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Leiomyosarcoma of the Inferior Vena Cava
0022-5347 /83/1302-0401 Vol. 130 Printed in
THE JOURNAL OF UROLOGY
Copyright© 1983 by The Williams & Wilkins Co.
ABSTRACTS INFECTIONS AND ANTIBIOTICS Pharmacokinetics of Resrnrcinol in the .Rat
P. C. MERKER, D. YEUNG, D. DOUGHTY AND S. NACHT, Departments of Pharmacology and Toxicology and Dermatology Research, Vicks Research Center, Richardson- Vicks, i:':!r,ietiuti. Connecticut Res. Comm. Chem. Path. Pharm., 38: 367-388 (Dec.) 1982 Resorcinol is a phenol compound, which when used at a 2 to 20 per cent concentration in various skin preparations is as effective as an antifungal, antimicrobial and keratolytic agent. There have been scant data of this drug's metabolism and pharmacology. In this study pharmacokinetic data on resorcinol were obtained with the rat model. When the drug was administered subcutaneously in an aqueous solution it cleared the plasma within 2 hours and did not accumulate in tissues. Approximately 95 per cent of the drug was recovered in the urine, mostly as the glucuronide metabolite. There was no evidence that the drug was eliminated by the enterohepatic in the rat. When resorcinol was administered for 30 days with maximum tolerated daily doses of 100 mg./kg. no significant alterations of pharmacokinetic parameters were identified and there were no signs of toxicity or other adverse r.eactions. The animal's body weight, hematology parameters, levels of serum T3 and T4, and gross microscopic appearances of the thyroid gland and spinal cord remained within normal limits throughout the study. These data are consistent with evidence for rapid metabolism and elimination of resorcinol absorbed from the skin of man.
J.D.S. 3 figures, 4 tables, 19 references
Evaluation of the Antimicrobial Removal Device When Used With the BACTEC Blood Culture System C. L. STRAND, Department Long Memorial Hospital Georgia
Pathology, The Crawford W. Emory University, Atlanta,
Amer. J. Clin. Path., 78: 853-856 (Dec.) 1982 The presence of antibiotics in the bloodstream may interfere with attempts to perform blood cultures with the antibiotics inhibiting the growth of organisms. A suggested method to avoid this problem is the use of the antimicrobial removal device, which contains cationic and polymeric absorbent resins that can remove up to 100 mcg. antibiotics per ml. blood. The author performed parallel blood cultures using a 3-bottle radiometric blood culture system (BACTEC) alone versus samples processed first by the antimicrobial removal device and then the BACTEC system. In the course of l year 622 duplicate sets of cultures were obtained on patients with and without concurrent antibiotic When the culture results of all patients were considered the BACTEC system alone outperformed the combination of the antimicrobial removal device and BACTEC culture techniques. When only patients receiving antibiotic therapy were considered more organisms were cultured in the BACTEC system alone but the results were not statistically significant.
The use of the 3-bottle BACTEC media (aerobic, anaerobic and hypertonic tryptic soy broth) increases the yield of nn.~n,vP cultures compared to the use of only aerobic and anaerobic media. It is concluded that there is no advantage of using the antimicrobial removal device system over that of the 3-bottle BACTEC system for blood cultures. In addition, the antimicrobial removal device system requires increased costs and labor. If the antimicrobial removal device plus BACTEC systems are to be used parallel cultures are required since some organisms are cultured more easily in the blood processed without the antimicrobial removal device. J. D. S. 2 tables, 9 references
ONCOLOGY AND CHEMOTHERAPY Phase I Study of 13-cis-Retinoic Acid Toxicity
P.R. BAND, J.
R. LECLAIRE, C. GIRARD, G. DrnRm, M. GELINAS AND D. LAROCHELLE, Institut du Cancer de Montreal, Hopital Notre-Dame and of Pharmacy, University of Montreal, Quebec, Canada G. BESNER,
M. DESCHAMPS,
Cancer Treat. Rep., 66: 1759-1761 (Sept.) 1982 Retinoids (vitamin A and its analogues) are essential for the growth and differentiation of epithelial tissues, and prevent the development of some experimental tumors. Natural and synthetic retinoids can induce regression of some tumors (including bladder) in man. The authors report a phase I study to assess the maximum tolerated dose of 13-cis-retinoic acid for use as a chemopreventive. Sixteen patients with head and neck cancer were studied. Drug doses >60 mg./m. 2 induced headaches, urethritis, desquamative dermatitis, vertigo and ataxia. The severity of these effects limits the drug usefulness to doses <60 mg./m. 2 • J. H. N. l table, 11 references
Leiomyosarcoma o:f the Inferior Vena Cava
J. K PATEL AND L. S. ENGLANDER, Department New York State Department of Health, Roswell Parh Memorial Institute, Buffalo, New York J. Surg. Oncol., 21: 238-240 (Dec.) 1982 Leiomyosarcoma of the inferior vena cava is an m1-r1>111umt and fatal neoplasm that deserves some discussion. These authors have reported a case of leiomyosarcoma of the inferior vena cava in a 46-year-old man and reviewed the literature. There are 51 case reports in the literature, only 9 of which involved male patients. The middle third of the inferior vena cava between the hepatic and renal veins is the most common site of this tumor. The most common sites of distant metastases are liver and lungs. The initial presentation may include failure, hepatomegaly and edema of the extremities. vcm1µn, local resection and administration of postoperative radiotherapy constitute the best available therapy presently available. Because of the paucity of information on chemotherapy there is no effective agent or regimen. N. J. 3 figures, l table, 14 references 401
THE JOURNAL OF UROLOGY
Copyright© 1983 by The Williams & Wilkins Co.
