korea, Republic Of Rationale: Vitamin D has been associated with higher risks for metabolic syndrome and type 2 diabetes. The purpose of our study is elucidate the relationship between serum 25-hydroxyvitamin D and glucose control of established type 2 diabetes. Methods: A total 86 patients with established type 2 diabetes, aged 35 77 years at baseline, with measurement for serum 25-hydroxyvitamin D were enrolled. We measured HbA1c at baseline, 1 year, 2 years and 3 years. The data were grouped according to vitamin D level <30 ng/ml (n = 33) and 30 ng/ml (n = 53). These groups were compared using student t-test. Results: 33 patients were grouped as “Vitamin D deficiency” and their mean age: 55.93±12.46 years old, mean duration: 8.67±6.65 years, HbA1c: 8.08 ±1.54%, BMI: 25.37±2.88, 25-hydroxyvitamin D concentration: 23.69±4.89 ng/ml. 53 patients were grouped as “Vitamin D sufficiency” and their mean age: 58.92±10.68 years old, mean duration: 8.76±6.96 years, HbA1c 7.64±1.10%, BMI: 24.37±3.13, 25-hydroxyvitamin D concentration: 58.75±31.04 ng/ml. Except 25-hydroxyvitamin D concentration, there were no difference between other parameters of two groups. After 1 year, Hba1c of 27 patients of Vit D deficiency group were checked: 7.95±1.25% and the other group’s: 7.67±1.35%. There were no difference between two groups. Between HbA1Cs at 2 years (8.18±1.34% & 7.18±1.40%) and 3 years (8.17±1.18% & 7.82±1.23%) we could not find any difference. Conclusion: In this study there is no difference between Vitamin D deficiency group and others with established type 2 diabetes about HbA1c at baseline and at 3 years. Disclosure of Interest: None Declared
LB027-MON THE EFFECT OF KAMPO NINJINYOEITO ON THE INDUCTION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN PRIMARY CULTURED RAT HEPATOCYTES Y. Tanaka1 , M. Kaibori1 , M. Oishi1 , H. Miki1 , K. Tokuhara1 , M. Nishizawa2 , T. Okumura1,2 , A.-H. Kwon1 . 1 Kansai Medical University, Moriguchi, 2 Ritsumeikan University, Kusatsu, Japan Rationale: A Japanese herbal medicine, kampo ninjinyoeito (NYT), has been used for the treatment of complaints in patients with general fatigue, anorexia and anemia, and has recently been applied in patients with cirrhosis. However, there is little scientific evidence to demonstrate the liver-protective effects of NYT. In the inflamed liver, proinflammatory cytokines stimulate the induction of inducible nitric oxide synthase (iNOS). Excessive amount of nitric oxide (NO) by iNOS has been
LB025-MON QUALITY OF LIFE, COGNITION AND PHYSICAL FUNCTIONING BETWEEN HIGHER AND LOWER INTAKES OF NUTRIENTS OF HOME-DWELLING OLDER AD PATIENTS S. Jyv¨ akorpi1 , T. Puranen1 , M.H. Suominen1 . 1 Society For Memory Disorders Expertise in Finland, Helsinki, Finland Rationale: Sufficient energy and nutrient intake is important in maintaining nutritional status, health and quality of life of AD patients. Aim of this study is to describe differences in quality of life, cognition and physical functioning of home dwelling AD patients between higher and lower intakes of energy, protein and other nutrients. Methods: AD patients (age <65 years) were tested for cognition (MMSE) and the spouse was questioned of AD patients’ physical functioning (IADL) and depression (Cornell). AD patients completed health related quality of life (HRQoL) form independently or assisted by spouse. The spouse filled a 3-day food diary. Nutritional intakes of energy, protein, calcium, folate, vitamin C and E were categorized into two groups using medians or RDAs for the nutrients. In female medians were used for categorizing all nutrients. In males RDAs were used for Calcium and vitamin C and medians for other nutrients. Males and