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Leukemia markers
383
Leukemia Markers, edited by W. Knapp. Academic Press, London, 1981. (xv + 574 pp.) £20.-- ($48.--). This book contains the proceedings of the Leukemia Markers Conference held in Vienna in February 1981, under the sponsorship of W H O and the National Cancer Institute, Bethesda, U.S.A. The text comprises over 80 papers grouped in 9 parts devoted to the following topics: I, Differentiation markers of normal and malignant lymphoid cells;II, The nature of hairy cell leukemia cells; III, Myeloid cell surface antigens; IV, Erythroid differentiation markers; V, Animal models; VI, Cell line studies; VII, Functional activities of normal and malignant leukocyte subsets; VIII, Antibodies as therapeutic tools; IX, Clinicalrelevance of leukocyte marker studies. Characteristic for the presentations and reflecting the current trend in methodology is the prevalent use of hybridoma-secreted monoclonal antibodies specific for leukemic cell surface proteins as diagnostic reagents or, occasionally, as manipulative tools. Most of the papers in parts I through VII deal with the detection of cell-surface antigens either by indirect immunofluorescence or by immunoperoxidase staining techniques. In some cases the fluorescent antibody-stained cells are analyzed by quantitative microfluoromerry. A m o n g other marker
F. Borek Lymphocytic Regulation by Antibodies, edited by C. Bona and P.-A. Cazenave. Wiley, New York, 1981 (324 pp., illus.) £28.25. It is n o w commonly accepted by immunologists that the immune response is initiated and regulated by a complex interaction between the antigen and the lympho-reticular system of the host with the participation of lympho-
Leukemia Markers, edited by W. Knapp. Academic Press, London, 1981. (xv + 574 pp.) £20.-- ($48.--). This book contains the proceedings of the Leukemia Markers Conference held in Vienna in February 1981, under the sponsorship of W H O and the National Cancer Institute, Bethesda, U.S.A. The text comprises over 80 papers grouped in 9 parts devoted to the following topics: I, Differentiation markers of normal and malignant lymphoid cells;II, The nature of hairy cell leukemia cells; III, Myeloid cell surface antigens; IV, Erythroid differentiation markers; V, Animal models; VI, Cell line studies; VII, Functional activities of normal and malignant leukocyte subsets; VIII, Antibodies as therapeutic tools; IX, Clinicalrelevance of leukocyte marker studies. Characteristic for the presentations and reflecting the current trend in methodology is the prevalent use of hybridoma-secreted monoclonal antibodies specific for leukemic cell surface proteins as diagnostic reagents or, occasionally, as manipulative tools. Most of the papers in parts I through VII deal with the detection of cell-surface antigens either by indirect immunofluorescence or by immunoperoxidase staining techniques. In some cases the fluorescent antibody-stained cells are analyzed by quantitative microfluoromerry. A m o n g other marker
F. Borek Lymphocytic Regulation by Antibodies, edited by C. Bona and P.-A. Cazenave. Wiley, New York, 1981 (324 pp., illus.) £28.25. It is n o w commonly accepted by immunologists that the immune response is initiated and regulated by a complex interaction between the antigen and the lympho-reticular system of the host with the participation of lympho-