ABSTRACTS INFECTIONS AND ANTIBIOTICS Pharmacokinetics of Resrnrcinol in the .Rat
P. C. MERKER, D. YEUNG, D. DOUGHTY AND S. NACHT, Departments of Pharmacology and Toxicology and Dermatology Research, Vicks Research Center, Richardson- Vicks, i:':!r,ietiuti. Connecticut Res. Comm. Chem. Path. Pharm., 38: 367-388 (Dec.) 1982 Resorcinol is a phenol compound, which when used at a 2 to 20 per cent concentration in various skin preparations is as effective as an antifungal, antimicrobial and keratolytic agent. There have been scant data of this drug's metabolism and pharmacology. In this study pharmacokinetic data on resorcinol were obtained with the rat model. When the drug was administered subcutaneously in an aqueous solution it cleared the plasma within 2 hours and did not accumulate in tissues. Approximately 95 per cent of the drug was recovered in the urine, mostly as the glucuronide metabolite. There was no evidence that the drug was eliminated by the enterohepatic in the rat. When resorcinol was administered for 30 days with maximum tolerated daily doses of 100 mg./kg. no significant alterations of pharmacokinetic parameters were identified and there were no signs of toxicity or other adverse r.eactions. The animal's body weight, hematology parameters, levels of serum T3 and T4, and gross microscopic appearances of the thyroid gland and spinal cord remained within normal limits throughout the study. These data are consistent with evidence for rapid metabolism and elimination of resorcinol absorbed from the skin of man.
J.D.S. 3 figures, 4 tables, 19 references
Evaluation of the Antimicrobial Removal Device When Used With the BACTEC Blood Culture System C. L. STRAND, Department Long Memorial Hospital Georgia
Pathology, The Crawford W. Emory University, Atlanta,
Amer. J. Clin. Path., 78: 853-856 (Dec.) 1982 The presence of antibiotics in the bloodstream may interfere with attempts to perform blood cultures with the antibiotics inhibiting the growth of organisms. A suggested method to avoid this problem is the use of the antimicrobial removal device, which contains cationic and polymeric absorbent resins that can remove up to 100 mcg. antibiotics per ml. blood. The author performed parallel blood cultures using a 3-bottle radiometric blood culture system (BACTEC) alone versus samples processed first by the antimicrobial removal device and then the BACTEC system. In the course of l year 622 duplicate sets of cultures were obtained on patients with and without concurrent antibiotic When the culture results of all patients were considered the BACTEC system alone outperformed the combination of the antimicrobial removal device and BACTEC culture techniques. When only patients receiving antibiotic therapy were considered more organisms were cultured in the BACTEC system alone but the results were not statistically significant.
The use of the 3-bottle BACTEC media (aerobic, anaerobic and hypertonic tryptic soy broth) increases the yield of nn.~n,vP cultures compared to the use of only aerobic and anaerobic media. It is concluded that there is no advantage of using the antimicrobial removal device system over that of the 3-bottle BACTEC system for blood cultures. In addition, the antimicrobial removal device system requires increased costs and labor. If the antimicrobial removal device plus BACTEC systems are to be used parallel cultures are required since some organisms are cultured more easily in the blood processed without the antimicrobial removal device. J. D. S. 2 tables, 9 references
ONCOLOGY AND CHEMOTHERAPY Phase I Study of 13-cis-Retinoic Acid Toxicity
P.R. BAND, J.
R. LECLAIRE, C. GIRARD, G. DrnRm, M. GELINAS AND D. LAROCHELLE, Institut du Cancer de Montreal, Hopital Notre-Dame and of Pharmacy, University of Montreal, Quebec, Canada G. BESNER,
M. DESCHAMPS,
Cancer Treat. Rep., 66: 1759-1761 (Sept.) 1982 Retinoids (vitamin A and its analogues) are essential for the growth and differentiation of epithelial tissues, and prevent the development of some experimental tumors. Natural and synthetic retinoids can induce regression of some tumors (including bladder) in man. The authors report a phase I study to assess the maximum tolerated dose of 13-cis-retinoic acid for use as a chemopreventive. Sixteen patients with head and neck cancer were studied. Drug doses >60 mg./m. 2 induced headaches, urethritis, desquamative dermatitis, vertigo and ataxia. The severity of these effects limits the drug usefulness to doses <60 mg./m. 2 • J. H. N. l table, 11 references
Leiomyosarcoma o:f the Inferior Vena Cava
J. K PATEL AND L. S. ENGLANDER, Department New York State Department of Health, Roswell Parh Memorial Institute, Buffalo, New York J. Surg. Oncol., 21: 238-240 (Dec.) 1982 Leiomyosarcoma of the inferior vena cava is an m1-r1>111umt and fatal neoplasm that deserves some discussion. These authors have reported a case of leiomyosarcoma of the inferior vena cava in a 46-year-old man and reviewed the literature. There are 51 case reports in the literature, only 9 of which involved male patients. The middle third of the inferior vena cava between the hepatic and renal veins is the most common site of this tumor. The most common sites of distant metastases are liver and lungs. The initial presentation may include failure, hepatomegaly and edema of the extremities. vcm1µn, local resection and administration of postoperative radiotherapy constitute the best available therapy presently available. Because of the paucity of information on chemotherapy there is no effective agent or regimen. N. J. 3 figures, l table, 14 references 401