females were analyzed separately. Higher and lower nutrient intake groups were compare with MMSE, Cornell, IADL, and the 15D-HRQoL scores. This data is part of a baseline data of nutritional treatment RCT Results: In male (n = 65) higher intake of protein was associated with less depression (p = 0.045) and Vitamin-E intake was positively associated with higher IADL scores (p = 0.035). In female (n = 31) with higher vitamin C intake scored better on HRQoL (p = 0.025). Other nutrients examined were not significantly associated with measured parameters. Conclusion: These results suggest that sufficient nutrient intake may have positive effect on AD patients’ quality of life and physical functioning. Interventions aimed at improving nutrient intakes and diet quality in older individuals with AD, are needed. Disclosure of Interest: None Declared
275 LB026-MON THE RELATIONSHIP BETWEEN 25-HYDROXYVITAMIN D AND HbA1c IN TYPE 2 DIABETES J.Y. Nam1 , S.Y. Nam2 , E. Kang3 . 1 Endocrinology and metabolism, National Health Insurance Cooperation, Ilsan Hospital, Koyang Shi, 2 Obstetrics and gynecology, Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, 3 Nephrology, National Health Insurance Cooperation, Koyang Shi, Korea, Republic Of Rationale: Vitamin D has been associated with higher risks for metabolic syndrome and type 2 diabetes. The purpose of our study is elucidate the relationship between serum 25-hydroxyvitamin D and glucose control of established type 2 diabetes. Methods: A total 86 patients with established type 2 diabetes, aged 35 77 years at baseline, with measurement for serum 25-hydroxyvitamin D were enrolled. We measured HbA1c at baseline, 1 year, 2 years and 3 years. The data were grouped according to vitamin D level <30 ng/ml (n = 33) and 30 ng/ml (n = 53). These groups were compared using student t-test. Results: 33 patients were grouped as “Vitamin D deficiency” and their mean age: 55.93±12.46 years old, mean duration: 8.67±6.65 years, HbA1c: 8.08 ±1.54%, BMI: 25.37±2.88, 25-hydroxyvitamin D concentration: 23.69±4.89 ng/ml. 53 patients were grouped as “Vitamin D sufficiency” and their mean age: 58.92±10.68 years old, mean duration: 8.76±6.96 years, HbA1c 7.64±1.10%, BMI: 24.37±3.13, 25-hydroxyvitamin D concentration: 58.75±31.04 ng/ml. Except 25-hydroxyvitamin D concentration, there were no difference between other parameters of two groups. After 1 year, Hba1c of 27 patients of Vit D deficiency group were checked: 7.95±1.25% and the other group’s: 7.67±1.35%. There were no difference between two groups. Between HbA1Cs at 2 years (8.18±1.34% & 7.18±1.40%) and 3 years (8.17±1.18% & 7.82±1.23%) we could not find any difference. Conclusion: In this study there is no difference between Vitamin D deficiency group and others with established type 2 diabetes about HbA1c at baseline and at 3 years. Disclosure of Interest: None Declared
LB027-MON THE EFFECT OF KAMPO NINJINYOEITO ON THE INDUCTION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN PRIMARY CULTURED RAT HEPATOCYTES Y. Tanaka1 , M. Kaibori1 , M. Oishi1 , H. Miki1 , K. Tokuhara1 , M. Nishizawa2 , T. Okumura1,2 , A.-H. Kwon1 . 1 Kansai Medical University, Moriguchi, 2 Ritsumeikan University, Kusatsu, Japan Rationale: A Japanese herbal medicine, kampo ninjinyoeito (NYT), has been used for the treatment of complaints in patients with general fatigue, anorexia and anemia, and has recently been applied in patients with cirrhosis. However, there is little scientific evidence to demonstrate the liver-protective effects of NYT. In the inflamed liver, proinflammatory cytokines stimulate the induction of inducible nitric oxide synthase (iNOS). Excessive amount of nitric oxide (NO) by iNOS has been